ML0015

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Showing 1-7 of 7 results for "ML0015" within Papers

Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals.

F Errico et al.

Translational psychiatry, 4, e417-e417 (2014-07-30)

D-aspartate (D-Asp) is an atypical amino acid, which is especially abundant in the developing mammalian brain, and can bind to and activate N-methyl-D-Aspartate receptors (NMDARs). In line with its pharmacological features, we find that mice chronically treated with D-Asp show

Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis.

Paul M Kim et al.

Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3175-3179 (2010-02-06)

D-aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L-aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin

Synthesis of Nonessential Amino Acids and Amino Acid Degradation.

Litwack G, et al.

Human Biochemistry and Disease, 63-94 (2018)

d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces β-amyloid Aβ1-42 peptide in a long lasting model of neuropathic pain.

Antimo D'Aniello et al.

Neuroscience letters, 651, 151-158 (2017-05-11)

Depressive symptoms and other neuropsychiatric dysfunctions are common in neurodegenerative disorders, including chronic pain and dementia. A correlation between the β-amyloid protein accumulation and the development of depression has been suggested, however the underlying mechanisms are unknown. d-Aspartate (d-Asp) is

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Kıvanç Birsoy et al.

Cell, 162(3), 540-551 (2015-08-02)

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells lacking ETC function to proliferate. We used a CRISPR-based genetic

Facilitating understanding of the purine nucleotide cycle and the one-carbon pool: Part I: The purine nucleotide cycle.

Ifeanyi J Arinze

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 33(3), 165-168 (2005-05-01)

Some metabolic processes are readily understood because they are circumscribed in metabolic pathways that have clearly identifiable beginning points, end products, and other features. Other metabolic pathways that do not appear to be straightforward pose difficulties for students. One such

Pyrimidine Biosynthesis

Lennarz W J, et al.

Encyclopedia of Biological Chemistry, 600-605 (2004)

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