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Showing 1-30 of 292 results for "m9140" within Papers
Bhavani Madakashira et al.
Epigenetics, 12(9), 811-824 (2017-11-04)
The DNA methylome is re-patterned during discrete phases of vertebrate development. In zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first occurs before gastrulation when the parental methylome is changed to the zygotic pattern and the
Hendrik Manner et al.
Surgical endoscopy, 29(7), 1888-1896 (2014-10-09)
A prerequisite for endoscopic treatment (ET) of not only mucosal, but also submucosal early adenocarcinoma of the esophagus (EAC) would be a rate of lymph node (LN) metastasis below the mortality rate of esophagectomy (2-5%). The aim of the present
Monika Dabrzalska et al.
International journal of pharmaceutics, 492(1-2), 266-274 (2015-06-29)
Dendrimers due to their unique architecture may play an important role in drug delivery systems including chemotherapy, gene therapy and recently, photodynamic therapy as well. We investigated two dendrimer-photosensitizer systems in context of potential use of these systems in photodynamic
Sawsan Almohammed et al.
The journal of physical chemistry letters, 10(8), 1878-1887 (2019-03-30)
Semiconductor-graphene oxide-based surface-enhanced Raman spectroscopy substrates represent a new frontier in the field of surface-enhanced Raman spectroscopy (SERS). However, the application of graphene oxide has had limited success because of the poor Raman enhancement factors that are achievable in comparison
Nicole Seegers et al.
Journal of biomolecular screening, 19(9), 1266-1274 (2014-05-30)
Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug
Nuno-Valério Silva et al.
Frontiers in cell and developmental biology, 9, 674749-674749 (2021-06-22)
Inflammatory bowel diseases (IBD) with chronic infiltration of immune cells in the gastrointestinal tract are common and largely incurable. The therapeutic targeting of IBD has been hampered by the complex causality of the disease, with environmental insults like cholesterol-enriched Western
Verena Resch et al.
AMB Express, 4, 30-30 (2014-06-21)
The Michael hydratase - alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric
Holly Richendrfer et al.
Neurotoxicology, 49, 50-58 (2015-05-20)
Organophosphates, a type of neurotoxicant pesticide, are used globally for the treatment of pests on croplands and are therefore found in a large number of conventional foods. These pesticides are harmful and potentially deadly if ingested or inhaled in large
Miriam Bolz et al.
PLoS neglected tropical diseases, 9(8), e0004011-e0004011 (2015-08-15)
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries. The majority of clinical presentations seen in patients are ulcers on
Yanmin Zhou et al.
The Journal of experimental biology, 218(Pt 17), 2775-2781 (2015-07-25)
The flexibility of insect adhesive pads is crucial for their ability to attach on rough surfaces. Here, we used transparent substrates with micropillars to test in adult cockroaches (Nauphoeta cinerea) whether and how the stiffness of smooth adhesive pads changes
Elissa M Grzincic et al.
ACS nano, 9(7), 6801-6816 (2015-06-30)
Gold nanomaterials are intensively studied for applications in disease detection, diagnosis and therapeutics, and this has motivated considerable research to determine their interaction with biomolecules, cells and cell behaviors. However, few studies look at how nanomaterials alter the extracellular matrix
Madeleine Witting et al.
International journal of pharmaceutics, 486(1-2), 52-58 (2015-03-31)
Solid microneedles (MN) are a promising tool for dermal drug delivery. Particular focus lies on the field of vaccination due to pain-free, safe, hygienic and patient compliant antigen deposition. Diverse coating techniques and formulations have been developed to preserve vaccine
Vanessa E DeLey Cox et al.
Annals of the New York Academy of Sciences, 1479(1), 196-209 (2020-04-15)
Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all mammals. Many countries have restricted its use, and modern-day accidental
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
Tanur Sinha et al.
Journal of colloid and interface science, 453, 115-131 (2015-05-16)
The common household material, egg shell of Anas platyrhynchos is utilized for the synthesis of Silver and Gold-Silver core shell nanoparticles using greener, environment friendly and economic way. The egg shell extracts were acting as a stabilizing and reducing agents.
Shan Zhao et al.
Cell, 180(4), 796-812 (2020-02-16)
Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. Adult human organs are particularly challenging to render transparent because of the accumulation of dense and sturdy molecules in decades-aged tissues. To overcome these challenges, we
D Martin-Gili et al.
