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Showing 1-30 of 45 results for "i5523" within Papers
Christian Pehmøller et al.
Diabetes, 61(11), 2743-2752 (2012-08-02)
Excess lipid availability causes insulin resistance. We examined the effect of acute exercise on lipid-induced insulin resistance and TBC1 domain family member 1/4 (TBCD1/4)-related signaling in skeletal muscle. In eight healthy young male subjects, 1 h of one-legged knee-extensor exercise
Eliana Mariño et al.
Diabetes, 57(2), 395-404 (2007-11-21)
B-cells are important for disease pathogenesis in the nonobese diabetic (NOD) mouse model of type 1 diabetes. Recent studies demonstrate that marginal-zone B-cells (MZBs), which connect innate with adaptive immune responses, are increased in NOD mice. However, beyond this, the
Ilan Y Benador et al.
Cell metabolism, 27(4), 869-885 (2018-04-05)
Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure and remain adherent
Quanyan Liu et al.
Nutrition (Burbank, Los Angeles County, Calif.), 27(6), 633-640 (2010-08-27)
The metabolic response to gastrointestinal cancer in patients undergoing surgery is associated with hypermetabolism and insulin resistance. The potential use of synergetic anabolic hormones in conjunction with hypocaloric parenteral nutrition (HPN) has become a significant area of investigation. The presented
Yosuke Ida et al.
Scientific reports, 10(1), 16018-16018 (2020-10-01)
2D and 3D cultures of 3T3-L1 cells were employed in a study of the effects of Omidenepag (OMD), interacting with a non-prostanoid EP2 receptor, on adipogenesis. Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes (Pparγ
M T Ackermans et al.
Annals of clinical biochemistry, 45(Pt 4), 429-430 (2008-06-28)
The aim of this study is to compare the performance of three commonly used insulin assays with respect to the detection of exogenous human and porcine insulin added to human or rat plasma. The DPC Immulite human insulin assay, the
A Tone et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 118(5), 320-324 (2010-01-15)
To compare the glycemic variability of insulin detemir and insulin glargine in type 1 and type 2 diabetic patients. 15 type 1 and 14 type 2 diabetic patients receiving intensive insulin therapy with insulin glargine were enrolled. Before and after
J Hans DeVries
Current diabetes reviews, 1(1), 23-26 (2008-01-29)
Insulin pump therapy enjoys a steadily growing number of users and is associated with an approximately 0.5% lower A1c as compared to flexible insulin injection therapy in type 1 diabetes patients. An important question is whether superiority of insulin pump
Fumihito Hikage et al.
Endocrinology, 160(1), 20-35 (2018-11-06)
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which no effective pharmacological treatment has been established. Despite a suggested role played by autoimmune thyrotropin receptor activation
H Hanaire et al.
Diabetes & metabolism, 34(4 Pt 2), 401-423 (2008-10-31)
The aim of diabetes treatment is to achieve tight glucose control to avoid the development of chronic diabetic complications while reducing the frequency of hypoglycaemic episodes. Continuous subcutaneous insulin infusion (CSII) using an external pump is an intensive diabetes therapy
S D Luzio et al.
Diabetes, obesity & metabolism, 12(1), 82-87 (2009-10-01)
Randomized, open, single-centre, two-way crossover study comparing the pharmacokinetic (PK) and pharmacodynamic (PD) properties of subcutaneous (sc) regular human insulin (Actrapid) and oral insulin in a capsule form (Capsulin). Sixteen persons (12 males) with type 2 diabetes on oral hypoglycaemic
L Bresson et al.
Journal de gynecologie, obstetrique et biologie de la reproduction, 39(7), 588-591 (2010-07-16)
We describe an acute onset of diabetes mellitus during third trimester of pregnancy revealed by ketoacidosis, complicated by fetal death, which could evoke fulminant type 1 diabetes, a novel subtype of type 1 diabetes first described in Japan and rarely
Kumiko Iwata et al.
Current aging science, 3(1), 26-33 (2010-03-20)
In cartilage regenerative medicine, which is highly expected in the face of our aging society, insulin is the potent factor for culture media. To secure the safety of culture media, we attempted to use medical insulin formulations, and compared their
Xin Zhou et al.
Nature communications, 11(1), 6088-6088 (2020-12-02)
The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, it is not clear how this complex is regulated at
M Socha et al.
Drug delivery, 16(8), 430-436 (2009-10-21)
Nanoparticles loaded with two different commercial insulins (Actrapid, Novorapid and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit RS) were characterized in vitro. The zeta potential was positive whenever Eudragit RS was
Yosuke Ida et al.
