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Showing 1-30 of 6432 results for "L5750" within Papers
Vanessa Kruse et al.
PloS one, 10(5), e0125544-e0125544 (2015-05-08)
Human induced pluripotent stem cells (hiPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, iPSC-derived grafts are at risk of giving rise to teratomas in the host, if
Xiao Wu et al.
Molecular medicine reports, 12(1), 1405-1412 (2015-04-01)
Numerous epidemiological and experimental animal studies have indicated that chronic psychological stress may promote tumor development. However, the underlying molecular mechanisms by which chronic stress promotes tumorigenesis remain to be fully elucidated and animal models have not yet been well
Toshihiro Nagai et al.
Arthritis research & therapy, 16(5), 427-427 (2014-09-19)
Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated the efficacy of bevacizumab, an antibody against vascular endothelial growth factor and an inhibitor of angiogenesis, in the treatment of OA using a rabbit model of anterior
Dana J Levine et al.
ACS chemical biology, 10(5), 1269-1277 (2015-02-20)
The phosphotungstate anion (PTA) is widely used to facilitate the precipitation of disease-causing prion protein (PrP(Sc)) from infected tissue for applications in structural studies and diagnostic approaches. However, the mechanism of this precipitation is not understood. In order to elucidate
Yu Si et al.
Scientific reports, 5, 16683-16683 (2015-12-08)
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs
Tamanna Zerin et al.
Molecules and cells, 38(7), 610-615 (2015-06-19)
Alveolar epithelial cells have been functionally implicated in Mycobacterium tuberculosis infection. This study investigated the role of ursolic acid (UA)-a triterpenoid carboxylic acid with potent antioxidant, anti-tumor, anti-inflammatory, and anti-tuberculosis properties in mycobacterial infection of alveolar epithelial A549 cells. We
Anna Benrick et al.
Acta diabetologica, 51(6), 963-972 (2014-09-15)
To compare the effect of a single session of acupuncture with either low-frequency electrical or manual stimulation on insulin sensitivity and molecular pathways in the insulin-resistant dihydrotestosterone-induced rat polycystic ovary syndrome (PCOS) model. Both stimulations cause activation of afferent nerve
Poonam Sonawane et al.
British journal of pharmacology, 171(23), 5330-5344 (2014-07-22)
Isotretinoin (13-cis-retinoic acid; 13-cRA) is a differentiation inducer used to treat minimal residual disease after myeloablative therapy for high-risk neuroblastoma. However, more than 40% of children develop recurrent disease during or after 13-cRA treatment. The plasma concentrations of 13-cRA in
Hulda R Jonsdottir et al.
Laboratory investigation; a journal of technical methods and pathology, 95(12), 1418-1428 (2015-09-22)
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this
Fujun Yu et al.
Digestive diseases and sciences, 60(8), 2346-2352 (2015-05-16)
Previously, we reported that microRNA-181b (miR-181b) activates hepatic stellate cells partly through the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt pathway. The main objective of this study was to ascertain whether serum miR-181b expression is correlated with that
Yongxiang Gao et al.
Soft matter, 11(32), 6360-6370 (2015-06-24)
Coarsening and kinetic arrest of colloidal systems undergoing spinodal decomposition (SD) is a conserved motif for forming hierarchical, bicontinuous structures. Although the thermodynamic origins of SD in colloids are widely known, the microstructural processes responsible for its coarsening and associated
Xueyi Xuan et al.
International journal of pharmaceutics, 490(1-2), 258-264 (2015-05-12)
A new biomembrane-mimetic liquid chromatographic method using a C8 stationary phase and phosphatidylcholine-modified (PC-modified) microemulsion mobile phase was used to estimate unionized and ionized drugs lipophilicity expressed as an n-octanol/water partition coefficient (logP and logD). The introduction of PC into
Claudia E Mohn et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(2), 241-250 (2015-02-20)
The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation
Christine Mehner et al.
Oncotarget, 6(34), 35737-35754 (2015-10-06)
Ovarian cancer represents the most lethal tumor type among malignancies of the female reproductive system. Overall survival rates remain low. In this study, we identify the serine protease inhibitor Kazal type 1 (SPINK1) as a potential therapeutic target for a
Emilie Bédard et al.
FEMS microbiology letters, 356(2), 226-234 (2014-06-05)
This study investigated how quickly cells of the opportunistic pathogen Pseudomonas aeruginosa recover culturability after exposure to two of the most common environmental stressors present in drinking water, free chlorine and copper ions. Viable but nonculturable (VBNC) P. aeruginosa undetected by
Mauro Siragusa et al.
