CN
Search Within
l4777
Applied Filters:
Keyword:'l4777'
Showing 31-60 of 155 results for "l4777" within Papers
Verónica Miksztowicz et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 669-675 (2014-01-25)
To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride
Filippo Fabbri et al.
International journal of molecular sciences, 22(16) (2021-08-28)
In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE® Pro 13 (Sartorius) was used to develop a full-factorial design of experiments (DoE) to analyse the
Shaoqing He et al.
The Journal of biological chemistry, 285(9), 6706-6715 (2009-12-26)
Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in humans.
Properties and purification of adipose tissue lipase.
W S LYNN et al.
The Journal of biological chemistry, 235, 1912-1916 (1960-07-01)
D L Christie et al.
FEBS letters, 278(2), 190-194 (1991-01-28)
To determine the active site residue, human milk bile-salt stimulated lipase (BSSL) was labelled with [3H]diisopropyl fluorophosphate (DFP). Partial sequence analysis of cyanogen bromide fragments (a total of 146 residues from 6 peptides) revealed 84% sequence identity with a putative
O Tiebel et al.
Human mutation, 12(3), 216-216 (2000-02-05)
Human hepatic lipase (hHL) plays an important role in hydrolysis of triglycerides from plasma lipoproteins. The enzyme also hydrolyzes HDL2 lipids resulting in smaller HDL particles with a lower cholesterol content and properties similar to HDL3. hHL is localized in
Ji Young Kim et al.
American journal of physiology. Endocrinology and metabolism, 291(1), E115-E127 (2006-05-18)
The minimal adipose phenotype of hormone-sensitive lipase (HSL)-null mice suggested that other hormonally responsive lipase(s) were present in adipocytes. Recent studies have characterized a new adipose tissue triglyceride lipase, ATGL/PNPLA2/destnutrin/iPLA2zeta/TTS2.2 (ATGL). We had previously cloned a novel adipose-enriched transcript by
Lipase: An Industrial Enzyme Through Metagenomics (2018)
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation.
Nathalie Griffon et al.
The Journal of biological chemistry, 284(35), 23322-23330 (2009-07-02)
Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase. EL has a tropism for high density lipoprotein, and its level of
M Jaye et al.
Nature genetics, 21(4), 424-428 (1999-04-07)
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation in HDL levels have not been fully
Krystyna Tatarkiewicz et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(7), R490-R498 (2014-01-31)
Glucagon-like peptide 1 receptors (GLP-1R) are expressed in multiple tissues and activation results in metabolic benefits including enhanced insulin secretion, slowed gastric emptying, suppressed food intake, and improved hepatic steatosis. Limited and inconclusive knowledge exists regarding whether the effects of
Geoff P Lin-Cereghino et al.
Gene, 519(2), 311-317 (2013-03-05)
The methylotrophic yeast, Pichia pastoris, has been genetically engineered to produce many heterologous proteins for industrial and research purposes. In order to secrete proteins for easier purification from the extracellular medium, the coding sequence of recombinant proteins is initially fused
Yuan Xie et al.
The Journal of biological chemistry, 289(11), 7994-8006 (2014-01-23)
Enzyme stability is an important issue for protein engineers. Understanding how rigidity in the active site affects protein kinetic stability will provide new insight into enzyme stabilization. In this study, we demonstrated enhanced kinetic stability of Candida antarctica lipase B
Roland Klingenberg et al.
The Journal of clinical investigation, 123(3), 1323-1334 (2013-02-22)
Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; however, the mechanism underlying this protection remains elusive. To define the role of FOXP3-expressing Tregs in atherosclerosis, we used
Y Mechref et al.
