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Showing 1-30 of 87 results for "M6385" within Papers
Corinna Speth et al.
eLife, 7 (2018-08-29)
Intron splicing increases proteome complexity, promotes RNA stability, and enhances transcription. However, introns and the concomitant need for splicing extend the time required for gene expression and can cause an undesirable delay in the activation of genes. Here, we show
Patrick S Wray et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 748-757 (2013-01-08)
This work uses ATR-FTIR spectroscopic imaging to study the dissolution of delayed release and pH resistant compressed coating pharmaceutical tablets. Tablets with an inner core and outer shell were constructed using a custom designed compaction cell. The core of the
Gautam Singhvi et al.
Pharmaceutical development and technology, 19(6), 708-716 (2013-08-13)
The objective of this study was to design oral controlled release (CR) matrix tablets of Milnacipran using hydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of various formulation factors such as polymer proportion, polymer viscosity, compression
Ana M Cerdeira et al.
International journal of pharmaceutics, 443(1-2), 209-220 (2013-01-08)
Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect. To increase their dissolution rate, the compounds were nanoground by media milling to produce nanosuspensions with mean particle size of approximately
Noriaki Nagai et al.
Toxicology, 319, 53-62 (2014-03-07)
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that
Karen J Wedekind et al.
Modern rheumatology, 27(5), 838-848 (2016-11-17)
This study was performed to evaluate the potential efficacy of natural eggshell membrane (NEM) in collagen-induced arthritic rats, a well-established rodent model of inflammation and rheumatoid arthritis. Rats with developing type II collagen-induced arthritis (CIA) were treated once daily by
Navideh Anarjan et al.
International journal of food sciences and nutrition, 64(6), 744-748 (2013-04-18)
The emulsification and stabilization ability of four selected polysaccharides, namely, gum Arabic, xanthan gum, pectin and methyl cellulose, in the preparation of water-dispersible astaxanthin nanoparticles using the emulsification-evaporation technique was investigated in this study. The chemical and molecular structure of
Gabriela Andrejeva et al.
Autophagy, 16(6), 1044-1060 (2019-09-14)
Macroautophagy/autophagy can enable cancer cells to withstand cellular stress and maintain bioenergetic homeostasis by sequestering cellular components into newly formed double-membrane vesicles destined for lysosomal degradation, potentially affecting the efficacy of anti-cancer treatments. Using 13C-labeled choline and 13C-magnetic resonance spectroscopy
Xiuhua Zhao et al.
International journal of pharmaceutics, 454(1), 278-284 (2013-07-09)
Insulin is the most effective and durable drug in the treatment of advanced stage diabetes. However, oral delivering insulin was a tough task for rapid enzymatic degradation. In this work, we designed and developed a delivery system composed of enteric
Martin Kuentz et al.
Drug development and industrial pharmacy, 39(9), 1476-1483 (2012-10-10)
An automated version of uniaxial powder flow testing has recently been developed and there is a need for experimental data from pharmaceutical powders. To compare the novel testing method with an annular shear cell using different pharmaceutical excipients. A particular
Yihan Xu et al.
Journal of pharmaceutical sciences, 102(5), 1532-1543 (2013-03-26)
In drug release systems using hydrogels as carriers, the presence of the polymer network will reduce the drug release rate, which can extend the release period. For a controlled-release process of drug, usually the ideal situation is to get a
Erik Kaunisto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 698-708 (2013-01-10)
In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer
Dirk van den Brand et al.
Biochimica et biophysica acta, 1860(6), 1342-1349 (2018-03-20)
Drug delivery into tumors and metastases is a major challenge in the eradication of cancers such as epithelial ovarian carcinoma. Cationic cell-penetrating peptides (CPPs) are a promising group of delivery vehicles to mediate cellular entry of molecules that otherwise poorly
Timo Z Nazari-Shafti et al.
