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Showing 1-30 of 174 results for "m32631" within Papers
Emelie Berglund et al.
BMC genomics, 21(1), 298-298 (2020-04-16)
Interest in studying the spatial distribution of gene expression in tissues is rapidly increasing. Spatial Transcriptomics is a novel sequencing-based technology that generates high-throughput information on the distribution, heterogeneity and co-expression of cells in tissues. Unfortunately, manual preparation of high-quality
Florelle Domart et al.
eLife, 9 (2020-12-09)
Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level. We correlate
Julie Bolcaen et al.
Nuclear medicine and biology, 42(1), 38-45 (2014-09-15)
Discrimination between (high-grade) brain tumor recurrence and radiation necrosis (RN) remains a diagnostic challenge because both entities have similar imaging characteristics on conventional magnetic resonance imaging (MRI). Metabolic imaging, such as positron emission tomography (PET) could overcome this diagnostic dilemma.
Dorottya Czövek et al.
Respiratory research, 15, 81-81 (2014-08-15)
Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able
Chang Seok Lee et al.
The Journal of biological chemistry, 289(37), 25556-25570 (2014-07-24)
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes
Cécile Philippe et al.
European journal of pharmacology, 735, 177-183 (2014-05-02)
The MCHR1 is an interesting pharmacological and pharmaceutical target, due to its involvement in pathologies as diabetes, gut inflammation and adiposity. in vivo PET-studies of the MCHR1 in energy homeostasis and diabetes could be of great value for deeper understanding
G Tan et al.
Scandinavian journal of rheumatology, 44(2), 150-156 (2014-12-03)
To investigate whether serum anti-high mobility group box 1 (anti-HMGB1) antibodies are related to the development of skin lesions in systemic lupus erythematosus (SLE). This study involved 21 SLE patients with skin lesions, 18 without skin lesions, and 22 healthy
Heow Won Lee et al.
Neuropeptides, 82, 102058-102058 (2020-06-09)
Brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling in the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) is associated with cardiovascular regulation. Exercise increases plasma BDNF and attenuates activation of central pathways in the PVN and RVLM post myocardial
Martina Seifert et al.
The Journal of surgical research, 193(2), 933-941 (2014-12-03)
Undesirable processes of inflammation, calcification, or immune-mediated reactions are limiting factors in long-term survival of heart valves in patients. In this study, we target the modulatory effects of ice-free cryopreservation (IFC) of xenogeneic heart valve leaflet matrices, without decellularization, on
Emmanuelle Charrin et al.
British journal of haematology, 168(5), 747-756 (2014-11-11)
Oxidative stress plays a crucial role in sickle cell disease (SCD) physiopathology. Given that chronic physical activity is known to decrease reactive oxygen species (ROS) and increase nitric oxide (NO) bioavailability in healthy subjects and in patients with cardiovascular or
Behnia S Lashkari et al.
Journal of reproductive immunology, 107, 43-51 (2014-12-04)
Pelvic infections and sexually transmitted diseases place a burden on health resources and may be associated with premature birth. The mechanisms by which the female reproductive tract (FRT) combats these infections remain ill understood, but are likely to involve the
Javier Morán et al.
Experimental gerontology, 58, 104-112 (2014-08-03)
Menopause leads to a decrease in estrogen production that increases central insulin resistance, contributing to the development of neurodegenerative diseases. We have evaluated the influence of aging and estradiol or genistein treatments on some key stages of the insulin signaling
M Quiviger et al.
