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Keyword:'M2786'
Showing 1-30 of 195 results for "M2786" within Papers
Tao Xie et al.
Neurology, 84(4), 415-420 (2014-12-30)
To study whether 60-Hz stimulation, compared with routine 130 Hz, improves swallowing function and freezing of gait (FOG) in patients with Parkinson disease (PD) who undergo bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). We studied 7 patients with PD
Hovy Ho-Wai Wong et al.
Neuron, 95(4), 852-868 (2017-08-07)
Nascent proteins can be positioned rapidly at precise subcellular locations by local protein synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major determinant of synaptic connectivity, is shaped by localized growth responses, but it is unknown whether
Xu Wang et al.
Journal of biomedical nanotechnology, 15(7), 1482-1491 (2019-06-15)
As a widely used first-line chemotherapy drug for tumor, Doxorubicin (DOX) can induce various side effects on normal tissues because of its non-specific distribution in the body. Emerging evidence has shown that platelets have the capability to recognize and interact
Ayodeji O Oyelami et al.
Environmental science. Processes & impacts, 17(7), 1302-1310 (2015-06-13)
This study investigates the impact of different types of carbon nanomaterials (CNMs) namely C60, multi-walled carbon nanotubes (MWCNTs) and fullerene soot on the catabolism of (14)C-phenanthrene in soil by indigenous microorganisms. Different concentrations (0%, 0.01%, 0.1% and 1%) of the
Jeffrey X Xie et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 33(7), 1138-1149 (2018-01-03)
Recent studies have highlighted a critical role for CD40 in the pathogenesis of renal injury and fibrosis. However, little is currently understood about the regulation of CD40 in this setting. We use novel Na/K-ATPase cell lines and inhibitors in order
Martina Nagel et al.
Development (Cambridge, England), 145(13) (2018-06-10)
The leading-edge mesendoderm (LEM) of the Xenopus gastrula moves as an aggregate by collective migration. However, LEM cells on fibronectin in vitro show contact inhibition of locomotion by quickly retracting lamellipodia upon mutual contact. We found that a fibronectin-integrin-syndecan module
Moonsup Lee et al.
The Journal of cell biology, 218(8), 2659-2676 (2019-07-05)
Cilia are critical for proper embryonic development and maintaining homeostasis. Although extensively studied, there are still significant gaps regarding the proteins involved in regulating ciliogenesis. Using the Xenopus laevis embryo, we show that Dishevelled (Dvl), a key Wnt signaling scaffold
D M Grieger et al.
Journal of animal science, 68(11), 3747-3754 (1990-11-01)
This study evaluated the antigenicity of LH-ovalbumin complexes produced using different conjugation techniques. Two homobifunctional cross-linkers, glutaraldehyde (Glut) and carbodiimide (ECDI), were evaluated together with one heterobifunctional reagent, m-maleimido-benzoyl N-hydroxysuccinimide ester (MBS). Polyacrylamide gel electrophoresis and Western transfer techniques were
Candace Elaine Rapchak et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 93(4), 396-404 (2015-07-08)
The polo-like kinases are a family of conserved serine/threonine kinases that play multiple roles in regulation of the cell cycle. Unlike its four other family members, the role of Plk4 in embryonic development has not been well characterized. In mice
Yuehua Yu et al.
Biochemical and biophysical research communications, 491(3), 642-648 (2017-08-02)
MYB transcription factors are a large family of proteins involved in plant development and responses to stress. In this study, the wheat salinity-induced R2R3-MYB transcription factor TaSIM was functionally characterized, with a focus on its role in salt stress tolerance.
Abolfazl Saboury et al.
Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 30(6), 545-550 (2018-11-06)
To evaluate the effect of screw access hole design on the fracture resistance of cement-retained implant-supported zirconia-based restorations with screw access holes. Thirty cement-retained implant-supported zirconia-based molar crown specimens were fabricated. The specimens were divided into 3 groups of 10:
Karen M Neilson et al.
Developmental biology, 467(1-2), 39-50 (2020-09-07)
The Six1 transcription factor plays a major role in craniofacial development. Mutations in SIX1 and its co-factor, EYA1, are causative for about 50% of Branchio-otic/Branchio-oto-renal syndrome (BOR) patients, who are characterized by variable craniofacial, otic and renal malformations. We previously
Kaili Yang et al.
The Analyst, 142(19), 3740-3746 (2017-09-08)
A target-induced cyclic strategy for DNAzyme formation was proposed to achieve simple, sensitive and universal detection of protein biomarkers with convenient colorimetric or chemiluminescence imaging readout. In the assay, the target protein was recognized by a pair of DNA-labeled antibodies
E Hazum et al.
Journal of biochemical and biophysical methods, 24(1-2), 95-106 (1992-03-01)
In this study we have searched for sulfhydryl reagents which can be radiolabeled and detect minute quantities of SH-proteins. Iodoacetamidotyramine reacts with sulfhydryls at a low rate, having a pseudo-first order rate constant, kappa obs = 3 +/- 0.2 M-1
Elisabetta Muntoni et al.
Pharmaceutics, 11(2) (2019-02-06)
Glioblastoma is the most common and invasive primary tumor of the central nervous system and normally has a negative prognosis. Biodistribution in healthy animal models is an important preliminary study aimed at investigating the efficacy of chemotherapy, as it is
Samuele Fiorini et al.
