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Showing 1-30 of 122 results for "M0387" within Papers
Matthia A Karreman et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(3), 236-247 (2012-12-25)
One of the major challenges for correlative microscopy is the preparation of the sample; the protocols for transmission electron microscopy (TEM) and fluorescence microscopy (FM) often prove to be incompatible. Here, we introduce 2+Staining: an improved contrasting procedure for Tokuyasu
Rathapon Asasutjarit et al.
Pharmaceutics, 13(8) (2021-08-29)
Andrographolide (AG) is an active compound isolated from Andrographis paniculata (Family Acanthaceae). Although it possesses beneficial bioactivities to the skin, there is insufficient information of its applications for treatment of skin disorders due to low water solubility leading to complications
Ram Dixit et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(2), 492-497 (2009-01-08)
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening, particularly at the more dynamic plus-end. Microtubule plus-end tracking proteins (+TIPs) localize to and track with growing microtubule plus-ends in the cell. +TIPs regulate microtubule
Kofi Asare-Addo et al.
Colloids and surfaces. B, Biointerfaces, 104, 54-60 (2013-01-10)
Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate
Osama A A Ahmed et al.
Expert opinion on drug delivery, 11(7), 1005-1013 (2014-04-08)
To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches. Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were used in the preparation of
Guobao Li et al.
Frontiers in molecular neuroscience, 12, 126-126 (2019-06-11)
The centrosomal protein γ-tubulin complex protein 3 (Tubgcp3/GCP3) is required for the assembly of γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs), which play critical roles in mitotic spindle formation during mitosis. However, its function in vertebrate embryonic development
Eunmyong Lee et al.
Autophagy, 10(4), 572-587 (2014-01-21)
Genetic analyses indicate that autophagy, an evolutionarily conserved lysosomal degradation pathway, is essential for eukaryotic differentiation and development. However, little is known about whether autophagy contributes to morphogenesis during embryogenesis. To address this question, we examined the role of autophagy
David M Woolley et al.
The Journal of experimental biology, 212(Pt 14), 2215-2223 (2009-06-30)
Flagellar synchronisation has been observed between bull spermatozoa as they swam in a viscous medium, confined to a glass surface. This process is of interest in understanding the regulation of flagellar oscillation in general. Exact and persisting synchrony between bull
Jim Boonyaratanakornkit et al.
mAbs, 13(1), 1912884-1912884 (2021-04-21)
Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting in tens of thousands of hospitalizations
Siyuan Hao et al.
bioRxiv : the preprint server for biology (2020-09-02)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates throughout human airways. The polarized human airway epithelium (HAE) cultured at an airway-liquid interface (HAE-ALI) is an in vitro model mimicking the in vivo human mucociliary airway epithelium and supports the replication
Yihan Xu et al.
Journal of pharmaceutical sciences, 102(5), 1532-1543 (2013-03-26)
In drug release systems using hydrogels as carriers, the presence of the polymer network will reduce the drug release rate, which can extend the release period. For a controlled-release process of drug, usually the ideal situation is to get a
Fumiyo Takabayashi et al.
The British journal of nutrition, 110(7), 1195-1200 (2013-02-26)
We have observed a stiffening of the gastric wall in mice following oral administration of viscous methyl cellulose (MC) solution as a vehicle for food chemicals, an effect which has not previously been reported. To further investigate this effect, young
Erik Kaunisto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 698-708 (2013-01-10)
In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer
Sahar I Da'as et al.
Cells, 9(8) (2020-07-31)
Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). Here, we report a novel homozygous nonsense mutation in PGAP3 (c.265C>T-p.Gln89*), in a 3-year-old boy with unique novel
Oktay Algin et al.
Journal of computer assisted tomography, 37(1), 65-74 (2013-01-17)
To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients
D M Woolley et al.
Biophysical journal, 83(4), 2162-2169 (2002-09-27)
When mouse spermatozoa swim in media of high viscosity, additional waves of bending are superimposed on the primary traveling wave. The additional (secondary) waves are relatively small in scale and high in frequency. They originate in the proximal part of
Min-Soo Kim et al.
International journal of pharmaceutics, 445(1-2), 108-116 (2013-02-12)
The purpose of this study was to develop supersaturatable formulations for the enhanced solubility and oral absorption of sirolimus. Supersaturatable formulations of hydrophilic polymers and/or surfactants were screened by formulation screening, which is based on solvent casting. The solid dispersion
Muhammad Akram et al.
Pakistan journal of pharmaceutical sciences, 26(2), 323-332 (2013-03-05)
The objective of the present study was to formulate an insulin emulgel, selection of an optimize formulation through in vitro drug release kinetics and finally evaluate its hypoglycemic activity in animal model. Insulin emulgel was prepared using emu oil as
Fernanda Bajanca et al.
Nature communications, 10(1), 1518-1518 (2019-04-05)
When migrating in vivo, cells are exposed to numerous conflicting signals: chemokines, repellents, extracellular matrix, growth factors. The roles of several of these molecules have been studied individually in vitro or in vivo, but we have yet to understand how
Raghunath Das et al.
Colloids and surfaces. B, Biointerfaces, 110, 236-241 (2013-06-05)
In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone
J Siepmann et al.
International journal of pharmaceutics, 441(1-2), 826-834 (2012-12-25)
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects
Sulayman Mourabit et al.
Integrative and comparative biology, 52(6), 761-768 (2012-05-18)
The self-fertilizing mangrove killifish, Kryptolebias marmoratus, is an upcoming model species for a range of biological disciplines. To further establish this model in the field of developmental biology, we examined several techniques for embryonic manipulation and for imaging that can
Li Li et al.
Pakistan journal of pharmaceutical sciences, 26(5), 929-937 (2013-09-17)
The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor
Alexandra Schauer et al.
eLife, 9 (2020-04-07)
Embryonic stem cell cultures are thought to self-organize into embryoid bodies, able to undergo symmetry-breaking, germ layer specification and even morphogenesis. Yet, it is unclear how to reconcile this remarkable self-organization capacity with classical experiments demonstrating key roles for extrinsic
Parej Nath et al.
EMBO reports, 22(11), e52948-e52948 (2021-09-02)
The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study
Navideh Anarjan et al.
International journal of food sciences and nutrition, 64(6), 744-748 (2013-04-18)
The emulsification and stabilization ability of four selected polysaccharides, namely, gum Arabic, xanthan gum, pectin and methyl cellulose, in the preparation of water-dispersible astaxanthin nanoparticles using the emulsification-evaporation technique was investigated in this study. The chemical and molecular structure of
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
Sohei Nakayama et al.
Development, growth & differentiation, 54(2), 202-215 (2012-02-22)
Zebrafish is a good model for studying vertebrate development because of the availability of powerful genetic tools. We are interested in the study of the craniofacial skeletal structure of the zebrafish. For this purpose, we performed a gene trap screen
Adel Ahmed Ali et al.
Pharmaceutical development and technology, 18(5), 1238-1246 (2012-05-16)
Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together
Yong Zhang et al.
Methods in molecular biology (Clifton, N.J.), 1323, 273-292 (2015-08-22)
While zebrafish have for some time been regarded as a powerful model organism with which to study early events in hematopoiesis, recent evidence suggests that it also ideal for unraveling the molecular requirements for T cell development in the thymus.
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