L2254

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Showing 1-30 of 69 results for "L2254" within Papers

The anti-obesity effect of natural vanadium-containing Jeju ground water.

Seon-Joo Park et al.

Biological trace element research, 151(2), 294-300 (2012-12-04)

This study investigated the anti-obesity effects of Jeju ground water containing the vanadium components S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.09 μg/l) on the differentiation of 3 T3-L1 preadipocytes and obesity in mice that were fed a

mRNA Expression of lipogenic enzymes in mammary tissue and fatty acid profile in milk of dairy cows fed flax hulls and infused with flax oil in the abomasum.

Marie-France Palin et al.

The British journal of nutrition, 111(6), 1011-1020 (2013-11-16)

In the present study, the effect of flax hulls with or without flax oil bypassing the rumen on the expression of lipogenic genes in the mammary tissue of dairy cows was investigated. A total of eight dairy cows were used

[Primary hyperchylomicronemia].

Shizuya Yamashita

Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1578-1583 (2013-11-12)

Primary hyperchylomicronemia is characterized by a marked hypertriglyceridemia due to an increase in chylomicrons, which may cause acute pancreatitis and eruptive xanthomas. This entity includes familial lipoprotein lipase (LPL) deficiency, familial apolipoprotein C-II deficiency, primary type V hyperlipoproteinemia, and idiopathic

Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress.

Linda L Lee et al.

American journal of physiology. Cell physiology, 312(4), C500-C516 (2017-01-13)

Elevation of blood triglycerides, primarily as triglyceride-rich lipoproteins (TGRL), has been linked to cerebrovascular inflammation, vascular dementia, and Alzheimer's disease (AD). Brain microvascular endothelial cells and astrocytes, two cell components of the neurovascular unit, participate in controlling blood-brain barrier (BBB)

Alipogene tiparvovec for the treatment of lipoprotein lipase deficiency.

K Haddley

Drugs of today (Barcelona, Spain : 1998), 49(3), 161-170 (2013-03-26)

Alipogene tiparvovec is the first adeno-associated virus (AAV)-mediated gene therapy to be approved for the treatment of a metabolic disorder. Lipoprotein lipase (LPL) deficiency (LPLD) is a rare autosomal-recessive disorder in which gene mutations cause the production of a catalytically

The effects of miR-467b on lipoprotein lipase (LPL) expression, pro-inflammatory cytokine, lipid levels and atherosclerotic lesions in apolipoprotein E knockout mice.

Guo-Ping Tian et al.

Biochemical and biophysical research communications, 443(2), 428-434 (2013-12-07)

Atherosclerosis is a lipid disorder disease characterized by chronic blood vessel wall inflammation driven by the subendothelial accumulation of macrophages. Studies have shown that lipoprotein lipase (LPL) participates in lipid metabolism, but it is not yet known whether post-transcriptional regulation

Diet-induced hypercholesterolemia alters liver glycosaminoglycans and associated-lipoprotein receptors in rats.

Gangappa Kiran et al.

Journal of physiology and biochemistry, 73(4), 539-550 (2017-08-02)

Glycosaminoglycans (GAGs) play an important role in lipoprotein metabolism. In liver, it facilitates the uptake of remnants through receptor-independent endocytosis. However, changes in liver GAGs during diet-induced hypercholesterolemia with normal levels of fat feeding are unknown. Present paper highlights the

Effects of lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene variants on metabolic syndrome traits.

Tamara Bozina et al.

Collegium antropologicum, 37(3), 801-808 (2013-12-07)

Peroxisome proliferator activated receptor-gamma (PPARG) and lipoprotein lipase (LPL) play important role in lipid homeostasis, insulin resistance and adipogenesis, and their gene variability could be considered as predictive genetic markers for metabolic syndrome (MetSy). The aim of the study was

Lipoprotein lipase in chronic lymphocytic leukaemia - strong biomarker with lack of functional significance.

Edit Porpaczy et al.

Leukemia research, 37(6), 631-636 (2013-03-13)

In chronic lymphocytic leukaemia (CLL), lipoprotein lipase (LPL) mRNA overexpression is an established poor prognostic marker, its function, however, is poorly understood. Measuring extracellular LPL enzymatic activity and protein, we found no difference between levels in CLL patients and those

A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis.

Sumita Jain et al.

Infection and immunity, 81(4), 1277-1286 (2013-02-06)

Infection by the chronic periodontitis-associated pathogen Porphyromonas gingivalis activates a Toll-like receptor 2 (TLR2) response that triggers inflammation in the host but also promotes bacterial persistence. Our aim was to define ligands on the surfaces of intact P. gingivalis cells

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage.

Sonja Kallendrusch et al.

PloS one, 7(12), e51208-e51208 (2013-01-04)

The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations. To better understand the mechanism beyond physiological signaling we used Organotypic Entorhino-Hippocampal Slice

Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways.

Hnin Hnin Aung et al.

Journal of lipid research, 57(6), 955-968 (2016-04-19)

Dysfunction of the cerebrovasculature plays an important role in vascular cognitive impairment (VCI). Lipotoxic injury of the systemic endothelium in response to hydrolyzed triglyceride-rich lipoproteins (TGRLs; TGRL lipolysis products) or a high-fat Western diet (WD) suggests similar mechanisms may be

Apolipoprotein F concentration, activity, and the properties of LDL controlling ApoF activation in hyperlipidemic plasma.

