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Showing 31-60 of 186 results for "N-007" within Papers
[Long-acting naltrexone--a new way out of opiate addiction?].
Live Sanderud Stavseth et al.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(21), 2231-2232 (2013-11-15)
Arnt Schellekens
Nederlands tijdschrift voor geneeskunde, 157(23), A5725-A5725 (2013-06-07)
This article describes the current scientific knowledge regarding pharmacogenetic predictors of treatment outcome for substance-dependent patients. PubMed was searched for articles on pharmacogenetics and addiction. This search yielded 53 articles, of which 27 were selected. The most promising pharmacogenetic findings
Edna B Foa et al.
JAMA, 310(5), 488-495 (2013-08-09)
Alcohol dependence comorbid with posttraumatic stress disorder (PTSD) has been found to be resistant to treatment. In addition, there is a concern that prolonged exposure therapy for PTSD may exacerbate alcohol use. To compare the efficacy of an evidence-based treatment
Pawel Mierzejewski et al.
Neuroscience letters, 556, 99-103 (2013-10-19)
Zolpidem is a non-benzodiazepine hypnotic drug acting preferentially at α1-containing GABAA receptors expressed in various parts of the brain, including the basal ganglia. The aim of the present study was to provide preliminary characteristics of zolpidem-induced catalepsy in Wistar rats.
Jessica A Immonen et al.
Experimental biology and medicine (Maywood, N.J.), 238(10), 1127-1135 (2013-08-30)
Wound repair involves a series of overlapping phases that include inflammation, proliferation, and tissue remodeling, with the latter phase requiring months for proper healing. Delays in any of these processes can result in infection, chronic ulceration, and possible amputation. Diabetes
G Corder et al.
Science (New York, N.Y.), 341(6152), 1394-1399 (2013-09-21)
Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury
Kimberly L Rainwater et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 44(3), 596-604 (2013-09-26)
A crossover study was performed in 12 Himalayan tahr (Hemitragus jemlahicus) undergoing preshipment examinations to compare a partially reversible to a fully reversible intramuscular chemical immobilization protocol. The partially reversible protocol (MKA) consisted of induction with medetomidine (0.06 +/- 0.009
Ahmad A Altarifi et al.
Behavioural pharmacology, 24(5-6), 459-470 (2013-07-25)
Intracranial self-stimulation (ICSS) is an operant procedure in which responding is maintained by electrical brain stimulation. Stimulation frequency can be varied rapidly to maintain a wide range of baseline response rates, and drugs' effects can be evaluated simultaneously on both
Monthly injectable naltrexone for pathological gambling.
Gihyun Yoon et al.
The American journal of psychiatry, 170(6), 682-683 (2013-06-05)
The clinical conundrum of perioperative pain management in patients with opioid dependence: lessons from two cases.
Jacqueline S Israel et al.
Plastic and reconstructive surgery, 131(4), 657e-658e (2013-04-02)
John R Cashman et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 171-180 (2014-05-13)
A substituted aryl amide derivative of 6-naltrexamine--17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-trimethylfluoro)benzamido]morphinan-hydrochloride--(compound 5), previously shown to be a potent κ-opioid receptor antagonist, was used to characterize the physicochemical properties and efficacy to decrease alcohol self-administration in alcohol-preferring rats (P-rats) and binge-like P-rats. Previous studies showed
Jessica H Harvey et al.
Methods in molecular biology (Clifton, N.J.), 995, 43-54 (2013-03-16)
Calcium signaling plays a major role in the function of cells. Measurement of intracellular calcium mobilization is a robust assay that can be performed in a high-throughput manner to study the effect of compounds on potential drug targets. Pharmaceutical companies
Therapy for posttraumatic stress and alcohol dependence.
Lisa M Najavits
JAMA, 310(22), 2457-2458 (2013-12-12)
Bernard Bihari, MD: low-dose naltrexone for normalizing immune system function.
