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Showing 1-30 of 858 results for "H9658" within Papers
Qi Yang et al.
Virologica Sinica, 34(5), 521-537 (2019-06-05)
The phosphatidylserine-specific phospholipase A1 (PLA1A) is an essential host factor in hepatitis C virus (HCV) assembly. In this study, we mapped the E2, NS2 and NS5A involved in PLA1A interaction to their lumenal domains and membranous parts, through which they
Rasmi Rekha Mishra et al.
PloS one, 6(12), e28433-e28433 (2011-12-14)
Alternative splicing of mRNAs is known to involve a major regulation of gene expression at RNA level in mammalian cells. The PTEN (Phosphatase and TENsin homologue deleted from the human chromosome 10), TPTE (Transmembrane Phosphatase with TEnsin homology) and TPIP
Nawneet Mishra et al.
Journal of cellular biochemistry, 119(8), 6695-6703 (2018-04-26)
Human APOBEC3B (A3B), like other APOBEC3 members, is a cytosine deaminase which causes hypermutation of single stranded genome. Recent studies have shown that A3B is predominantly elevated in multiple cancer tissues and cell lines such as the bladder, cervix, lung
Chia-Yen Chen et al.
Journal of virology, 90(24), 11062-11074 (2016-09-30)
Although HIV-2 does not encode a vpu gene, the ability to antagonize bone marrow stromal antigen 2 (BST-2) is conserved in some HIV-2 isolates, where it is controlled by the Env glycoprotein. We previously reported that a single-amino-acid difference between
Vincent Dussupt et al.
Journal of virology, 85(5), 2304-2315 (2010-12-17)
The p6 region of HIV-1 Gag contains two late (L) domains, PTAP and LYPXnL, that bind the cellular proteins Tsg101 and Alix, respectively. These interactions are thought to recruit members of the host fission machinery (ESCRT) to facilitate HIV-1 release.
Annika Weber et al.
Molecular cell, 63(5), 827-839 (2016-08-30)
The Doa10 quality control ubiquitin (Ub) ligase labels proteins with uniform lysine 48-linked poly-Ub (K48-pUB) chains for proteasomal degradation. Processing of Doa10 substrates requires the activity of two Ub conjugating enzymes. Here we show that the non-canonical conjugating enzyme Ubc6
Wang-Yu Cai et al.
Hepatology (Baltimore, Md.), 65(4), 1206-1221 (2016-11-04)
Great progress has been achieved in the study of Hippo signaling in regulating tumorigenesis; however, the downstream molecular events that mediate this process have not been completely defined. Moreover, regulation of Hippo signaling during tumorigenesis in hepatocellular carcinoma (HCC) remains
Sayda Dhaouadi et al.
Frontiers in immunology, 12, 635166-635166 (2021-04-02)
The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited. Therefore, we generated dromedary single-domain nanobodies Nb3 and Nb4 highly specific for human
Sangin Kim et al.
PloS one, 18(5), e0285337-e0285337 (2023-05-19)
Proliferating cell nuclear antigen (PCNA) is a maestro of DNA replication. PCNA forms a homotrimer and interacts with various proteins, such as DNA polymerases, DNA ligase I (LIG1), and flap endonuclease 1 (FEN1) for faithful DNA replication. Here, we identify
Michelle Grace Acoba et al.
Cell reports, 34(11), 108869-108869 (2021-03-18)
Mitochondrial carriers (MCs) mediate the passage of small molecules across the inner mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized reactions. Despite MCs representing the largest family of solute carriers in mammals, most have not been subjected to a comprehensive
A R Mardinly et al.
Nature, 531(7594), 371-375 (2016-03-10)
Inhibitory neurons regulate the adaptation of neural circuits to sensory experience, but the molecular mechanisms by which experience controls the connectivity between different types of inhibitory neuron to regulate cortical plasticity are largely unknown. Here we show that exposure of
Aleksei Innokentev et al.
eLife, 9 (2020-12-16)
Mitophagy plays an important role in mitochondrial homeostasis. In yeast, the phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 is essential for mitophagy. This phosphorylation is counteracted by the yeast equivalent of the STRIPAK complex consisting of the
Tianning Wang et al.
Cell reports, 29(7), 2078-2091 (2019-11-14)
In animal cells, centriole number is strictly controlled in order to guarantee faithful cell division and genetic stability, but the mechanism by which the accuracy of centrosome duplication is maintained is not fully understood. Here, we show that CCDC84 constrains
Fangzhou Li et al.
Nature communications, 11(1), 4184-4184 (2020-08-23)
Oncogenic processes exert their greatest effect by targeting regulators of cell proliferation. Studying the mechanism underlying growth augmentation is expected to improve clinical therapies. The ovarian tumor (OTU) subfamily deubiquitinases have been implicated in the regulation of critical cell-signaling cascades
Lixia Hui et al.
PLoS pathogens, 16(4), e1008509-e1008509 (2020-04-18)
Zika virus (ZIKV) is a unique flavivirus with high tropism to the testes. ZIKV can persist in human semen for months and can cause testicular damage in male mice. However, the mechanisms through which ZIKV enters the testes remain unclear.
