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Showing 1-30 of 250 results for "H7750" within Papers
Bettina Krieg et al.
Pharmaceutical research, 32(6), 1957-1974 (2014-12-10)
Release of siRNA from nanoscale polyplexes is a crucial yet little investigated process, important during all stages of therapeutic research. Here we develop new methods to characterize polyplex stability early on in the development of new materials. We used double
Matej Zábrady et al.
PloS one, 9(10), e109875-e109875 (2014-10-10)
With the growing availability of genomic sequence information, there is an increasing need for gene function analysis. Antibody-mediated "silencing" represents an intriguing alternative for the precise inhibition of a particular function of biomolecules. Here, we describe a method for selecting
Neha Sawhney et al.
Applied and environmental microbiology, 80(19), 6114-6125 (2014-07-27)
Methylglucuronoarabinoxylan (MeGAXn) from agricultural residues and energy crops is a significant yet underutilized biomass resource for production of biofuels and chemicals. Mild thermochemical pretreatment of bagasse yields MeGAXn requiring saccharifying enzymes for conversion to fermentable sugars. A xylanolytic bacterium, Paenibacillus
Penny Beckerson et al.
The Biochemical journal, 465(1), 127-137 (2014-10-21)
Cytoglobin (Cygb) is a hexa-co-ordinate haem protein from the globin superfamily with a physiological function that is unclear. We have previously reported that the haem co-ordination is changed in the presence of lipids, potentially transforming the redox properties of the
Xiao-Li Feng et al.
Protein and peptide letters, 22(2), 193-201 (2014-10-30)
Gastric cancer is a major cause of mortality and morbidity around world. However the effectiveness of the current approaches to the diagnosis and treatment of gastric cancer is limited. Recombinant targeted toxins may represent a novel direction of cancer therapy.
Maria Diaz et al.
International journal of food microbiology, 215, 117-123 (2015-09-24)
In food, the biogenic amine (BA) histamine is mainly produced by histidine decarboxylation catalysed by microbial histidine decarboxylase. The consumption of foods containing high concentrations of histamine can trigger adverse neurological, gastrointestinal and respiratory reactions. Indeed, histamine is one of
Zhen Zeng et al.
Food chemistry, 188, 591-595 (2015-06-05)
The formation of 2-vinylfuran from the corresponding 4-oxo-2-hexenal (OHE, a lipid oxidation product) under the catalysis of amino acid were studied. The effects of amino acids, reaction temperature, reaction time, water content, pH, metallic ions and some food additives on
Wenwen Du et al.
Molecular pharmaceutics, 12(5), 1467-1476 (2015-03-27)
Although transferrin receptor (TfR) is widely accepted as a target for cancer therapy, few studies have elaborated on delivery efficiency of TfR upon interactions with TfR-targeted nanomedicine. Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the
Lin Yu et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 24(7), 1158-1164 (2014-07-06)
Ovarian cancer is 1 kind of a highly malignant gynecologic tumor, and current treatments have not achieved satisfactory effects. Human epidermal growth factor receptor 2 (HER2)-targeted therapies including trastuzumab and trastuzumab-DM1 (T-DM1) (antibody-cytotoxic drug conjugates) have been applied to treat
Daniele Lettieri Barbato et al.
Scientific reports, 5, 13091-13091 (2015-08-12)
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione
Alexandra S Burk et al.
Scientific reports, 5, 9370-9370 (2015-04-01)
Using planar lipid membranes with precisely defined concentrations of specific ligands, we have determined the binding strength between human hematopoietic stem cells (HSC) and the bone marrow niche. The relative significance of HSC adhesion to the surrogate niche models via
Li Feng et al.
Oncotarget, 6(36), 39151-39164 (2015-10-17)
MicroRNAs (miRNAs) regulate disease-relevant metabolic pathways. However, most current pathway identification methods fail to consider miRNAs in addition to genes when analyzing pathways. We developed a powerful method called Subpathway-GMir to construct miRNA-regulated metabolic pathways and to identify miRNA-mediated subpathways
Galit Katsir et al.
BMC microbiology, 15, 174-174 (2015-08-27)
The Escherichia coli response regulator NarL controls transcription of genes involved in nitrate respiration during anaerobiosis. NarL consists of two domains joined by a linker that wraps around the interdomain interface. Phosphorylation of the NarL N-terminal receiver domain (RD) releases
Yuanjiao Feng et al.
Talanta, 140, 128-133 (2015-06-07)
Herein, an innovative and simple method for synthesizing carbon dots (CDs) with satisfactory fluorescence has been successfully established while rose flowers served as carbon source for the first time. Meanwhile, the fluorescence (FL) mechanism of current CDs was elucidated in
Prevalence and Characterization of High Histamine-Producing Bacteria in Gulf of Mexico Fish Species.
Kristin Bjornsdottir-Butler et al.
