I17001

Applied Filters:

Keyword:'I17001'

Showing 1-15 of 15 results for "I17001" within Papers

Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory α7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm.

Yen-Kuang Lin et al.

Oxidative medicine and cellular longevity, 2022, 9964689-9964689 (2022-02-01)

Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7-nicotinic acetylcholine receptor (α7-nAChR) may play an important role in the development of coronary artery spasm (CAS). In CAS, the association between Lp(a) and the α7-nAChR-modulated inflammatory macrophage polarization and

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to IFN Types I, II, and III.

David A Constant et al.

ImmunoHorizons, 6(7), 416-429 (2022-07-06)

The three types of IFN have roles in antimicrobial immunity and inflammation that must be properly balanced to maintain tissue homeostasis. For example, IFNs are elevated in the context of inflammatory bowel disease and may synergize with inflammatory cytokines such

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes.

Hiroshi Nomoto et al.

Diabetologia, 63(1), 149-161 (2019-11-14)

The conserved hypoxia inducible factor 1 α (HIF1α) injury-response pro-survival pathway has recently been implicated in early beta cell dysfunction but slow beta cell loss in type 2 diabetes. We hypothesised that the unexplained prolonged prediabetes phase in type 1

DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.

Corina M Borza et al.

JCI insight, 7(3) (2021-12-24)

Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen, contributes to chronic kidney disease. However, its role in acute kidney injury and subsequent development of kidney fibrosis is not clear. Thus, we performed a model of severe

Clinical use of interferon?γ.

Miller C H, et al.

Annals of the New York Academy of Sciences, 1182(1), 69-79 (2009)

Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response.

Yifei Wang et al.

Science advances, 8(49), eadd0005-eadd0005 (2022-12-09)

The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8+ T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

Sarah E Nystrom et al.

JCI insight, 7(11) (2022-04-27)

COVID-19 infection causes collapse of glomerular capillaries and loss of podocytes, culminating in a severe kidney disease called COVID-19-associated nephropathy (COVAN). The underlying mechanism of COVAN is unknown. We hypothesized that cytokines induced by COVID-19 trigger expression of pathogenic APOL1

Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor.

Hibino Y, et al.

The Journal of Biological Chemistry, 266(11), 6948-6951 (1991)

Targeted pharmacological therapy restores β-cell function for diabetes remission.

Stephan Sachs et al.

Nature metabolism, 2(2), 192-209 (2020-07-23)

Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be targeted by pharmacological intervention for diabetes remission, and ways in which this could

Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.

Renauld J C.

Nature Reviews: Immunology, 3(8), 667-667 (2003)

Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.

Hiatt, et al.

Clinical Cancer Research, 28, 4551-4564 (2023)

In vitro and in vivo cytotoxic effect of AntiGan against tumor cells.

Lombardi V R, et al.

Experimental and Therapeutic Medicine, 15(3), 2547-2556 (2018)

The IFNγ receptor: a paradigm for cytokine receptor signaling.

Bach E A, et al.

Annual Review of Immunology, 15(1), 563-591 (1997)

Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty.

Livia S A Passos et al.

Frontiers in cardiovascular medicine, 8, 804111-804111 (2022-02-08)

Mitral regurgitation (MR) is a major complication of the percutaneous mitral valvuloplasty (PMV). Despite high technical expertise and cumulative experience with the procedure, the incidence rate of severe MR has not decreased. Although some of MR can be anticipated by

Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis.

Alexandra C Title et al.

Frontiers in endocrinology, 13, 854094-854094 (2022-07-22)

Restoration of β-cell mass through the induction of proliferation represents an attractive therapeutic approach for the treatment of diabetes. However, intact and dispersed primary islets suffer from rapidly deteriorating viability and function ex vivo, posing a significant challenge for their

Page 1 of 1