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Showing 1-30 of 255 results for "L8912" within Papers
Pelin Onsekizoglu Bagci et al.
Journal of food science, 80(9), N2071-N2078 (2015-08-05)
Gold nanoparticles (AuNPs) were synthesized at room temperature following a simple, rapid, and green route using fresh-squeezed apple juice as a reducing reagent. The optimal AuNPs, based on the particle color, stability, and color change suitable for colorimetric detection of
Cell biology. Making sense of amino acid sensing.
Robert T Abraham
Science (New York, N.Y.), 347(6218), 128-129 (2015-01-13)
Karla C F Bordon et al.
The journal of venomous animals and toxins including tropical diseases, 21, 26-26 (2015-08-15)
Crotalus durissus terrificus venom (CdtV) is one of the most studied snake venoms in Brazil. Despite presenting several well known proteins, its L-amino acid oxidase (LAAO) has not been studied previously. This study aimed to isolate, characterize and evaluate the
Myriam M Chaumeil et al.
Cancer research, 74(16), 4247-4257 (2014-05-31)
Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade glioma and secondary glioblastoma, represent an early pathogenic event, and are associated with epigenetically driven modulations of metabolism. Of particular interest is the recently uncovered
Daniela Russo et al.
The journal of physical chemistry. B, 117(10), 2829-2836 (2013-02-19)
Molecular dynamics simulations and elastic neutron scattering experiments have been used to highlight how the structural organization of hydration water is able in some cases to locally constrain atomic movements at biologic interfaces. Using fully hydrated small peptides as models
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
Jian-ping Jia et al.
Chinese medical journal, 117(8), 1161-1164 (2004-09-14)
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD). The purpose of
M Allen McAlexander et al.
The Journal of pharmacology and experimental therapeutics, 349(1), 118-125 (2014-02-08)
Prior studies have demonstrated that the ion channel transient receptor potential vanilloid 4 (TRPV4) is functionally expressed in airway smooth muscle cells and that TRPV4 single nucleotide polymorphisms are associated with airflow obstruction in patients with chronic obstructive pulmonary disease.
Rajagopal Kavitha et al.
The Malaysian journal of pathology, 34(2), 127-132 (2013-02-22)
Forensic entomology applies knowledge about insects associated with decedent in crime scene investigation. It is possible to calculate a minimum postmortem interval (PMI) by determining the age and species of the oldest blow fly larvae feeding on decedent. This study
Riyanto Heru Nugroho et al.
Journal of bioscience and bioengineering, 120(4), 396-404 (2015-03-22)
Acid stress has been reported to inhibit cell growth and decrease productivity during bio-production processes. In this study, a metabolomics approach was conducted to understand the effect of lactic acid induced stress on metabolite pools in Saccharomyces cerevisiae. Cells were
C Marques et al.
Cell death & disease, 4, e507-e507 (2013-02-23)
Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apoptosis in CRC cells and may therefore be relevant in CRC prevention and
Wataru Imamura et al.
Journal of nutritional science and vitaminology, 59(1), 45-55 (2013-03-29)
The present study was conducted to identify reliable gene biomarkers for the adverse effects of excessive leucine (Leu) in Sprague-Dawley rats by DNA microarray. It has long been known that the adverse effects of excessive amino acid intake depend on
Humberto Nicastro et al.
Amino acids, 40(2), 287-300 (2010-06-02)
The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have
Ethan G Geier et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5480-5485 (2013-03-20)
The Large-neutral Amino Acid Transporter 1 (LAT-1)--a sodium-independent exchanger of amino acids, thyroid hormones, and prescription drugs--is highly expressed in the blood-brain barrier and various types of cancer. LAT-1 plays an important role in cancer development as well as in
P Schadewaldt et al.
Clinical chemistry, 45(10), 1734-1740 (1999-10-03)
The significance of plasma L-alloisoleucine, which is derived from L-isoleucine in vivo, for diagnosis of maple syrup urine disease (MSUD) was examined. Branched-chain L-amino acids were measured by automatic amino acid analysis. Alloisoleucine reference values in plasma were established in
Pang-Hung Hsu et al.