Bernard Bihari
Alternative therapies in health and medicine, 19(2), 56-65 (2013-04-19)
Approval of antiobesity drug is "major regression for patients' safety," says health watchdog.
Nigel Hawkes
BMJ (Clinical research ed.), 349, g7805-g7805 (2014-12-30)
T V Agibalova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(6 Pt 2), 63-68 (2013-07-28)
This review of literature describes a role of chronic stress in the development of substance dependence including alcohol dependence. It is focused on neurochemical mechanisms of this dependence and approaches to its treatment in people with mental adaptation disorders. An
Anjana Chakravorty et al.
The Journal of infectious diseases, 210(3), 483-492 (2014-02-20)
Gas gangrene is a potentially fatal disease that is primarily caused by the ubiquitous, anaerobic bacteria Clostridium perfringens and Clostridium septicum. Treatment is limited to antibiotic therapy, debridement of the infected tissue, and, in severe cases, amputation. The need for
M Sałaga et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 69-78 (2014-06-04)
The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal (GI) motility
Daniel E Jonas et al.
JAMA, 311(18), 1889-1900 (2014-05-16)
Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused. To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others) for adults with alcohol use
Amelia Rodrigues et al.
Pediatric blood & cancer, 60(10), 1667-1670 (2013-06-15)
Pediatric oncology patients can experience opioid-induced constipation, which may not respond to laxative treatment. Methylnaltrexone is an opioid receptor antagonist that can reverse opioid-induced constipation without affecting analgesia. Published literature on the use of methylnaltrexone in children is very limited.
N Dubols et al.
Revue medicale de Liege, 68(5-6), 298-302 (2013-07-31)
Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and
Alexander T Podolsky et al.
Life sciences, 93(25-26), 1010-1016 (2013-10-03)
Approximately one third of the adult U.S. population suffers from some type of on-going, chronic pain annually, and many more will have some type of acute pain associated with trauma or surgery. First-line therapies for moderate to severe pain include
Leila Moezi et al.
Neuropharmacology, 72, 1-8 (2013-04-30)
Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in various paradigms. This study investigated the effect of the interaction
Ying Nie et al.
Peptides, 47, 99-109 (2013-07-31)
The prohormone convertases, PC1/3 and PC2 are thought to be responsible for the activation of many prohormones through processing including the endogenous opioid peptides. We propose that maintenance of hormonal homeostasis can be achieved, in part, via alterations in levels
Tao Chen et al.
Experimental neurology, 255, 127-136 (2014-03-13)
Hypoxic/ischemic brain injury is a potential cause of Parkinson's disease (PD) with ɑ-synuclein playing a critical role in the pathophysiology. Since δ-opioid receptor (DOR) is neuroprotective against hypoxic/ischemic insults, we sought to determine if DOR regulates ɑ-synuclein under hypoxia and/or
Xin Su et al.
American journal of physiology. Renal physiology, 305(1), F52-F60 (2013-05-03)
The role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve (SN) stimulation was studied in anesthetized female rats, using the rat model of isovolumetric bladder contraction. SN stimulation at a fixed frequency of 10
Treatment of comorbid substance dependence and posttraumatic stress disorder.
Katherine Mills
JAMA, 310(5), 482-483 (2013-08-09)
The role of methylnaltrexone in opioid-induced constipation.
Thaddaus R Hellwig et al.
South Dakota medicine : the journal of the South Dakota State Medical Association, 66(10), 425-425 (2013-11-20)
William T Birdsong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 4118-4127 (2013-03-01)
Prolonged exposure to high-efficacy agonists results in desensitization of the μ-opioid receptor (MOR). Desensitized receptors are thought to be unable to couple to G-proteins, preventing downstream signaling; however, the changes to the receptor itself are not well characterized. In the
S V Geĭn et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(1), 30-34 (2013-03-07)
It is established that rotation and immobilization stress produces bidirectional effect on AFC number in spleen and on proliferative response of splenocytes. The rotation stress results in augmentation of AFC formation and promotion of spontaneous proliferative activity of splenocytes. The
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