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M6385
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Showing 1-30 of 87 results for "M6385" within Papers
Daniel Appadurai et al.
Molecular biology of the cell, 31(4), 287-303 (2019-12-19)
Eisosomes are membrane furrows at the cell surface of yeast that have been shown to function in two seemingly distinct pathways, membrane stress response and regulation of nutrient transporters. We found that many stress conditions affect both of these pathways
Yuki Kojima et al.
Drug development and industrial pharmacy, 39(9), 1484-1493 (2012-06-08)
The purpose of this study is to determine the process parameters of the laboratory-scale spray dryer affecting the solubility behavior and physical stability of solid dispersions. Solid dispersions of the model drug (nilvadipine or nifedipine) and hypromellose (HPMC) (w/w: 1/1)
Le Ma et al.
Journal of virology, 92(12) (2018-03-30)
Signal peptidase complex subunit 1 (SPCS1) is a newly identified host factor that regulates flavivirus replication, but the molecular mechanism is not fully understood. Here, using Japanese encephalitis virus (JEV) as a model, we investigated the mechanism through which the
Osama A A Ahmed et al.
Expert opinion on drug delivery, 11(7), 1005-1013 (2014-04-08)
To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches. Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were used in the preparation of
Faaiza Qazi et al.
Pakistan journal of pharmaceutical sciences, 26(4), 653-663 (2013-07-03)
The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different formulations
Yihua Wang et al.
Biochemistry, 52(9), 1611-1621 (2013-02-07)
Myosin powers contraction in heart and skeletal muscle and is a leading target for mutations implicated in inheritable muscle diseases. During contraction, myosin transduces ATP free energy into the work of muscle shortening against resisting force. Muscle shortening involves relative
Fumiyo Takabayashi et al.
The British journal of nutrition, 110(7), 1195-1200 (2013-02-26)
We have observed a stiffening of the gastric wall in mice following oral administration of viscous methyl cellulose (MC) solution as a vehicle for food chemicals, an effect which has not previously been reported. To further investigate this effect, young
Muhammad Akram et al.
Pakistan journal of pharmaceutical sciences, 26(2), 323-332 (2013-03-05)
The objective of the present study was to formulate an insulin emulgel, selection of an optimize formulation through in vitro drug release kinetics and finally evaluate its hypoglycemic activity in animal model. Insulin emulgel was prepared using emu oil as
Oktay Algin et al.
Journal of computer assisted tomography, 37(1), 65-74 (2013-01-17)
To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients
Maria Chiara Lionetti et al.
Journal of clinical medicine, 9(8) (2020-08-14)
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine
Jesse E Hanson et al.
Cell reports, 30(2), 381-396 (2020-01-16)
NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via allosteric modulation are largely unknown. We examine the in vivo effects
Methylcellulose
Kieth H.
xPharm: The Comprehensive Pharmacology Reference, 1-3 (2007)
Matthia A Karreman et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(3), 236-247 (2012-12-25)
One of the major challenges for correlative microscopy is the preparation of the sample; the protocols for transmission electron microscopy (TEM) and fluorescence microscopy (FM) often prove to be incompatible. Here, we introduce 2+Staining: an improved contrasting procedure for Tokuyasu
Min-Soo Kim et al.
International journal of pharmaceutics, 445(1-2), 108-116 (2013-02-12)
The purpose of this study was to develop supersaturatable formulations for the enhanced solubility and oral absorption of sirolimus. Supersaturatable formulations of hydrophilic polymers and/or surfactants were screened by formulation screening, which is based on solvent casting. The solid dispersion
Ram Dixit et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(2), 492-497 (2009-01-08)
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening, particularly at the more dynamic plus-end. Microtubule plus-end tracking proteins (+TIPs) localize to and track with growing microtubule plus-ends in the cell. +TIPs regulate microtubule
Guangfu Mu et al.
