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Showing 1-30 of 134 results for "I3408" within Papers
Mohamed Yacine Ameur Messaoud et al.
Beilstein journal of organic chemistry, 11, 1475-1485 (2015-10-02)
The synthesis of N-arylated pyrroles and indoles is documented, as well as their functionalization by deprotonative metallation using the base in situ prepared from LiTMP and ZnCl2·TMEDA (1/3 equiv). With N-phenylpyrrole and -indole, the reactions were carried out in hexane
Xiaoqing Tang et al.
PloS one, 9(9), e102963-e102963 (2014-09-27)
Isatis indigotica, the source of the traditional Chinese medicine Radix isatidis (Ban-Lan-Gen), is an extremely important economical crop in China. To facilitate biological, biochemical and molecular research on the medicinal chemicals in I. indigotica, here we report the first I.
Claude Saint-Ruf et al.
Journal of bacteriology, 196(17), 3059-3073 (2014-07-02)
The evolutionary success of bacteria depends greatly on their capacity to continually generate phenotypic diversity. Structured environments are particularly favorable for diversification because of attenuated clonal interference, which renders selective sweeps nearly impossible and enhances opportunities for adaptive radiation. We
Danica E DeGroot et al.
Chemical research in toxicology, 28(6), 1176-1185 (2015-05-23)
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates the toxic and biological effects of structurally diverse chemicals, including the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of a larger effort to identify the full spectrum of chemicals
Saori Ishizaka et al.
Journal of equine science, 25(4), 65-72 (2015-01-06)
The effects of probiotics on horses are still controversial. The present study was a randomized, double-blinded, placebo-controlled crossover study designed to evaluate the ability of probiotics to improve intestinal conditions in adult horses. Fermented probiotics were administered to 10 healthy
Sudharsana Sundarrajan et al.
Journal of molecular modeling, 21(9), 247-247 (2015-09-02)
The cell wall of Mycobacterium tuberculosis interacts with the host counterpart during the pathogenesis of tuberculosis. L-rhamnosyl (L-Rha) residue, a linker connects the arabinogalactan and peptidoglycan moieties in the bacterial cell wall. The biosynthesis of L-rhamnose utilizes four successive enzymes
Toshiyuki Ueki et al.
Journal of ethnopharmacology, 166, 23-30 (2015-03-04)
Yokukansan, a traditional Japanese (Kampo) medicine, has recently been used to treat the behavioral and psychological symptoms of dementia (BPSD), including aggressiveness, excitability, and hallucination. The present study was designed to investigate the mechanisms underlying the ameliorative effects of yokukansan
Maryam Goudarzi et al.
Radiation and environmental biophysics, 53(4), 645-657 (2014-07-23)
Metabolomics has been shown to have utility in assessing responses to exposure by ionizing radiation (IR) in easily accessible biofluids such as urine. Most studies to date from our laboratory and others have employed γ-irradiation at relatively high dose rates
Anastasiya Lapytsko et al.
BMC bioinformatics, 16, 392-392 (2015-11-22)
The number of γH2AX foci per nucleus is an accepted measure of the number of DNA double-strand breaks in single cells. One of the experimental techniques for γH2AX detection in cultured cells is immunofluorescent labelling of γH2AX and nuclei followed
C J van der Horst
Cytobios, 45(181), 85-95 (1986-01-01)
Both in the male and in the female reproductive tract glucose can be converted via either the pentose pathway or the sorbitol pathway. It is shown that a disturbed carbohydrate metabolism can lead to infertility, i.e. in the cow and
Alex Van Moerkercke et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(26), 8130-8135 (2015-06-17)
Plants make specialized bioactive metabolites to defend themselves against attackers. The conserved control mechanisms are based on transcriptional activation of the respective plant species-specific biosynthetic pathways by the phytohormone jasmonate. Knowledge of the transcription factors involved, particularly in terpenoid biosynthesis
Christine Frederickx et al.
Journal of forensic sciences, 59(1), 242-249 (2013-08-29)
This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. Nasonia vitripennis is a common parasitoid of Dipteran pupae found in association with decaying carrion. Behavioral assays were used to investigate
Ashley A Reinke et al.
Bioorganic & medicinal chemistry letters, 19(17), 4952-4957 (2009-07-31)
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological activities. However, known chemical
Can indole-based extracts prevent colorectal cancer via early apoptotic pathways?
Shusuke Toden et al.
Cancer biology & therapy, 9(5), 380-382 (2010-02-20)
Shengnan Shi et al.
