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Showing 1-30 of 322 results for "M0200000" within Papers
Feng He et al.
Diabetologia, 57(8), 1726-1736 (2014-06-09)
The contribution of aberrantly expressed microRNAs (miRNAs) to diabetic nephropathy in vivo is poorly understood. Integrated comparative miRNA array profiling was used to examine the expression of serum miRNAs in patients with diabetic nephropathy. The abundance of miRNA-135a (miR-135a) was
Yasuyuki Ikematsu et al.
Chemical & pharmaceutical bulletin, 63(3), 156-163 (2015-03-12)
The purpose of the present study was to develop orally disintegrating tablets (ODTs) containing fat-soluble drugs that disintegrate rapidly while having appropriate tablet strength. We chose vitamin E (VE) as a model drug; d-α-tocopheryl acetate, as the oily VE (VE-OI)
Emil Meng-Lund et al.
Journal of pharmaceutical sciences, 103(7), 2053-2061 (2014-05-16)
The pH partition theory proposes a correlation between fraction of unionized drug substance and permeability. The aim of this study was to compare the permeability of metoprolol and mannitol in ex vivo human and porcine buccal mucosa models at varying
A Kiyoshima et al.
Journal of chromatography. B, Biomedical sciences and applications, 758(1), 103-108 (2001-08-03)
A simple, reliable and sensitive gas chromatographic-mass spectrometric method was devised to determine the level of mannitol in various human brain tissues obtained at autopsy. Mannitol was extracted with 10% trichloroacetic acid solution which effectively precipitated brain tissues. The supernatant
Anja Verhulst et al.
PloS one, 10(3), e0121861-e0121861 (2015-03-11)
Zoledronic acid, a highly potent nitrogen-containing bisphosphonate used for the treatment of pathological bone loss, is excreted unmetabolized via the kidney if not bound to the bone. In cancer patients receiving high doses of the compound renal excretion may be
F Dreher et al.
Skin pharmacology and applied skin physiology, 15 Suppl 1, 31-39 (2002-12-12)
Human skin models, such as EpiDerm and Episkin, are not easily mounted into static or dynamic diffusion cells that are commonly used to perform bioavailability studies with human skin ex vivo. For various reasons, such as fragility, small sample size
Liliana Costa et al.
Journal of photochemistry and photobiology. B, Biology, 120, 10-16 (2013-02-19)
Microbial photodynamic inactivation (PDI), involving the use of a photosensitizer (PS), light and molecular oxygen, with the subsequent production of reactive oxygen species (ROS), has been considered a promising and effective technology for viral inactivation. Although singlet oxygen is generally
Edward Sisco et al.
The Analyst, 140(8), 2785-2796 (2015-02-27)
This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstration of the effect of various parameters, such as ion polarity and
Katri V Typpo et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 16(1), 37-44 (2014-08-28)
Children with congenital heart disease have loss of intestinal epithelial barrier function, which increases their risk for postoperative sepsis and organ dysfunction. We do not understand how postoperative cardiopulmonary support or the inflammatory response to cardiopulmonary bypass might alter intestinal
Zoltán Liptai et al.
Ideggyogyaszati szemle, 66(1-2), 67-71 (2013-04-24)
Authors, most of them Japanese, have recently published an increasing number of articles on mild encephalitis/encephalopathy with a reversible splenial lesion. We report on two new white European patients and compare published data with our own observations. A 15-year-old girl
Gustavo H C Varca et al.
Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)
The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture
Daniel O Amakye et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(3), 182-184 (2013-08-31)
A positive response to indirect airway challenges (eg, mannitol) that cause release of mast cell mediators causes refractoriness to a repeat exposure to the same or different indirect stimulus that lasts for at least several hours. Allergen challenge causes increased
M Tokuda et al.
Connective tissue research, 56(1), 44-49 (2014-11-06)
To examine the responses of mouse odontoblast-lineage cell line (OLC) cultures to xylitol-induced hypertonic stress. OLCs were treated with xylitol, sucrose, sorbitol, mannitol, arabinose and lyxose. Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium assay. The expression of transient receptor
Mario Del Piano et al.
Journal of clinical gastroenterology, 48 Suppl 1, S56-S61 (2014-10-08)
Leaky gut, or intestinal permeability, is the phenomenon of the gut wall exhibiting increased absorbency. It is pretty well recognised that an altered or damaged bowel lining or gut wall may result from unbalanced diet, parasites, infection, or medications and
Daniela Dal Molim Ghisleni et al.