Cancer management and research, 12, 783-792 (2020-02-27)
AML1-ETO produced by t(8;21) abnomality has multiple effects on the leukemogenesis of acute myeloid leukemia (AML). SET domain, bifurcated 2 (SETDB2) can mediate gene silencing by trimethylation of the ninth lysine residue of histone H3 protein (H3K9) of the promoter
Kofi Asare-Addo et al.
Colloids and surfaces. B, Biointerfaces, 104, 54-60 (2013-01-10)
Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate
K Kogermann et al.
International journal of pharmaceutics, 444(1-2), 40-46 (2013-02-02)
The main purpose of this study was to investigate the effect of different polymers, with varying physicochemical properties and molecular weight on the stability and dissolution of co-milled amorphous solid dispersions (ASDs) of piroxicam (PRX). The stability of amorphous PRX
Hisham Al-Obaidi et al.
International journal of pharmaceutics, 443(1-2), 95-102 (2013-01-10)
Solid dispersions of varying weight ratios compositions of the nonionic drug, griseofulvin and the hydrophilic, anionic polymer, hydroxylpropylmethyl cellulose acetate succinate, have been prepared by ball milling and the resulting samples characterized using a combination of Fourier transform infra-red spectroscopy
Xiaodong Zheng et al.
Cornea, 32(9), 1260-1264 (2013-07-19)
To compare 3 ocular lubricants containing sodium hyaluronate (SH), carboxymethylcellulose (CMC), and hydroxypropyl methylcellulose (HPMC) for their ability to enhance water retention and to protect human corneal epithelial cells (HCECs) from dehydration. Experiments were performed using 0.1% and 0.3% solutions
Raghunath Das et al.
Colloids and surfaces. B, Biointerfaces, 110, 236-241 (2013-06-05)
In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone
Melvin X L Tan et al.
Drug development and industrial pharmacy, 39(9), 1389-1400 (2012-10-13)
Foam granulation technology is a new wet granulation approach for pharmaceutical formulations. This study evaluates the performance of foam and spray granulation in achieving uniform drug distribution using a model formulation. To observe wetting and nuclei formation, single drop/foam penetration
Noriaki Nagai et al.
Toxicology, 319, 53-62 (2014-03-07)
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that
Dirk van den Brand et al.
Biochimica et biophysica acta, 1860(6), 1342-1349 (2018-03-20)
Drug delivery into tumors and metastases is a major challenge in the eradication of cancers such as epithelial ovarian carcinoma. Cationic cell-penetrating peptides (CPPs) are a promising group of delivery vehicles to mediate cellular entry of molecules that otherwise poorly
Patrick S Wray et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 748-757 (2013-01-08)
This work uses ATR-FTIR spectroscopic imaging to study the dissolution of delayed release and pH resistant compressed coating pharmaceutical tablets. Tablets with an inner core and outer shell were constructed using a custom designed compaction cell. The core of the
Gamal M El Maghraby et al.
Pharmaceutical development and technology, 19(6), 641-650 (2013-07-12)
Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fast disintegrating tablets
Adel Ahmed Ali et al.
Pharmaceutical development and technology, 18(5), 1238-1246 (2012-05-16)
Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together
Corinna Speth et al.
eLife, 7 (2018-08-29)
Intron splicing increases proteome complexity, promotes RNA stability, and enhances transcription. However, introns and the concomitant need for splicing extend the time required for gene expression and can cause an undesirable delay in the activation of genes. Here, we show
D Golchert et al.
International journal of pharmaceutics, 453(2), 322-328 (2013-06-26)
Swellable core technology (SCT) represents a broadly applicable oral osmotic drug delivery platform for the controlled release of drugs. SCT tablets control drug delivery by using osmosis to regulate the influx of water into the tablet's core. The tablet consists
Karen J Wedekind et al.
Modern rheumatology, 27(5), 838-848 (2016-11-17)
This study was performed to evaluate the potential efficacy of natural eggshell membrane (NEM) in collagen-induced arthritic rats, a well-established rodent model of inflammation and rheumatoid arthritis. Rats with developing type II collagen-induced arthritis (CIA) were treated once daily by
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