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Showing 31-60 of 3888 results for "m4880" within Papers
Parmila Kumari et al.
Journal of biochemistry, 157(2), 113-119 (2014-11-20)
The safety of drinking water is essential to our health. In this context, the mutagenicity of water needs to be checked strictly. However, from the methodological limit, the lower concentration (less than parts per million) of mutagenicity could not be
Vanessa Mondol et al.
RNA (New York, N.Y.), 21(8), 1396-1403 (2015-06-18)
MicroRNAs (miRNAs) are a class of small noncoding RNAs that use partial base-pairing to recognize and regulate the expression of messenger RNAs (mRNAs). Mature miRNAs arise from longer primary transcripts (pri-miRNAs) that are processed to a shorter hairpin precursor miRNA
J Durlach et al.
Magnesium research, 18(3), 187-192 (2005-11-02)
MgSO4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO4 and MgCl2 effects in order to answer the question whether MgSO4 could be or not replaced by MgCl2. Considering that the
R J Flassig et al.
Molecular bioSystems, 10(7), 1978-1986 (2014-05-17)
Reliable and efficient detection of DNA damage constitutes a vital capability of human cells to maintain genome stability. Following DNA damage, the histone variant H2AX becomes rapidly phosphorylated by the DNA damage response kinases DNA-PKcs and ATM. H2AX phosphorylation plays
Tatsuki Kunoh et al.
SpringerPlus, 3, 30-30 (2014-01-31)
Highly conserved chromatin assembly factor 1 (CAF-1) is required for histone deposition onto newly synthesized DNA to maintain genome stability. This study shows that the fission yeast Pcf1, the large subunit in CAF-1, is crucial for maintaining checkpoint kinase Cds1.
Philip Hasel et al.
Biochimica et biophysica acta, 1853(9), 2066-2076 (2014-12-30)
Neurodegenerative and neurological disorders are often characterised by pathological changes to dendrites, in advance of neuronal death. Oxidative stress, energy deficits and excitotoxicity are implicated in many such disorders, suggesting a potential vulnerability of dendrites to these situations. Here we
Wayne K Greene et al.
Parasites & vectors, 8, 368-368 (2015-07-15)
The cat flea (Ctenocephalides felis) is a blood-feeding ectoparasitic insect and particular nuisance pest of companion animals worldwide. Identification of genes that are differentially expressed in response to feeding is important for understanding flea biology and discovering targets for their
Surabhi Khandige et al.
PLoS pathogens, 11(8), e1005109-e1005109 (2015-08-21)
Uropathogenic Escherichia coli (UPEC) are capable of occupying physiologically distinct intracellular and extracellular niches within the urinary tract. This feat requires the timely regulation of gene expression and small RNAs (sRNAs) are known to mediate such rapid adjustments in response
Kristen E Howery et al.
Journal of bacteriology, 197(15), 2499-2507 (2015-05-20)
A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs phosphorelay, hyperswarm on solid agar and differentiate into swarmer cells
Hao-Ching Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8768-8773 (2015-07-01)
Decline in mitochondrial morphology and function is a hallmark of neuronal aging. Here we report that progressive mitochondrial fragmentation is a common manifestation of aging Caenorhabditis elegans neurons and body wall muscles. We show that sensory-evoked activity was essential for
Christopher J Konop et al.
ACS chemical neuroscience, 6(6), 855-870 (2015-03-31)
Neuropeptides are known to have dramatic effects on neurons and synapses; however, despite extensive studies of the motorneurons in the parasitic nematode Ascaris suum, their peptide content had not yet been described. We determined the peptide content of single excitatory
Chun-Xiao Li et al.
Parasites & vectors, 8, 325-325 (2015-06-13)
Aedes aegypti is an important vector for dengue virus and thus has been targeted with pyrethroid insecticides in many areas of the world. As such, resistance has been detected to several of these insecticides, including in China, but the mechanisms
Kuan-Ho Lin et al.
Journal of cellular biochemistry, 116(6), 1113-1120 (2014-12-24)
The insulin-like growth factor-II/mannose 6-phosphate receptor (IGF2R) over-expression correlates with heart disease progression. The IGF2R is not only an IGF2 clearance receptor, but it also triggers signal transduction, resulting in cardiac hypertrophy, apoptosis and fibrosis. The present study investigated the
Gary E Gilbert et al.
Blood, 126(10), 1237-1244 (2015-07-15)
Thrombin-stimulated platelets expose very little phosphatidylserine (PS) but express binding sites for factor VIII (fVIII), casting doubt on the role of exposed PS as the determinant of binding sites. We previously reported that fVIII binding sites are increased three- to
Dongmei Tan et al.