Richard E Morton et al.

Journal of lipid research, 63(2), 100166-100166 (2022-01-13)

Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are poorly understood.

Human lipoprotein lipase. I. Purification and substrate specificity.

C J Fielding

Biochimica et biophysica acta, 206(1), 109-117 (1970-04-22)

Gene therapy enters the pharma market: the short story of a long journey.

Hildegard Büning

EMBO molecular medicine, 5(1), 1-3 (2013-01-04)

Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function.

Raffay S Khan et al.

American journal of physiology. Endocrinology and metabolism, 305(11), E1339-E1347 (2013-10-03)

Hearts utilize fatty acids as a primary source of energy. The sources of those lipids include free fatty acids and lipoprotein triglycerides. Deletion of the primary triglyceride-hydrolyzing enzyme lipoprotein lipase (LPL) leads to cardiac dysfunction. Whether heart LPL-knockout (hLPL0) mice

Biochemistry and pathophysiology of intravascular and intracellular lipolysis.

Stephen G Young et al.

Genes & development, 27(5), 459-484 (2013-03-12)

All organisms use fatty acids (FAs) for energy substrates and as precursors for membrane and signaling lipids. The most efficient way to transport and store FAs is in the form of triglycerides (TGs); however, TGs are not capable of traversing

Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.

T Egelrud et al.

Biochimica et biophysica acta, 306(1), 115-127 (1973-04-13)

Lipoprotein lipase (LPL) is associated with neurite pathology and its levels are markedly reduced in the dentate gyrus of Alzheimer's disease brains.

Huilin Gong et al.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(12), 857-868 (2013-09-06)

Lipoprotein lipase (LPL) is involved in regulation of fatty acid metabolism, and facilitates cellular uptake of lipoproteins, lipids and lipid-soluble vitamins. We evaluated LPL distribution in healthy and Alzheimer's disease (AD) brain tissue and its relative levels in cerebrospinal fluid.

Chlorophyll Inhibits the Digestion of Soybean Oil in Simulated Human Gastrointestinal System.

Wang, et al.

Nutrients, 14 (2022)

Positional specificity of lipoprotein lipase.

N Morley et al.

The Journal of biological chemistry, 247(20), 6389-6393 (1972-10-25)

Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling.

Maria H Jäntti et al.

Molecular pharmacology, 83(3), 621-632 (2012-12-13)

It has been proposed that OX(1) orexin receptors and CB(1) cannabinoid receptors can form heteromeric complexes, which affect the trafficking of OX(1) receptors and potentiate OX(1) receptor signaling to extracellular signal-regulated kinase (ERK). We have recently shown that OX(1) receptor

[Hypertriglyceridemia-induced pancreatitis].

Daiji Nagayama et al.

Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1602-1605 (2013-11-12)

In Japan, the frequency of acute pancreatitis is 27.7 per 100,000, which includes 1.4 % of hypertriglyceridemia-induced pancreatitis(HTGP). Severity and complication rates with HTGP have been reported as higher in comparison to acute pancreatitis from other etiologies. Havel has suggested

Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells.

Leslie E Lupien et al.

Journal of lipid research, 61(2), 205-218 (2019-12-07)

We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the presence of LPL. We now report a model in which LPL is bound to

Evaluation of seven common lipid associated loci in a large Indian sib pair study.

Sajjad Rafiq et al.

Lipids in health and disease, 11, 155-155 (2012-11-16)

Genome wide association studies (GWAS), mostly in Europeans have identified several common variants as associated with key lipid traits. Replication of these genetic effects in South Asian populations is important since it would suggest wider relevance for these findings. Given

Role for leptin in promoting glucose mobilization during acute hyperosmotic stress in teleost fishes.

David A Baltzegar et al.

The Journal of endocrinology, 220(1), 61-72 (2013-11-07)

Osmoregulation is critical for survival in all vertebrates, yet the endocrine regulation of this metabolically expensive process is not fully understood. Specifically, the function of leptin in the regulation of energy expenditure in fishes, and among ectotherms, in general, remains

CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.

Brian C Shonesy et al.

Nature neuroscience, 16(4), 456-463 (2013-03-19)

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates activity-dependent depression of excitatory neurotransmission at central synapses, but the molecular regulation of 2-AG synthesis is not well understood. Here we identify a functional interaction between the 2-AG synthetic enzyme diacylglycerol lipase-α (DGLα) and calcium/calmodulin

The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.

S Valdeolivas et al.

Cell death & disease, 4, e862-e862 (2013-10-19)

The cannabinoid CB2 receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-AG), protects striatal neurons from apoptotic death caused by the local administration of malonate, a rat model of Huntington's disease (HD). In the present study, we investigated whether endocannabinoids

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects.

Camila C Leança et al.

Cardiovascular diabetology, 12, 173-173 (2013-11-26)

We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. We have measured the activities of several plasma components that are critically influenced by insulin

Molecular cloning and transcript expression of genes encoding two types of lipoprotein lipase in the ovary of cutthroat trout, Oncorhynchus clarki.

Yong-Woon Ryu et al.

Zoological science, 30(3), 224-237 (2013-03-14)

Large amounts of neutral lipids (NLs) are stored as lipid droplets in the ooplasm of fish oocytes, providing an essential energy resource for developing embryos and larvae. However, little is known about the origin of such lipids or about mechanisms

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