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Showing 1-30 of 80 results for "L6250" within Papers
Jingyi Hu et al.
Journal of ethnopharmacology, 266, 113394-113394 (2020-09-18)
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the gastrointestinal tract, consisting of ulcerative colitis (UC) and Crohn's disease (CD). Gut microbiota and their metabolites may play a role in the pathogen of IBD, especially of
Charlotte Avet et al.
eLife, 11 (2022-03-19)
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are activated by a given receptor. Here, we
V V Kollerov et al.
Steroids, 78(3), 370-378 (2013-01-22)
Selected actinobacteria and filamentous fungi of different taxonomy were screened for the ability to carry out regio- and stereospecific hydroxylation of lithocholic acid (LCA) at position 7β. The production of ursodeoxycholic acid (UDCA) was for the first time shown for
Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes.
Lamichhane, et al.
Cell reports. Medicine, 3, 100762-100762 (2023)
Nianbai Fang et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 488-497 (2014-10-12)
High-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are generally accepted as the preferred techniques for detecting and quantitating analytes of interest in biological matrices on the basis of the rule that one chemical compound yields one LC-peak
Xiaoyan Chu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 851-863 (2015-03-31)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for
Shasha Song et al.
The journal of physical chemistry. B, 116(42), 12850-12856 (2012-10-03)
Supramolecular hydrogels were prepared in the mixtures of a chiral amphiphilic lithocholic acid (LCA) and a nonionic surfactant, dodecyldimethylamine oxide (C(12)DMAO), in water. With the addition of LCA to C(12)DMAO micellar solutions, a transition from micelles to gels occurs at
Lithocholic acid, cholestasis, and liver disease.
J E King et al.
Mayo Clinic proceedings, 47(10), 725-730 (1972-10-01)
Jing-Chun Han et al.
Pharmaceutical biology, 52(12), 1624-1628 (2014-10-08)
Glycyrrhizin (GL), the major ingredient isolated from licorice, exerts multiple pharmacological activities. To elucidate the protective mechanism of GL towards lithocholic acid (LCA)-induced liver toxicity using lipidomics. GL (200 mg/kg) dissolved in corn oil was treated intraperitoneally for 7 d. On the
Vincent R Richard et al.
Aging, 5(4), 234-269 (2013-04-05)
Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in yeast, we
Nathalie Ménard et al.
Pharmaceutical research, 29(7), 1882-1896 (2012-03-28)
Novel surfactants made of diglutamic acid (DG) polar head linked to lithocholic, arachidonic, linoleic or stearic acids were designed for drug solubilization. Surfactants 3-D conformer and packing parameter were determined by molecular modelling and self-assembling properties by pyrene fluorescence measurements.
Claudiu Saracut et al.
Acta cirurgica brasileira, 30(9), 624-631 (2015-10-16)
To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon. The study used C57BL6 female mice divided into four groups.
Yukako Okazaki et al.
Journal of nutritional science and vitaminology, 58(5), 366-370 (2013-01-19)
To examine the effect of supplemental dietary vitamin B(6) on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected
Tanmay Bera et al.
Langmuir : the ACS journal of surfaces and colloids, 29(1), 387-392 (2012-12-21)
The concentration level of bile acids is a clinical biomarker for the diagnosis of intestinal diseases because individuals suffering from intestinal diseases have a sharply increased concentration of bile acids at micromolar levels. Here, we report the detection of lithocholic
Anna N Bukiya et al.
ChemMedChem, 7(10), 1784-1792 (2012-09-05)
Large conductance, calcium- and voltage-gated potassium (BK) channels regulate various physiological processes and represent an attractive target for drug discovery. Numerous BK channel activators are available. However, these agents usually interact with the ubiquitously distributed channel-forming subunit and thus cannot
Yang Li et al.
Scientific reports, 5, 9758-9758 (2015-05-23)
Dissecting the gene expression programs which control the early stage cardiovascular development is essential for understanding the molecular mechanisms of human heart development and heart disease. Here, we performed transcriptome sequencing (RNA-seq) of highly purified human Embryonic Stem Cells (hESCs)
Su-Mi Lee et al.
