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Showing 1-30 of 372 results for "L1012" within Papers
Sivaprakash Ramalingam et al.
Current gene therapy, 14(6), 461-472 (2014-09-24)
Generation and precise genetic correction of patient-derived hiPSCs have great potential in regenerative medicine. Such targeted genetic manipulations can now be achieved using gene-editing nucleases. Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively from
Maik Dahlhoff et al.
Experimental cell research, 332(1), 146-155 (2014-12-20)
Lipid metabolism depends on lipid droplets (LD), cytoplasmic structures surrounded by a protein-rich phospholipid monolayer. Although lipid synthesis is the hallmark of sebaceous gland cell differentiation, the LD-associated proteins of sebocytes have not been evaluated systematically. The LD fraction of
Ryo Sawamura et al.
Biochemical and biophysical research communications, 458(2), 387-391 (2015-02-07)
Clarification of the mechanism of chickens' taste sense will provide meaningful information for creating and improving new feedstuff for chickens, because the character of taste receptors in oral tissues affects feeding behavior in animals. Although fatty acids are partly recognized
Andrea Lindenmair et al.
Cell and tissue banking, 15(2), 213-225 (2014-05-16)
Human amniotic membrane (hAM) represents a tissue that is well established as biomaterial in the clinics with potential for new applications in regenerative medicine. For tissue engineering (TE) strategies, cells are usually combined with inductive factors and a carrier substrate.
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
Jason Nardella et al.
Archives of biochemistry and biophysics, 579, 73-84 (2015-06-04)
The gypsy moth utilizes a pheromone, (7R,8S)-2-methyl-7,8-epoxyoctadecane, for mate location. The pheromone is detected by sensory hairs (sensilla) on the antennae of adult males. Sensilla contain the dendrites of olfactory neurons bathed in lymph, which contains pheromone binding proteins (PBPs).
Susan K Raatz et al.
Journal of the Academy of Nutrition and Dietetics, 113(2), 282-287 (2013-01-29)
Enhanced n-3 fatty acid intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish
Shuyu Liu et al.
Ecotoxicology and environmental safety, 169, 564-572 (2018-11-27)
PFOS and PFOA are two of the most abundant perfluorinated compounds (PFCs) in the environment. Previous studies have reported they have a long half-life (up to five years) once they enter into the human body. Moreover, they can potentially promote
Gulsen Tel et al.
Pharmaceutical biology, 53(6), 824-830 (2015-02-28)
Recently, mushrooms are interesting natural products to be investigated due to exhibiting various bioactivities. This study determines the antioxidant and anticholinesterase activities of various extracts of five wild mushroom species. In addition, the total bioactive contents, namely, ascorbic acid, β-carotene
Lara Mouttham et al.
Journal of assisted reproduction and genetics, 32(8), 1239-1250 (2015-08-08)
The objective of this study is to characterize the impact of exposure to cryoprotectants followed by vitrification on primordial follicle survival and activation using a fetal bovine model. In the first study, fetal bovine cortical pieces were exposed to cryoprotectants
Yusuke Komiya et al.
iScience, 27(6), 109816-109816 (2024-05-23)
Muscle fiber type composition (% slow-twitch and % fast-twitch fibers) is associated with metabolism, with increased slow-twitch fibers alleviating metabolic disorders. Previously, we reported that dietary fish oil intake induced a muscle fiber-type transition in a slower direction in rats.
Leen Bussche et al.
Stem cells translational medicine, 3(12), 1514-1525 (2014-10-15)
Mesenchymal stromal cells (MSCs) have received much attention as a potential treatment of ischemic diseases, including ischemic tissue injury and cardiac failure. The beneficial effects of MSCs are thought to be mediated by their ability to provide proangiogenic factors, creating
M Mostafaei et al.
Ultrasonics sonochemistry, 27, 54-61 (2015-07-19)
This paper evaluates and optimizes the continuous production of biodiesel from waste cooking oil. In this research work, methanol and potassium hydroxide were used as catalyst engaging response surface methodology. For this purpose, the central composite experimental design (CCED), the
Rachael Dangarembizi et al.
Natural product communications, 8(3), 411-414 (2013-05-18)
Aloe ferox is an important medicinal plant in Southern Africa whose seeds could be useful as a source of oil. The fatty acid composition of A. ferox seed oil was determined using gas chromatography. The physicochemical properties of the oil
Joong-Seok Min et al.
