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Showing 1-30 of 889 results for "H9658" within Papers
Xiaobo Lei et al.
Nature communications, 11(1), 3810-3810 (2020-08-01)
The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood. Here we show that SARS-CoV-2 induces overt but delayed type-I
Mao-Tian Zhou et al.
Molecular & cellular proteomics : MCP, 14(9), 2535-2549 (2015-07-01)
Compared with whole-cell proteomic analysis, subcellular proteomic analysis is advantageous not only for the increased coverage of low abundance proteins but also for generating organelle-specific data containing information regarding dynamic protein movement. In the present study, peroxisome-enriched fractions from Sendai
Yi-Ting Wang et al.
Cell reports, 38(8), 110354-110354 (2022-02-24)
Excessive generation and accumulation of highly reactive oxidizing molecules causes oxidative stress and oxidative damage to cellular components. Accumulating evidence indicates that autophagy diminishes oxidative damage in cells and maintains redox homeostasis by degrading and recycling intracellular damaged components. Here
Jiwei Liu et al.
EMBO reports, 21(2), e48597-e48597 (2019-12-14)
Histone lysine demethylase 1 (LSD1), the first identified histone demethylase, is overexpressed in multiple tumor types, including breast cancer. However, the mechanisms that cause LSD1 dysregulation in breast cancer remain largely unclear. Here, we report that protein arginine methyltransferase 4
Matthew E Randolph et al.
iScience, 27(2), 108925-108925 (2024-02-07)
We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR).
Andriana Margariti et al.
Journal of cell science, 122(Pt 4), 460-470 (2009-01-29)
Histone deacetylases (HDACs) have a central role in the regulation of gene expression. Here we investigated whether HDAC7 has an impact on embryonic stem (ES) cell differentiation into smooth muscle cells (SMCs). ES cells were seeded on collagen-IV-coated flasks and
Pankaj Lamba et al.
Molecular endocrinology (Baltimore, Md.), 23(7), 1001-1013 (2009-03-28)
Selective synthesis and release of FSH from pituitary gonadotropes is regulated by activins. Activins directly stimulate murine FSHbeta (Fshb) subunit gene transcription through a consensus 8-bp Sma- and Mad-related protein-binding element (SBE) in the proximal promoter. In contrast, the human
Sian Bailey et al.
Biochimica et biophysica acta. Biomembranes, 1861(5), 997-1003 (2019-03-04)
Corticotrophin releasing factor (CRF) acts via two family B G-protein-coupled receptors, CRFR1 and CRFR2. Additional subtypes exist due to alternative splicing. CRFR1α is the most widely expressed subtype and lacks a 29-residue insert in the first intracellular loop that is
Yapeng Ji et al.
Nature communications, 8, 15308-15308 (2017-05-19)
Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for colorectal cancer (CRC) patients with poor prognosis and relapse. However, the context-dependent metabolic traits of CRCSCs remain poorly elucidated. Here we report that
Benjamin M Schwenk et al.
The EMBO journal, 35(21), 2350-2370 (2016-11-04)
Nuclear clearance of TDP-43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP-43 knockdown specifically reduces the number and motility
Emilie Brûlé et al.
Science advances, 7(51), eabl4391-eabl4391 (2021-12-16)
Follicle-stimulating hormone (FSH), a key regulator of ovarian function, is often used in infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells. The TGFβ type III receptor, betaglycan, is required for inhibin A suppression of FSH. The inhibin
Andree Schmidt et al.
The Journal of clinical investigation, 134(16) (2024-06-18)
The β-secretase β-site APP cleaving enzyme (BACE1) is a central drug target for Alzheimer's disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet little is known about physiological BACE2 substrates and functions in vivo. Here, we identify
Xuejuan Gao et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 94(3), 256-264 (2016-05-25)
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is a highly promising therapeutic agent for cancer treatment, owing to its ability to selectively target tumor cells for cell death while having little effect on most normal cells. However, recent research has
Xiao Liu et al.
The Journal of allergy and clinical immunology, 140(4), 1054-1067 (2017-02-22)
The Nod-like receptor NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK) are protagonists in innate and adaptive immunity, respectively. NLRP3 senses exogenous and endogenous insults, leading to inflammasome activation, which occurs spontaneously in patients with
Juliet Morrison et al.