Molecular medicine reports, 25(4) (2022-02-17)
Bile acids have been linked to pathomechanism and prognosis in various types of cancers. The present study aimed to investigate the effect of bile acids on the molecular change in gastric epithelial cancer cells and to evaluate gastric bile acid
Xiao-yin Wang et al.
Acta pharmacologica Sinica, 35(11), 1463-1472 (2014-10-07)
TGR5 is a G protein-coupled receptor that is expressed in intestinal L-cells and stimulates glucagon-like peptide 1 (GLP-1) secretion. TGR5 may represent a novel target for the treatment of metabolic disorder. Here, we sought to design and synthesize a series
Kent A Willis et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(2), G322-G335 (2020-01-07)
Bile acid receptors regulate the metabolic and immune functions of circulating enterohepatic bile acids. This process is disrupted by administration of parenteral nutrition (PN), which may induce progressive hepatic injury for unclear reasons, especially in the newborn, leading to PN-associated
Makoto Ishii et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132(3), 301-310 (2012-03-03)
Living organisms eliminate foreign low-antigenic substances, such as drugs and environmental pollutants, by detoxification mediated by metabolizing cytochrome P450 (CYP). We have examined the possible regulation of CYP expression by enteric bacteria. Cyp mRNA expression levels, Cyp3a protein expression level
F J Reen et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(10), 1763-1771 (2014-05-13)
Chronic respiratory infections are a leading global cause of morbidity and mortality. However, the molecular triggers that cause respiratory pathogens to adopt persistent and often untreatable lifestyles during infection remain largely uncharacterised. Recently, bile aspiration caused by gastro-oesophageal reflux (GOR)
Biao Nie et al.
Hepatology (Baltimore, Md.), 56(4), 1300-1310 (2012-04-26)
Bile acids are known to play important roles as detergents in the absorption of hydrophobic nutrients and as signaling molecules in the regulation of metabolism. We tested the novel hypothesis that naturally occurring bile acids interfere with protein-mediated hepatic long
Michael D Jones et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 200-207 (2014-05-13)
Ultra high resolution SFC-MS (on sub-2μm particles) coupled to mass spectrometry has been evaluated for the metabolic profiling of rat and dog bile. The selectivity of the SFC separation differed from that seen in previous reversed-phase UPLC-MS studies on bile
Ji Hye Jun et al.
Cells, 11(2) (2022-01-22)
Changes in the structure and function of blood vessels are important factors that play a primary role in regeneration of injured organs. WKYMVm has been reported as a therapeutic factor that promotes the migration and proliferation of angiogenic cells. Additionally
Jeffrey R Maslanka et al.
Gut microbes, 12(1), 1-15 (2020-12-12)
Clostridioides difficile is an enteric bacterial pathogen that can a cause nosocomial infection leading to debilitating colitis. The development of a murine model of C. difficile infection has led to fundamental discoveries in disease pathogenesis and the host immune response
Michelle T Burstein et al.
Cell cycle (Georgetown, Tex.), 11(18), 3443-3462 (2012-08-17)
Our studies revealed that LCA (lithocholic bile acid) extends yeast chronological lifespan if added to growth medium at the time of cell inoculation. We also demonstrated that longevity in chronologically aging yeast is programmed by the level of metabolic capacity
Kazuaki Yoneno et al.
Immunology, 139(1), 19-29 (2013-04-10)
Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate
Manish Singh et al.
Biochimica et biophysica acta, 1828(8), 1926-1937 (2013-04-18)
We synthesized four cationic bile acid based facial amphiphiles featuring trimethyl ammonium head groups. We evaluated the role of these amphiphiles for cytotoxic activities against colon cancer cells and their membrane interactions by varying charge, hydration and hydrophobicity. The singly
Hai-Bing He et al.
Bioorganic & medicinal chemistry letters, 22(23), 7237-7242 (2012-10-17)
Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of both insulin and leptin signals. For years, inhibiting of PTP1B has been considered to be a potential therapeutics for treating Type 2 diabetes and obesity. Recently, we recognized lithocholic
Sidhartha R Sinha et al.
Cell host & microbe, 27(4), 659-670 (2020-02-27)
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in intestinal inflammation, we performed metabolomic, microbiome, metagenomic, and transcriptomic profiling of
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