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Showing 1-30 of 488 results for "H8627" within Papers
Alberto Alvarez-Larrán et al.
Annals of hematology, 93(12), 2037-2043 (2014-07-02)
Therapeutic options for patients with polycythemia vera (PV) and essential thrombocythemia (ET) resistant or intolerant to hydroxyurea are limited. Busulfan is effective as first-line therapy, but there is scarce information on this drug as second-line treatment. The efficacy of busulfan
Qin Xiao et al.
Insects, 12(12) (2021-12-24)
Understanding virus-host interaction is very important for delineating the mechanism involved in viral replication and host resistance. Baculovirus, an insect virus, can cause S or G2/M phase arrest in insect cells. However, the roles and mechanism of Baculovirus-mediated S or
Gergana Popova et al.
Journal of medicinal chemistry, 63(8), 3915-3934 (2020-03-28)
Human dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo pyrimidine synthesis pathway, is a target for the treatment of rheumatoid arthritis and multiple sclerosis and is re-emerging as an attractive target for cancer therapy. Here we describe the optimization
The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, et al.
Molecular Cell, 82, 3350-3365 (2022)
Jessica S Williams et al.
Methods in molecular biology (Clifton, N.J.), 1703, 241-257 (2017-11-28)
Ribonucleotides incorporated into DNA by the DNA polymerases can be incised by Topoisomerase 1 (Top1) to initiate removal of ribonucleotides from the genome. This Top1-dependent ribonucleotide removal has been demonstrated to result in multiple forms of genome instability in yeast.
Naseema Gangat et al.
European journal of haematology, 94(1), 31-36 (2014-06-04)
Vascular events in essential thrombocythemia (ET) are associated with advanced age and thrombosis history. Recent information suggests additional effect from the presence of specific mutations. To examine the influence of age and thrombosis history on the reported association between mutational
The utility of tetraspanin CD9 as a biomarker for metastatic clear cell renal cell carcinoma
Garner JM, et al.
Biochemical and Biophysical Research Communications, 471(1), 21-25 (2016)
Osama M Ahmed et al.
Cell reports, 27(9), 2527-2536 (2019-05-30)
Genetically wired neural mechanisms inhibit mating between species because even naive animals rarely mate with other species. These mechanisms can evolve through changes in expression or function of key genes in sensory pathways or central circuits. Gr32a is a gustatory
Sema Oncel et al.
Cells, 10(4) (2021-05-01)
Nonsteroidal anti-inflammatory drugs cause gastric ulcers and gastritis. No drug that treats GI injury directly stimulates mucosal healing. ZINC40099027 (ZN27) activates focal adhesion kinase (FAK) and heals acute indomethacin-induced small bowel injury. We investigated the efficacy of ZN27 in rat
The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.
Miller, et al.
Cell Reports, 42, 112264-112264 (2023)
Nina Saban et al.
Cancer chemotherapy and pharmacology, 64(2), 213-221 (2009-04-08)
Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main
Douglas R Mackay et al.
Molecular biology of the cell, 26(12), 2217-2226 (2015-04-24)
Aurora B regulates cytokinesis timing and plays a central role in the abscission checkpoint. Cellular events monitored by this checkpoint are beginning to be elucidated, yet signaling pathways upstream of Aurora B in this context remain poorly understood. Here we
Zhao Wei et al.
Free radical biology & medicine, 79, 1-13 (2014-12-03)
Tumor suppressor p53 is known to regulate the level of intracellular reactive oxygen species (ROS). It can either alleviate oxidative stress under physiological and mildly stressed conditions or exacerbate oxidative stress under highly stressed conditions. We here report that a
Jiaxing Sun et al.
Cell death discovery, 9(1), 49-49 (2023-02-08)
Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase 4 (PLK4) and targets mitosis. In this study, we aim
H Jia et al.
Oncogene, 34(27), 3568-3581 (2014-09-10)
The DNA damage response (DDR) helps to maintain genome integrity, suppress tumorigenesis and mediate the radiotherapeutic and chemotherapeutic effects on cancer. Here we report that p57Kip2, a cyclin-dependent kinase (CDK) inhibitor implicated in the development of tumor-prone Beckwith-Wiedemann syndrome, is
Flavia Rubia Pallis et al.
British journal of haematology, 164(2), 286-295 (2014-01-05)
Inflammation, leucocyte and red cell adhesion to the endothelium contribute to the pathogenesis of sickle cell anaemia. Neutrophils appear to be important for vaso-occlusion, however, eosinophils may also participate in this phenomenon. The role of eosinophils in the pathophysiology of
Miriam Schonbrun et al.