PloS one, 14(10), e0211844-e0211844 (2019-10-19)
The first line of treatment for people with Diabetes mellitus is metformin. However, over the course of the disease metformin may fail to achieve appropriate glycemic control, and a second-line therapy may become necessary. In this paper we introduce Tangle
Emiliano Trias et al.
Glia, 68(6), 1165-1181 (2019-12-21)
Distal axonopathy is a recognized pathological feature of amyotrophic lateral sclerosis (ALS). In the peripheral nerves of ALS patients, motor axon loss elicits a Wallerian-like degeneration characterized by denervated Schwann cells (SCs) together with immune cell infiltration. However, the pathogenic
Mariya Maruyama et al.
The Biological bulletin, 229(1), 58-69 (2015-09-05)
Egg formation in terrestrial insects is an absorptive process, accommodated not only by packing proteins and lipids into yolk but also by filling chorions with water. An osmotic swelling of ovarian follicles takes place during oocyte maturation. This study investigated
Y Okamura et al.
Biochimica et biophysica acta, 1073(3), 538-542 (1991-04-09)
Anti-bilirubin-IX alpha monoclonal antibodies exclusively specific for unconjugated bilirubin-IX alpha are prepared and characterized. Using modified MBS (metamaleimidobenzoyl-N-hydroxysuccinimide ester) method, bilirubin-IX alpha was covalently coupled to bovine serum albumin (BSA) retaining its intramolecular hydrogen bonds as well as three-dimensional structure.
Ximena Soto et al.
The EMBO journal, 39(12), e103558-e103558 (2020-05-13)
Noise is prevalent in biology and has been widely quantified using snapshot measurements. This static view obscures our understanding of dynamic noise properties and how these affect gene expression and cell state transitions. Using a CRISPR/Cas9 Zebrafish her6::Venus reporter combined
Sarela Garcia-Santamarina et al.
Nature chemical biology, 16(3), 337-344 (2020-01-15)
Infection by the fungal pathogen Cryptococcus neoformans causes lethal meningitis, primarily in immune-compromised individuals. Colonization of the brain by C. neoformans is dependent on copper (Cu) acquisition from the host, which drives critical virulence mechanisms. While C. neoformans Cu+ import
Rodney A Velliquette et al.
Obesity (Silver Spring, Md.), 26(1), 126-134 (2017-11-23)
To examine specific molecular mechanisms involved in modulating hepatic lipogenesis and mitochondria biogenesis signals by Lithospermum erythrorhizon (gromwell) root extract. Stable cell lines with luciferase reporter constructs were generated to examine sterol regulatory element binding protein 1c (SREBP1c) and peroxisome
Esra Acar Soykut et al.
Folia microbiologica, 64(6), 751-763 (2019-02-14)
Nowadays, phage therapy emerges as one of the alternative solutions to the problems arising from antibiotic resistance in pathogenic bacteria. Although phage therapy has been successfully applied both in vitro and in vivo, one of the biggest concerns in this
Ruiyan Tao et al.
Plant physiology, 184(4), 1684-1701 (2020-10-24)
Light is indispensable for the anthocyanin accumulation of red pear (Pyrus pyrifolia). Anthocyanin biosynthesis is catalyzed by a series of enzymes encoded by structural genes, which are regulated by a MYB-basic/helix-loop-helix-WD repeat (MYB-bHLH-WDR [MBW]) complex. The bHLH proteins of subgroup
Yurim Ji et al.
Antioxidants & redox signaling, 30(14), 1731-1745 (2018-09-08)
Peroxiredoxin5 (Prdx5), a thioredoxin peroxidase, is an antioxidant enzyme that is widely studied for its antioxidant properties and protective roles in neurological and cardiovascular disorders. This study is aimed at investigating the functional significance of Prdx5 in mitochondria and at
Muhammad R Haque et al.
Journal of controlled release : official journal of the Controlled Release Society, 258, 10-21 (2017-04-24)
Islet transplantation is as effective as but also less immunogenic than pancreas transplantation for the treatment of type 1 diabetes mellitus. However, as the complete elimination of immunogenicity still remains a major obstacle in islet transplantation, layer-by-layer encapsulation (LbL) of
Jian Li et al.
Nature plants, 6(7), 848-859 (2020-06-17)
Photosynthesis provides food, fibre and fuel that support our society; understanding the mechanisms controlling dynamic changes in this process helps identify new options to improve photosynthesis. Photosynthesis shows diel changes, which have been largely attributed to external light/dark conditions, as
Nikola Sladojevic et al.
Journal of the American Heart Association, 9(18), e017533-e017533 (2020-09-03)
Background Regulator of G-protein signaling 5 (RGS5) is a negative modulator of G-protein-coupled receptors. The role of RGS5 in brain endothelial cells is not known. We hypothesized that RGS5 in brain microvascular endothelial cells may be an important mediator of
L R Iwasaki et al.
Journal of dental research, 96(8), 895-901 (2017-04-18)
Cartilage fatigue may be a factor in the precocious development of degenerative changes in the temporomandibular joint (TMJ). This cross-sectional study estimated potential for cartilage fatigue via TMJ energy densities (ED) and jaw muscle duty factors (DF), which were combined
Shota Yamana et al.
PloS one, 10(4), e0124259-e0124259 (2015-04-22)
Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells. When the cells were confluently cultured, Necl-4 was up-regulated
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