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Showing 1-30 of 85 results for "MAB4301" within Papers
Hui Yang et al.
Cell, 149(3), 605-617 (2012-05-01)
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these haESCs, which is needed
Kazuto Kimura et al.
Molecular reproduction and development, 88(6), 395-404 (2021-05-20)
Canine induced pluripotent stem cells (ciPSCs) provide a platform for regenerative veterinary medicine, disease modeling, and drug discovery. However, in the conventional method, ciPSCs are maintained using chemically-undefined media containing unknown animal components under on-murine embryonic fibroblast feeder conditions, which
Xun Jin et al.
Nature medicine, 23(11), 1352-1361 (2017-10-17)
Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile, and hypoxic regions showing a mesenchymal pattern. As these regions
Raquel V G de Castro et al.
Stem cells international, 2020, 8814989-8814989 (2021-01-19)
The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental oxygen concentration), and the aging process. Herein, we aimed to generate and maintain equine iPSCs (eiPSCs) derived from fibroblasts
Hiroki Kawai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11867-11880 (2017-11-05)
In the adult mammalian brain, neural stem cells (NSCs) generate new neurons throughout the mammal's lifetime. The balance between quiescence and active cell division among NSCs is crucial in producing appropriate numbers of neurons while maintaining the stem cell pool
Qingzhong Xiao et al.
Arteriosclerosis, thrombosis, and vascular biology, 26(10), 2244-2251 (2006-08-12)
Embryonic stem cells possess the ability to differentiate into endothelium. The ability to produce large volumes of endothelium from embryonic stem cells could provide a potential therapeutic modality for vascular injury. We describe an approach that selects endothelial cells using
Dakang Xu et al.
Methods in molecular biology (Clifton, N.J.), 329, 327-338 (2006-07-19)
Embryonic stem (ES) cells, and the inner cell mass from which they are derived, are hypersensitive to DNA damage and appear to have specific cellular defense systems for DNA repair and the elimination of damaged cells. These mechanisms differ from
Lida Radan et al.
Stem cells and development, 23(17), 2046-2066 (2014-04-23)
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell function. In this study, human embryonic stem cells (hESCs) were cultured in 20% or 2% O2 microenvironments for up to 5 days and evaluated for telomerase reverse
Yan-Min Feng et al.
Cell cycle (Georgetown, Tex.), 13(5), 782-791 (2014-01-09)
A critical process of early oogenesis is the entry of mitotic oogonia into meiosis, a cell cycle switch regulated by a complex gene regulatory network. Although Notch pathway is involved in numerous important aspects of oogenesis in invertebrate species, whether
C T D Kwok et al.
Stem cell research, 16(3), 651-661 (2016-04-12)
Human embryonic stem cells (hESCs) exhibit unique cell cycle structure, self-renewal and pluripotency. The Forkhead box transcription factor M1 (FOXM1) is critically required for the maintenance of pluripotency in mouse embryonic stem cells and mouse embryonal carcinoma cells, but its
Katherine A Hartjes et al.
Stem cells (Dayton, Ohio), 32(9), 2350-2359 (2014-05-08)
The value of induced pluripotent stem cells (iPSCs) within regenerative medicine is contingent on predictable and consistent iPSC differentiation. However, residual influence of the somatic origin or reprogramming technique may variegate differentiation propensity and confound comparative genotype/phenotype analyses. The objective
Bovine induced pluripotent stem cells are more resistant to apoptosis than testicular cells in response to mono-(2-ethylhexyl) phthalate.
Lin, YC; Kuo, KK; Wuputra, K; Lin, SH; Ku, CC; Yang, YH; Wang, SW; Wang, SW; Wu, DC; Wu et al.
International Journal of Molecular Sciences null
Hyunjin Yoo et al.
Molecular reproduction and development, 83(7), 588-593 (2016-05-06)
Jumonji C domain-containing demethylase 4 (JMJD4) is thought to help regulate mRNA translation, yet its precise in vivo role during mouse development has not been addressed. In the present study, we examined the contribution of this demethylase to embryonic stem
Manuel Mayr et al.
Circulation research, 102(9), 1046-1056 (2008-04-05)
We have recently demonstrated that stem cell antigen 1-positive (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mice and contribute to smooth muscle cell (SMC) accumulation in vein graft atherosclerosis. Using a combined proteomic and metabolomic approach
Chunli Zhao et al.
Cell research, 17(1), 80-87 (2007-01-11)
Therapeutic cloning, whereby embryonic stem cells (ESCs) are derived from nuclear transfer (NT) embryos, may play a major role in the new era of regenerative medicine. In this study we established forty nuclear transfer-ESC (NT-ESC) lines that were derived from
Francesco Neri et al.
