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Showing 1-30 of 145 results for "M9768" within Papers
Patient and graft survival following kidney transplantation in recipients with cystinosis: a cohort study.
Rebecca A Spicer et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 65(1), 172-173 (2014-09-23)
Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer.
Fujisawa T, et al.
PLoS ONE, 7(4), e34437-e34437 (2012)
Fabian U Zwettler et al.
Nature communications, 11(1), 3222-3222 (2020-06-28)
The synaptonemal complex (SC) is a meiosis-specific nuclear multiprotein complex that is essential for proper synapsis, recombination and segregation of homologous chromosomes. We combined structured illumination microscopy (SIM) with different expansion microscopy (ExM) protocols including U-ExM, proExM, and magnified analysis
C Gibrat et al.
Progress in neuro-psychopharmacology & biological psychiatry, 35(2), 380-389 (2010-11-30)
Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by a progressive and specific loss of certain brain cell populations. Current therapeutic approaches for the treatment of these disorders are mainly designed towards symptom management and do not
M Yudkoff et al.
The New England journal of medicine, 304(3), 141-145 (1981-01-15)
We studied the effects of cysteamine in five children with nephropathic cystinosis who were treated for up to 30 months. Cysteamine caused a decline in leukocyte cystine levels to the range seen in clinically unaffected heterozygotes; both plasma and urinary
Khodor S Hazime et al.
Scientific reports, 11(1), 7899-7899 (2021-04-14)
The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia. Before entering the ciliary compartment, IFT complexes and
Ravendra Naidoo et al.
Bacteriophage, 2(1), 15-24 (2012-06-06)
Bacteriophages offer interesting alternatives to antibodies for the specific capture and detection of pathogenic bacteria onto biosensing surfaces. Procedures for the optimal chemical immobilization of lytic bacteriophages onto surfaces are presented. More specifically, the removal of lysate contaminants from bacteriophage
Enrico Klotzsch et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(1), 130-135 (2014-12-24)
Because different proteins compete for the proton gradient across the inner mitochondrial membrane, an efficient mechanism is required for allocation of associated chemical potential to the distinct demands, such as ATP production, thermogenesis, regulation of reactive oxygen species (ROS), etc.
Renata Grzywa et al.
European journal of obstetrics, gynecology, and reproductive biology, 182, 38-42 (2014-09-15)
Cathepsin G is a serine peptidase whose physiological role is mainly associated with an early immune response, anti-microbial activity as well as platelet activation or hydrolysis of coagulation factors. In addition, since the activity of cathepsin G has been associated
Natalia Canel et al.
Cell division, 7(1), 23-23 (2012-11-24)
Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transfer, which consists of injecting a somatic micronucleus into
J A Schneider et al.
Journal of inherited metabolic disease, 18(4), 387-397 (1995-01-01)
Cysteamine bitartrate capsules (Cystagon) have been approved by the US Food and Drug Administration for use in patients with nephropathic cystinosis. Plasma cysteamine concentrations were virtually identical at various times following ingestion of either cysteamine hydrochloride or Cystagon capsules in
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Jiying Pei et al.
Analytica chimica acta, 757, 63-68 (2012-12-05)
High-quality cysteamine-coated CdTe quantum dots (CA-CdTe QDs) were successfully synthesized in aqueous phase by a facile one-pot method. Through hydroxylamine hydrochloride-promoted kinetic growth strategy, water-soluble CA-CdTe QDs could be obtained conveniently in a conical flask by a stepwise addition of
William A Gahl
European journal of pediatrics, 162 Suppl 1, S38-S41 (2003-11-12)
Nephropathic cystinosis is an autosomal recessive lysosomal storage disorder in which intracellular cystine accumulates due to impaired transport out of lysosomes. The clinical manifestations include renal tubular Fanconi syndrome in the 1st year of life, with hypophosphatemic rickets, hypokalemia, polyuria
Atsushi Mahara et al.
Journal of biomaterials science. Polymer edition, 25(14-15), 1590-1601 (2014-07-19)
We previously developed an antibody-conjugated cell rolling column that successfully separates stem cell subpopulations depending on the cell surface marker density, but a large amount of the injected cells were retained in the column because of non-specific interactions. In this
[Effect of cysteamine on the exhaustion of somatotropin release inhibiting hormone and its mechanism].