Journal of food protection, 78(7), 1335-1342 (2015-07-22)
Recent developments in detection and enumeration of histamine-producing bacteria (HPB) have created powerful molecular-based tools to better understand the presence of spoilage bacteria and conditions, resulting in increased risk of scombrotoxin fish poisoning. We examined 235 scombrotoxin-forming fish from the
Yongdae Shin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(29), E3826-E3835 (2015-07-08)
Kinesin-8s are plus-end-directed motors that negatively regulate microtubule (MT) length. Well-characterized members of this subfamily (Kip3, Kif18A) exhibit two important properties: (i) They are "ultraprocessive," a feature enabled by a second MT-binding site that tethers the motors to a MT
Michael Hinneh et al.
Food research international (Ottawa, Ont.), 111, 607-620 (2018-07-17)
The practice of pod storage (PS) has been applied in many cocoa producing countries, especially by Ghanaian farmers over the years. However, the study of PS has not received much attention, hence, until now, its potential impact on specific flavor
Total inhibition of (1)O2-induced oxidative damage to guanine bases of DNA/RNA by turmeric extracts.
Prakash C Joshi et al.
Biochemical and biophysical research communications, 452(3), 515-519 (2014-09-03)
The guanine base of nucleic acids is known to be very reactive towards degradation by (1)O2-induced oxidative stress. Oxidative reactions of DNA are linked to many human diseases including cancer. Among the various forms of reactive O2 species (OH, (1)O2
Christine E Engeland et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1949-1959 (2014-08-27)
We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and
Neha Khandelwal et al.
Colloids and surfaces. B, Biointerfaces, 130, 84-92 (2015-04-25)
Recombinant expression of Capsicum annuum proteinase inhibitors (CanPI-13) and its application via synthetic carrier for the crop protection is the prime objective of our study. Herein, we explored proteinase inhibitor peptide immobilization on silica based nanospheres and rods followed by
Eva M Fernandez et al.
PloS one, 10(1), e0117206-e0117206 (2015-01-23)
Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation. The family of Brain Expressed and X-linked (Bex) proteins consists of 5
Vivian T Martins et al.
Parasites & vectors, 8, 363-363 (2015-07-15)
LiHyV is an antigenic hypothetical protein present in both promastigote and amastigote stages of Leishmania infantum, which was recently identified by an immunoproteomic approach. A recombinant version of this protein (rLiHyV) was evaluated as a diagnostic marker for canine VL
Patrick Lugenbiel et al.
PloS one, 10(3), e0116395-e0116395 (2015-03-17)
Atrial fibrillation (AF) and heart failure (HF) are two of the most common cardiovascular diseases. They often coexist and account for significant morbidity and mortality. Alterations in cellular Ca2+ homeostasis play a critical role in AF initiation and maintenance. This
Anna-Lena Henche et al.
Extremophiles : life under extreme conditions, 18(5), 905-913 (2014-08-12)
In Archaea, type IV prepilins and prearchaellins are processed by designated signal peptidase III (SPaseIII) prior to their incorporation into pili and the archaellum, respectively. These peptidases belong to the family of integral membrane aspartic acid proteases that contain two
W Ma et al.
Fungal genetics and biology : FG & B, 79, 94-101 (2015-06-21)
Pathogenic fungi are constantly emerging resistance to anti-fungal treatments. Therefore, identification of new fungicide targets is important. Good candidates are essential fungal proteins and their regulators. An efficient way to reveal the molecular environment of an essential protein is the
Ramreddy Tippana et al.
Nucleic acids research, 42(12), 8106-8114 (2014-06-13)
The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a quantitative analysis on the conformations and
Nicole C Gossan et al.
Nucleic acids research, 42(9), 5765-5775 (2014-04-15)
Post-translational modifications (such as ubiquitination) of clock proteins are critical in maintaining the precision and robustness of the evolutionarily conserved circadian clock. Ubiquitination of the core clock transcription factor BMAL1 (brain and muscle Arnt-like 1) has recently been reported. However
P Krumpochova et al.
Journal of pharmaceutical and biomedical analysis, 114, 398-407 (2015-06-27)
The analysis of amino acids has become a central task in many aspects. While amino acid analysis has traditionally mainly been carried out using either gas chromatography (GC) in combination with flame ionization detection or liquid chromatography (LC) with either
Carole Laffont et al.
PloS one, 10(1), e0116819-e0116819 (2015-01-07)
Cytokinins are phytohormones that regulate many developmental and environmental responses. The Medicago truncatula cytokinin receptor MtCRE1 (Cytokinin Response 1) is required for the nitrogen-fixing symbiosis with rhizobia. As several cytokinin signaling genes are modulated in roots depending on different biotic
Vladimir Mishin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 344-352 (2014-07-26)
Microsomal enzymes generate H2O2 in the presence of NADPH. In this reaction, referred to as "oxidase" activity, H2O2 is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H2O2 can form
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