M0960000

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Showing 1-30 of 288 results for "M0960000" within Papers

Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor.

Kathryn E Livingston et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18369-18374 (2014-12-10)

Positive allosteric modulation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represents a potential approach for the management of pain. We recently reported on positive allosteric modulators of MOPr (mu-PAMs), a class A G

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Feiran Zhang et al.

Journal of medicinal chemistry, 56(10), 3996-4016 (2013-05-03)

Methionine aminopeptidases (MetAPs), which remove the initiator methionine from nascent peptides, are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

Maaike Kockx et al.

PloS one, 9(10), e111186-e111186 (2014-10-28)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of

Selective purification of supercoiled p53-encoding pDNA with L-methionine-agarose matrix.

J F A Valente et al.

Analytical biochemistry, 459, 61-69 (2014-05-28)

The p53 tumor suppressor gene has been widely explored for gene therapy as an alternative to the common treatments. Recently, the supercoiled conformation of a p53-encoding plasmid proved to be more efficient in cell transfection and protein expression than the

Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor.

James B Thoden et al.

Biochemistry, 53(48), 7615-7624 (2014-11-08)

Here we report the first complete structure of a bacterial Fe-S l-serine dehydratase determined to 2.25 Å resolution. The structure is of the type 2 l-serine dehydratase from Legionella pneumophila that consists of a single polypeptide chain containing a catalytic

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Methionine metabolism: major pathways and enzymes involved and strategies for control and diversification of volatile sulfur compounds in cheese.

María Del Carmen Martínez-Cuesta et al.

Critical reviews in food science and nutrition, 53(4), 366-385 (2013-01-17)

For economical reasons and to accommodate current market trends, cheese manufacturers and product developers are increasingly interested in controlling cheese flavor formation and developing new flavors. Due to their low detection threshold and diversity, volatile sulfur compounds (VSCs) are of

Effects of genistein on stereological and hormonal characteristics of the pituitary somatotrophs in rats.

Svetlana Trifunović et al.

Endocrine, 47(3), 869-877 (2014-04-23)

The hypothalamic-pituitary somatotropic system plays a pivotal role in the regulation of physiological processes and metabolism, which is modulated by gonadal steroids. Considering that genistein belongs to the phytoestrogen family and acts via similar mechanisms to estrogens, the present study

Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma.

Jennifer R Diamond et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(16), e254-e258 (2013-04-24)

Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

Alexander Wehr et al.

PloS one, 9(11), e112327-e112327 (2014-11-06)

Non-alcoholic fatty liver disease (NAFLD) is a major cause of morbidity and mortality in developed countries, resulting in steatohepatitis (NASH), fibrosis and eventually cirrhosis. Modulating inflammatory mediators such as chemokines may represent a novel therapeutic strategy for NAFLD. We recently

Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading.

I B Sardharwalla et al.

Archives of disease in childhood, 49(7), 553-559 (1974-07-01)

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients.

Yetrib Hathout et al.

Human molecular genetics, 23(24), 6458-6469 (2014-07-17)

It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy developments. Here, we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes

GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency.

A Collin de l'Hortet et al.

Endocrinology, 155(7), 2545-2554 (2014-04-09)

GH pathway has been shown to play a major role in liver regeneration through the control of epidermal growth factor receptor (EGFR) activation. This pathway is down-regulated in nonalcoholic fatty liver disease. Because regeneration is known to be impaired in

Dietary L-arginine modulates immunosuppression in broilers inoculated with an intermediate strain of infectious bursa disease virus.

Jian-Zhuang Tan et al.

Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)

The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:

Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.

Ianai Fishbein et al.

Brain : a journal of neurology, 137(Pt 12), 3235-3247 (2014-10-30)

The involvement of the protein α-synuclein (SNCA) in the pathogenesis of Parkinson's disease is strongly supported by the facts that (i) missense and copy number mutations in the SNCA gene can cause inherited Parkinson's disease; and (ii) Lewy bodies in

Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.

Valentina Medici et al.

Alcoholism, clinical and experimental research, 38(6), 1540-1549 (2014-04-16)

Alcoholic steatohepatitis (ASH) is caused in part by the effects of ethanol (EtOH) on hepatic methionine metabolism. To investigate the phenotypic and epigenetic consequences of altered methionine metabolism in this disease, we studied the effects of 4-week intragastric EtOH feeding

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

The budding yeast amphiphysin complex is required for contractile actin ring (CAR) assembly and post-contraction GEF-independent accumulation of Rho1-GTP.