Journal of AOAC International, 97(3), 908-912 (2014-07-24)
Caspofungin is an echinocandin antifungal used in the treatment of invasive fungal infections. Several methods have been reported for the quantitative analysis of echinocandins; however, there is no microbiological assay for determination of caspofungin potency in the presence of its
Stephan Seitz et al.
BMC cancer, 14, 847-847 (2014-11-21)
Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing hormone) can be successfully targeted with AEZS-108 [AN-152], an analog
Lorenzo Drago et al.
The International journal of artificial organs, 37(5), 414-421 (2014-06-27)
Staphylococci are responsible for approximately half of all prosthetic joint infections (PJIs) and they are often multi-drug resistant. The main purpose of this study was to evaluate the incidence of PJIs caused by staphylococci in our hospital from March 2010
Bo Yi et al.
Experimental and therapeutic medicine, 8(4), 1185-1190 (2014-09-05)
Activation of the receptor for advanced glycation end products (RAGE) axis may have an important role in apoptosis. Glucagon-like peptide-1 (GLP-1) is a gut hormone that has been proposed as a therapeutic target for the treatment of diabetes, and GLP-1
Shiwen Peng et al.
PloS one, 10(1), e116389-e116389 (2015-01-07)
Clinical studies suggest that responses to HPV16 E6E7L2 fusion protein (TA-CIN) vaccination alone are modest, and GPI-0100 is a well-tolerated, potent adjuvant. Here we sought to optimize both the immunogenicity of TA-CIN via formulation with GPI-0100 and treatment of HPV16+
Gang Zhao et al.
World journal of gastroenterology, 9(9), 2105-2108 (2003-09-13)
To investigate the effect of nutritional support therapy on severe acute pancreatitis (SAP). A total of 96 patients with severe acute pancreatitis were divided randomly into control and treatment groups. The former group received total parenteral nutrition (TPN) via central
Meng-Xia Chen et al.
Carbohydrate polymers, 111, 298-304 (2014-07-20)
Paclitaxel (PTX) loaded multilayered liposomes were prepared using layer-by-layer assembly in an effort to improve the stabilization of the liposomal compositions for PTX delivery. Stearyl amine was used to provide positive charge to the PTX-liposomes, and subsequently coated with anionic
L-B Li et al.
Transplantation proceedings, 45(2), 523-527 (2013-03-19)
Clinically, donor hearts cannot be preserved for >6 hours between explantation and recipient implantation. A better approach is needed to preserve donor hearts for a longer time. We tested whether low-flow perfusion (LFP) could satisfactorily preserve isolated rat hearts with
Željka Vanić et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 443-454 (2014-06-15)
The purpose of this study was to develop a novel drug delivery system for challenging drugs with potential for scale-up manufacturing and controlled release of incorporated drug. Pre-liposomes powder containing metronidazole, lecithin and mannitol, prepared by spray-drying, was mixed with
J-H La et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1730-1742 (2014-10-14)
A low-level inflammation has been hypothesized to mediate visceral hypersensitivity in functional bowel disorders that persist after or even in the absence of gut inflammation. We aimed to test the efficacy of a steroidal anti-inflammatory treatment, and identify local inflammatory
A double-edged sword.
Prescrire international, 23(148), 91-91 (2014-05-27)
Overcoming the undesirable properties of dry-powder inhalers with novel engineered mannitol particles.
Ali Nokhodchi et al.
Therapeutic delivery, 4(8), 879-882 (2013-08-08)
Etiology and management of exercise-associated hyponatremic encephalopathy (EAHE).
Ian R Rogers et al.
The American journal of emergency medicine, 32(7), 806-807 (2014-04-29)
Marie-Claire Arrieta et al.
Inflammatory bowel diseases, 21(1), 8-18 (2014-12-18)
Increased intestinal permeability is found in noninflamed portions of the gut of inflammatory bowel disease patients and in their first-degree relatives, suggesting that it is not a consequence of inflammation. Additionally, increased small intestinal permeability precedes colonic disease in animal
Halinder S Mangat et al.
Journal of neurosurgery, 122(1), 202-210 (2014-11-08)
Increased intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is associated with a higher mortality rate and poor outcome. Mannitol and hypertonic saline (HTS) have both been used to treat high ICP, but it is unclear which one
Soyoung Kwak et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(9), 779-787 (2014-06-14)
Fisetin, an active compound isolated from flowering plants in the family Fabaceae, was reported to have antiviral, neuroprotective, and anti-inflammatory effects. Vascular inflammatory processes have been suggested to play key roles in the initiation and progression of atherosclerosis, a major
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