Gene therapy, 21(12), 1001-1007 (2014-08-22)
Mucopolysaccharidosis type IIIA (MPS-IIIA) or Sanfilippo A syndrome is a lysosomal storage genetic disease that results from the deficiency of the N-sulfoglucosamine sulfohydrolase (SGSH) protein, a sulfamidase required for the degradation of heparan sulfate glycosaminoglycans (GAGs). The accumulation of these
Katrina L Paumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-883 (2014-10-01)
In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effects in Parkinson's disease. The present study investigated whether chronic treatment with a frequently prescribed tricyclic antidepressant
Chengcao Sun et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(2), 224-237 (2015-01-17)
Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as
Craig M McKittrick et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(4), 638-647 (2015-01-08)
Blood brain barrier (BBB) breakdown and neuroinflammation are key events in ischemic stroke morbidity and mortality. The present study investigated the effects of mast cell deficiency and stabilization on BBB breakdown and neutrophil infiltration in mice after transient middle cerebral
Thomas Wälchli et al.
Nature protocols, 10(1), 53-74 (2014-12-17)
During development and in various diseases of the CNS, new blood vessel formation starts with endothelial tip cell selection and vascular sprout migration, followed by the establishment of functional, perfused blood vessels. Here we describe a method that allows the
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Angèle Nalbandian et al.
Human gene therapy methods, 26(1), 13-24 (2014-12-30)
Inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia is attributed to mutations in the valosin-containing protein (VCP) gene, mapped to chromosomal region 9p13.3-12. Affected individuals exhibit scapular winging and die from progressive muscle weakness and
Katharina M Prautsch et al.
Bioengineering (Basel, Switzerland), 7(2) (2020-05-10)
Peripheral nerve injuries often result in lifelong disabilities despite advanced surgical interventions, indicating the urgent clinical need for effective therapies. In order to improve the potency of adipose-derived stem cells (ASC) for nerve regeneration, the present study focused primarily on
David Van Mater et al.
Cancer research, 75(3), 605-614 (2014-12-17)
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation.
Halima Amhaoul et al.
Neurobiology of disease, 82, 526-539 (2015-09-22)
A hallmark in the neuropathology of temporal lobe epilepsy is brain inflammation which has been suggested as both a biomarker and a new mechanistic target for treatments. The translocator protein (TSPO), due to its high upregulation under neuroinflammatory conditions and
Javier Catalán
The journal of physical chemistry. A, 114(2), 811-816 (2009-12-19)
A photophysical study of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indole dissolved in 2-methylbutane at decreasing temperatures from 293 to 93 K revealed the presence of two different fluorescence emissions due to doubly hydrogen-bonded dimers of the monomer species. One of the emissions is assigned to
Mathieu Lecocq et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(8), 1594-1601 (2014-12-24)
Electrical currents have deleterious effects on biomedical metallic implants. However, following arthroplasty, neuro-myoelectrostimulation (NMES) is often used in patient rehabilitation. Such a rehabilitation technique could compromise patient recovery through deleterious effects on metallic alloys and biological tissues. The purpose of
Riley K Driscoll et al.
Aging, 13(11), 14557-14570 (2021-06-04)
GRSF1 is a mitochondrial RNA-binding protein important for maintaining mitochondrial function. We found that GRSF1 is highly expressed in cultured skeletal myoblasts differentiating into myotubes. To understand the physiological function of GRSF1 in vivo, we generated mice in which GRSF1
Sara A Olenich et al.
The Journal of physiology, 592(15), 3325-3338 (2014-06-22)
Temporal expression of positive and negative angiogenic factors in response to detraining is poorly understood. We report the protein expression of anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors (vascular endothelial growth factor, VEGF; matrix metalloproteinases-2 and
Anna K Kopec et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 288-297 (2014-08-21)
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis
M Udawela et al.
Translational psychiatry, 5, e615-e615 (2015-08-05)
Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area
Benedikt Galliker et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(25), 6161-6168 (2009-05-14)
We have identified two intermediates in the autoxidation of NO*: ONOO*, which was detected by EPR spectroscopy at 295 K and atmospheric pressure in the gas phase, and ONOONO, a red substance produced at 113 K in 2-methylbutane. The red
Fernando Eduardo Padovan-Neto et al.
Neuropharmacology, 89, 87-99 (2014-09-10)
It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID). Here, we investigated the ability of
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