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Showing 1-30 of 96 results for "M1407" within Papers
Enxiang Wei et al.
Organic & biomolecular chemistry, 12(33), 6389-6392 (2014-07-11)
An efficient synthesis of γ-ketoamides was developed by the one-pot multicomponent reaction of chalcones, malononitrile and DMF (as both the reactant and solvent) in the presence of NaOH (3.0 equiv.). The reaction features high atom economy, easily available starting materials
Liang Sun et al.
Nature communications, 5, 5746-5746 (2014-12-18)
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a
S A Ponomarenko et al.
Faraday discussions, 174, 313-339 (2014-10-04)
This contribution describes recent progress in the design, synthesis and properties of solution-processible star-shaped oligomers and their application in organic photovoltaics. Even though alternative chemistry has been used to design such oligomers, the most successful approach is based on a
Ji-Hyun Park et al.
Experimental biology and medicine (Maywood, N.J.), 239(12), 1705-1714 (2014-05-30)
Melittin, a major polypeptide in honeybee venom, have been used to treat inflammatory disease. Various studies have demonstrated the anti-bacterial, anti-viral, anti-inflammatory and anticancer effects of bee venom and melittin. However, the precise mechanism of melittin in liver disease is
Zhi-Peng Hu et al.
The Journal of organic chemistry, 76(10), 3797-3804 (2011-04-07)
Organocatalytic conjugate addition of malononitrile to conformationally restricted dienones has been studied. A series of chiral primary and tertiary amine catalysts were screened. A piperidine-based thiourea-tertiary amine was found to be the efficient catalyst. Chiral pyran derivatives were obtained in
Huan Zhan et al.
Biophysical journal, 104(3), 643-654 (2013-02-28)
Implicit membrane models usually treat the membrane as a hydrophobic slab and neglect lateral pressure/curvature stress effects. As a result, they cannot distinguish, for example, PE from PC lipids. Here, the implicit membrane model IMM1 is extended to include these
D Baracchi et al.
Toxicon : official journal of the International Society on Toxinology, 71, 105-112 (2013-06-12)
Apis mellifera venom is one of the best characterized venoms among Hymenoptera, yet relatively little is known about venom belonging to other species in the genus Apis. Melittin, one of the most important bioactive peptides, has been isolated and characterized
Christiane Menzfeld et al.
Glia, 63(6), 1083-1099 (2015-03-04)
The putative protein tyrosine kinase (PTK) inhibitor tyrphostin AG126 has proven beneficial in various models of inflammatory disease. Yet molecular targets and cellular mechanisms remained enigmatic. We demonstrate here that AG126 treatment has beneficial effects in experimental autoimmune encephalomyelitis (EAE)
Kieran F Geoghegan et al.
Protein expression and purification, 87(1), 27-34 (2012-10-17)
The T helper cell-derived cytokine interleukin-17A (IL-17A) is a variably glycosylated disulfide-linked homodimer of 34-38 kDa. Its polypeptide monomer contains one canonical N-glycosylation site at Asn68, and human recombinant IL-17A was partly N-glycosylated when expressed in human kidney (HEK293) cells
Y Dombrowski et al.
Allergy, 67(11), 1400-1407 (2012-09-15)
Following allergen exposure, cytokines and other pro-inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous and endogenous danger signals and trigger IL-1β and IL-18 activation which in turn shape Th2 responses. Honey
Goran Gajski et al.
Environmental toxicology and pharmacology, 36(2), 697-705 (2013-07-31)
Melittin (MEL) is a major peptide constituent of bee venom that has been proposed as one of the upcoming possibilities for anticancer therapy. Recent reports point to several mechanisms of MEL cytotoxicity in different types of cancer cells such as
Wenkai Zhang et al.
The journal of physical chemistry. B, 116(37), 11527-11536 (2012-09-01)
The interplay between reaction environment and photochemical outcome has wide ranging implications for designing and directing light driven chemical conversions. We present a detailed mechanistic description of photoisomerization in julolidine malononitrile (JDMN) as the first step to characterizing this interplay
Yanyang Qu et al.
Chemical communications (Cambridge, England), 47(13), 3912-3914 (2011-02-23)
An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(II) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%.
Dayong Tian et al.
Toxicology and applied pharmacology, 272(2), 551-558 (2013-07-03)
Intracellular chemical reaction of chemical mixtures is one of the main reasons that cause synergistic or antagonistic effects. However, it still remains unclear what the influencing factors on the intracellular chemical reaction are, and how they influence on the toxicological
Brandon Findlay et al.
Antimicrobial agents and chemotherapy, 54(10), 4049-4058 (2010-08-11)
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse class of antibacterial agents currently validated in preclinical and clinical settings for the treatment of infections caused by antimicrobial-resistant bacteria. Numerous studies with linear, cyclic, and diastereomeric AMPs
Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin.