PloS one, 10(8), e0135174-e0135174 (2015-08-14)
The budding yeast Saccharomyces cerevisiae has recently been described as an emerging opportunistic fungal pathogen. Fungal cell wall mannoproteins have been demonstrated to be involved in adhesion to inert surfaces and might be engaged in virulence. In this study, we
Qian Wang et al.
International journal of cancer, 135(5), 1060-1071 (2014-02-18)
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each specific amino acid into cells, some of which are increased in cancer. These amino acids consequently activate the
Frances H A Huisman et al.
Biochemical and biophysical research communications, 433(2), 249-254 (2013-03-19)
α-Isopropylmalate synthase (α-IPMS) is a multi-domain protein catalysing the condensation of α-ketoisovalerate (α-KIV) and acetyl coenzyme A (AcCoA) to form α-isopropylmalate. This reaction is the first committed step in the leucine biosynthetic pathway in bacteria and plants, and α-IPMS is
Kayleigh M Dodd et al.
American journal of physiology. Endocrinology and metabolism, 302(11), E1329-E1342 (2012-02-23)
Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When amino acid supplies become restricted, mammalian cells employ homeostatic mechanisms to rapidly inhibit processes such as protein synthesis, which demands high levels of amino acids. Muscle
Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Sylvia M
Bioscience Reports (2016)
Yuwen Li et al.
Frontiers in plant science, 12, 628328-628328 (2021-09-08)
Amino acids are the building blocks of biomacromolecules in organisms, among which isoleucine (Ile) is the precursor of JA-Ile, an active molecule of phytohormone jasmonate (JA). JA is essential for diverse plant defense responses against biotic and abiotic stresses. Botrytis
(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells
Edwards S J, et al.
The Journal of Nutritional Biochemistry, 110, 109150- 109150 (2022)
Ai Tsuji et al.
Bioscience, biotechnology, and biochemistry, 79(2), 292-299 (2014-10-11)
Increased abnormal oocytes due to meiotic chromosome misalignment and spindle defects lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Here, we investigated the effect of biotin deficiency on oocyte quality. Three-week-old female ICR mice were fed a biotin-deficient
Steve Swinnen et al.
Eukaryotic cell, 14(9), 884-897 (2015-06-28)
Very high ethanol tolerance is a distinctive trait of the yeast Saccharomyces cerevisiae with notable ecological and industrial importance. Although many genes have been shown to be required for moderate ethanol tolerance (i.e., 6 to 12%) in laboratory strains, little
Hemmi N Bhagavan et al.
Mitochondrion, 7 Suppl, S78-S88 (2007-05-08)
Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a
Takeshi Haraguchi et al.
Biochemical and biophysical research communications, 440(4), 490-494 (2013-09-18)
All class II myosins have the conserved amino acid sequence Pro-Leu-Leu at their head-tail junctions. We systematically altered this sequence in smooth muscle heavy meromyosin (HMM) by site-directed mutagenesis and examined the effects of these mutations on actin-myosin interactions. Deletion
Leila Bousmaha-Marroki et al.
Journal of food science and technology, 52(8), 4708-4723 (2015-08-06)
The objective of this study was to identify and study the heterogeneity of technological traits of lactobacilli from goat's milk of Algeria and to evaluate in vitro their safety aspect. Using API50 CHL system and 16S rDNA sequencing, 51 % of
Scott M Wheatley et al.
American journal of physiology. Endocrinology and metabolism, 306(1), E91-E99 (2013-11-07)
Many low-birth-weight infants experience failure to thrive. The amino acid leucine stimulates protein synthesis in skeletal muscle of the neonate, but less is known about the effects of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). To determine the effects of HMB on
Jiqiang Ling et al.
Nucleic acids research, 42(1), 499-508 (2013-09-21)
The discovery of diverse codon reassignment events has demonstrated that the canonical genetic code is not universal. Studying coding reassignment at the molecular level is critical for understanding genetic code evolution, and provides clues to genetic code manipulation in synthetic
Sirpa Rainesalo et al.
Neurochemical research, 29(1), 319-324 (2004-03-03)
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epilepsy, patients with refractory localization-related epilepsies, and patients with acute seizures (within
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