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Showing 1-30 of 42 results for "N142" within Papers
Mateo Vélez-Fort et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(20), 6921-6929 (2010-05-21)
NG2 cells, oligodendrocyte precursors, play a critical role in myelination during postnatal brain maturation, but a pool of these precursors is maintained in the adult and recruited to lesions in demyelinating diseases. NG2 cells in immature animals have recently been
Georg Höfner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(17-18), 1356-1364 (2009-12-29)
The present study describes the use of short columns to speed up LC-MS quantification in MS binding assays. The concept of MS binding assays follows closely the principle of traditional radioligand binding but uses MS for the quantification of bound
B Brawek et al.
Naunyn-Schmiedeberg's archives of pharmacology, 379(4), 361-369 (2008-11-13)
One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels (VSCC). We therefore analyzed the effects of gabapentin and pregabalin on K(+)-evoked release of (3)H-gamma-aminobutyric acid (GABA) and (3)H-glutamate
Norio Sogawa et al.
Pharmacology, biochemistry, and behavior, 103(2), 267-272 (2012-09-12)
The potency of anesthetics changes during development, probably due not only to pharmacokinetic factors such as differential distribution and/or metabolism, but also to pharmacodynamic factors such as changes to the GABAergic system in the brain. To explore the latter mechanism
Adam C Lu et al.
eLife, 9 (2020-09-10)
Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures. Here, we show that
Moonsun Sa et al.
Experimental neurobiology, 31(3), 147-157 (2022-07-06)
The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus (ARC) of the hypothalamus are shown to transform into reactive
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Hong-Yan Liu et al.
CNS neuroscience & therapeutics, 18(12), 1030-1032 (2012-11-21)
E M Guimarães-Souza et al.
Journal of neuroscience research, 90(12), 2349-2361 (2012-09-19)
Glutamate, the major excitatory neurotransmitter in the retina, functions by activation of both ionotropic (iGluR) and metabotropic (mGluR) glutamate receptors. Group III mGluRs, except for mGluR6, are mostly found in the inner plexiform layer (IPL), and their retinal functions are
Rebekah L Fleming et al.
Alcohol (Fayetteville, N.Y.), 45(6), 577-583 (2011-05-24)
In recent years, the effect of ethanol on tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has become a topic of intensive investigation and some controversy. The high ethanol sensitivity of extrasynaptic GABA(A) receptors containing the δ subunit combined with
Sampsa T Sipilä et al.
The European journal of neuroscience, 25(3), 717-722 (2007-02-15)
Tonic activation of GABA(A) receptors takes place before the development of functional synapses in cortical structures. We studied whether inefficient GABA uptake might explain the presence of a tonic GABA(A)-mediated current (I(GABA-A)) in early postnatal hippocampal pyramidal neurons. The data
C J Dong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(5 Pt 1), 2648-2658 (1994-05-01)
The effects of GABA and related agents were studied in solitary rod- and cone-driven horizontal cells, acutely isolated from the catfish retina using enzymatic and mechanical treatment. Both types of horizontal cells, which normally receive glutamatergic input from photoreceptors, responded
Ivan Marchionni et al.
The Journal of physiology, 581(Pt 2), 515-528 (2007-02-24)
In the adult hippocampus, two different forms of GABA(A) receptor-mediated inhibition have been identified: phasic and tonic. The first is due to the activation of GABA(A) receptors facing the presynaptic releasing sites, whereas the second is due to the activation
Guillermo Gonzalez-Burgos et al.
Journal of neurophysiology, 101(2), 533-547 (2008-12-17)
The plasma membrane GABA transporter GAT1 is thought to mediate uptake of synaptically released GABA. In the primate dorsolateral prefrontal cortex (DLPFC), GAT1 expression changes significantly during development and in schizophrenia. The consequences of such changes, however, are not well
Elena E Bagley et al.
Nature neuroscience, 14(12), 1548-1554 (2011-11-01)
Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly increased
Anton Dvorzhak et al.
The Journal of physiology, 588(Pt 13), 2351-2360 (2010-04-28)
GABAergic synapses on Cajal-Retzius neurons in layer I of the murine neocortex experience GABA(B) receptor (GABA(B)R)-mediated tonic inhibition. Extracellular GABA concentration ([GABA](o)) that determines the strength of GABA(B)R-mediated inhibition is controlled by GABA transporters (GATs). In this study, we hypothesized
GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum.
Knut Kirmse et al.