B Bechinger
The Journal of membrane biology, 156(3), 197-211 (1997-04-01)
Qiao-Yan Li et al.
Molecular diversity, 16(3), 431-439 (2012-06-29)
A convenient and practical method for the synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines has been developed via a three-component, one-pot reaction from aldehydes, malononitrile and S-alkylisothiouronium salts in water at room temperature. A series of polysubstituted pyrimidines were prepared by this method in
Jonghan Shin et al.
Journal of Alzheimer's disease : JAD, 26 Suppl 3, 135-145 (2011-10-06)
2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile (FDDNP) is the first positron emission tomography (PET) molecular imaging probe to visualize Alzheimer's disease (AD) pathology in living humans. The most unique features of FDDNP are that (1) it is the only currently available radiotracer to image neurofibrillary
Won-Mi Cho et al.
Bioorganic & medicinal chemistry letters, 17(21), 5772-5776 (2007-09-11)
We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism
Thomas Gutsmann et al.
Antimicrobial agents and chemotherapy, 54(9), 3817-3824 (2010-07-08)
Systemic bacterial infections are associated with high mortality. The access of bacteria or constituents thereof to systemic circulation induces the massive release of immunomodulatory mediators, ultimately causing tissue hypoperfusion and multiple-organ failure despite adequate antibiotic treatment. Lipid A, the "endotoxic
H Raghuraman et al.
Bioscience reports, 27(4-5), 189-223 (2006-12-02)
Melittin is the principal toxic component in the venom of the European honey bee Apis mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 amino acid residues in which the amino-terminal region is
Switchable catalysis with a light-responsive cavitand.
Orion B Berryman et al.
Angewandte Chemie (International ed. in English), 50(40), 9400-9403 (2011-09-10)
Jörg Andrä et al.
The Journal of biological chemistry, 282(20), 14719-14728 (2007-03-29)
The peptide NK-2 is an effective antimicrobial agent with low hemolytic and cytotoxic activities and is thus a promising candidate for clinical applications. It comprises the alpha-helical, cationic core region of porcine NK-lysin a homolog of human granulysin and of
Melittin-loaded immunoliposomes against viral surface proteins, a new approach to antiviral therapy.
Alberto Falco et al.
Antiviral research, 97(2), 218-221 (2012-12-25)
In this study, melittin, a well-characterized pore-forming lytic amphiphilic peptide susceptible to be vehiculized in lipid membranes, has been utilized to study their antiviral properties. For this purpose, an assay based on melittin loaded-immunoliposomes previously described by our group was
Daniela Comegna et al.
Bioorganic & medicinal chemistry, 18(5), 2010-2018 (2010-02-16)
The synthesis and screening of neutral and cationic, linear and cyclic peptoids (N-alkylglycine peptidomimetics) is described. Structure-activity relationship studies show that the in vitro activities of the tested peptoids depend on both cyclization and decoration with cationic groups. The most
Hao-Wu Lin et al.
Advanced materials (Deerfield Beach, Fla.), 24(17), 2269-2272 (2012-04-05)
Small-molecule organic solar cells with microcavity structures utilizing very thin solar-absorbing active layers are simulated and fabricated. By carefully fine-tuning the in-cell spacer layer and out-of-cell capping layer, highly efficient top-illuminated indium tin oxide-free solar cells are created on glass
Xiao-Gang Yin et al.
Organic & biomolecular chemistry, 10(8), 1506-1509 (2012-01-11)
A cascade Michael/Michael/oxa-Michael reaction between curcumins and isatylidene malononitriles has been developed. Multicyclic spirooxindoles were prepared in excellent yields and diastereoselectivities. DMAP was found to catalyze this transformation efficiently under mild reaction conditions.
Joan G Schellinger et al.
Biomaterials, 34(9), 2318-2326 (2012-12-25)
Non-viral gene delivery systems capable of transfecting cells in the brain are critical in realizing the potential impact of nucleic acid therapeutics for diseases of the central nervous system. In this study, the membrane-lytic peptide melittin was incorporated into block
Charles H Chen et al.
Biochimica et biophysica acta, 1838(9), 2243-2249 (2014-04-29)
Unbiased molecular simulation is a powerful tool to study the atomic details driving functional structural changes or folding pathways of highly fluid systems, which present great challenges experimentally. Here we apply unbiased long-timescale molecular dynamics simulation to study the ab
Dingding Wang et al.
International journal of oncology, 47(3), 1160-1168 (2015-07-15)
Vascular endothelial growth factor and its tyrosine kinase receptors have been identified as key mediators of the regulation of pathologic blood vessel growth and maintenance in the promotion of angiogenesis and tumor growth. Therefore, an alternative approach to destroying tumor
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