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Showing 1-30 of 76 results for "N5501" within Papers
Yoshihiko Kito et al.
The Journal of physiology, 592(21), 4733-4745 (2014-09-14)
Four types of electrical activity were recorded and related to cell structure by intracellular recording and dye injection into impaled cells in muscles of rabbit small intestine. The specific cell types from which recordings were made were longitudinal smooth muscle
Masatomo Watanabe et al.
Experimental neurology, 247, 645-652 (2013-03-19)
Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals. We previously reported that the background NO levels under physiological conditions negatively regulate
Lisa Gasperini et al.
Antioxidants & redox signaling, 22(9), 772-784 (2014-12-10)
Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein (PrP(C)) in neuroprotection. Therefore, the loss of PrP(C) function occurring in prion disorders may contribute to
Kelly M Clapp et al.
The Journal of biological chemistry, 287(51), 42601-42610 (2012-10-31)
Nitric-oxide synthase, a cytochrome P450-like hemoprotein enzyme, catalyzes the synthesis of nitric oxide, a critical signaling molecule in a variety of physiological processes. Our laboratory has discovered that certain drugs suicide-inactivate neuronal nitric-oxide synthase (nNOS) and lead to the preferential
Andreas Petry et al.
Thrombosis and haemostasis, 108(5), 849-862 (2012-09-28)
Disruption of endothelial homeostasis results in endothelial dysfunction, characterised by a dysbalance between nitric oxide (NO) and reactive oxygen species (ROS) levels often accompanied by a prothrombotic and proproliferative state. The serine protease thrombin not only is instrumental in formation
Xiao-Fang Wu et al.
Toxicology letters, 230(1), 19-27 (2014-08-05)
Methamphetamine (METH) belongs to Amphetamine-type stimulants, METH abusers are at high risk of neurodegenerative disorders, including Parkinson's disease (PD). However, there are still no effective treatments to METH-induced neurodegeneration because its mechanism remains unknown. In order to investigate METH's neurotoxic
Helmut Prast et al.
Life sciences, 134, 79-84 (2015-05-27)
Nitric oxide (NO), is a simple but multifarious molecule. It is implicated in physiological and pathological processes within the striatum, mainly in the nucleus accumbens (NAc). The aim of the present study was to determine the origin of NO in
Kimihiro Kimura et al.
Life sciences, 91(13-14), 644-650 (2012-05-10)
It has been reported that endothelin-1 (ET-1) overproduction and reduced nitric oxide (NO) production are closely related to the progression of renal diseases. In the present study, we examined the interrelation between ET-1 and NO system using rats treated with
Carol Yu et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H386-H397 (2014-12-21)
Angiopoietin like-2 (angptl2) is a circulating pro-inflammatory and pro-oxidative protein, but its role in regulating cerebral endothelial function remains unknown. We hypothesized that in mice knockdown (KD) of angptl2, cerebral endothelial function would be protected against ANG II-induced damage. Subcutaneous
Marta Obara-Michlewska et al.
Neurochemistry international, 88, 20-25 (2014-12-03)
Astroglial inward rectifying Kir4.1 potassium channels are fundamental for the maintenance of ion and water homeostasis in the central nervous system (CNS). Down-regulation of Kir4.1 expression is observed in CNS disorders associated with excessive extracellular glutamate (Glu) accumulation, including hepatic
Styliani Goulopoulou et al.
American journal of physiology. Heart and circulatory physiology, 309(2), H297-H304 (2015-05-10)
Impaired nitric oxide (NO), soluble guanylyl cyclase (sGC), and cyclic guanosine monophosphate (cGMP) signaling (NO-sGC-cGMP) has been implicated in the pathogenesis of diabetic vascular dysfunction. Efforts to directly target this signaling have led to the development of sGC agonists that
Serge Simonet et al.
British journal of pharmacology, 167(4), 854-867 (2012-06-01)
The purpose of the study was to investigate renal endothelium-dependent vasodilatation in a model of severe hypertension associated with kidney injury. Changes in perfusion pressure were measured in isolated, perfused kidneys taken from 18-week-old Wistar-Kyoto rat (WKY), spontaneously hypertensive rats
Ahmed E Gehad et al.
The Journal of investigative dermatology, 132(11), 2642-2651 (2012-06-22)
Squamous cell carcinomas (SCCs) are sun-induced skin cancers that are particularly numerous and aggressive in immunosuppressed individuals. SCCs evade immune detection at least in part by downregulating E-selectin on tumor vessels, thereby restricting entry of skin-homing T cells into tumors.
Bart Pauwels et al.
The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21)
Erectile dysfunction (ED), as well as many cardiovascular diseases, is associated with impaired nitric oxide (NO) bioavailability. Recently, oxime derivatives have emerged as vasodilators due to their NO-donating capacities. However, whether these oximes offer therapeutic perspectives as an alternative NO
Zhenkun Li et al.