Molecular and cellular biology, 32(4), 840-851 (2011-12-21)
Myc family members are critical to maintain embryonic stem cells (ESC) in the undifferentiated state. However, the mechanism by which they perform this task has not yet been elucidated. Here we show that Myc directly upregulates the transcription of all
Bo Pan et al.
Molecular human reproduction, 17(9), 550-561 (2011-03-24)
Regulation of germ-cell-specific transcription is essential for the differentiation and other physiological processes of germ cells. Germ-cell-specific transcription factors, Sohlh2 and Figla, play key roles in gametogenesis. To elucidate whether an epigenetic mechanism is involved in the controlled expression of
Yan-Liang Lai et al.
Redox biology, 15, 51-61 (2017-12-08)
Heme oxygenase (HO)-1 is an inducible stress response protein and well known to protect cells and tissues against injury. Despite its important function in cytoprotection against physiological stress, the role of HO-1 in embryonic stem cell (ESC) differentiation remains largely
Nigel G Kooreman et al.
Cell stem cell, 22(4), 501-513 (2018-02-20)
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated
Max Villa et al.
Biomedical microdevices, 12(2), 253-261 (2009-12-17)
We present optimal perfusion conditions for the growth of primary mouse embryonic fibroblasts (mEFs) and mouse embryonic stem cells (mESCs) using a microfluidic perfusion culture system. In an effort to balance nutrient renewal while ensuring the presence of cell secreted
Jeffrey Harding et al.
Nature biomedical engineering (2023-11-24)
The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the advancement of cell therapies. Here we show that the overexpression of eight immunomodulatory transgenes (Pdl1, Cd200, Cd47, H2-M3, Fasl, Serpinb9, Ccl21 and Mfge8) in mouse embryonic
Kwang-Hwan Choi et al.
Stem cell reports, 13(1), 221-234 (2019-07-02)
Pig embryonic stem cells (pESCs) have been considered an important candidate for preclinical research on human therapies. However, the lack of understanding of pig pluripotent networks has hampered establishment of authentic pESCs. Here, we report that FGF2, ACTVIN, and WNT
A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.
Vuoristo, S; Toivonen, S; Weltner, J; Mikkola, M; Ustinov, J; Trokovic, R; Palgi, J; Lund et al.
Testing null
Guangyu An et al.
Stem cells (Dayton, Ohio), 28(9), 1560-1567 (2010-08-04)
B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a, an A+T-rich interaction domain protein, was originally discovered in B lymphocyte lineage cells. However, expression patterns and high lethality levels in knockout mice suggested that it had additional functions. Three independent lines
Derek C Liberti et al.
Developmental biology, 454(2), 108-117 (2019-06-27)
Lung endoderm development occurs through a series of finely coordinated transcriptional processes that are regulated by epigenetic mechanisms. However, the role of DNA methylation in regulating lung endoderm development remains poorly understood. We demonstrate that DNA methyltransferase 1 (Dnmt1) is
Chen Li et al.
International journal of molecular sciences, 24(15) (2023-08-12)
Mixed-lineage leukemia 1 (MLL1) introduces 1-, 2- and 3-methylation into histone H3K4 through the evolutionarily conserved set domain. In this study, bovine embryonic stem cells (bESCs, known as bESCs-F7) were established from in vitro-fertilized (IVF) embryos via Wnt signaling inhibition;
Hui Zhu et al.
Biomaterials, 196, 31-45 (2018-02-20)
Appropriate and abundant sources of bone-forming osteoblasts are essential for bone tissue engineering. Pluripotent stem cells can self-renew and thereby offer a potentially unlimited supply of osteoblasts, a significant advantage over other cell sources. We generated mouse embryonic stem cells
Deanne J Whitworth et al.
Stem cells and development, 28(3), 151-164 (2018-11-13)
The platypus (Ornithorhynchus anatinus) is an egg-laying monotreme mammal whose ancestors diverged ∼166 million years ago from the evolutionary pathway that eventually gave rise to both marsupial and eutherian mammals. Consequently, its genome is an extraordinary amalgam of both ancestral
Daniel J Hiler et al.
Nature protocols, 11(10), 1955-1976 (2016-09-23)
Postmitotic differentiated neurons are among the most difficult cells to reprogram into induced pluripotent stem cells (iPSCs) because they have poor viability when cultured as dissociated cells. To overcome this, other protocols have required the inactivation of the p53 tumor
Hongguo Cao et al.
International journal of biological sciences, 8(4), 498-511 (2012-03-30)
Pluripotent stem cells from domesticated animals have potential applications in transgenic breeding. Here, we describe induced pluripotent stem (iPS) cells derived from bovine fetal fibroblasts by lentiviral transduction of Oct4, Sox2, Klf4 and c-Myc defined-factor fusion proteins. Bovine iPS cells
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