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Showing 1-30 of 174 results for "M32631" within Papers
Chang Seok Lee et al.
The Journal of biological chemistry, 289(37), 25556-25570 (2014-07-24)
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes
Dorottya Czövek et al.
Respiratory research, 15, 81-81 (2014-08-15)
Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able
David Van Mater et al.
Cancer research, 75(3), 605-614 (2014-12-17)
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation.
Halima Amhaoul et al.
Neurobiology of disease, 82, 526-539 (2015-09-22)
A hallmark in the neuropathology of temporal lobe epilepsy is brain inflammation which has been suggested as both a biomarker and a new mechanistic target for treatments. The translocator protein (TSPO), due to its high upregulation under neuroinflammatory conditions and
Craig M McKittrick et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(4), 638-647 (2015-01-08)
Blood brain barrier (BBB) breakdown and neuroinflammation are key events in ischemic stroke morbidity and mortality. The present study investigated the effects of mast cell deficiency and stabilization on BBB breakdown and neutrophil infiltration in mice after transient middle cerebral
Chengcao Sun et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(2), 224-237 (2015-01-17)
Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as
Heow Won Lee et al.
Neuropeptides, 82, 102058-102058 (2020-06-09)
Brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling in the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) is associated with cardiovascular regulation. Exercise increases plasma BDNF and attenuates activation of central pathways in the PVN and RVLM post myocardial
Emmanuelle Charrin et al.
British journal of haematology, 168(5), 747-756 (2014-11-11)
Oxidative stress plays a crucial role in sickle cell disease (SCD) physiopathology. Given that chronic physical activity is known to decrease reactive oxygen species (ROS) and increase nitric oxide (NO) bioavailability in healthy subjects and in patients with cardiovascular or
G Tan et al.
Scandinavian journal of rheumatology, 44(2), 150-156 (2014-12-03)
To investigate whether serum anti-high mobility group box 1 (anti-HMGB1) antibodies are related to the development of skin lesions in systemic lupus erythematosus (SLE). This study involved 21 SLE patients with skin lesions, 18 without skin lesions, and 22 healthy
Cécile Philippe et al.
European journal of pharmacology, 735, 177-183 (2014-05-02)
The MCHR1 is an interesting pharmacological and pharmaceutical target, due to its involvement in pathologies as diabetes, gut inflammation and adiposity. in vivo PET-studies of the MCHR1 in energy homeostasis and diabetes could be of great value for deeper understanding
Julie Bolcaen et al.
Nuclear medicine and biology, 42(1), 38-45 (2014-09-15)
Discrimination between (high-grade) brain tumor recurrence and radiation necrosis (RN) remains a diagnostic challenge because both entities have similar imaging characteristics on conventional magnetic resonance imaging (MRI). Metabolic imaging, such as positron emission tomography (PET) could overcome this diagnostic dilemma.
Martina Seifert et al.
The Journal of surgical research, 193(2), 933-941 (2014-12-03)
Undesirable processes of inflammation, calcification, or immune-mediated reactions are limiting factors in long-term survival of heart valves in patients. In this study, we target the modulatory effects of ice-free cryopreservation (IFC) of xenogeneic heart valve leaflet matrices, without decellularization, on
Sara A Olenich et al.
The Journal of physiology, 592(15), 3325-3338 (2014-06-22)
Temporal expression of positive and negative angiogenic factors in response to detraining is poorly understood. We report the protein expression of anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors (vascular endothelial growth factor, VEGF; matrix metalloproteinases-2 and
Jill M Goldstein et al.
Cell reports, 27(4), 1254-1264 (2019-04-25)
In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use
Anna K Kopec et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 288-297 (2014-08-21)
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis
M Udawela et al.
Translational psychiatry, 5, e615-e615 (2015-08-05)
Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area
Javier Morán et al.
Experimental gerontology, 58, 104-112 (2014-08-03)
Menopause leads to a decrease in estrogen production that increases central insulin resistance, contributing to the development of neurodegenerative diseases. We have evaluated the influence of aging and estradiol or genistein treatments on some key stages of the insulin signaling
Katrina L Paumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-883 (2014-10-01)
In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effects in Parkinson's disease. The present study investigated whether chronic treatment with a frequently prescribed tricyclic antidepressant
David Santos et al.
American journal of dentistry, 22(5), 315-320 (2010-03-17)
To compare the effects of a new gel-to-foam dentifrice to two standard fluoride control dentifrices on foam generation, levels of total viable anaerobes and total viable volatile sulfur compound (VSC)-producing bacteria in expectorate after brushing. 36 subjects participated in this
Javier Catalán
The journal of physical chemistry. A, 114(2), 811-816 (2009-12-19)
A photophysical study of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indole dissolved in 2-methylbutane at decreasing temperatures from 293 to 93 K revealed the presence of two different fluorescence emissions due to doubly hydrogen-bonded dimers of the monomer species. One of the emissions is assigned to
Davide Rubbini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15752-15766 (2015-11-27)
During development, otic sensory progenitors give rise to hair cells and supporting cells. In mammalian adults, differentiated and quiescent sensory cells are unable to generate new hair cells when these are lost due to various insults, leading to irreversible hearing
Shailaja Kesaraju et al.
Journal of neurochemistry, 109(5), 1413-1426 (2009-05-30)
Freshwater turtles survive prolonged anoxia and reoxygenation without overt brain damage by well-described physiological processes, but little work has been done to investigate the molecular changes associated with anoxic survival. We examined stress proteins and apoptotic regulators in the turtle
Emelie Berglund et al.
BMC genomics, 21(1), 298-298 (2020-04-16)
Interest in studying the spatial distribution of gene expression in tissues is rapidly increasing. Spatial Transcriptomics is a novel sequencing-based technology that generates high-throughput information on the distribution, heterogeneity and co-expression of cells in tissues. Unfortunately, manual preparation of high-quality
Christian Giordano et al.
Human molecular genetics, 24(8), 2147-2162 (2015-01-02)
Toll-like receptor 4 (TLR4) recognizes specific structural motifs associated with microbial pathogens and also responds to certain endogenous host molecules associated with tissue damage. In Duchenne muscular dystrophy (DMD), inflammation plays an important role in determining the ultimate fate of
Benedikt Galliker et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(25), 6161-6168 (2009-05-14)
We have identified two intermediates in the autoxidation of NO*: ONOO*, which was detected by EPR spectroscopy at 295 K and atmospheric pressure in the gas phase, and ONOONO, a red substance produced at 113 K in 2-methylbutane. The red
Dorota Haznar-Garbacz et al.
AAPS PharmSciTech, 12(4), 1183-1185 (2011-09-16)
A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an
Jackob Moskovitz et al.
Neuropathology and applied neurobiology, 41(7), 941-951 (2015-02-03)
The enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine
Florelle Domart et al.
eLife, 9 (2020-12-09)
Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level. We correlate
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Y C Hsu et al.
Chemosphere, 42(3), 227-234 (2000-12-02)
Motor vehicle emission factors of carbon monoxide (CO) and non-methane volatile organic compounds (NMVOCs) were calculated inside the Chung-Cheng Tunnel of Kaohsiung in Taiwan. The results were compared with those model predictions from the Mobile Taiwan 2.0 model. Individual concentrations
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