Molecular and cellular biology, 29(16), 4584-4594 (2009-06-24)
The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related kinases (PIKKs). TOR proteins are found at the core of two distinct evolutionarily conserved complexes, TORC1 and TORC2. Disruption of TORC1 or TORC2 results in
Paula A Agudelo Garcia et al.
The Journal of biological chemistry, 295(25), 8363-8373 (2020-05-06)
The replisome is a protein complex on the DNA replication fork and functions in a dynamic environment at the intersection of parental and nascent chromatin. Parental nucleosomes are disrupted in front of the replication fork. The daughter DNA duplexes are
Choon-Ho Park et al.
Biochimica et biophysica acta, 1853(7), 1738-1748 (2015-04-23)
Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity. Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports
Marvin van Toorn et al.
Molecular cell, 82(7), 1343-1358 (2022-03-11)
Nucleotide excision repair (NER) counteracts the onset of cancer and aging by removing helix-distorting DNA lesions via a "cut-and-patch"-type reaction. The regulatory mechanisms that drive NER through its successive damage recognition, verification, incision, and gap restoration reaction steps remain elusive.
Nabil Matmati et al.
The Journal of biological chemistry, 288(24), 17272-17284 (2013-04-27)
Recent studies showed that deletion of ISC1, the yeast homologue of the mammalian neutral sphingomyelinase, resulted in an increased sensitivity to hydroxyurea (HU). This raised an intriguing question as to whether sphingolipids are involved in pathways initiated by HU. In
Marzia Rizzo et al.
PLoS genetics, 18(12), e1010576-e1010576 (2022-12-28)
A delicate balance between genome stability and instability ensures genome integrity while generating genetic diversity, a critical step for evolution. Indeed, while excessive genome instability is harmful, moderated genome instability can drive adaptation to novel environments by maximising genetic variation.
Deyun He et al.
iScience, 25(5), 104313-104313 (2022-05-24)
A genome-wide analysis in Schizosaccharomyces pombe indicated that double-deletion mutants of Chl1 and histone H3K9 methyltransferase complex factors are synthetically sick. Here, we show that loss of Chl1 increases the accumulation of RNA-DNA hybrids at pericentromeric dg and dh repeats
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Jana Peremartí et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(1), 93-104 (2014-08-06)
Chronic arsenic exposure is known to enhance the genotoxicity/carcinogenicity of other DNA-damaging agents by inhibiting DNA repair activities. Interference with nucleotide excision repair and base excision repair are well documented, but interactions with other DNA repair pathways are poorly explored
Hydroxyurea-induced leg ulceration in a patient with a homozygous MTHFR polymorphism misdiagnosed as pyoderma gangrenosum.
Sunita C Crittenden et al.
JAMA dermatology, 150(7), 780-781 (2014-03-07)
Gui-Zhen Wang et al.
Cancer science, 106(7), 902-908 (2015-04-22)
The Fanconi anemia (FA) pathway plays a key role in interstrand crosslink (ICL) repair and maintenance of the genomic stability, while inhibition of this pathway may sensitize cancer cells to DNA ICL agents and ionizing radiation (IR). The active FA
Benjamin D Landry et al.
The EMBO journal, 33(9), 1044-1060 (2014-04-10)
To maintain genome stability, regulators of chromosome segregation must be expressed in coordination with mitotic events. Expression of these late cell cycle genes is regulated by cyclin-dependent kinase (Cdk1), which phosphorylates a network of conserved transcription factors (TFs). However, the
Victoria Heymans et al.
Molecules (Basel, Switzerland), 26(21) (2021-11-14)
Prooxidative therapy is a well-established concept in infectiology and parasitology, in which prooxidative drugs like artemisinin and metronidazole play a pivotal clinical role. Theoretical considerations and earlier studies have indicated that prooxidative therapy might also represent a promising strategy in
Ali Khalaj et al.
Bioorganic & medicinal chemistry letters, 16(23), 6034-6038 (2006-09-23)
Two novel dual functional agents, 3[3-(2,4-dinitro-phenylamino)-propyl]-5-fluoro-1H-pyrimidine-2,4-dione 7 and N-[3-(2,4-dinitro-phenylamino)-propoxy]urea 8, resulting from linkage of 2,4-dinitrophenylamine through three carbon atoms with 5-fluorouracil 5 and hydroxyurea 6, respectively, were prepared and their in vitro aerobic cytotoxicities in HT-29 cell line with and
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