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Showing 31-60 of 2408 results for "H6167" within Papers
Xiaofen Wu et al.
Heart and vessels, 30(1), 108-114 (2014-01-21)
Acute coronary syndrome is a serious medical emergency. It occurs when an atherosclerotic plaque ruptures, leading to thrombus formation within a coronary artery. Previous studies have shown that T cells are involved in the initiation and progression of acute coronary
Oana Herlea-Pana et al.
Cardiovascular research, 106(2), 324-337 (2015-03-15)
Atherosclerosis manifests itself as arterial plaques, which lead to heart attacks or stroke. Treatments supporting plaque regression are therefore aggressively pursued. Studies conducted in models in which hypercholesterolaemia is reversible, such as the Reversa mouse model we have employed in
Jaime Uribarri et al.
The Journal of clinical endocrinology and metabolism, 100(5), 1957-1966 (2015-02-20)
Although obesity can predispose to the metabolic syndrome (MS), diabetes, and cardiovascular disease, not all obese subjects develop MS, hence the need for new indicators of risk for this syndrome. Advanced glycation end products (AGEs) correlate with factors involved in
Daniel I Swerdlow et al.
Lancet (London, England), 385(9965), 351-361 (2014-09-30)
Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR
Yan Zhao et al.
Biomaterials, 68, 54-66 (2015-08-13)
Lipid-calcium-phosphate nanoparticle (NP) delivery of Trp2 peptide vaccine is one of the most effective vaccine strategies against melanoma. However, due to the immunosuppressive microenvironment in the tumor, the achievement of potent immune responses remains a major challenge. NP delivery systems
Erik van Kampen et al.
Journal of leukocyte biology, 96(5), 833-841 (2014-07-16)
Alterations in DNA methylation patterns in peripheral blood leukocytes precede atherosclerotic lesion development in mouse models of atherosclerosis and have been linked to cardiovascular death in patients. The aim of this study is to investigate the long-term changes induced by
Siwei Zhang et al.
International journal of clinical and experimental medicine, 8(4), 6388-6396 (2015-07-02)
The present study aims to study the possible renal protective effect of simvastatin in the development and progression of type 2 diabetic nephropathy. A rat model of T2DN was induced by high-fat diet together with single low-dose of streptozotocin. The
Jung Eun Kim et al.
The American journal of clinical nutrition, 102(1), 75-83 (2015-05-29)
Dietary lipids are one of the most effective stimulators of carotenoid absorption, but very limited data exist on the impact of endogenous food sources of lipids to enhance carotenoid absorption. The co-consumption of whole egg with carotenoid-rich foods may increase
Pinkesh G Sutariya et al.
Talanta, 147, 590-597 (2015-11-26)
A new, simple, ultra-sensitive and selective approach has been reported for the "on spot" colorimetric detection of creatinine based on calix[4]arene functionalized gold nanoparticles (AuNPs) with excellent discrimination in the presence of other biomolecules. The lower detection limit of the
Lina Ma et al.
Yonsei medical journal, 56(1), 89-94 (2014-12-17)
Insulin resistance plays a role in the development of dementia and hypertension. We investigated a possible relationship between cognitive impairment and insulin resistance in elderly Chinese patients with primary hypertension. One hundred and thirty-two hypertensive elderly patients (>60 years) were
Godofredo Bautista et al.
Biophysical journal, 107(10), 2230-2236 (2014-11-25)
Cells store excess lipids as two major compounds, triacylglycerols (TAGs) and cholesteryl esters (CEs), inside lipid droplets (LDs). The degree of lipid ordering is considered to play a major role in the mobility and enzymatic processing of lipids in LDs.
Khushbu K Modi et al.
PloS one, 10(6), e0130398-e0130398 (2015-06-24)
This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in attenuating oxidative stress and protecting memory and learning in an animal model of Alzheimer's disease (AD). NaB, but
Malaina Gaddis et al.
Epigenetics & chromatin, 8, 9-9 (2015-07-21)
Due to the hyper-activation of WNT signaling in a variety of cancer types, there has been a strong drive to develop pathway-specific inhibitors with the eventual goal of providing a chemotherapeutic antagonist of WNT signaling to cancer patients. A new
Eun-Kyung Shin et al.
Theriogenology, 84(2), 252-260 (2015-04-16)
We determined the relationships among ketosis, serum metabolites, body condition, and reproductive disorders and performance in dairy cows. Blood samples from 213 dairy cows were collected at 4 and 2 weeks prepartum, just after calving, and at 1, 2, 4
Vladimiro Cardenia et al.