Biomolecules, 10(9) (2020-09-26)
The cardioprotective properties of extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) are currently being investigated in preclinical studies. Although microRNAs (miRNAs) encapsulated in EVs have been identified as one component responsible for the cardioprotective effect of MSCs, their
Li Li et al.
Pakistan journal of pharmaceutical sciences, 26(5), 929-937 (2013-09-17)
The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor
Marcelo Dutra Duque et al.
Pharmaceutical development and technology, 18(5), 1247-1254 (2012-06-08)
A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constraints on the
Yuki Kojima et al.
Drug development and industrial pharmacy, 39(9), 1484-1493 (2012-06-08)
The purpose of this study is to determine the process parameters of the laboratory-scale spray dryer affecting the solubility behavior and physical stability of solid dispersions. Solid dispersions of the model drug (nilvadipine or nifedipine) and hypromellose (HPMC) (w/w: 1/1)
Le Ma et al.
Journal of virology, 92(12) (2018-03-30)
Signal peptidase complex subunit 1 (SPCS1) is a newly identified host factor that regulates flavivirus replication, but the molecular mechanism is not fully understood. Here, using Japanese encephalitis virus (JEV) as a model, we investigated the mechanism through which the
Raghunath Das et al.
Colloids and surfaces. B, Biointerfaces, 110, 236-241 (2013-06-05)
In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone
J Siepmann et al.
International journal of pharmaceutics, 441(1-2), 826-834 (2012-12-25)
Three mathematical models were applied to quantify drug release from HPMC/lactose-based matrix tablets loaded with varying amounts of theophylline: (i) a numerical model considering drug diffusion in axial and radial direction in cylinders as well as limited drug solubility effects
Gamal M El Maghraby et al.
Pharmaceutical development and technology, 19(6), 641-650 (2013-07-12)
Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fast disintegrating tablets
D Golchert et al.
International journal of pharmaceutics, 453(2), 322-328 (2013-06-26)
Swellable core technology (SCT) represents a broadly applicable oral osmotic drug delivery platform for the controlled release of drugs. SCT tablets control drug delivery by using osmosis to regulate the influx of water into the tablet's core. The tablet consists
Melvin X L Tan et al.
Drug development and industrial pharmacy, 39(9), 1389-1400 (2012-10-13)
Foam granulation technology is a new wet granulation approach for pharmaceutical formulations. This study evaluates the performance of foam and spray granulation in achieving uniform drug distribution using a model formulation. To observe wetting and nuclei formation, single drop/foam penetration
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
Adel Ahmed Ali et al.
Pharmaceutical development and technology, 18(5), 1238-1246 (2012-05-16)
Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together
Oktay Algin et al.
Journal of computer assisted tomography, 37(1), 65-74 (2013-01-17)
To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients
Fumiyo Takabayashi et al.
The British journal of nutrition, 110(7), 1195-1200 (2013-02-26)
We have observed a stiffening of the gastric wall in mice following oral administration of viscous methyl cellulose (MC) solution as a vehicle for food chemicals, an effect which has not previously been reported. To further investigate this effect, young
Daniel Appadurai et al.
Molecular biology of the cell, 31(4), 287-303 (2019-12-19)
Eisosomes are membrane furrows at the cell surface of yeast that have been shown to function in two seemingly distinct pathways, membrane stress response and regulation of nutrient transporters. We found that many stress conditions affect both of these pathways
Guangfu Mu et al.
Cancer management and research, 12, 783-792 (2020-02-27)
AML1-ETO produced by t(8;21) abnomality has multiple effects on the leukemogenesis of acute myeloid leukemia (AML). SET domain, bifurcated 2 (SETDB2) can mediate gene silencing by trimethylation of the ninth lysine residue of histone H3 protein (H3K9) of the promoter
Yihua Wang et al.
Biochemistry, 52(9), 1611-1621 (2013-02-07)
Myosin powers contraction in heart and skeletal muscle and is a leading target for mutations implicated in inheritable muscle diseases. During contraction, myosin transduces ATP free energy into the work of muscle shortening against resisting force. Muscle shortening involves relative
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