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Showing 1-30 of 895 results for "H9658" within Papers
Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition.
Wei H, et al.
Neuropharmacology, 56(2), 399-404 (2009)
Huiqing Hu et al.
Journal of cell science, 130(24), 4108-4119 (2017-10-28)
Cytokinesis in trypanosomes occurs uni-directionally along the longitudinal axis from the cell anterior towards the cell posterior and requires a trypanosome-specific CIF1-CIF2 protein complex. However, little is known about the contribution of the structural motifs in CIF1 and CIF2 to
Chika Higuchi et al.
Biology open, 8(10) (2019-10-24)
During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role in the onset of zygotic transcription.
Yali Chen et al.
Nucleic acids research, 45(5), 2516-2530 (2016-12-13)
To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homologous recombination repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in
Nunziata Maio et al.
Haematologica, 104(9), 1756-1767 (2019-02-16)
Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting a special sulfur species for use
Broc T McCune et al.
mBio, 8(4) (2017-07-13)
The
Matthias Hillenbrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1181-E1190 (2015-03-04)
Agonist binding to G-protein-coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different
Qin Zhou et al.
Nature communications, 11(1), 2639-2639 (2020-05-28)
Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR is also used by cancer cells to promote therapeutic resistance. Therefore, inducing HR deficiency (HRD) is a viable strategy to
Michael Neubauer et al.
Molecular microbiology, 98(5), 930-945 (2015-08-15)
Mitochondria within eukaryotic cells continuously fuse and divide. This phenomenon is called mitochondrial dynamics and crucial for mitochondrial function and integrity. We performed a comprehensive analysis of mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus. Phenotypic characterization of respective mutants
Maria Elena Fernandez-Sanchez et al.
The Journal of biological chemistry, 285(23), 17390-17397 (2010-04-10)
The COP9 signalosome (CSN) is an essential multisubunit complex that regulates the activity of cullin-RING ubiquitin ligases by removing the ubiquitin-like peptide NEDD8 from cullins. Here, we demonstrate that the CSN can affect other components of the ubiquitination cascade. Down-regulation
Xiaomu Wei et al.
PLoS genetics, 10(12), e1004819-e1004819 (2014-12-17)
Understanding the functional relevance of DNA variants is essential for all exome and genome sequencing projects. However, current mutagenesis cloning protocols require Sanger sequencing, and thus are prohibitively costly and labor-intensive. We describe a massively-parallel site-directed mutagenesis approach, "Clone-seq", leveraging
Dai Shimizu et al.
Anticancer research, 39(1), 99-106 (2018-12-29)
Certain chromosomal arms are clonally amplified in colorectal cancer (CRC) and may contain novel driver genes. The aim of this study was to identify a novel driver gene for colorectal cancer carcinogenesis on long arm of chromosome 7 and the
Sian Bailey et al.
Biochimica et biophysica acta. Biomembranes, 1861(5), 997-1003 (2019-03-04)
Corticotrophin releasing factor (CRF) acts via two family B G-protein-coupled receptors, CRFR1 and CRFR2. Additional subtypes exist due to alternative splicing. CRFR1α is the most widely expressed subtype and lacks a 29-residue insert in the first intracellular loop that is
Jinxin Xu et al.
Structure (London, England : 1993), 25(8), 1251-1263 (2017-07-18)
E-Cadherin is a major component of adherens junctions on cell surfaces. SNX16 is a unique member of sorting nexins that contains a coiled-coil (CC) domain downstream of the PX domain. We report here that SNX16 regulates the recycling trafficking of
Dong-E Tang et al.
Cancer science, 110(10), 3145-3156 (2019-08-09)
Yes-associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has
Xiaodong Dong et al.
The Journal of biological chemistry, 292(20), 8472-8483 (2017-03-30)
Herpes simplex virus 1 (HSV-1) infection manipulates distinct host DNA-damage responses to facilitate virus proliferation, but the molecular mechanisms remain to be elucidated. One possible HSV-1 target might be DNA damage-tolerance mechanisms, such as the translesion synthesis (TLS) pathway. In
Erin M Stitt-Cavanagh et al.
Journal of the American Society of Nephrology : JASN, 21(10), 1678-1690 (2010-07-31)
Inhibition of p38 mitogen-activated protein kinase and cyclooxygenase-2 reduces albuminuria in models of chronic kidney disease marked by podocyte injury. Previously, we identified a feedback loop in podocytes whereby an in vitro surrogate for glomerular capillary pressure (i.e., mechanical stretch)
Deborah Argaud et al.