Applied biochemistry and biotechnology, 169(4), 1088-1097 (2013-01-12)
Biotransformation of indole to indigo in liquid-liquid biphasic systems was performed in Escherichia coli cells expressing phenol hydroxylase. It was suggested that indole could inhibit the cell growth even at low concentration of 0.1 g/L. The critical Log P for strain
Rebecca A Brady et al.
PloS one, 10(4), e0124877-e0124877 (2015-04-23)
Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTI), which are primarily self-limiting. We conducted a comprehensive analysis of the host transcriptome during a S. aureus SSTI to provide insight on the protective mechanisms that thwart
Matthias Erb et al.
Nature communications, 6, 6273-6273 (2015-02-17)
Herbivore-induced volatile organic compounds prime non-attacked plant tissues to respond more strongly to subsequent attacks. However, the key volatiles that trigger this primed state remain largely unidentified. In maize, the release of the aromatic compound indole is herbivore-specific and occurs
Shu-Ming Li
Applied microbiology and biotechnology, 84(4), 631-639 (2009-07-28)
A series of putative indole prenyltransferase genes could be identified in the genome sequences of different fungal strains including Aspergillus fumigatus and Neosartorya fischeri. The gene products show significant sequence similarities to dimethylallyltryptophan synthases from various fungi. These genes belong
N A Martynova et al.
Gigiena i sanitariia, (6)(6), 61-64 (2013-03-06)
The toxic properties of indole have been studied in terms of LD50 indole was established to refer to moderately hazardous substances: in case of indole introducing into the stomach in rats and mice, DL50 is 1200 mg/kg and 750 mg/kg
Katharina Tondera et al.
International journal of hygiene and environmental health, 218(8), 731-741 (2015-10-04)
Fecal contamination of water resources is a major public health concern in densely populated areas since these water bodies are used for drinking water production or recreational purposes. A main source of this contamination originates from combined sewer overflows (CSOs)
Chun-Peng Yang et al.
Nature communications, 6, 8058-8058 (2015-08-25)
Lithium metal is one of the most attractive anode materials for electrochemical energy storage. However, the growth of Li dendrites during electrochemical deposition, which leads to a low Coulombic efficiency and safety concerns, has long hindered the application of rechargeable
Vida Mashayekhi et al.
Chemical & pharmaceutical bulletin, 61(2), 144-150 (2012-11-17)
Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental
Anton A Toutov et al.
Nature, 518(7537), 80-84 (2015-02-06)
Heteroaromatic compounds containing carbon-silicon (C-Si) bonds are of great interest in the fields of organic electronics and photonics, drug discovery, nuclear medicine and complex molecule synthesis, because these compounds have very useful physicochemical properties. Many of the methods now used
Kun Xu et al.
Nature communications, 6, 7616-7616 (2015-07-04)
The asymmetric synthesis of N-allylic indoles is important for natural product synthesis and pharmaceutical research. The regio- and enantioselective N-allylation of indoles is a true challenge due to the favourable C3-allylation. We develop here a new strategy to the asymmetric
Lei Chen et al.
PloS one, 10(6), e0128696-e0128696 (2015-06-06)
Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more
Israel Alvarado et al.
Journal of bacteriology, 195(5), 1005-1011 (2012-12-25)
Paenibacillus larvae is the causative agent of American foulbrood (AFB), a disease affecting honey bee larvae. First- and second-instar larvae become infected when they ingest food contaminated with P. larvae spores. The spores then germinate into vegetative cells that proliferate
Kai Chen et al.
Antonie van Leeuwenhoek, 108(3), 703-710 (2015-07-15)
Strain Y1(T), a Gram-negative, non-spore-forming, rod-shaped bacterium, was isolated from activated sludge. This strain is able to degrade several commonly used chloroacetamide herbicides, such as butachlor, acetochlor and alachlor. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain
Guiming Dou et al.
Antonie van Leeuwenhoek, 108(2), 403-413 (2015-06-04)
A moderately halophilic bacterium, designated strain 9-2(T), was isolated from saline and alkaline soil collected in Lindian county, Heilongjiang province, China. The strain was observed to be strictly aerobic, Gram-negative, rod-shaped, oxidase-positive, catalase-positive and motile. It was found to require
Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: entry into the Fischer indole synthesis.
Fuxu Zhan et al.
Angewandte Chemie (International ed. in English), 52(4), 1266-1269 (2012-12-12)
Stephen J Heffernan et al.
Chemical communications (Cambridge, England), 49(23), 2314-2316 (2013-02-13)
The Au(I)-catalysed rearrangement of propargylic esters formed from an ynamide has been studied. The reaction is facile, and when conducted in the presence of a reactive indole nucleophile, leads to a cascade process whereby γ-indolyl α-acyloxyenamides are formed in good
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