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Showing 1-30 of 195 results for "M2786" within Papers
Takayuki Miyanishi et al.
Biochemistry, 41(17), 5429-5438 (2002-04-24)
In the presence of myosin S1 or myosin heads, actin filaments tend to form bundles. The biological meaning of the bundling of actin filaments has been unclear. In this study, we found that the cardiac myosin heads can form the
D Heintz et al.
FEBS letters, 329(1-2), 9-12 (1993-08-23)
By reacting trimethylammoniobromobimane bromide (TMB bromide) with rabbit muscle actin, a fluorescent reporter group was linked to cysteine at position 374. Fluorescence of TMB-actin decreased significantly on addition of thymosin beta 4 (T beta 4), a peptide of 43 amino
R J Edwards et al.
Journal of immunological methods, 117(2), 215-220 (1989-02-24)
A polyclonal antibody raised against a peptide conjugated using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride to maleic anhydride-derivatised lysozyme showed substantial cross-reactivity with m-maleimidobenzoyl-N-hydroxysuccinimide ester-derivatised haemocyanin. This was due to antibodies produced against maleic anhydride-derivatised groups on lysozyme that reacted with m-maleimidobenzoyl-N-hydroxysuccinimide ester-derivatised groups
Yusheng Hou et al.
Nano letters, 19(4), 2472-2477 (2019-03-15)
We propose the use of ferromagnetic insulator MnBi2Se4/Bi2Se3/antiferromagnetic insulator Mn2Bi2Se5 heterostructures for the realization of the axion insulator state. Importantly, the axion insulator state in such heterostructures only depends on the magnetization of the ferromagnetic insulator and, hence, can be
Khanhky Phamluong et al.
Frontiers in molecular neuroscience, 10, 273-273 (2017-09-16)
The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum
Dingran Chang et al.
Scientific reports, 7(1), 3110-3110 (2017-06-10)
We report on a new colorimetric DNA detection method that takes advantage of the power of polymerase chain reaction (PCR) and the simplicity of the classic litmus test. The strategy makes use of a modified set of primers for PCR
Natalia Chmielewska et al.
Journal of neuroimmunology, 332, 57-63 (2019-04-06)
In our study, we assessed the potency of the brain-derived proteins ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), matrix metalloproteinase 9 (MMP-9), glial fibrillary acidic protein (GFAP) and the immune activation indicators interleukin 1β (IL-1β) and interleukin 6 (IL-6) as peripheral biomarkers
Danni Wang et al.
Analytica chimica acta, 1111, 67-74 (2020-04-22)
Human telomerase RNA (hTR), one of the essential components of telomerase, serves as a reverse template to add repeated segments of (TTAGGG)n to the 3' end of telomere DNA for maintaining the length of telomere DNA, endowing cells indefinite proliferation
P Devanna et al.
Molecular psychiatry, 23(5), 1375-1384 (2017-03-16)
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their prevalence and potential severity for quality of life. While large-scale genomic screens have made major advances in this area, for many disorders the genetic underpinnings
Opioids Binding Mu and Delta Receptors Exhibit Diverse Efficacy in the Activation of Gi2and Gx/z Transducer Proteins in Mouse Periaqueductal Gray Matter.
Garzon J
Journal of Pharmacology and Experimental Therapeutics, 281, 549-557 (1997)
Chikako Yokoyama et al.
Biochemical and biophysical research communications, 511(4), 916-920 (2019-03-11)
Leydig cells play a pivotal function in the synthesis of a male sex steroid, testosterone. The ability of the steroid production is dependent on the expression of the steroidogenic genes, such as HSD3B (3β-hydroxysteroid dehydrogenase/Δ5- Δ4 isomerase). It has been
Qing Xiao et al.
Analytica chimica acta, 1032, 130-137 (2018-08-26)
A multiplexed chemiluminescence (CL) imaging assay was designed for sensitive screen detection of a panel of protein biomarkers by integrating DNA microarray with proximity binding-induced hybridization chain reaction (HCR) amplification. The DNA microarray was manufactured by printing hairpin DNAs for
Masataka Goto et al.
Journal of bacteriology, 202(21) (2020-08-21)
Bordetella pertussis uses a type III secretion system (T3SS) to inject virulence proteins into host cells. Although the B. pertussis T3SS was presumed to be involved in host colonization, efficient secretion of type III secreted proteins from B. pertussis has
Gaofeng Wu et al.
Amino acids, 50(7), 863-875 (2018-04-08)
One pathogenic mechanism of ethanol-induced liver injury is the excessive production of reactive oxygen species (ROS), which may result in alcoholic liver disease (ALD) characterized by cell death due to necrosis and apoptosis. Taurine was proved to protect against liver
J F Heneghan et al.
American journal of physiology. Cell physiology, 309(5), C332-C347 (2015-06-26)
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode
Deo R Singh et al.
