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Showing 1-30 of 652 results for "I7018" within Papers
David R Janero et al.
ACS chemical neuroscience, 6(8), 1400-1410 (2015-05-16)
The cannabinoid 1 receptor (CB1R) is one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system. CB1R involvement in multiple physiological processes, especially neurotransmitter release and synaptic function, has made this GPCR a prime drug discovery
Zhanna Kobalava et al.
British journal of clinical pharmacology, 79(6), 937-945 (2014-12-17)
Serelaxin is a recombinant form of human relaxin-2 in development for treatment of acute heart failure. This study aimed to evaluate the pharmacokinetics (PK) of serelaxin in patients with hepatic impairment. Secondary objectives included evaluation of immunogenicity, safety and tolerability
Shikha Sharma et al.
Journal of cellular physiology, 230(3), 657-666 (2014-09-05)
Therapeutic potential of mesenchymal stem cells (MSCs) demands assurance of the quality, safety, and genetic stability. Nuclear blebs (NBs) and Micronuclei (MNs) are considered as biomarkers for cancer and an increase in their numbers is associated with malignancy and other
Chen Du et al.
Journal of lipid research, 55(9), 1886-1896 (2014-07-16)
Increasing evidence indicates that transcription and alternative splicing are coordinated processes; however, our knowledge of specific factors implicated in both functions during the process of adipocyte differentiation is limited. We have previously demonstrated that the zinc finger protein ZNF638 plays
Michele R Hutchison et al.
Endocrinology, 156(2), 499-510 (2014-11-19)
Prostaglandins, particularly PGE2, are important to adult bone and joint health, but how prostaglandins act on growth plate cartilage to affect bone growth is unclear. We show that growth plate cartilage is distinct from articular cartilage with respect to cyclooxygenase
Carol B Hanna et al.
Contraception, 91(5), 418-422 (2015-02-04)
Studies in mice suggest that cilostazol, an FDA-approved phosphodiesterase 3 (PDE3) inhibitor, might have a contraceptive effect within the approved dose range. We sought to evaluate the potential contraceptive effects of cilostazol in a nonhuman primate model. Adult female rhesus
Fabian Alexander Grimm et al.
Assay and drug development technologies, 13(9), 529-546 (2015-11-06)
Cell-based high-content screening (HCS) assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safety assessment. The time- and cost-effectiveness of HCS assays, combined with the organotypic nature of
Yubin Chen et al.
BMC cardiovascular disorders, 20(1), 214-214 (2020-05-08)
Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodeling remains unknown. Hematoxylin and eosin (H&E) and Masson's trichrome stains were used to
Robert K Amanfu et al.
Molecular pharmacology, 86(2), 222-230 (2014-05-29)
β-Adrenergic receptor blockers (β-blockers) are commonly used to treat heart failure, but the biologic mechanisms governing their efficacy are still poorly understood. The complexity of β-adrenergic signaling coupled with the influence of receptor polymorphisms makes it difficult to intuit the
Christina Maria Anna Pia Schuh et al.
Cytotherapy, 16(12), 1666-1678 (2014-09-02)
Adipose-derived progenitor/stem cells (ASCs) are discussed as a promising candidate for various tissue engineering approaches. However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity as
Nicoleta C Olarescu et al.
The Journal of endocrinology, 226(1), 13-23 (2015-05-07)
GH influences adipocyte differentiation, but both stimulatory and inhibitory effects have been described. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are multipotent and are able to differentiate into adipocytes, among other cells. Canonical Wnt/β-catenin signaling activation impairs adipogenesis. The aim of
Zhaoyang Liu et al.
Science signaling, 8(386), ra71-ra71 (2015-07-23)
Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling components are substantially increased in abundance in posttraumatic osteoarthritis in humans and mice, suggesting either a
Xiaofeng Wang et al.
Autophagy, 16(1), 154-166 (2019-04-23)
Damaged or redundant peroxisomes and their luminal cargoes are removed by pexophagy, a selective autophagy pathway. In yeasts, pexophagy depends mostly on the pexophagy receptors, such as Atg30 for Pichia pastoris and Atg36 for Saccharomyces cerevisiae, the autophagy scaffold proteins
Yu-Hua Chao et al.
PloS one, 9(10), e110338-e110338 (2014-10-23)
Sepsis remains an important cause of death worldwide, and vigorous immune responses during sepsis could be beneficial for bacterial clearance but at the price of collateral damage to self tissues. Mesenchymal stem cells (MSCs) have been found to modulate the
Anna Wiktorowska-Owczarek et al.
