M7439

Applied Filters:

Keyword:'M7439'

Showing 1-12 of 12 results for "M7439" within Papers

Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.

Maoyong Fu et al.

PloS one, 6(5), e19945-e19945 (2011-06-04)

Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival is epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate with and modify surface expression

Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells.

Henri J Huttunen et al.

Journal of molecular neuroscience : MN, 37(1), 6-15 (2008-07-12)

A common pathogenic event that occurs in all forms of Alzheimer's disease is the progressive accumulation of amyloid beta-peptide (Abeta) in brain regions responsible for higher cognitive functions. Inhibition of acyl-coenzyme A: cholesterol acyltransferase (ACAT), which generates intracellular cholesteryl esters

Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents.

Nikita Mundhara et al.

Scientific reports, 9(1), 7638-7638 (2019-05-23)

Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction force, cell stiffness, focal adhesions, and intracellular drug accumulation. In addition to a

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.

Laurie Hamtiaux et al.

PloS one, 6(10), e26823-e26823 (2011-11-03)

The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity

Expression and shedding of endothelial protein C receptor in prostate cancer cells.

Mario Menschikowski et al.

Cancer cell international, 11, 4-4 (2011-02-16)

Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out

Min Jiang et al.

The Journal of biological chemistry, 294(36), 13487-13501 (2019-07-25)

Junctophilins (JPH1-JPH4) are expressed in excitable and nonexcitable cells, where they tether endoplasmic/sarcoplasmic reticulum (ER/SR) and plasma membranes (PM). These ER/SR-PM junctions bring Ca-release channels in the ER/SR and Ca as well as Ca-activated K channels in the PM to

Decorin antagonizes corneal fibroblast migration via caveolae-mediated endocytosis of epidermal growth factor receptor.

Rajiv R Mohan et al.

Experimental eye research, 180, 200-207 (2019-01-07)

Decorin (Dcn), a small leucine-rich proteoglycan, is involved in the regulation of corneal wound healing. Epidermal growth factor receptor (EGFR) plays a critical role in corneal fibroblasts proliferation, migration and extracellular matrix (ECM) modulation upon injury or infection. The present

Differential effects of filipin and methyl-beta-cyclodextrin on B cell receptor signaling.

M Awasthi-Kalia et al.

Biochemical and biophysical research communications, 287(1), 77-82 (2001-09-11)

Methyl-beta-cyclodextrin and filipin are cholesterol-binding reagents often used interchangeably to investigate functional requirements for lipid rafts in receptor-mediated signal transduction. Recently, contradictory results were reported by two groups using these reagents in different model systems to investigate the role of

Membrane cholesterol modulates cochlear electromechanics.

William E Brownell et al.

Pflugers Archiv : European journal of physiology, 461(6), 677-686 (2011-03-05)

Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement, suggesting that a similar manipulation would alter cochlear mechanics. We examined cochlear function before and after depletion of membrane cholesterol

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.

Elena Rahn et al.

PloS one, 6(10), e25464-e25464 (2011-10-25)

Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s). Most studies into virus entry have used cultured fibroblasts but since keratinocytes represent the

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Sara Rodríguez-Acebes et al.

The Biochemical journal, 420(2), 305-315 (2009-03-06)

Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol

Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes.

Yanqi Zhu et al.

Journal of molecular and cellular cardiology, 97, 204-212 (2016-06-04)

Low serum cholesterol levels are associated with cardiac arrhythmias and poor prognosis in patients with chronic heart failure. However, the underlying mechanisms by which decreases in cholesterol content lead to cardiac dysfunction remain unclear. Multiple studies have implicated damage to

Page 1 of 1