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Showing 1-30 of 47 results for "K401" within Papers
Jordan M Wilkins et al.
Aging, 12(14), 15134-15156 (2020-07-09)
Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited.
Seralathan Kamala-Kannan et al.
Journal of basic microbiology, 50(2), 200-205 (2010-01-19)
The enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase cleaves the ethylene precursor ACC into alpha-ketobutyrate and ammonia. The decreased level of ethylene allows the plant to be more resistant to a wide environmental stress including plant pathogens. In the present study, we characterized
Pingxi Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16592-16597 (2014-10-29)
Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes
Christopher L Sprague et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(8), 986-992 (2003-07-18)
Epidemiological studies have indicated that 1,3-butadiene exposure is associated with an increased risk of leukemia. In human liver microsomes, 1,3-butadiene is rapidly oxidized to butadiene monoxide, which can then be hydrolyzed to 3-butene-1,2-diol (BDD). In this study, BDD and several
Julia D Burman et al.
BMC structural biology, 7, 30-30 (2007-05-18)
The YjgF/YER057c/UK114 family of proteins is widespread in nature, but has as yet no clearly defined biological role. Members of the family exist as homotrimers and are characterised by intersubunit clefts that are delineated by well-conserved residues; these sites are
Biorefinery applications of Corynebacterium glutamicum
Jojima T, et al.
Corynebacterium glutamicum, 149-172 (2013)
Chao Gao et al.
Applied and environmental microbiology, 76(5), 1679-1682 (2010-01-19)
2-Oxobutyrate is an important intermediate in the chemical, drug, and food industries. Whole cells of Pseudomonas stutzeri SDM, containing NAD-independent lactate dehydrogenases, effectively converted 2-hydroxybutyrate into 2-oxobutyrate. Under optimal conditions, the biocatalytic process produced 2-oxobutyrate at a high concentration (44.4
Min Chai et al.
Cell reports, 27(12), 3413-3421 (2019-06-20)
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen)
K Yaegaki et al.
Clinical preventive dentistry, 14(1), 5-9 (1992-01-01)
Many oral microorganisms possess hydrophobic outer surfaces. A two-phase, oil-water mouthwash has, therefore, recently been developed to remove such oral microorganisms. The oil phase consists of olive oil and other essential oils. The aqueous phase includes cetylpyridinium chloride, which is
Berin A Boughton et al.
Bioorganic & medicinal chemistry, 16(23), 9975-9983 (2008-11-04)
We report the synthesis of (2E,5E)-4-oxoheptadienedioic acid and (2E)-4-oxoheptenedioic acid and evaluation of both diester and diacid analogues as inhibitors of bacterial dihydrodipicolinate synthase. Enzyme kinetic studies allowed the determination of second-order rate constants of inactivation; and substrate co-incubation studies
Sergey V Smirnov et al.
FEMS microbiology letters, 273(1), 70-77 (2007-06-15)
A two-step enzymatic synthesis process of 4-hydroxyisoleucine is suggested. In the first step, the aldol condensation of acetaldehyde and alpha-ketobutyrate catalyzed by specific aldolase results in the formation of 4-hydroxy-3-methyl-2-keto-pentanoate (HMKP). In the second step, amination of HMKP by the
Asymmetric formal [3+2] cycloaddition reaction of isocyanoesters to 2-oxobutenoate esters by a multifunctional chiral silver catalyst.
Jin Song et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(28), 7786-7790 (2011-05-28)
Nora Weber et al.
Microbial cell factories, 16(1), 51-51 (2017-03-25)
Saccharomyces cerevisiae (baker's yeast) has great potential as a whole-cell biocatalyst for multistep synthesis of various organic molecules. To date, however, few examples exist in the literature of the successful biosynthetic production of chemical compounds, in yeast, that do not
Shufen Huang et al.
Journal of molecular biology, 396(3), 708-718 (2009-12-08)
In recent years, increased interest has been directed towards hydrogen sulfide (H2S) as the third gasotransmitter and its role in various diseases. Cystathionine-gamma-lyase (CSE) is one of the enzymes responsible for the endogenous production of H2S in mammals. With the
Tomokazu Ito et al.
Journal of bacteriology, 195(24), 5439-5449 (2013-10-08)
Escherichia coli YggS is a member of the highly conserved uncharacterized protein family that binds pyridoxal 5'-phosphate (PLP). To assist with the functional assignment of the YggS family, in vivo and in vitro analyses were performed using a yggS-deficient E.
Synthesis of potential chemotherapic quinoxalinone derivatives by biocatalysis or microwave-assisted Hinsberg reaction
Gris J, et al.