Bioengineered, 13(4), 10038-10046 (2022-04-14)
Praeruptorin A (PA) is a natural coumarin compound from the roots of Radix Peucedani and is commonly used in the treatment of certain respiratory diseases and hypertension. Although previous studies identified relaxant effects of PA on tracheal and arterial preparations
J Evers et al.
Experimental physiology, 98(2), 397-404 (2012-08-09)
Nitric oxide is known to relax the internal anal sphincter, but its effect on the external anal sphincter (EAS) is unknown. The aim of this study was to investigate whether there is a nitrergic nerve plexus that modulates the EAS
Anke Böhmer et al.
Platelets, 26(6), 583-588 (2014-11-02)
Reports on expression and functionality of nitric oxide synthase (NOS) activity in human blood platelets and erythrocytes are contradictory. We used a specific gas chromatography-mass spectrometry (GC-MS) method to detect NOS activity in human platelets. The method measures simultaneously [(15)N]nitrite
Svetlana I Sofronova et al.
European journal of pharmacology, 765, 598-605 (2015-09-30)
Previously we showed that endothelium of 1-2-weeks old rats exerts an anticontractile effect due to spontaneous NO production which correlates with a higher eNOS expression level compared to adult rats. Oestrogens are powerful regulators of eNOS expression and activity in
Liudmila Efremova et al.
British journal of pharmacology, 172(16), 4119-4132 (2015-05-20)
Few neuropharmacological model systems use human neurons. Moreover, available test systems rarely reflect functional roles of co-cultured glial cells. There is no human in vitro counterpart of the widely used 1-methyl-4-phenyl-tetrahydropyridine (MPTP) mouse model of Parkinson's disease We generated such
Dirk A Ridder et al.
The Journal of experimental medicine, 212(10), 1529-1549 (2015-09-09)
Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively
Gabriele Serreli et al.
Nutrients, 13(6) (2021-07-03)
Wholegrain oats contain a variety of phenolic compounds thought to help maintain healthy vascular function, through the maintenance of local levels of the vasodilator nitric oxide (NO). Thus, the full molecular mechanisms involved are not yet clear. With this work
Helena Janols et al.
Journal of leukocyte biology, 96(5), 685-693 (2014-06-15)
The causative microorganisms dictate the type of MDSC generated in sepsis patients, and a large proportion of PMN-MDSCs in gram-positive sepsis includes immunosuppressive myeloid blasts. MDSCs constitute a heterogeneous population of immature myeloid cells that potently suppress immune responses. They
Galya Stavreva et al.
Acta neurobiologiae experimentalis, 72(2), 185-193 (2012-07-20)
Disturbances of enteric nerve-mediated anorectal evacuation mechanisms have medical and social impact. The study aimed at further eliciting the contribution of cholinergic and nitrergic neurotransmission systems to modular nerve networks in different regions of Wistar rat anorectum. Electrical field stimulation
Gyula Telegdy et al.
Peptides, 39, 171-174 (2012-11-08)
The widespread distribution of apelin-13 and apelin receptors in the brain suggests an important function of this neuropeptide in the brain that has not been explored extensively so far. In the present work, apelin-13 was found to facilitate the consolidation
Changlong An et al.
PloS one, 10(8), e0134876-e0134876 (2015-08-11)
Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or carbachol (CCh), and the phosphorylation of telokin S13, myosin
Song-Jung Kim et al.
Life sciences, 91(23-24), 1201-1206 (2012-10-10)
Isoflurane has been demonstrated to produce late preconditioning against myocardial stunning. We tested the hypothesis that this effect is dependent upon an increased production of nitric oxide. Studies were performed in 18 conscious dogs, chronically instrumented to measure coronary blood
Samera Nademi et al.
Frontiers in physiology, 11, 853-853 (2020-08-15)
Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented
W Joost Lesterhuis et al.
Scientific reports, 5, 12298-12298 (2015-07-22)
Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex network of interacting gene products and that by mapping this network we could
Michael J Glass et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9558-9567 (2015-07-03)
Hypertension induced by angiotensin II (Ang II) is associated with glutamate-dependent dysregulation of the hypothalamic paraventricular nucleus (PVN). Many forms of glutamate-dependent plasticity are mediated by NMDA receptor GluN1 subunit expression and the distribution of functional receptor to the plasma
Jagmohan Singh et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G292-G300 (2015-07-04)
Changes in oxidative stress may affect basal tone and relaxation of the internal anal sphincter (IAS) smooth muscle in aging. We examined this issue by investigating the effects of the oxidative stress inducer 6-anilino-5,8-quinolinedione (LY-83583) in basal as well as
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