Journal of medical virology, 87(3), 498-503 (2015-01-22)
A molecular epidemiological study of Norovirus (NoV) infections in children aged <5 years was conducted in the outpatient department of a hospital between January 2010 and December 2011 in Nanning City, Guangxi Zhuang Autonomous Region of China. Fecal samples were
Martin Vaeth et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 1202-1217 (2015-06-26)
Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is essential for immunity to infection. CRAC channels are formed by ORAI1 proteins in the plasma membrane and activated by stromal interaction molecule (STIM)1 and STIM2 in the endoplasmic reticulum.
Sandra Dupouy et al.
Oncotarget, 5(18), 8235-8251 (2014-09-25)
A present challenge in breast oncology research is to identify therapeutical targets which could impact tumor progression. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 20% of breast cancers, and NTSR1 overexpression was shown to predict
Elena Sinkiewicz-Darol et al.
Neurogenetics, 16(1), 27-32 (2014-10-25)
Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) represent the most common heritable neuromuscular disorders. Molecular diagnostics of CMT1A/HNPP diseases confirm clinical diagnosis, but their value is limited to the clinical course and prognosis.
Kahori Shiba-Fukushima et al.
PLoS genetics, 10(12), e1004861-e1004861 (2014-12-05)
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb chain.
Arnav Moudgil et al.
Cell, 182(4), 992-1008 (2020-07-28)
Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no technology links cell identity to TF binding sites (TFBS) in those cell types. We present self-reporting transposons
Darizy Flavia Silva et al.
PloS one, 10(11), e0143171-e0143171 (2015-11-26)
In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels in vascular tissue. Thus
Srilatha Nalluri et al.
Cancer biology & therapy, 16(2), 276-286 (2015-03-11)
The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inhibit Mcl(-)1 clinically are in high
Jiao Liu et al.
Experimental neurology, 273, 253-262 (2015-09-17)
Cyclin-dependent kinase 5 (Cdk5) is an important serine/threonine kinase that plays critical roles in many physiological processes. Recently, Cdk5 has been reported to phosphorylate TRPV1 at threonine 407 (Thr-407) in humans (Thr-406 in rats), which enhances the function of TRPV1
B Bertolasi et al.
Annals of botany, 115(4), 683-692 (2015-03-01)
Ulmus minor has been severely affected by Dutch elm disease (DED). The introduction into Europe of the exotic Ulmus pumila, highly tolerant to DED, has resulted in it widely replacing native U. minor populations. Morphological and genetic evidence of hybridization
Carolina Cefaliello et al.
Journal of neuroscience research, 92(11), 1573-1580 (2014-07-01)
Synaptosomal protein synthesis from rat brain is selectively increased by learning and is massively enhanced during the recovery period from brain ischemia. To lay the groundwork for identification of the involved synaptic elements, we examined the effects induced by varying
Lars Björn Riecken et al.
Human mutation, 36(2), 270-278 (2014-12-17)
Gain-of-function alterations in several components and modulators of the Ras-MAPK pathway lead to dysregulation of the pathway and cause a broad spectrum of autosomal dominant developmental disorders, collectively known as RASopathies. These findings demonstrate the importance of tight multilevel Ras
Juan Li et al.
Parasitology research, 114(7), 2697-2704 (2015-04-23)
In the present study, near-complete mitochondrial (mt) genome sequences for Schistosoma japonicum from different regions in the Philippines and Japan were amplified and sequenced. Comparisons among S. japonicum from the Philippines, Japan, and China revealed a geographically based length difference
Estefanía Mondragón et al.
Nucleic acids research, 43(15), 7544-7555 (2015-07-18)
Restriction endonucleases (REases) recognize and cleave short palindromic DNA sequences, protecting bacterial cells against bacteriophage infection by attacking foreign DNA. We are interested in the potential of folded RNA to mimic DNA, a concept that might be applied to inhibition
Mariana Brizuela et al.
Molecular and cellular neurosciences, 66(Pt B), 129-140 (2015-02-17)
Neuronal cytoskeletal alterations, in particular the loss and misalignment of microtubules, are considered a hallmark feature of the degeneration that occurs after traumatic brain injury (TBI). Therefore, microtubule-stabilizing drugs are attractive potential therapeutics for use following TBI. The best-known drug
Francesca De Amicis et al.
Journal of cellular and molecular medicine, 18(11), 2252-2265 (2014-09-13)
The tumour suppressor activity of the phosphatase and tensin homologue on chromosome 10 (PTEN) is subject of intense investigative efforts, although limited information on its regulation in breast cancer is available. Herein, we report that, in breast cancer cells, progesterone
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