Lipids in health and disease, 14, 77-77 (2015-07-24)
Cholesterol oxidation products (COPs) are produced during thermal processing of animal origin foods and are considered to have negative health impacts. The model systems are helpful to understand the impact of various factors on oxidation changes in foods during cooking
Sharon Janssens et al.
American journal of physiology. Endocrinology and metabolism, 309(10), E874-E883 (2015-10-01)
Insulin resistance is associated with ectopic lipid accumulation. Physical activity improves insulin sensitivity, but the impact of exercise on lipid handling in insulin-resistant tissues remains to be elucidated. The present study characterizes the effects of acute exercise on lipid content
Mariana Macedo de Almeida et al.
Journal of oleo science, 64(5), 539-551 (2015-04-07)
Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some
M Y Yang et al.
Physiological genomics, 47(12), 600-611 (2015-10-08)
The signals that regulate activation, a key transition in ovarian follicular development, are still not well understood, especially in nonrodent species. To gain insight into the regulation of this transition in cattle, we combined a microarray approach with an in
Michael Dudek et al.
Nature, 592(7854), 444-449 (2021-03-26)
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer1,2. The accumulation of metabolites leads to cell stress and inflammation in the liver3, but mechanistic understandings of liver damage in NASH
Cyril Jacquot et al.
Bioorganic & medicinal chemistry letters, 18(22), 5959-5962 (2008-09-17)
The reaction of soybean lipoxygenase-1 with linoleic acid has been extensively studied and displays very large kinetic isotope effects. In this work, substrate and solvent kinetic isotope effects as well as the viscosity dependence of the oxidation of arachidonic acid
Yuvaraj Mahendran et al.
The American journal of clinical nutrition, 99(1), 79-85 (2013-10-25)
The significance of erythrocyte membrane fatty acids (EMFAs) and their ratios to predict hyperglycemia and incident type 2 diabetes is unclear. We investigated EMFAs as predictors of the worsening of hyperglycemia and incident type 2 diabetes in a 5-y follow-up
Silvia Lopa et al.
Biotechnology and bioengineering, 112(7), 1457-1471 (2015-02-14)
Three-dimensional (3D) culture models are widely used in basic and translational research. In this study, to generate and culture multiple 3D cell spheroids, we exploited laser ablation and replica molding for the fabrication of polydimethylsiloxane (PDMS) multi-well chips, which were
Establishment of alternative culture method for spermatogonial stem cells using knockout serum replacement.
Aoshima K, et al.
PLoS ONE, 8(10), e77715-e77715 (2013)
A K Batta et al.
Journal of lipid research, 30(12), 1953-1962 (1989-12-01)
We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis. Bile acids were characterized by gas-liquid chromatography-mass spectrometry and quantified by capillary gas-liquid chromatography. Serum
Ying Zhang et al.
Acta biomaterialia, 20, 39-50 (2015-04-12)
As a tissue-specific stem cell for chondrogenesis, synovium-derived stem cells (SDSCs) are a promising cell source for cartilage repair. However, a small biopsy can only provide a limited number of cells. Cell senescence from both in vitro expansion and donor
Reynier Suardíaz et al.
The journal of physical chemistry. B, 117(14), 3747-3754 (2013-03-19)
15-Lipoxygenases (15-LOs) catalyze the peroxidation reaction of linoleic acid (LA) in mammals producing almost exclusively 13-(S)-hydroperoxyoctadecadienoic acid (13-(S)-HPODE). Although several hypotheses have been formulated, the molecular basis of such enzymatic regiospecificity is unclear. We have here combined quantum mechanics/molecular mechanics
Oluwabunmi A Tokede et al.
The American journal of clinical nutrition, 97(4), 698-705 (2013-03-01)
Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF). Our goal was to assess associations of plasma and dietary TFAs with HF
Mariana Macedo de Almeida et al.
Lipids in health and disease, 13, 200-200 (2014-12-24)
Evidence from in vitro and animal studies indicates that conjugated linoleic acid (CLA) possesses anti-diabetic properties, which appear to be attributed to cis-9, trans-11 CLA, the major CLA isomer in ruminant fat. However, there is a shortage of studies addressing
Wan Mohd Nuzul Hakimi Wan Salleh et al.
Natural product communications, 10(7), 1297-1300 (2015-09-29)
This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in the essential oils, which made up 86.8% and 89.7%
Maik Dahlhoff et al.
FEBS letters, 589(12), 1376-1382 (2015-04-19)
The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile
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