J L Liu
Sheng li ke xue jin zhan [Progress in physiology], 21(3), 271-274 (1990-07-01)
Yifan Wang et al.
The Journal of biological chemistry, 295(33), 11789-11802 (2020-07-01)
Cysteamine dioxygenase (ADO) has been reported to exhibit two distinct biological functions with a nonheme iron center. It catalyzes oxidation of both cysteamine in sulfur metabolism and N-terminal cysteine-containing proteins or peptides, such as regulator of G protein signaling 5
Yi He et al.
Analytical and bioanalytical chemistry, 407(22), 6741-6746 (2015-06-25)
A label-free and enzyme-free demultiplexer system for the fabrication of 1:2 molecular demultiplexer with luminol functionalized gold nanoparticles (Lum-AuNPs) as signal transducers was developed for the first time. The Lum-AuNPs had both chemiluminescence (CL) activity and surface plasmon resonance property.
Raghuraj S Chouhan et al.
Biosensors & bioelectronics, 69, 26-33 (2015-02-24)
In this study, we surface engineered living S. cerevisiae cells by decorating quantum dots (QDs) and traced the fate of QDs on molecular landscape of single mother cell through several generation times (progeny cells). The fate of QDs on cell-surface
Patricia Rodrigues Orsi et al.
Journal of ethnopharmacology, 143(1), 81-90 (2012-07-04)
Hymenaea stigonocarpa Mart. ex Hayne (Fabaceae) is a medicinal species commonly found in the Brazilian savannah. The stem bark of this medicinal plant, popularly known as "jatobá-do-cerrado", is widely used in tea form to treat gastric pain, ulcers, diarrhoea and
Pierre Bon et al.
Nature communications, 6, 7764-7764 (2015-07-28)
Meeting the nanometre resolution promised by super-resolution microscopy techniques (pointillist: PALM, STORM, scanning: STED) requires stabilizing the sample drifts in real time during the whole acquisition process. Metal nanoparticles are excellent probes to track the lateral drifts as they provide
Annalia Focà et al.
International journal of molecular sciences, 16(9), 21342-21362 (2015-09-16)
Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells
M Tariq et al.
The International journal of neuroscience, 83(3-4), 165-175 (1995-12-01)
The present investigation was undertaken to study the effect of cysteamine on experimental dyskinesia in rats. The movement disorders were produced by intraperitoneal administration of iminodipropionitrile (IDPN) in the dose of 100 mg/kg per day for 11 days. Cysteamine was
W A Gahl et al.
Biochemical medicine and metabolic biology, 48(3), 275-285 (1992-12-01)
Nephropathic cystinosis is a lysosomal storage disorder characterized by renal failure, multisystem organ damage, and poor growth. Oral cysteamine therapy retards renal deterioration and enhances growth, but parenchymal organ cystine depletion has never been documented. We measured skeletal muscle cystine
Ziad Omran et al.
Bioorganic & medicinal chemistry, 19(11), 3492-3496 (2011-05-04)
As part of our continuing work to obtain new pro-drugs for the treatment of nephropathic cystinosis, a number of glutaric and succinic acid derivatives of cystamine have been designed, synthesised and biologically evaluated in vitro. These compounds have been designed
Dae Won Kim et al.
BMB reports, 46(2), 124-129 (2013-02-26)
FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease
Daryl M Okamura et al.
Journal of the American Society of Nephrology : JASN, 25(1), 43-54 (2013-09-07)
Therapy to slow the relentless expansion of interstitial extracellular matrix that leads to renal functional decline in patients with CKD is currently lacking. Because chronic kidney injury increases tissue oxidative stress, we evaluated the antifibrotic efficacy of cysteamine bitartrate, an
Dandan Fang et al.
Mikrochimica acta, 186(9), 608-608 (2019-08-09)
An ultrasensitive competitive-type electrochemiluminescence immunoassay for the mycotoxin zearalenone is described. The method is based on the use of (a) a mimotope peptide that was selected from a phage displayed peptide library and used to substitute ZEN for designing the
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Y C Liu et al.
Analytical biochemistry, 299(2), 130-135 (2001-12-04)
In this study, a quartz crystal microbalance (QCM) system operated repetitively in flow injection analysis (FIA) mode, is reported. Four immobilization approaches of seven different methods include: (i) physical adsorption; (ii) two thioamine thiolation methods, using cysteamine and cystamine for
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