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M0262
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Showing 1-30 of 123 results for "M0262" within Papers
Scott D Hansen et al.
Molecular biology of the cell, 24(23), 3710-3720 (2013-09-27)
The actin-binding protein αE-catenin may contribute to transitions between cell migration and cell-cell adhesion that depend on remodeling the actin cytoskeleton, but the underlying mechanisms are unknown. We show that the αE-catenin actin-binding domain (ABD) binds cooperatively to individual actin
Patrick S Wray et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 748-757 (2013-01-08)
This work uses ATR-FTIR spectroscopic imaging to study the dissolution of delayed release and pH resistant compressed coating pharmaceutical tablets. Tablets with an inner core and outer shell were constructed using a custom designed compaction cell. The core of the
Yifei Zhong et al.
Journal of the American Society of Nephrology : JASN, 24(5), 801-811 (2013-04-06)
The Connectivity Map database contains microarray signatures of gene expression derived from approximately 6000 experiments that examined the effects of approximately 1300 single drugs on several human cancer cell lines. We used these data to prioritize pairs of drugs expected
Gautam Singhvi et al.
Pharmaceutical development and technology, 19(6), 708-716 (2013-08-13)
The objective of this study was to design oral controlled release (CR) matrix tablets of Milnacipran using hydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of various formulation factors such as polymer proportion, polymer viscosity, compression
Ana M Cerdeira et al.
International journal of pharmaceutics, 443(1-2), 209-220 (2013-01-08)
Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect. To increase their dissolution rate, the compounds were nanoground by media milling to produce nanosuspensions with mean particle size of approximately
V Clausse et al.
Cell death & disease, 7(4), e2195-e2195 (2016-04-15)
Inactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while
K Lutek et al.
Integrative organismal biology (Oxford, England), 3(1), obab024-obab024 (2021-09-14)
Locomotion relies on the successful integration of sensory information to adjust brain commands and basic motor rhythms created by central pattern generators. It is not clearly understood how altering the sensory environment impacts control of locomotion. In an aquatic environment
Noriaki Nagai et al.
Toxicology, 319, 53-62 (2014-03-07)
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that
Navideh Anarjan et al.
International journal of food sciences and nutrition, 64(6), 744-748 (2013-04-18)
The emulsification and stabilization ability of four selected polysaccharides, namely, gum Arabic, xanthan gum, pectin and methyl cellulose, in the preparation of water-dispersible astaxanthin nanoparticles using the emulsification-evaporation technique was investigated in this study. The chemical and molecular structure of
Liyan Ping et al.
FEMS microbiology ecology, 86(1), 36-44 (2013-01-26)
Motility is an important trait for some bacteria living in nature and the analyses of it can provide important information on bacterial ecology. While the swimming behavior of peritrichous bacteria such as Escherichia coli has been extensively studied, the monotrichous
Xiuhua Zhao et al.
International journal of pharmaceutics, 454(1), 278-284 (2013-07-09)
Insulin is the most effective and durable drug in the treatment of advanced stage diabetes. However, oral delivering insulin was a tough task for rapid enzymatic degradation. In this work, we designed and developed a delivery system composed of enteric
D M Woolley et al.
Journal of anatomy, 213(3), 336-341 (2008-06-10)
Electron microscopy has been used to investigate whether the transversely striated columns of the connecting piece in the neck region of guinea pig spermatozoa, undergo lengthening and shortening as a result of the forces generated during motility. Motile spermatozoa were
Martin Kuentz et al.
Drug development and industrial pharmacy, 39(9), 1476-1483 (2012-10-10)
An automated version of uniaxial powder flow testing has recently been developed and there is a need for experimental data from pharmaceutical powders. To compare the novel testing method with an annular shear cell using different pharmaceutical excipients. A particular
Xiju Wang et al.
Journal of experimental & clinical cancer research : CR, 38(1), 505-505 (2020-01-01)
Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 and Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether MSI2 and Notch1 are involved in the maintenance of
Yihan Xu et al.
Journal of pharmaceutical sciences, 102(5), 1532-1543 (2013-03-26)
In drug release systems using hydrogels as carriers, the presence of the polymer network will reduce the drug release rate, which can extend the release period. For a controlled-release process of drug, usually the ideal situation is to get a
Erik Kaunisto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 698-708 (2013-01-10)
In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer
Peter Bieling et al.
The EMBO journal, 37(1), 102-121 (2017-11-17)
WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex. Here, we show that WASP-family proteins also function as polymerases that accelerate elongation of uncapped actin filaments. When clustered on
Li Li et al.
Pakistan journal of pharmaceutical sciences, 26(5), 929-937 (2013-09-17)
The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor
Marcelo Dutra Duque et al.
Pharmaceutical development and technology, 18(5), 1247-1254 (2012-06-08)
A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constraints on the
Yuki Kojima et al.
Drug development and industrial pharmacy, 39(9), 1484-1493 (2012-06-08)
The purpose of this study is to determine the process parameters of the laboratory-scale spray dryer affecting the solubility behavior and physical stability of solid dispersions. Solid dispersions of the model drug (nilvadipine or nifedipine) and hypromellose (HPMC) (w/w: 1/1)
Raghunath Das et al.
Colloids and surfaces. B, Biointerfaces, 110, 236-241 (2013-06-05)
In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone
J Siepmann et al.
International journal of pharmaceutics, 441(1-2), 826-834 (2012-12-25)
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects
Zhenxiong Zhao et al.
Cancer management and research, 11, 5737-5744 (2019-07-13)
Both cancer-associated fibroblasts (CAFs) and liver cancer stem cells (LCSCs) play an important part in the tumorigenesis, development and metastasis of hepatocellular carcinoma (HCC). Moreover, the stem-like properties in HCC cells could be promoted by CAFs. However, the mechanism remains
Gamal M El Maghraby et al.
Pharmaceutical development and technology, 19(6), 641-650 (2013-07-12)
Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fast disintegrating tablets
D Golchert et al.
International journal of pharmaceutics, 453(2), 322-328 (2013-06-26)
Swellable core technology (SCT) represents a broadly applicable oral osmotic drug delivery platform for the controlled release of drugs. SCT tablets control drug delivery by using osmosis to regulate the influx of water into the tablet's core. The tablet consists
Yuxiang Jiang et al.
Bio-protocol, 7(5), e2146-e2146 (2017-03-05)
Total internal reflection fluorescence (TIRF) microscopy is a powerful tool for visualizing the dynamics of actin filaments at single-filament resolution in vitro. Thanks to the development of various fluorescent probes, we can easily monitor all kinds of events associated with
Melvin X L Tan et al.
Drug development and industrial pharmacy, 39(9), 1389-1400 (2012-10-13)
Foam granulation technology is a new wet granulation approach for pharmaceutical formulations. This study evaluates the performance of foam and spray granulation in achieving uniform drug distribution using a model formulation. To observe wetting and nuclei formation, single drop/foam penetration
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
Adel Ahmed Ali et al.
Pharmaceutical development and technology, 18(5), 1238-1246 (2012-05-16)
Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together
Oktay Algin et al.
Journal of computer assisted tomography, 37(1), 65-74 (2013-01-17)
To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients
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