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Showing 1-30 of 82 results for "M0430" within Papers
Ram Dixit et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(2), 492-497 (2009-01-08)
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening, particularly at the more dynamic plus-end. Microtubule plus-end tracking proteins (+TIPs) localize to and track with growing microtubule plus-ends in the cell. +TIPs regulate microtubule
Kofi Asare-Addo et al.
Colloids and surfaces. B, Biointerfaces, 104, 54-60 (2013-01-10)
Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate
Muhammad Akram et al.
Pakistan journal of pharmaceutical sciences, 26(2), 323-332 (2013-03-05)
The objective of the present study was to formulate an insulin emulgel, selection of an optimize formulation through in vitro drug release kinetics and finally evaluate its hypoglycemic activity in animal model. Insulin emulgel was prepared using emu oil as
Fumiyo Takabayashi et al.
The British journal of nutrition, 110(7), 1195-1200 (2013-02-26)
We have observed a stiffening of the gastric wall in mice following oral administration of viscous methyl cellulose (MC) solution as a vehicle for food chemicals, an effect which has not previously been reported. To further investigate this effect, young
Matthia A Karreman et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(3), 236-247 (2012-12-25)
One of the major challenges for correlative microscopy is the preparation of the sample; the protocols for transmission electron microscopy (TEM) and fluorescence microscopy (FM) often prove to be incompatible. Here, we introduce 2+Staining: an improved contrasting procedure for Tokuyasu
Osama A A Ahmed et al.
Expert opinion on drug delivery, 11(7), 1005-1013 (2014-04-08)
To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches. Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were used in the preparation of
Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance
Li S, et al.
Breast Cancer Research, 17(1), 91-91 (2015)
Oktay Algin et al.
Journal of computer assisted tomography, 37(1), 65-74 (2013-01-17)
To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients
Min-Soo Kim et al.
International journal of pharmaceutics, 445(1-2), 108-116 (2013-02-12)
The purpose of this study was to develop supersaturatable formulations for the enhanced solubility and oral absorption of sirolimus. Supersaturatable formulations of hydrophilic polymers and/or surfactants were screened by formulation screening, which is based on solvent casting. The solid dispersion
Yihan Xu et al.
Journal of pharmaceutical sciences, 102(5), 1532-1543 (2013-03-26)
In drug release systems using hydrogels as carriers, the presence of the polymer network will reduce the drug release rate, which can extend the release period. For a controlled-release process of drug, usually the ideal situation is to get a
Erik Kaunisto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 698-708 (2013-01-10)
In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer
Erik R Nelson et al.
Oncotarget, 7(51), 84030-84042 (2016-10-22)
Although most triple-negative breast cancer (TNBC) patients initially respond to chemotherapy, residual tumor cells frequently persist and drive recurrent tumor growth. Previous studies from our laboratory and others' indicate that TNBC is heterogeneous, being composed of chemo-sensitive and chemo-resistant tumor
Raghunath Das et al.
Colloids and surfaces. B, Biointerfaces, 110, 236-241 (2013-06-05)
In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone
J Siepmann et al.
International journal of pharmaceutics, 441(1-2), 826-834 (2012-12-25)
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects
Li Li et al.
Pakistan journal of pharmaceutical sciences, 26(5), 929-937 (2013-09-17)
The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor
Handbook of Adhesives and Surface Preparation (2011)
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
Yanan Xu et al.
Scientific reports, 8(1), 6892-6892 (2018-05-04)
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors.
Melvin X L Tan et al.
Drug development and industrial pharmacy, 39(9), 1389-1400 (2012-10-13)
Foam granulation technology is a new wet granulation approach for pharmaceutical formulations. This study evaluates the performance of foam and spray granulation in achieving uniform drug distribution using a model formulation. To observe wetting and nuclei formation, single drop/foam penetration
Noriaki Nagai et al.
Toxicology, 319, 53-62 (2014-03-07)
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that
Xiuhua Zhao et al.
International journal of pharmaceutics, 454(1), 278-284 (2013-07-09)
Insulin is the most effective and durable drug in the treatment of advanced stage diabetes. However, oral delivering insulin was a tough task for rapid enzymatic degradation. In this work, we designed and developed a delivery system composed of enteric
D Golchert et al.
International journal of pharmaceutics, 453(2), 322-328 (2013-06-26)
Swellable core technology (SCT) represents a broadly applicable oral osmotic drug delivery platform for the controlled release of drugs. SCT tablets control drug delivery by using osmosis to regulate the influx of water into the tablet's core. The tablet consists
Navideh Anarjan et al.
International journal of food sciences and nutrition, 64(6), 744-748 (2013-04-18)
The emulsification and stabilization ability of four selected polysaccharides, namely, gum Arabic, xanthan gum, pectin and methyl cellulose, in the preparation of water-dispersible astaxanthin nanoparticles using the emulsification-evaporation technique was investigated in this study. The chemical and molecular structure of
Martin Kuentz et al.
Drug development and industrial pharmacy, 39(9), 1476-1483 (2012-10-10)
An automated version of uniaxial powder flow testing has recently been developed and there is a need for experimental data from pharmaceutical powders. To compare the novel testing method with an annular shear cell using different pharmaceutical excipients. A particular
Marcelo Dutra Duque et al.
Pharmaceutical development and technology, 18(5), 1247-1254 (2012-06-08)
A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constraints on the
Yihua Wang et al.
Biochemistry, 52(9), 1611-1621 (2013-02-07)
Myosin powers contraction in heart and skeletal muscle and is a leading target for mutations implicated in inheritable muscle diseases. During contraction, myosin transduces ATP free energy into the work of muscle shortening against resisting force. Muscle shortening involves relative
Xiaodong Zheng et al.
Cornea, 32(9), 1260-1264 (2013-07-19)
To compare 3 ocular lubricants containing sodium hyaluronate (SH), carboxymethylcellulose (CMC), and hydroxypropyl methylcellulose (HPMC) for their ability to enhance water retention and to protect human corneal epithelial cells (HCECs) from dehydration. Experiments were performed using 0.1% and 0.3% solutions
Melissa L Barker-Haliski et al.
Neurochemical research, 42(7), 1904-1918 (2017-03-18)
The successful identification of promising investigational therapies for the treatment of epilepsy can be credited to the use of numerous animal models of seizure and epilepsy for over 80 years. In this time, the maximal electroshock test in mice and rats
Faaiza Qazi et al.
Pakistan journal of pharmaceutical sciences, 26(4), 653-663 (2013-07-03)
The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different formulations
Hisham Al-Obaidi et al.
International journal of pharmaceutics, 443(1-2), 95-102 (2013-01-10)
Solid dispersions of varying weight ratios compositions of the nonionic drug, griseofulvin and the hydrophilic, anionic polymer, hydroxylpropylmethyl cellulose acetate succinate, have been prepared by ball milling and the resulting samples characterized using a combination of Fourier transform infra-red spectroscopy
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