Michael John Cundell et al.

PloS one, 9(5), e97663-e97663 (2014-05-31)

The late events of the budding yeast cell division cycle, cytokinesis and cell separation, require the assembly of a contractile actomyosin ring (CAR), primary and secondary septum formation followed by enzymatic degradation of the primary septum. Here we present evidence

Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A).

Coraline Mlynarczyk et al.

Nature communications, 5, 5067-5067 (2014-10-09)

Endoplasmic reticulum (ER) stress occurs in poorly perfused tissues and activates the p53 isoform p53/47 to promote G2 arrest via 14-3-3σ. This contrasts with the p21(CDKN1A)-dependent G1 arrest caused by p53 following DNA damage. It is not known how cells

A case of glioblastoma invasion clearly demonstrated on 11C-methionine positron emission tomography.

Makoto Ohno et al.

Japanese journal of clinical oncology, 43(4), 448-448 (2013-03-28)

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.

Ping Xie et al.

Atherosclerosis, 237(2), 609-617 (2014-12-03)

The correlation between intestinal cholesterol absorption values and plasma low-density lipoprotein-cholesterol (LDL-C) levels remains controversial. Niemann-Pick-C1-Like 1 (NPC1L1) is essential for intestinal cholesterol absorption, and is the target of ezetimibe, a cholesterol absorption inhibitor. However, studies with NPC1L1 knockout mice

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.

Youngjoo Lee et al.

Cancer, 120(14), 2090-2098 (2014-04-17)

Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.

Paula Dominguez-Salas et al.

The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)

Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were

Changes in transcription and metabolism during the early stage of replicative cellular senescence in budding yeast.

Yuka Kamei et al.

The Journal of biological chemistry, 289(46), 32081-32093 (2014-10-09)

Age-related damage accumulates and a variety of biological activities and functions deteriorate in senescent cells. However, little is known about when cellular aging behaviors begin and what cellular aging processes change. Previous research demonstrated age-related mRNA changes in budding yeast

Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.

Reiko Nishihara et al.

The American journal of clinical nutrition, 100(6), 1479-1488 (2014-11-21)

Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood. We hypothesized that excess alcohol consumption might increase risk of colorectal carcinoma with hypomethylation of insulin-like growth factor

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.

Martha S Field et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(2), 400-405 (2014-12-31)

An inborn error of metabolism associated with mutations in the human methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene has been identified. The proband presented with SCID, megaloblastic anemia, and neurologic abnormalities, but the causal metabolic impairment is unknown. SCID has been associated

Pokeweed antiviral protein alters splicing of HIV-1 RNAs, resulting in reduced virus production.

Alice Zhabokritsky et al.

RNA (New York, N.Y.), 20(8), 1238-1247 (2014-06-22)

Processing of HIV-1 transcripts results in three populations in the cytoplasm of infected cells: full-length RNA, singly spliced, and multiply spliced RNAs. Rev, regulator of virion expression, is an essential regulatory protein of HIV-1 required for transporting unspliced and singly

Effects of randomized supplementation of methionine or alanine on cysteine and glutathione production during the early phase of treatment of children with edematous malnutrition.

Curtis O Green et al.

The American journal of clinical nutrition, 99(5), 1052-1058 (2014-03-07)

We have shown that a low glutathione concentration and synthesis rate in erythrocytes are associated with a shortage of protein-derived cysteine in children with edematous severe acute malnutrition (SAM). We tested the hypothesis that methionine supplementation may increase protein-derived cysteine

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Filipe Cabreiro et al.

Cell, 153(1), 228-239 (2013-04-02)

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic

Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.

Vanessa R da Silva et al.

American journal of physiology. Endocrinology and metabolism, 307(1), E93-101 (2014-05-16)

Low vitamin B-6 nutritional status is associated with increased risk for cardiovascular disease and certain cancers. Pyridoxal 5'-phosphate (PLP) serves as a coenzyme in many cellular processes, including several reactions in one-carbon (1C) metabolism and the transsulfuration pathway of homocysteine

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