Steroids, 99(Pt B), 161-171 (2015-04-08)
Cholesterol oxidation in food and model systems is usually monitored by evaluating cholesterol oxidation products, but the analysis is time-consuming and expensive. Therefore, the determination of volatile compounds deriving from cholesterol thermoxidation could be valuable to identify other possible oxidation
Ryan M Sheehy et al.
Cancer biology & therapy, 16(8), 1259-1268 (2015-06-06)
Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein (Pgp), in a manner analogous to other natural products, might enhance schweinfurthins' growth inhibitory actions by increasing intracellular
Shozo Sonoda et al.
Current eye research, 39(12), 1200-1206 (2014-10-14)
To see the relationship between blood components and optical coherence tomography (OCT) reflectivity using an animal model in which the aqueous humor was substituted by different experimental solutions without changing the integrity of the retina. The aqueous humor of an
Lenka Novakova et al.
Journal of the neurological sciences, 358(1-2), 201-206 (2015-09-08)
Natalizumab therapy reduces inflammation and degeneration of the CNS in relapsing-remitting multiple sclerosis (RRMS). In cerebrospinal fluid (CSF) the concentration of 24S-hydroxycholesterol (24OHC) reflect neurodegeneration, whereas 27-hydroxycholesterol (27OHC) is dependent on the integrity of the blood-brain barrier (BBB). To measure
Ryuji Kato et al.
European journal of pharmacology, 765, 7-14 (2015-08-16)
Ezetimibe is as an inhibitor of NPC1L1 protein, which has a key role in cholesterol absorption. The aim of this study was to evaluate the influence of ezetimibe on the plasma lipid profile, atherosclerotic lesions, and cardiomyocyte ultrastructure in an
Isabelle Herter-Aeberli et al.
The Journal of nutrition, 145(9), 2067-2075 (2015-07-24)
In iodine deficiency, thyrotropin (TSH) may increase to stimulate thyroidal iodine uptake. In iodine-sufficient populations, higher TSH predicts higher total cholesterol. Whether higher TSH caused by iodine deficiency affects serum lipids is uncertain. Our aim was to determine if iodine
Min Xu et al.
The Journal of nutrition, 145(6), 1289-1294 (2015-05-01)
Hepatic lipase (HL) plays a pivotal role in the metabolism of HDL and LDL. Recent genome-wide association studies have identified common variants in the HL gene (LIPC) associated with HDL cholesterol. We tested the effect of a common variant in
Zhi H Huang et al.
Journal of lipid research, 56(2), 215-226 (2014-11-26)
apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate
Alice Verchère et al.
Nature communications, 6, 6890-6890 (2015-04-23)
Antibiotic resistance is a major public health issue and many bacteria responsible for human infections have now developed a variety of antibiotic resistance mechanisms. For instance, Pseudomonas aeruginosa, a disease-causing Gram-negative bacteria, is now resistant to almost every class of
Masahiko Yamaguchi et al.
Biochemical pharmacology, 93(4), 482-495 (2015-01-13)
Platelet-activating factor (PAF) is a well-known phospholipid that mediates acute inflammatory responses. In the present study, we investigated whether PAF/PAF receptor signaling contributed to chronic inflammation in the white adipose tissue (WAT) of PAF receptor-knockout (PAFR-KO) mice. Body and epididymal
Martin Rudolf et al.
Investigative ophthalmology & visual science, 55(8), 4759-4767 (2014-07-06)
To investigate the effects of Bruch's membrane (BrM) neutral lipid deposition in mouse models and its significance to aging and age-related macular degeneration, it is essential to reliably detect small quantities of neutral lipids including esterified cholesterol (EC). In chorioretinal
Changting Xiao et al.
Diabetes, 63(7), 2394-2401 (2014-03-04)
The dipeptidyl peptidase-4 inhibitor sitagliptin, an antidiabetic agent, which lowers blood glucose levels, also reduces postprandial lipid excursion after a mixed meal. The underlying mechanism of this effect, however, is not clear. This study examined the production and clearance of
Seth G Thacker et al.
Journal of lipid research, 56(7), 1282-1295 (2015-05-13)
LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results. To gain insight into LCAT and the role of free cholesterol (FC) in atherosclerosis, we examined
Qiyan Xiong et al.
Vaccine, 32(27), 3445-3451 (2014-04-16)
Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after
John Munkhaugen et al.
Scandinavian cardiovascular journal : SCJ, 50(1), 1-8 (2015-10-22)
This project aims to identify socio-demographic, medical and psychosocial factors (study factors) associated with coronary risk control and prognosis, and to test their impact in a representative sample of coronary heart disease (CHD) patients. The first phase includes a cross-sectional
Genovefa Kolovou et al.
Genetics and molecular biology, 38(2), 129-137 (2015-08-15)
In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who
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