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Showing 1-30 of 49 results for "N0290" within Papers
Benjamin Speich et al.
Parasites & vectors, 6, 3-3 (2013-01-08)
Pathogenic intestinal protozoa infections are common in school-aged children in the developing world and they are frequently associated with malabsorption syndromes and gastrointestinal morbidity. Since diagnosis of these parasites is difficult, prevalence data on intestinal protozoa is scarce. We collected
Seong Keun Hong et al.
International immunopharmacology, 13(1), 23-27 (2012-03-21)
Suppression of interleukin (IL)-6 production has beneficial effects against various inflammatory diseases. Through a rapid screening system, we found that nitazoxanide, or 2-acetyloxy-N-(5-nitro-2-thiazolyl) benzamide, which is a well-known antiparasitic agent, suppressed lipopolysaccharide (LPS)-induced production of IL-6 from RAW 264.7 cells
Jean-François Rossignol et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 106(3), 167-173 (2012-02-04)
We conducted a double-blind, placebo-controlled clinical trial to demonstrate the efficacy of nitazoxanide suspension for the treatment of presumed infectious diarrhea in children. Eligible patients must have had diarrheal illness lasting 3-29 days. Patients were randomized to receive either nitazoxanide
Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway.
Wang, et al.
Autophagy, 18, 2350-2367 (2023)
Yijun Zhu et al.
Cell host & microbe, 31(1), 18-32 (2022-12-23)
Recent studies show gut microbiota-dependent metabolism of dietary phenylalanine into phenylacetic acid (PAA) is critical in phenylacetylglutamine (PAGln) production, a metabolite linked to atherosclerotic cardiovascular disease (ASCVD). Accordingly, microbial enzymes involved in this transformation are of interest. Using genetic manipulation
Marcelo Donadel Malesuik et al.
Talanta, 93, 206-211 (2012-04-10)
Stress studies of the broad-spectrum antiparasitic nitazoxanide were conducted in order to isolate and elucidate the major degradation product involved in thermal, acid, alkaline, oxidative and photolytic decomposition of the drug in solution and solid state. The major degradation product
Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis
Lam KYK
PLoS Pathogens, 8(5), 340-351 (2012)
José A Pérez-Molina et al.
The American journal of tropical medicine and hygiene, 84(2), 351-356 (2011-02-05)
We aimed to evaluate the effectiveness of nitazoxanide in disseminated cystic echinococcosis (DCE) that failed to respond to surgical and antiparasitic therapy. We report on seven patients (five of them with bony involvement): two cases from the literature and five
Siddhartha Mahanty et al.
Antimicrobial agents and chemotherapy, 57(2), 990-995 (2012-12-12)
Neurocysticercosis (NCC), an infection of the brain with the larval stage of the Taenia solium tapeworm, is responsible for an estimated one-third of adult-onset epilepsy cases in regions of the world where it is endemic. Currently, anthelmintic drugs used for
Giuseppe Belardo et al.
Antimicrobial agents and chemotherapy, 59(2), 1061-1069 (2014-12-03)
The emergence of drug-resistant influenza A virus (IAV) strains represents a serious threat to global human health and underscores the need for novel approaches to anti-influenza chemotherapy. Combination therapy with drugs affecting different IAV targets represents an attractive option for
Part XI. Trimethoprim-sulfamethoxazole, nitrofurantoin, chloramphenicol, metronidazole and tinidazole, rifaximin, and nitazoxanide.
Bhanu Sud et al.
The Journal of the Oklahoma State Medical Association, 100(7), 267-272 (2007-09-28)
A case of Cryptosporidium infection in a child of celiac disease.
N Pal et al.
Journal of postgraduate medicine, 58(2), 160-160 (2012-06-22)
S M Kabil et al.
Journal of the Egyptian Society of Parasitology, 41(2), 251-261 (2011-10-11)
This study is an extension of an earlier, randomized; placebo-controlled that showed the efficacy of nitazoxanide (NTZ) 500 mg tablets twice daily for 6 months in treating HCV genotype 4. Access was available to 13/32 patients of the original study
Cynthia L Chappell et al.
The American journal of tropical medicine and hygiene, 92(1), 50-55 (2014-10-15)
Although Cryptosporidium parvum and C. hominis cause the majority of human cryptosporidiosis cases, other Cryptosporidium species are also capable of infecting humans, particularly when individuals are immunocompromised. Ten C. muris cases have been reported, primarily in human immunodeficiency virus (HIV)
Stanley A Cohen
Current medical research and opinion, 21(7), 999-1004 (2005-07-12)
Despite advances in the management of diarrheal disorders, diarrhea is the second most frequent illness in the world. Persistent diarrhea, common in community pediatrics, is often caused by organisms such as Giardia lamblia, Cryptosporidium parvum and, less frequently, Cyclospora, Isospora
Irit Krause et al.