Sumoylation of histone deacetylase 1 regulates MyoD signaling during myogenesis
Joung H, et al.
Experimental & Molecular Medicine, 50(1), e427-e427 (2018)
Fabien Brossier et al.
Eukaryotic cell, 7(4), 664-674 (2008-03-04)
Rhomboids are serine proteases that cleave their substrates within the transmembrane domain. Toxoplasma gondii contains six rhomboids that are expressed in different life cycle stages and localized to different cellular compartments. Toxoplasma rhomboid protein 1 (TgROM1) has previously been shown
Juanjuan Su et al.
Biochimica et biophysica acta, 1860(6), 1292-1300 (2018-03-05)
Pex11p plays a crucial role in peroxisome fission. Previously, it was shown that a conserved N-terminal amphipathic helix in Pex11p, termed Pex11-Amph, was necessary for peroxisomal fission in vivo while in vitro studies revealed that this region alone was sufficient
Yueh-Ling Pai et al.
Cell death & disease, 14(8), 540-540 (2023-08-23)
Accumulating evidence has shown that the quality of proteins must be tightly monitored and controlled to maintain cellular proteostasis. Misfolded proteins and protein aggregates are targeted for degradation through the ubiquitin proteasome (UPS) and autophagy-lysosome systems. The ubiquitination and deubiquitinating
Xiaolu Guan et al.
Journal of virology, 92(1) (2017-10-27)
Chicken Na+/H+ exchanger type I (chNHE1), a multispan transmembrane protein, is a cellular receptor of the subgroup J avian leukosis virus (ALV-J). To identify the functional determinants of chNHE1 responsible for the ALV-J receptor activity, a series of chimeric receptors
Tetsuya Hirata et al.
Molecular biology of the cell, 26(17), 3071-3084 (2015-07-15)
The importance of endosome-to-trans-Golgi network (TGN) retrograde transport in the anterograde transport of proteins is unclear. In this study, genome-wide screening of the factors necessary for efficient anterograde protein transport in human haploid cells identified subunits of the Golgi-associated retrograde
Shan Li et al.
Plant physiology, 176(1), 891-909 (2017-11-15)
Fruit development and ripening is regulated by genetic and environmental factors and is of critical importance for seed dispersal, reproduction, and fruit quality. Tomato (Solanum lycopersicum) ripening inhibitor (rin) mutant fruit have a classic ripening-inhibited phenotype, which is attributed to
Elena I Ilina et al.
iScience, 25(2), 103842-103842 (2022-02-25)
Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts revealed a significantly higher expression of Glycosyltransferase 8 domain
Yanyan Peng et al.
PLoS pathogens, 10(4), e1004041-e1004041 (2014-04-26)
RIG-I like receptors (RLRs) recognize cytosolic viral RNA and initiate innate immunity; they increase the production of type I interferon (IFN) and the transcription of a series of antiviral genes to protect the host organism. Accurate regulation of the RLR
Josephine Lösing et al.
Cells, 11(24) (2022-12-24)
Herpesviruses replicate their genomes and assemble their capsids in the host cell nucleus. To progress towards morphogenesis in the cytoplasm, herpesviruses evolved the strategy of nuclear egress as a highly regulated process of nucleo-cytoplasmic capsid transition. The process is conserved
Steffen Krauss et al.
Journal of virology, 83(24), 12854-12870 (2009-10-09)
Our previous work has shown that efficient evasion from type I interferon responses by human cytomegalovirus (hCMV) requires expression of the 72-kDa immediate-early 1 (IE1) protein. It has been suggested that IE1 inhibits interferon signaling through intranuclear sequestration of the
Jingran Zhang et al.
Stem cell research & therapy, 14(1), 63-63 (2023-04-05)
Post-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation modification, crotonylation of non-histone proteins remains largely unexplored, particularly in human embryonic stem cells (hESCs). We investigated the role of crotonylation
Weihan Zhao et al.
The Journal of biological chemistry, 281(41), 31106-31118 (2006-08-23)
The addition of sialic acid to glycoproteins and glycolipids requires Golgi sialyltransferases to have access to their glycoconjugate substrates and nucleotide sugar donor, CMP-sialic acid. CMP-sialic acid is transported into the lumen of the Golgi complex through the CMP-sialic acid
Aaron M Schaller et al.
Journal of virology, 94(14) (2020-05-15)
Short interspersed nuclear elements (SINEs) are RNA polymerase III (RNAPIII)-transcribed, retrotransposable noncoding RNA (ncRNA) elements ubiquitously spread throughout mammalian genomes. While normally silenced in healthy somatic tissue, SINEs can be induced during infection with DNA viruses, including the model murine
Troy Camarata et al.
The Journal of cell biology, 174(3), 339-348 (2006-08-02)
The limb- and heart-specific Tbx5 transcription factor coexpresses with and directly binds to the novel PDZ-LIM domain protein, LMP4. LMP4 is distributed in the cytoplasm associated with the actin cytoskeleton. In the presence of LMP4, Tbx5 shuttles dynamically between the
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