The Journal of physiology, 586(23), 5665-5678 (2008-10-04)
GABAergic medium-sized striatal output neurons (SONs) provide the principal output for the neostriatum. In vitro and in vivo data indicate that spike discharge of SONs is tightly controlled by effective synaptic inhibition. Although phasic GABAergic transmission critically depends on ambient
Christine Zepperitz et al.
Analytical and bioanalytical chemistry, 391(1), 309-316 (2008-03-18)
Following a recently developed concept of MS binding assays based on the quantification of a native marker by LC-MS a procedure to study binding of a low-affinity marker in kinetic, saturation, and competition experiments was established. Separation of bound and
Cholinergic control of striatal GABAergic microcircuits.
Kocaturk, et al.
Cell Reports, 41, 111531-111531 (2022)
E B Nielsen et al.
European journal of pharmacology, 196(3), 257-266 (1991-04-24)
Tiagabine (NO-328) (R(-)-N-[4,4-bis(3-methylthien-2-yl)but-3-enyl]nipecotic acid, hydrochloride) is a new centrally acting GABA uptake inhibitor. The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound. The sedative actions of
Melanie Hamann et al.
Journal of neural transmission (Vienna, Austria : 1996), 117(6), 747-757 (2010-05-11)
The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder. Previous experiments in the dt(sz) hamster, a model of primary paroxysmal dystonia, demonstrated reduced discharge rates and an abnormal pattern within the entopeduncular
Rocco Pizzarelli et al.
Frontiers in cellular neuroscience, 7, 85-85 (2013-06-14)
Autism Spectrum Disorders (ASDs) comprise an heterogeneous group of neuro-developmental abnormalities, mainly of genetic origin, characterized by impaired social interactions, communications deficits, and stereotyped behaviors. In a small percentage of cases, ASDs have been found to be associated with single
C G S Smith et al.
Neuropharmacology, 53(8), 975-981 (2007-11-06)
Mechanisms through which the reported antinociceptive activity of GABA re-uptake inhibitors is mediated (and where on the sensory neuraxis) have not been defined. Here, microdialysis in the anaesthetised rat was used to examine the effect of selective GABA transporter type
M Kammerer et al.
Naunyn-Schmiedeberg's archives of pharmacology, 384(1), 47-57 (2011-05-03)
In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs (AEDs) are thought to increase GABA release. Because little is known about corresponding presynaptic effects of AEDs in the human brain
Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
Santhakumar V, et al.
Neuroscience, 167(3), 644-655 (2010)
Clarissa De Sampaio Schitine et al.
Neurotoxicity research, 12(2), 145-153 (2007-10-31)
GABA is the main inhibitory aminoacid transmitter present in neurons and glial cells. Its uptake is carried out by specific high-affinity Na(+)/Cl (-) dependent transporters (GATs). It has been reported in the past that, in the avian retina, [(3)H]GABA appears
Sarah E Holstein et al.
Alcoholism, clinical and experimental research, 33(1), 108-120 (2008-10-24)
The gamma-aminobutyric acid (GABA) system is implicated in the neurobiological actions of ethanol, and pharmacological agents that increase the activity of this system have been proposed as potential treatments for alcohol use disorders. As ethanol has its own GABA mimetic
Yeechan Wu et al.
Journal of neurophysiology, 105(6), 2715-2728 (2011-03-25)
Noradrenergic (NAergic) A7 neurons that project axonal terminals to the dorsal horn of the spinal cord to modulate nociceptive signaling are suggested to receive tonic inhibition from local GABAergic interneurons, which are under the regulation of descending analgesic pathways. In
Zheng-Quan Tang et al.
PloS one, 7(4), e35831-e35831 (2012-05-01)
Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to
Kyoko Tossell et al.
The European journal of neuroscience, 53(6), 1722-1737 (2021-02-02)
The activity of midbrain dopamine neurons is strongly regulated by fast synaptic inhibitory γ-Aminobutyric acid (GABA)ergic inputs. There is growing evidence in other brain regions that low concentrations of ambient GABA can persistently activate certain subtypes of GABAA receptor to
Yue Li et al.
Neuroscience letters, 494(1), 6-9 (2011-03-01)
To investigate the analgesic effect of intrathecally administered γ-aminobutyric acid (GABA) transporter-1 inhibitor NO-711 on the sciatic nerve chronic constriction injury (CCI) rats. 5 days after intrathecal catheter placement, neuropathic pain model was established by CCI of sciatic nerve on
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