The Pediatric infectious disease journal, 31(11), 1135-1138 (2012-07-20)
Cryptosporidium parvum is a common cause of diarrhea. In immunocompetent individuals, spontaneous recovery is the rule. In immunocompromised patients, it may cause a serious disease. Data on cryptosporidiosis in children after solid organ transplantation are few. We report on 6
Vanessa R Anderson et al.
Drugs, 67(13), 1947-1967 (2007-08-29)
Nitazoxanide (Alinia, Daxon, Dexidex, Paramix, Kidonax, Colufase, Annita) has in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is effective in the treatment of protozoal and helminthic infections, including Cryptosporidium parvum or
Encapsulation of the antimicrobial and immunomodulator agent nitazoxanide within polymeric micelles.
Romina J Glisoni et al.
Journal of nanoscience and nanotechnology, 14(6), 4670-4682 (2014-04-18)
Nitazoxanide (NTZ) is a highly hydrophobic nitrothiazolyl-salicylamide that displays antimicrobial activity against a variety of parasites, anaerobic bacteria and viruses. More recently, its effectiveness in the pharmacotherapy of chronic hepatitis, the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC)
Ghada M Hadad et al.
Journal of chromatographic science, 50(6), 509-515 (2012-04-25)
A high-performance liquid chromatographic method was optimized and validated for the determination of desacetyl nitazoxanide (tizoxanide), the main active metabolite of nitazoxanide in human plasma, urine and breast milk. The proposed method used a CN column with mobile phase consisting
P Patrick Basu et al.
The American journal of gastroenterology, 106(11), 1970-1975 (2011-10-13)
Resistance to standard Helicobacter pylori (HP) treatment regimens has led to unsatisfactory cure rates in HP-infected patients. This study was designed to evaluate a novel four-drug regimen (three antibiotics and a proton pump inhibitor (PPI)) for eradication of HP infection
Sonal Girish et al.
Parasites & vectors, 8, 332-332 (2015-06-18)
In the local Malaysian context, herbal plants such as Eurycoma longifolia (Tongkat Ali), Orthosiphon stamineus (MisaiKucing), Ficus deltoidea (Mas Cotek), Zingiber officinale (Halia Bara) and Barringtonia racemosa (Putat) are known and widely used for its therapeutic properties. The first part
Nicholas E Nacca et al.
Pediatric emergency care, 27(10), 954-956 (2011-10-07)
Cryptosporidiosis is reported in an otherwise healthy child. Her history was significant for playing in natural waters during a camping trip 1 week prior. Several days later, she began improving despite an incorrect diagnosis and inappropriate antibiotic therapy. Nitazoxanide was
Hubert Bojar et al.
Wiadomosci parazytologiczne, 56(1), 11-18 (2010-05-11)
In present-day world intestinal parasitic infections are gaining importance as a cause of morbidity and mortality. One of the reasons behind it is the globalization and increased number of people travelling to endemic areas of parasitic diseases. Consequently, we need
[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Atsushi Hokari
Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 4, 196-200 (2011-11-22)
Noa Tejman-Yarden et al.
Antimicrobial agents and chemotherapy, 55(10), 4643-4651 (2011-08-10)
Infections with the diarrheagenic protozoan pathogen Giardia lamblia are most commonly treated with metronidazole (Mz). Treatment failures with Mz occur in 10 to 20% of cases and Mz resistance develops in the laboratory, yet clinically, Mz-resistant (Mz(r)) G. lamblia has
Olivier Vandenberg et al.
The Pediatric infectious disease journal, 31(1), 10-15 (2011-11-19)
Cryptosporidium outbreaks in day-care centers (DCCs) occur commonly. However, controlling spread of infection in these settings is difficult, and data about effectiveness of different control strategies are sparse. In this study, a Cryptosporidium outbreak in a large DCC located in
Karen K Y Lam et al.
PLoS pathogens, 8(5), e1002691-e1002691 (2012-05-17)
Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from infected macrophages. There is increasing evidence that manipulation of autophagy, a
Wojciech Senkowski et al.
Molecular cancer therapeutics, 14(6), 1504-1516 (2015-04-26)
Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we describe a high-throughput drug screening approach, using glucose-deprived multicellular tumor spheroids (MCTS)
Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmission
Wang YM, et al.
Antiviral Research, 135, 81-90 (2016)
Pathway-based drug repositioning for cancers: Computational prediction and experimental validation
Iwata M, et al.
Journal of Medicinal Chemistry, 61(21), 9583-9595 (2018)
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