Science signaling, 8(390), ra81-ra81 (2015-08-20)
Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser
Ying Fai Ngai et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(5), R613-R622 (2015-07-17)
Prenatal alcohol exposure (PAE) programs the fetal hypothalamic-pituitary-adrenal (HPA) axis, resulting in HPA dysregulation and hyperresponsiveness to stressors in adulthood. Molecular mechanisms mediating these alterations are not fully understood. Disturbances in one-carbon metabolism, a source of methyl donors for epigenetic
Can Tepeköylü et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(3), e80-e90 (2014-11-26)
Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading to graft failure and incomplete in vitro repopulation with recipient cells remain challenging. Shock waves (SWs) were shown to modulate inflammation and to enhance re-epithelialization.
Caio Maximino et al.
Pharmacology, biochemistry, and behavior, 124, 425-433 (2014-07-16)
Alarm reactions to a substance secreted by the damaged skin of conspecifics and closely-related species are increasingly being recognized as fear-like responses in fish. The neurochemical underpinnings of these effects are so far unknown; however, given the role of the
Maria Licursi et al.
PloS one, 10(5), e0126174-e0126174 (2015-05-08)
Internal ribosome entry site (IRES)-mediated translation is an essential replication step for certain viruses. As IRES-mediated translation is regulated differently from cap-dependent translation under various cellular conditions, we sought to investigate whether temperature influences efficiency of viral IRES-mediated translation initiation
Shenshen Zhang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 239-246 (2014-04-08)
Ganoderma atrum polysaccharide (PSG-1) has been commonly suggested as a candidate for prevention and therapy of cancer. We investigated the antitumor effect and the underlying molecular mechanisms of PSG-1. The results showed that PSG-1 inhibited tumor growth and resulted in
Satoshi Wada et al.
Histochemistry and cell biology, 144(1), 13-20 (2015-03-31)
Cell differentiation is controlled by specific transcription factors. The functions and expression levels of these transcription factors are regulated by epigenetic modifications, such as histone modifications and cytosine methylation of the genome. In tendon tissue, tendon-specific transcription factors have been
Liang Deng et al.
Oncology letters, 10(5), 3323-3331 (2016-01-02)
Various human cancers have been revealed to contain cancer stem-like cells (CSCs) and the spherical colonies that possess stem-like properties and cancer-initiating abilities. Malignant fibrous histiocytoma (MFH) is a common soft-tissue sarcoma, and is considered to be a myxoma due
David R Colquhoun et al.
Proteomics, 15(12), 2066-2077 (2015-04-29)
Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation of the
José R Cussiol et al.
The EMBO journal, 34(12), 1704-1717 (2015-04-22)
In response to DNA damage, checkpoint signalling protects genome integrity at the cost of repressing cell cycle progression and DNA replication. Mechanisms for checkpoint down-regulation are therefore necessary for proper cellular proliferation. We recently uncovered a phosphatase-independent mechanism for dampening
Jacqueline A Hubbard et al.
ASN neuro, 7(5) (2015-10-23)
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system. Expression is particularly high around areas in contact with cerebrospinal fluid, suggesting that AQP4 plays a role in fluid exchange between the cerebrospinal
William G Herrick et al.
Cellular and molecular bioengineering, 8(3), 333-348 (2015-10-27)
Smooth muscle cell (SMC) invasion into plaques and subsequent proliferation is a major factor in the progression of atherosclerosis. During disease progression, SMCs experience major changes in their microenvironment, such as what integrin-binding sites are exposed, the portfolio of soluble
Jaimie Hoh Kam et al.
Experimental eye research, 135, 59-66 (2015-04-30)
Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without
Sara El Hoss et al.
The Biochemical journal, 468(3), 401-407 (2015-07-15)
Although the protease inhibitor (PI) Lopimune has proven to be effective, no studies have examined the side effects of Lopimune on mitochondrial bioenergetics in hepatocytes. The objective of the present study is to evaluate mitochondrial respiration, production of reactive oxygen
Ye Yao et al.
European journal of medical research, 20, 8-8 (2015-01-30)
Exosomes secreted by tumor cells contain specific antigens that may have immunotherapeutic purposes. The aim of this study was to characterize the proteomic content of lymphoma cell-derived exosomes (LCEXs). In this study, exosomes derived from Raji cells (EXO(Raji)) were purified
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