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Showing 1-30 of 618 results for "I6125" within Papers
Ann Brinkmalm et al.
Molecular neurodegeneration, 9, 53-53 (2014-11-25)
Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic
Tingting Lian et al.
International journal of molecular sciences, 16(6), 13427-13441 (2015-06-26)
The search to date for accurate protein biomarkers in acute ischemic stroke has taken into consideration the stage and/or the size of infarction, but has not accounted for the site of stroke. In the present study, multiple reaction monitoring using
Laura L Kubik et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(1), 48-58 (2015-02-27)
Regions of the brain with high energy requirements are especially sensitive to perturbations in mitochondrial function. Hence, neurotoxicant exposures that target mitochondria in regions of high energy demand have the potential to accelerate mitochondrial damage inherently occurring during the aging
Yvonne S Ziegler et al.
PloS one, 9(7), e102341-e102341 (2014-07-17)
The use of broad spectrum chemotherapeutic agents to treat breast cancer results in substantial and debilitating side effects, necessitating the development of targeted therapies to limit tumor proliferation and prevent metastasis. In recent years, the list of approved targeted therapies
Andrew P Jackson et al.
Nucleic acids research, 42(11), 7113-7131 (2014-05-07)
Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic
Régis E Meyer et al.
Molecular biology of the cell, 26(17), 2986-3000 (2015-07-15)
In mitosis, the centromeres of sister chromosomes are pulled toward opposite poles of the spindle. In meiosis I, the opposite is true: the sister centromeres move together to the same pole, and the homologous chromosomes are pulled apart. This change
Francois Charih et al.
STAR protocols, 1(3), 100135-100135 (2020-12-31)
Protein lysine methylation mediates a variety of biological processes, and their dysregulation has been established to play pivotal roles in human disease. A number of these sites constitute attractive drug targets. However, systematic identification of methylation sites is challenging and
Matthew B Lohse et al.
Genetics, 216(2), 409-429 (2020-08-26)
An unusual feature of the opportunistic pathogen Candida albicans is its ability to switch stochastically between two distinct, heritable cell types called white and opaque. Here, we show that only opaque cells, in response to environmental signals, massively upregulate a
Masahiro Omori et al.
Stem cell research & therapy, 6, 124-124 (2015-06-20)
Surface modification of titanium (Ti) implants promotes bone formation and shortens the osseointegration period. The aim of this study was to promote bone regeneration and stability around implants using atmospheric pressure plasma (APP) pretreatment. This was followed by immobilization of
Sergio Alonso-Orgaz et al.
Journal of proteomics, 109, 368-381 (2014-07-30)
Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to
Julia Kennedy-Darling et al.
Journal of proteome research, 13(8), 3810-3825 (2014-07-08)
DNA-protein interactions play critical roles in the control of genome expression and other fundamental processes. An essential element in understanding how these systems function is to identify their molecular components. We present here a novel strategy, Hybridization Capture of Chromatin
Nida Zaidi et al.
The journal of physical chemistry. B, 118(46), 13025-13036 (2014-10-23)
Sodium dodecyl sulfate (SDS)-glycoprotein interaction serves as a model for a biological membrane. To get mechanistic insight into the interaction of SDS and glycoprotein, the effect of SDS on bovine serum fetuin (BSF) was studied in subcritical micellar concentrations at
Aubérie Parent et al.
Nature communications, 6, 5686-5686 (2015-01-20)
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the
Masaki Hiramoto et al.
International journal of molecular medicine, 36(1), 222-230 (2015-05-09)
Although recent genome-wide association studies (GWAS) have been extremely successful, it remains a big challenge to functionally annotate disease‑associated single nucleotide polymorphisms (SNPs), as the majority of these SNPs are located in non‑coding regions of the genome. In this study
Martin Pattky et al.
Analytical and bioanalytical chemistry, 407(22), 6637-6655 (2015-07-01)
In this study, we characterized unexpected side-products in a commercially synthesized peptide with the sequence RPRTRLHTHRNR. This so-called peptide D3 was selected by mirror phage display against low molecular weight amyloid-β-peptide (Aβ) associated with Alzheimer's disease. Capillary electrophoresis (CE) was
Tianshi Wang et al.
Molecular cell, 75(4), 823-834 (2019-07-16)
Sirt3, as a major mitochondrial nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, is required for mitochondrial metabolic adaption to various stresses. However, how to regulate Sirt3 activity responding to metabolic stress remains largely unknown. Here, we report Sirt3 as a SUMOylated protein in
Vincent Delorme et al.
Biochimie, 107 Pt A, 124-134 (2014-07-30)
A synthetic phosphonate inhibitor designed for lipase inhibition but displaying a broader range of activity was covalently immobilized on a solid support to generate a function-directed tool targeting serine hydrolases. To achieve this goal, straightforward and reliable analytical techniques were
Grace Kwan et al.