Journal of materials science. Materials in medicine, 26(7), 211-211 (2015-07-16)
This study shows the potential risk of microfiltration between two different types of implant-abutment connections screwed at 45 Ncm: external and internal. For the first time the use of a mechanical artificial mouth is used with the values (compression and
Hendrik Herzog et al.
Journal of the Royal Society, Interface, 14(130) (2017-05-05)
Fishes sense weak water motion using the lateral line. Among the thousands of described fish species, this organ may differ in size, shape and distribution of individual mechanoreceptors or lateral line canals. The reasons for this diversity remain unclear, but
Carolyn Kachuk et al.
Journal of chromatography. A, 1418, 158-166 (2015-10-01)
In proteomics, sodium dodecyl sulfate (SDS) is favored for protein solubilization and mass-based separation (e.g. GELFrEE or SDS PAGE). Numerous SDS depletion techniques are available to purify proteins ahead of mass spectrometry. The effectiveness of the purification has a controlling
Tse-Kai Fu et al.
Marine drugs, 17(6) (2019-06-19)
More than 80% of infectious bacteria form biofilm, which is a bacterial cell community surrounded by secreted polysaccharides, proteins and glycolipids. Such bacterial superstructure increases resistance to antimicrobials and host defenses. Thus, to control these biofilm-forming pathogenic bacteria requires antimicrobial
Yanglei Jia et al.
PloS one, 9(10), e110455-e110455 (2014-10-21)
The objective of the present study was to investigate the association between diabetes mellitus and colorectal carcinogenesis as well as the possible mechanism involved in this interaction. Diabetes rat models were induced with a low dose of STZ followed by
Thiago C Genaro-Mattos et al.
Biochemistry, 54(18), 2841-2850 (2015-04-14)
Lipid peroxidation is a well-known process that has been implicated in many diseases. Recent evidence has shown that mitochondrial cholesterol levels are increased under specific conditions, making it an important target for peroxidation inside the mitochondria. Cholesterol peroxidation generates, as
Yange Sun et al.
Talanta, 141, 300-306 (2015-05-13)
This paper presents a new electrochemical DNA biosensor constructed using a substrate electrode composed of a novel nanocomposite material prepared using gold nanoparticles (Au-NPs) and multiwalled carbon nanotubes (MWCNTs) and further modified with an Au electrode (AuE), which was used
Xiaohui Song et al.
Small (Weinheim an der Bergstrasse, Germany), 11(34), 4351-4365 (2015-06-13)
The origin of selectivity in the hollowing of silica nanoparticles is investigated to further understand silica. It is realized that, during the synthesis, the silica precursors are essentially ion-paired polyelectrolytes, whose nucleation depends on the concentration of the counter ions
Bram Vivijs et al.
Applied and environmental microbiology, 80(19), 6054-6061 (2014-07-27)
Some members of the family Enterobacteriaceae ferment sugars via the mixed-acid fermentation pathway. This yields large amounts of acids, causing strong and sometimes even lethal acidification of the environment. Other family members employ the 2,3-butanediol fermentation pathway, which generates comparatively
Jo-Il Kim et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2427-2436 (2014-10-11)
The solid matrices used for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) enable the analysis of small molecules by preventing fragmentations of organic matrix molecules in the low mass-to-charge ratio (m/z) range. In this work, a nylon nanoweb with TiO(2)
Kun Shan et al.
Experimental eye research, 197, 108107-108107 (2020-06-13)
Pathological ocular angiogenesis commonly results in visual impairment or even blindness. Unveiling the mechanisms of pathological angiogenesis is critical to identify the regulators and develop effective targeted therapies. Here, we used corneal neovascularization (CNV) model to investigate the mechanism of
Jingjing Wei et al.
International journal of molecular medicine, 36(5), 1384-1392 (2015-09-24)
Emphysema is a serious disease of the respiratory system and is associated with inflammation and oxidative stress. Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in heme biosynthesis, exerts potent anti-inflammatory, antioxidant, anti-apoptotic and anti‑proliferative effects in various diseases. In the
Ying Liu et al.
Biosensors & bioelectronics, 64, 43-50 (2014-09-06)
Inflammatory cytokines are secreted by immune cells in response to infection or injury. Quantification of multiple cytokines in parallel may help with disease diagnosis by illuminating inflammatory pathways related to disease onset and progression. This paper describes development of an
Marcus D Goncalves et al.
Science (New York, N.Y.), 363(6433), 1345-1349 (2019-03-23)
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS
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