Nucleic acids research, 47(16), 8424-8438 (2019-06-30)
ENPP2, which encodes for the enzyme autotaxin (ATX), is overexpressed during chronic inflammatory diseases and various cancers. However, the molecular mechanism involved in the ENPP2 transcription remains elusive. Here, in HEK 293T cells, we demonstrated that lipopolysaccharide (LPS) increased the
Takashi Miki et al.
BMC molecular biology, 12, 48-48 (2011-11-18)
dendritic mRNA transport machines. Although Stau2 is thought to be involved in the dendritic targeting of several mRNAs in neurons, the mechanism whereby Stau2 regulates these mRNAs is unknown. To elucidate the functions of Stau2, we screened for novel binding
T Alfonso-Pérez et al.
Oncogene, 33(23), 3064-3074 (2013-07-16)
Human SNF5 (hSNF5; INI1, SMARCB1 or BAF47) is a component of the human SWI/SNF chromatin remodelling complex and a tumour suppressor mutated in rhabdoid tumours. It also associates with the integrase of the human immunodeficiency virus (HIV)-1. We show by
Alexander Hammel et al.
Frontiers in plant science, 11, 868-868 (2020-07-14)
The productivity of plants and microalgae needs to be increased to feed the growing world population and to promote the development of a low-carbon economy. This goal can be achieved by improving photosynthesis via genetic engineering. In this study, we
Hao Wang et al.
The Journal of biological chemistry, 287(3), 2237-2246 (2011-11-30)
It is indicated that there are important molecules interacting with brain nervous systems to regulate feeding and energy balance by influencing the signaling pathways of these systems, but relatively few of the critical players have been identified. In the present
Duyen H Pham et al.
Human molecular genetics, 26(11), 2042-2052 (2017-03-24)
De novo and inherited mutations of X-chromosome cell adhesion molecule protocadherin 19 (PCDH19) cause frequent, highly variable epilepsy, autism, cognitive decline and behavioural problems syndrome. Intriguingly, hemizygous null males are not affected while heterozygous females are, contradicting established X-chromosome inheritance.
François Enchéry et al.
Communications biology, 4(1), 1292-1292 (2021-11-18)
Nipah virus (NiV) is a highly pathogenic emerging bat-borne Henipavirus that has caused numerous outbreaks with public health concerns. It is able to inhibit the host innate immune response. Since the NF-κB pathway plays a crucial role in the innate
Beth A Krizek
Nucleic acids research, 31(7), 1859-1868 (2003-03-26)
The Arabidopsis protein AINTEGUMENTA (ANT) is an important regulator of organ growth during flower development. ANT is a member of the AP2 subclass of the AP2/ERF family of plant-specific transcription factors. These proteins contain either one or two copies of
S L Alan Wong et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(9), 3348-3357 (2008-06-19)
In polyglutamine (polyQ) degeneration, disease protein that carries an expanded polyQ tract is neurotoxic. Expanded polyQ protein exists in different conformations that display distinct solubility properties. In this study, an inducible transgenic Drosophila model is established to define the pathogenic
Heng Zhang et al.
Scientific reports, 5, 18035-18035 (2015-12-17)
Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation. Accumulative evidences have showed that DMXAA and CMA selectively activate mouse, but not human STING signaling. The mechanism underlying this species selectivity remains poorly understood. In
Tzu-Hsuan Chang et al.
PLoS pathogens, 12(10), e1005918-e1005918 (2016-10-05)
The switch between latency and the lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is controlled by the expression of virally encoded ORF50 protein. Thus far, the regulatory mechanism underlying the protein stability of ORF50 is unknown. Our earlier studies have
Franck C Chatelain et al.
The Journal of biological chemistry, 288(49), 35081-35092 (2013-10-29)
The tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents. Despite 62% amino acid identity with THIK1, THIK2 is not active upon heterologous expression. Here, we show that this apparent lack of activity is due to a
Jianli Tao et al.
Journal of immunology (Baltimore, Md. : 1950), 198(9), 3627-3636 (2017-04-02)
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B-form DNA, cGAS synthesizes the second messenger 2'3'-cGAMP and triggers STING-dependent signaling to
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