Cellular & molecular biology letters, 20(2), 213-221 (2015-07-24)
Prostaglandin E2 (PGE2) is generated in various cells, including endothelial cells, and is responsible for various functions, such as vascular relaxation and angiogenesis. Effects of PGE2 are mediated via receptors EP1-EP4, among which EP2 and EP4 are coupled to Gs
May-Yun Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(9) (2021-02-24)
We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and sustained improvements in glycemia which persist long after treatment withdrawal. Ab-4 promoted β-cell
Peng-Long Li et al.
Obesity (Silver Spring, Md.), 31(6), 1584-1599 (2023-05-19)
Adipogenesis has been recognized as an attractive avenue for maintaining systemic homeostasis, with peroxisome proliferator-activated receptor γ (PPARγ) showing predominant roles in this process. This study aims to identify promising drug candidates by targeting PPARγ for adipogenesis-based metabolic homeostasis and
Mei Hua Jiang et al.
Cell research, 24(12), 1466-1485 (2014-11-25)
The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate cell replacement therapy. Leydig cells (LCs) are the primary source of androgen in the mammalian testis, and the prospective identification of stem Leydig cells (SLCs) may
Y Shetzer et al.
Cell death and differentiation, 21(9), 1419-1431 (2014-05-17)
p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal
Carine Gubelmann et al.
eLife, 3, e03346-e03346 (2014-08-29)
Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiation is centered on the transcriptional cascades
Fractionation analysis of the subcellular distribution of GLUT-4 in 3T3-L1 adipocytes.
Jeffrey S Elmendorf
Methods in molecular medicine, 83, 105-111 (2003-03-07)
Noriaki Kawanabe et al.
Clinical oral investigations, 19(2), 363-371 (2014-05-28)
It is well accepted that stage-specific embryonic antigen (SSEA)-4 is an antigen that is useful to isolate adult stem cells analogous to embryonic stem cells. Therefore, in the present study, we investigated whether SSEA-4 can also be used as a
Nausika Betriu et al.
Biomolecules, 10(5) (2020-05-02)
Hair follicle dermal papilla cells (HFDPC) are a specialized cell population located in the bulge of the hair follicle with unique characteristics such as aggregative behavior and the ability to induce new hair follicle formation. However, when expanded in conventional
Zhongyuan Wen et al.
Molecular and cellular endocrinology, 506, 110755-110755 (2020-02-12)
Adipocyte dysfunction is closely associated with the development of obesity, insulin resistance, and type 2 diabetes. In addition to having a positive effect on adiponectin pathway and insulin signaling through direct and/or indirect mechanisms, adapter protein APPL1 has also been
Tariq Fellous et al.
Biochemical pharmacology, 175, 113859-113859 (2020-02-18)
The cellular microenvironment plays a critical role in the maintenance of bone marrow-derived mesenchymal stem cells (BM-MSCs) and their subsequent cell lineage differentiation. Recent studies suggested that individuals with adipocyte-related metabolic disorders have altered function and adipogenic potential of adipose
S Heidari-Keshel et al.
Minerva medica, 106(2), 95-108 (2014-12-18)
The endometrial-proliferation related diseases leads to endometrial hyperplasia, i.e., endometriosis. Endometrial progenitor and stem cells play key roles in the beginning of endometrial proliferative disorders. The purpose of this study was the isolation of stem cells in the endometriosis lesion
Jonas Bergan et al.
Cellular and molecular life sciences : CMLS, 71(21), 4285-4300 (2014-04-18)
Shiga toxin-producing Escherichia coli bacteria cause hemorrhagic colitis and hemolytic uremic syndrome in humans. Currently, only supportive treatment is available for diagnosed patients. We show here that 24-h pretreatment with an ether lipid precursor, the alkylglycerol sn-1-O-hexadecylglycerol (HG), protects HEp-2
HaiYang Wang et al.
Current biology : CB, 32(18), 4013-4024 (2022-08-19)
The first asymmetric meiotic cell divisions in mouse oocytes are driven by formin 2 (FMN2)-nucleated actin polymerization around the spindle. In this study, we investigated how FMN2 is recruited to the spindle peripheral ER and how its activity is regulated
Ana Romarowski et al.
Developmental biology, 405(2), 237-249 (2015-07-15)
Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling
Ding Wang et al.
Journal of cellular and molecular medicine, 24(7), 4212-4222 (2020-03-03)
MSCs are kind of cultured cells that reside in different tissues as inducers or regulators of physiological and pathological processes. Here, we derived MSCs from amniotic fluid and compared their differentiation ability and immunosuppression effect on PHA-activated PBMC with those
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