Glycobiology, 9(3), 227-234 (1999-02-20)
The detailed structures of N- glycans derived from bile salt-stimulated lipase (BSSL) found in human milk were determined by combining exoglycosidase digestion with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The N- glycan structures were conclusively determined in terms of complexity
Rebecca E K MacPherson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R644-R650 (2013-02-15)
Evidence indicates that skeletal muscle lipid droplet-associated proteins (PLINs) regulate lipolysis through protein-protein interactions on the lipid droplet surface. In adipocytes, PLIN1 is thought to regulate lipolysis by directly interacting with comparative gene identification-58 (CGI-58), an activator of adipose triglyceride
Leslie A Lange et al.
American journal of human genetics, 94(2), 233-245 (2014-02-11)
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants.
Chemical and enzymatic interesterification of tristearin/triolein-rich blends: Chemical composition, solid fat content and thermal properties
Ahmadi L, et al.
European Journal of Lipid Science and Technology, 1014-1024 (2008)
Maxime Bessières et al.
Current protocols in nucleic acid chemistry, 59, 14-14 (2014-12-17)
The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross-metathesis reaction between two olefins selected based on their reactivity
Niels Grarup et al.
The Journal of clinical endocrinology and metabolism, 93(6), 2294-2299 (2008-03-28)
Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein. The objective was to investigate the impact of variants
How high-density lipoprotein fuels the failing heart.
Nina Schlueter et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 955-957 (2013-03-06)
Luigi Notari et al.
The Journal of biological chemistry, 281(49), 38022-38037 (2006-10-13)
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of
Euna Choi et al.
BMC research notes, 15(1), 370-370 (2022-12-13)
Staphylococcus epidermidis is a skin colonizer and a major cause of nosocomial infections that can lead to sepsis. It causes opportunistic infections by forming biofilms on medical devices, which are hard to control with conventional antibiotics. In an attempt to
S Terzyan et al.
Protein science : a publication of the Protein Society, 9(9), 1783-1790 (2000-10-25)
Bile-salt activated lipase (BAL) is a pancreatic enzyme that digests a variety of lipids in the small intestine. A distinct property of BAL is its dependency on bile salts in hydrolyzing substrates of long acyl chains or bulky alcoholic motifs.
Diane Nykamp et al.
The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 28(4), 247-251 (2013-04-05)
To report a case of acute pancreatitis associated with the administration of high doses of over-the-counter (OTC) antacids containing calcium carbonate. An acute care 276-bed community hospital. In this case report, a 68-year-old male was admitted to the hospital for
John E Collins et al.
Genome biology, 5(10), R84-R84 (2004-10-06)
We have developed a systematic approach to generating cDNA clones containing full-length open reading frames (ORFs), exploiting knowledge of gene structure from genomic sequence. Each ORF was amplified by PCR from a pool of primary cDNAs, cloned and confirmed by
Structure and organization of the human carboxyl ester lipase locus.
K Madeyski et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 9(4), 334-338 (1998-04-08)
John E Collins et al.
Genome research, 13(1), 27-36 (2003-01-17)
We report a second-generation gene annotation of human chromosome 22. Using expressed sequence databases, comparative sequence analysis, and experimental verification, we have extended genes, fused previously fragmented structures, and identified new genes. The total length in exons of annotation was
Boryana Todorova et al.
The Journal of clinical endocrinology and metabolism, 89(5), 2019-2023 (2004-05-06)
In population-based studies, dyslipidemia related to insulin resistance (high triglyceride level and low high-density lipoprotein cholesterol level) is a risk factor for type 2 diabetes. Therefore, variants in genes regulating lipid and lipoprotein metabolism are potential candidate genes for diabetes.
Akinobu Watanabe et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(7), 1513-1520 (2009-04-03)
Flutamide, an antiandrogen drug, is widely used for the treatment of prostate cancer. The initial metabolic pathways of flutamide are hydroxylation and hydrolysis. It was recently reported that the hydrolyzed product, 4-nitro-3-(trifluoromethyl)phenylamine (FLU-1), is further metabolized to N-hydroxy FLU-1, an
Page 2 of 6