Applied and environmental microbiology, 81(3), 861-873 (2014-11-25)
Salmonella enterica is a member of the plant microbiome. Growth of S. enterica in sprouting-seed exudates is rapid; however, the active metabolic networks essential in this environment are unknown. To examine the metabolic requirements of S. enterica during growth in
Kay Stubenrauch et al.
Journal of pharmaceutical and biomedical analysis, 114, 296-304 (2015-06-22)
Targeted immunocytokines (TICs) display potent activity in selective tumor suppression. This class of multi domain biotherapeutics (MDBs) is composed of the three major domains Fab, Fc, and a cytokine which may induce a complex polyclonal anti-drug antibody (ADA) response. However
Anton Iliuk et al.
International journal of mass spectrometry, 377, 744-753 (2015-05-09)
Tandem mass spectrometry (MS/MS) has enabled researchers to analyze complex biological samples since the original concept inception. It facilitates the identification and quantification of modifications within tens of thousands of proteins in a single large-scale proteomic experiment. Phosphorylation analysis, as
Yoshihiro Ojima et al.
Applied and environmental microbiology, 81(17), 5900-5906 (2015-06-21)
Microbial flocculation is a phenomenon of aggregation of dispersed bacterial cells in the form of flocs or flakes. In this study, the mechanism of spontaneous flocculation of Escherichia coli cells by overexpression of the bcsB gene was investigated. The flocculation
Chi-Chi Chou et al.
Journal of the American Society for Mass Spectrometry, 26(1), 120-132 (2014-11-07)
Protein S-glutathionylation is a reversible post-translational modification widely implicated in redox regulated biological functions. Conventional biochemical methods, however, often do not allow such a mixed disulfide modification to be reliably identified on specific cysteine residues or be distinguished from other
Jing Jiang et al.
Analytical and bioanalytical chemistry, 406(25), 6265-6274 (2014-08-01)
Recombinant human erythropoietin (rhEPO) has been extensively used as a pharmaceutical product for treating anemia. Glycosylation of rhEPO affects the biological activity, immunogenicity, pharmacokinetics, and in-vivo clearance rate of rhEPO. Characterization of the glycosylation status of rhEPO is of great
Ganna Tolstanova et al.
Laboratory investigation; a journal of technical methods and pathology, 92(1), 9-21 (2011-09-07)
The role of endothelial damage and increased vascular permeability (VP) in the pathogenesis of ulcerative colitis (UC) has not been investigated. We examined using functional, morphologic, and molecular biologic studies whether and to what extent the endothelial barrier dysfunction precedes
Tanya Burch et al.
Journal of assisted reproduction and genetics, 31(6), 757-765 (2014-03-25)
To identify the secreted proteins of murine embryos grown in vitro. Two-cell mouse embryos (n=432) were randomly allocated to culture to the blastocyst stage in protein-free and in protein-supplemented (3 % BSA) media. Proteins were separated by SDS-PAGE; bands were
Francesco Trepiccione et al.
Kidney international, 86(4), 757-767 (2014-05-03)
Almost half of patients receiving lithium salts have nephrogenic diabetes insipidus. Chronic lithium exposure induces AQP2 downregulation and changes in the cellular composition of the collecting duct. In order to understand these pathophysiological events, we determined the earliest lithium targets
Yuling Chen et al.
PloS one, 10(6), e0127788-e0127788 (2015-06-04)
Tuberculosis, caused by the pathogen Mycobacterium tuberculosis, is a worldwide public health threat. Mycobacterium tuberculosis is capable of resisting various stresses in host cells, including high levels of ROS and copper ions. To better understand the resistance mechanisms of mycobacteria
Amy S Rasson et al.
Journal of molecular biology, 427(4), 824-839 (2014-09-23)
The most recently identified class of actin nucleators, WASp homology domain 2 (WH2) nucleators, use tandem repeats of monomeric actin-binding WH2 domains to facilitate actin nucleation. WH2 domains are involved in a wide variety of actin regulatory activities. Structurally, they
Hiroki Kuyama et al.
Journal of pharmaceutical and biomedical analysis, 112, 116-125 (2015-05-16)
Human basic fetoprotein (BFP), found in fetal serum and tissue extracts as well as in extracts of various cancer tissues, has long been known as a marker protein for cancers; however, the primary sequence has not yet been reported. This
Bipasha Barua et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(45), 18425-18430 (2012-10-24)
Cooperative activation of actin-myosin interaction by tropomyosin (Tm) is central to regulation of contraction in muscle cells and cellular and intracellular movements in nonmuscle cells. The steric blocking model of muscle regulation proposed 40 y ago has been substantiated at
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