Tetrahedron Letters, 49, 1053-1056 (2008)
E V Sycheva et al.
Mikrobiologiia, 76(6), 805-812 (2008-02-27)
Overproduction of noncanonical amino acids norvaline and norleucine by Escherichia coli with inactivated acetohydroxy acid synthases was demonstrated. The cultivation conditions for the overproduction of noncanonical amino acids were studied. The effect of the restoration of acetohydroxy acid synthase activity
Fabrication of a microcapsule extinguishing agent with a core-shell structure for lithium-ion battery fire safety
Zhang W, et al.
Materials Advances, 2, 4634-4642 (2021)
Thomas Svoboda et al.
Frontiers in plant science, 10, 1072-1072 (2019-09-26)
Fusarium graminearum is a plant pathogenic fungus which is able to infect wheat and other economically important cereal crop species. The role of ethylene in the interaction with host plants is unclear and controversial. We have analyzed the inventory of
Carla Risso et al.
Journal of bacteriology, 190(7), 2266-2274 (2008-02-05)
The central metabolic model for Geobacter sulfurreducens included a single pathway for the biosynthesis of isoleucine that was analogous to that of Escherichia coli, in which the isoleucine precursor 2-oxobutanoate is generated from threonine. 13C labeling studies performed in G.
Kechun Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6234-6239 (2010-03-25)
The dramatic increase in healthcare cost has become a significant burden to the world. Many patients are denied the accessibility of medication because of the high price of drugs. Total biosynthesis of chiral drug intermediates is an environmentally friendly approach
Three-component assembly and divergent ring-expansion cascades of functionalized 2-iminooxetanes.
Weijun Yao et al.
Angewandte Chemie (International ed. in English), 49(48), 9210-9214 (2010-10-22)
Hongbo Ling et al.
Biochemical and biophysical research communications, 361(1), 196-201 (2007-07-31)
Nikkomycins are peptidyl nucleoside antibiotics with potent activities against phytopathogenic and human pathogenic fungi. The sanM and sanN genes are required for the nikkomycin biosynthesis of Streptomyces ansochromogenes. In the present study, interaction between SanM and SanN was identified by
Shota Atsumi et al.
Applied and environmental microbiology, 74(24), 7802-7808 (2008-10-28)
Biofuels synthesized from renewable resources are of increasing interest because of global energy and environmental problems. We have previously demonstrated production of higher alcohols from Escherichia coli using a 2-keto acid-based pathway. Here, we took advantage of the growth phenotype
Satomi Ito et al.
Bioscience, biotechnology, and biochemistry, 72(9), 2411-2414 (2008-09-09)
A methioninase inhibitor from Myrsine seguinii was purified and identified as myrsinoic acid B. Its inhibitory activities as to crude methioninase from periodontal bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola were determined. The IC50 values were 10.5
K Yaegaki et al.
Journal of periodontology, 63(9), 783-789 (1992-09-01)
The amounts of volatile sulfur compounds (VSC) and methyl mercaptan/hydrogen sulfide ratio in mouth air from patients with periodontal involvement were 8 times greater than those of control subjects. Our studies demonstrated that, in patients with periodontal disease: 1) the
Andreas Schedlbauer et al.
Journal of biomolecular NMR, 42(2), 111-127 (2008-09-03)
Direct methods in NMR based structure determination start from an unassigned ensemble of unconnected gaseous hydrogen atoms. Under favorable conditions they can produce low resolution structures of proteins. Usually a prohibitively large number of NOEs is required, to solve a
Bastian Blombach et al.
Applied and environmental microbiology, 75(2), 419-427 (2008-12-03)
The influence of acetohydroxy acid synthase (AHAS) on L-lysine production by Corynebacterium glutamicum was investigated. An AHAS with a deleted C-terminal domain in the regulatory subunit IlvN was engineered by truncating the ilvN gene. Compared to the wild-type AHAS, the
Lieven Goossens
Journal of biosciences, 36(2), 235-241 (2011-06-10)
Metallothioneins (MTs), a low-mass class of metalloproteins, are characterized by a high thiolate sulphur and metal content. MTs are involved in metal homeostasis and heavy metal detoxification, and are efficient scavengers of free radicals. This article describes zinc release from
Chaitanya Kumar Jha et al.
Journal of basic microbiology, 52(3), 285-295 (2011-09-29)
Decreased levels of ACC (1-aminocyclopropane-1-carboxylic acid) result in lower levels of endogenous ethylene, which eliminate the potentially inhibitory effects of stress-induced higher ethylene concentrations. It is worth noting the substantial ability of the bacterial species to colonize different environments, including
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