PLoS pathogens, 9(3), e1003265-e1003265 (2013-04-05)
An estimated 50 million dengue virus (DENV) infections occur annually and more than forty percent of the human population is currently at risk of developing dengue fever (DF) or dengue hemorrhagic fever (DHF). Despite the prevalence and potential severity of
Marina Garcia-Jove Navarro et al.
PloS one, 8(8), e71443-e71443 (2013-08-14)
The E2f transcription factor family has a pivotal role in controlling the cell fate in general, and in particular cancer development, by regulating the expression of several genes required for S phase entry and progression through the cell cycle. It
Yingzhou Edward Pan et al.
Journal of neurochemistry, 157(4), 1331-1350 (2020-10-23)
Mutations in the X-linked gene coding for the calcium-/calmodulin-dependent serine protein kinase (CASK) are associated with severe neurological disorders ranging from intellectual disability (in males) to mental retardation and microcephaly with pontine and cerebellar hypoplasia. CASK is involved in transcription
Hamze Beati et al.
The Journal of cell biology, 217(3), 1079-1095 (2018-01-24)
In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation
Lan Wang et al.
International journal of molecular sciences, 23(24) (2022-12-24)
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase 3 (TRIB3), a well-known stress
Ning Huang et al.
Current biology : CB, 31(14), 3098-3114 (2021-06-05)
Mitochondria supply adenosine triphosphate (ATP) essential for neuronal survival and regeneration. Brain injury and ischemia trigger acute mitochondrial damage and a local energy crisis, leading to degeneration. Boosting local ATP supply in injured axons is thus critical to meet increased
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory
Cohen SM, et al.
Nature Communications, 9(1), 2451-2451 (2018)
Kristin Franke et al.
The EMBO journal, 31(13), 2908-2921 (2012-05-17)
The small GTPase RhoG plays a central role in actin remodelling during diverse biological processes such as neurite outgrowth, cell migration, phagocytosis of apoptotic cells, and the invasion of pathogenic bacteria. Although it is known that RhoG stimulates neurite outgrowth
Zhongyu Wu et al.
International journal of molecular sciences, 23(9) (2022-05-15)
RNA polymerase III (Pol III) products play essential roles in ribosome assembly, protein synthesis, and cell survival. Deregulation of Pol-III-directed transcription is closely associated with tumorigenesis. However, the regulatory pathways or factors controlling Pol-III-directed transcription remain to be investigated. In
A Vines et al.
Journal of virology, 72(9), 7626-7631 (1998-08-08)
Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza viruses do not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino
Chuang Lyu et al.
International journal of molecular sciences, 21(9) (2020-05-06)
Bcl2-associated athanogene (BAG) 3, which is a chaperone-mediated selective autophagy protein, plays a pivotal role in modulating the life cycle of a wide variety of viruses. Both positive and negative modulations of viruses by BAG3 were reported. However, the effects
Shan Meltzer et al.
Neuron, 111(11), 1776-1794 (2023-04-08)
Light touch sensation begins with activation of low-threshold mechanoreceptor (LTMR) endings in the skin and propagation of their signals to the spinal cord and brainstem. We found that the clustered protocadherin gamma (Pcdhg) gene locus, which encodes 22 cell-surface homophilic
Abdalla Akef et al.
Nucleus (Austin, Tex.), 4(4), 326-340 (2013-08-13)
In vertebrates, the majority of mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain RNA elements that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that mRNAs containing ALREX-promoting elements are trafficked through nuclear speckles. Although ALREX-promoting
Lindsay M Angus et al.
American journal of physiology. Cell physiology, 289(4), C908-C917 (2005-06-03)
We examined whether calcineurin-NFAT (nuclear factors of activated T cells) signaling plays a role in specifically directing the expression of utrophin in the synaptic compartment of muscle fibers. Immunofluorescence experiments revealed the accumulation of components of the calcineurin-NFAT signaling cascade
Sarah T Bauer et al.
The Journal of eukaryotic microbiology, 64(1), 97-105 (2016-06-25)
Trypanosoma brucei is the causative agent of diseases that affect 30,000-50,000 people annually. Trypanosoma brucei harbors unique organelles named glycosomes that are essential to parasite survival, which requires growth under fluctuating environmental conditions. The mechanisms that govern the biogenesis of
Hagar Tadmor et al.
Journal of virology, 94(5) (2019-12-06)
The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) protein functions in latently infected cells as an essential participant in KSHV genome replication and as a driver of dysregulated cell growth. In a previous study, we have identified LANA-interacting proteins
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