Biochemical and biophysical research communications, 521(3), 775-778 (2019-11-11)
Metabotropic Glutamate Receptors (mGluRs) are Class C G-protein coupled receptors (GPCRs) that are expressed throughout the central nervous system and are involved in several neurological and psychiatric disorders. Although, many studies focused on Glutamate induced activation of mGluR2, however, the
M Tomita et al.
Biochimica et biophysica acta, 1055(3), 199-206 (1990-12-10)
Methods for pre-selecting B lymphocytes were studied and investigated. First, biotinylated antigen was used for selecting B lymphocytes. These pre-selected B lymphocytes were then combined with biotinylated myeloma cells by adding streptavidin. The final formula of the selected B cell-myeloma
Mohi Uddin et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(5), 889-896 (2020-01-05)
Epithelial-mesenchymal transition (EMT) contributes to the development of severe lung diseases, such as pulmonary fibrosis. Recently, it has been reported that EMT involves complex metabolic reprogramming triggered by several factors including transforming growth factor (TGF-β1) and that monocarboxylate transporter (MCT1)
Jing Che et al.
Plant & cell physiology, 61(8), 1387-1398 (2020-06-03)
About 60-85% of total phosphorus (P) in cereal crops is finally allocated to seeds, where it is required for seed development, germination and early growth. However, little is known about the molecular mechanisms underlying P allocation to seeds. Here, we
Rebecca Kozor et al.
Heart, lung & circulation, 30(3), 380-387 (2020-08-31)
Coronary artery disease (CAD) remains a major public health problem in Australia and globally. A variety of imaging techniques allow for both anatomical and functional assessment of CAD and selection of the optimal investigation pathway is challenging. Cardiovascular magnetic resonance
Matthew Lewis et al.
Contemporary clinical trials, 97, 106143-106143 (2020-09-16)
Cardiovascular disease (CVD) accounts for 40% of the excess mortality identified in people with severe mental illness (SMI). Modifiable CVD risk factors are higher and can be exacerbated by the cardiometabolic impact of psychotropic medications. People with SMI frequently attend
Deo R Singh et al.
Archives of biochemistry and biophysics, 697, 108632-108632 (2020-10-20)
The Metabotropic glutamate receptor 2 (mGluR2) is involved in several neurological and psychiatric disorders and is an attractive drug target. It is believed to form a strict dimer and the dimeric assembly is necessary for glutamate induced activation. Although many
Pavel Cermak et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 125(11), 1033-1038 (2017-09-30)
Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search
Shinichi Hayashi et al.
Developmental biology, 406(2), 271-282 (2015-08-19)
Many amphibians can regenerate limbs, even in adulthood. If a limb is amputated, the stump generates a blastema that makes a complete, new limb in a process similar to developmental morphogenesis. The blastema is thought to inherit its limb-patterning properties
Yoo-Kyung Kim et al.
Biochemical and biophysical research communications, 527(4), 896-901 (2020-05-21)
Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate regulation. The vertebrate homolog of Drosophila dachshund has gained considerable importance as an essential regulator of development, but its functions during
Radosław Skórzewski et al.
Analytical biochemistry, 394(1), 48-55 (2009-07-09)
Differential interactions of tropomyosin (TM) isoforms with actin can be important for determination of the thin filament functions. A mechanism of tropomyosin binding to actin was studied by comparing interactions of five alphaTM isoforms with actin modified with m-maleimidobenzoyl-N-hydroxysuccinimide ester
M Miki et al.
Biochemistry, 30(22), 5625-5630 (1991-06-04)
A chemical modification of G-actin with (m-maleimidobenzoyl)-N-hydroxysuccinimide ester (MBS) impairs actin polymerization [Bettache, N., Bertrand, R., & Kassab, R. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 6028-6032]. MBS-actin recovers the ability to polymerize when a 2-fold molar excess of phalloidin
Alejo Rodriguez-Vida et al.
BJU international, 126(5), 559-567 (2020-07-13)
To investigate the efficacy of alternating cycles of sunitinib and everolimus vs standard sequential treatment of sunitinib followed by everolimus in first-line metastatic renal cell carcinoma (mRCC), as alternating blockade of vascular endothelial growth factor receptor (VEGFR) and mammalian target
Andrea Messina et al.
Stem cells (Dayton, Ohio), 33(8), 2496-2508 (2015-04-29)
It has long been known that the depletion of bone morphogenetic protein (BMP) is one of the key factors necessary for the development of anterior neuroectodermal structures. However, the precise molecular mechanisms that underlie forebrain regionalization are still not completely
Shaun Purkiss et al.
ANZ journal of surgery, 90(5), 872-876 (2019-05-09)
Administrative data may have utility in the impartial assessment of surgical outcomes and rare events. We have used a publicly available sample of the Australian pharmaceutical and health service provision (medical benefits scheme) databases to assess outcomes following parathyroidectomy for
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