Scientific reports, 10(1), 7958-7958 (2020-05-16)
To establish a deepening of the upper eyelid sulcus (DUES) model that can be induced by prostaglandin (PG) analogues, a three-dimension (3D) tissue culture was employed. Upon adipogenesis of the 3T3-L1 organoid, the effects of either Bimatoprost acid (BIM-A), or
P H Bessette et al.
The Journal of biological chemistry, 274(12), 7784-7792 (1999-03-13)
We have characterized in vivo and in vitro the recently identified DsbG from Escherichia coli. In addition to sharing sequence homology with the thiol disulfide exchange protein DsbC, DsbG likewise was shown to form a stable periplasmic dimer, and it
Dominik Pesta et al.
Frontiers in endocrinology, 12, 693683-693683 (2021-10-19)
The rs540467 SNP in the NDUFB6 gene, encoding a mitochondrial complex I subunit, has been shown to modulate adaptations to exercise training. Interaction effects with diabetes mellitus remain unclear. We assessed associations of habitual physical activity (PA) levels with metabolic
Shiba Yousefvand et al.
Canadian journal of physiology and pharmacology, 96(12), 1301-1307 (2018-10-17)
Neuropeptide Y (NPY) plays a mediatory role in cerebral insulin function by maintaining energy balance. The current study was designed to determine the role of insulin in food intake and its interaction with NPY receptors in 8 experiments using broiler
Comparative study of two insulin regimes in pregnancy complicated by diabetes mellitus.
Mohamed Ismail Nor Azlin et al.
Acta obstetricia et gynecologica Scandinavica, 86(4), 407-408 (2007-05-09)
Expression of adipocyte biomarkers in a primary cell culture models reflects preweaning adipobiology.
Chu DT, Malinowska E, Gawronska-Kozak B, et al.
The Journal of Biological Chemistry, 289(26), 18478-18488 (2014)
K McKernan et al.
Adipocyte, 9(1), 212-222 (2020-05-15)
In obesity, high levels of saturated fatty acids (SFAs) contribute to adipose tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itself may play a role in generating the inflammatory milieu. Given our recent findings
[Absolute case for perfusion with an electric syringe].
Michèle Montero
Revue de l'infirmiere, (154)(154), 41-42 (2009-11-07)
M Socha et al.
Journal of drug targeting, 17(8), 575-585 (2009-08-22)
Nanoparticles (prepared from a mixture of polyester and a polycationic polymer) loaded with insulin were prepared by a double emulsion method followed by evaporation solvent. Low molecular weight heparin (LMWH) was bound by electrostatic interactions onto the surface of the
Sharon R Ladyman et al.
Endocrinology, 158(12), 4257-4269 (2017-10-14)
As part of the adaptation of maternal glucose regulation during pregnancy to ensure glucose provision to the fetus, maternal insulin concentrations become elevated. However, increased central actions of insulin, such as suppression of appetite, would be maladaptive during pregnancy. We
Neonatal diabetes mellitus due to pancreas agenesis: a new case report and review of the literature.
Daniela Seick Barbarini et al.
Pediatric diabetes, 10(7), 487-491 (2009-06-06)
Neonatal diabetes mellitus (NDM) is a rare condition (1:400,000 neonates) defined as hyperglycemia occurring in the first months of life, lasting more than 2 wk and requiring insulin for management. We here report on a 33-month-old girl with pancreatic agenesis
Toshinari Takamura et al.
Diabetes research and clinical practice, 75(3), 278-284 (2006-10-31)
This study investigated whether strict control of plasma glucose levels with mealtime dosing of a rapid-acting insulin analog improves early morning fasting plasma glucose (FPG) levels in patients with type 2 diabetes. A rapid-acting insulin analog was administered at each
Najam Zahid et al.
Diabetes research and clinical practice, 80(3), e11-e13 (2008-04-09)
Insulin adsorption onto infusion equipment may affect glycaemic control. The change in insulin concentration during delivery through tubing employed for adult ICU and neonatal patients was determined using continuous flow UV analysis. Insulin adsorption depended on tubing composition, dimensions and
Pamela J Boimel et al.
Breast cancer research : BCR, 14(1), R23-R23 (2012-02-09)
Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers in previous studies who used the mouse mammary tumor virus Neu-transgenic mouse model (MMTV-Neu) demonstrated that the Neu-YB line had increased production
Michael S Bonkowski et al.
PloS one, 4(2), e4567-e4567 (2009-02-24)
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or insulin signaling. Calorie restriction (CR) is the only intervention that reliably increases mouse longevity. There is considerable phenotypic overlap between long-lived mutant mice and
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