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Showing 1-30 of 186 results for "O104" within Papers
Nadja Haarmann et al.
International journal of medical microbiology : IJMM, 308(7), 912-920 (2018-06-27)
Escherichia coli O104:H4 (E. coli O104:H4), which caused in 2011 a massive foodborne outbreak in Germany, is characterized by an unusual combination of virulence traits. E. coli O104:H4 contains a prophage-encoded Shiga toxin (Stx) gene, which is the cardinal virulence
Nadja Saile et al.
International journal of medical microbiology : IJMM, 308(4), 459-468 (2018-04-03)
Enterohemorrhagic E. coli (EHEC) are serious bacterial pathogens which are able to cause a hemorrhagic colitis or the life-threatening hemolytic-uremic syndrome (HUS) in humans. EHEC strains can carry different numbers of phage-borne nanS-p alleles that are responsible for acetic acid
Alexey Fomenkov et al.
Nucleic acids research, 48(22), 12858-12873 (2020-12-04)
Analysis of genomic DNA from pathogenic strains of Burkholderia cenocepacia J2315 and Escherichia coli O104:H4 revealed the presence of two unusual MTase genes. Both are plasmid-borne ORFs, carried by pBCA072 for B. cenocepacia J2315 and pESBL for E. coli O104:H4.
Huikyong Lee et al.
Glia, 69(5), 1110-1125 (2020-12-15)
Vacuolar ATPase (v-ATPase) is the main proton pump that acidifies vesicles such as lysosomes. Disruption in the lysosomal localization of v-ATPase leads to lysosomal dysfunction, thus contributing to the pathogenesis of lysosomal storage disorders and neurodegenerative diseases such as Alzheimer's
Andrew Curtright et al.
PloS one, 10(1), e0116766-e0116766 (2015-01-15)
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely
M T Ventura et al.
Journal of biological regulators and homeostatic agents, 27(2), 589-594 (2013-07-09)
Corticosteroids are therapeutic drugs widely used in cases of allergic, inflammatory and autoimmune diseases, but sometimes allergic hypersensitivity reactions have been reported as a rare adverse effect of the corticosteroids themselves. Moreover, glucocorticoids can induce gastric lesions; thats why they
Sudhir K Yadav et al.
Biochimica et biophysica acta, 1830(6), 3776-3786 (2013-03-26)
The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically. Mice were pre-treated with APC for 1h followed by IND
V A Zolotarev et al.
Bulletin of experimental biology and medicine, 154(4), 415-418 (2013-03-15)
Proton pump inhibitors were shown to affect the sensitivity of the gastric mucosa to chemical agents. This effect is associated with inhibition of proton back-diffusion and increase in the permeability of the gastric epithelium. We studied the effect of omeprazole
M Morii et al.
The Journal of biological chemistry, 268(29), 21553-21559 (1993-10-15)
Omeprazole and E3810 were found to inhibit gastric H+,K(+)-ATPase following different biochemical mechanisms. Effects of the specific binding of the inhibitors on the conformational state of the enzyme were studied by measuring the fluorescence of the enzyme labeled with fluorescein
Omeprazole
Michelle I. Wilde and Donna Mc Tavish
Drugs, 48(1), 91-132 (1994)
Paul A Gurbel et al.
American heart journal, 165(2), 176-182 (2013-01-29)
A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction with
Horacio Reyes-Vivas et al.
Antimicrobial agents and chemotherapy, 58(12), 7072-7082 (2014-09-17)
Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the
Kazuhiro Shiizaki et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1690-1697 (2014-07-26)
Omeprazole (OME), a proton pump inhibitor used to treat gastritis, is also an aryl hydrocarbon receptor (AhR) activator. OME activates AhR in human hepatocytes and hepatoma cells, but not in mice in vivo or in vitro. We recently discovered that
M Ritter et al.
British journal of pharmacology, 124(4), 627-638 (1998-08-05)
1. Stimulation of chemotaxis of human polymorphonuclear leucocytes (PMNs) with the chemoattractive peptide fMLP (N-formyl-Met-Leu-Phe) is paralleled by profound morphological and metabolic alterations like changes of intracellular pH (pHi) and cell shape. The present study was performed to investigate the
Adrian G McNicholl et al.
Gut, 63(2), 244-249 (2013-05-15)
No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. Prospective randomised clinical trial in 11 Spanish hospitals.
Meng-Hooi Shu et al.
BMC complementary and alternative medicine, 13, 61-61 (2013-03-19)
Gracilaria changii (Xia et Abbott) Abbott, Zhang et Xia, a red algae commonly found in the coastal areas of Malaysia is traditionally used for foods and for the treatment of various ailments including inflammation and gastric ailments. The aim of
Blair Mell et al.
Physiological genomics, 47(6), 187-197 (2015-04-02)
The gut microbiota plays a critical role in maintaining physiological homeostasis. This study was designed to evaluate whether gut microbial composition affects hypertension. 16S rRNA genes obtained from cecal samples of Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats were
Shotaro Uehara et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(10), 1408-1416 (2015-08-01)
The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochrome P450 (P450) 2C18, 2C19, 2C58, and 2C76, were cloned
Is omeprazole helpful in the management of children with reflux oesophagitis?
Lizy A Varughese et al.
Archives of disease in childhood, 87(1), 78-80 (2002-06-29)
Yuan Zhang et al.
Die Pharmazie, 70(1), 47-54 (2015-05-16)
Polygonum multiflorum is a traditional Chinese medicinal herb used in clinical medicine to nourish the liver and kidney. However, in recent years, there have been increased reports of clinical adverse reactions associated with Polygonum multiflorum preparations, especially due to liver
M Espinosa Bosch et al.
Journal of pharmaceutical and biomedical analysis, 44(4), 831-844 (2007-05-29)
Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid
Yehia El-Garem et al.
Urology, 84(6), 1347-1350 (2014-11-30)
To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies
Kazuhiro Shiizaki et al.
Molecular pharmacology, 85(2), 279-289 (2013-11-23)
Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While
[Comment of the Delphi Care editors on Critical evaluation of interaction screening software available in pharmacies].
Daniel Duh et al.
Journal de pharmacie de Belgique, (4)(4), 14-15 (2013-01-29)
Profiling the hepatic effects of flutamide in rats: A microarray comparison with classical AhR ligands and atypical CYP1A inducers
Coe KJ, et al.
Drug Metabolism and Disposition (2006)
Yu-Qin Pan et al.
Biopharmaceutics & drug disposition, 36(4), 232-244 (2015-01-20)
Previous work has indicated that there is increased protein expression of multidrug resistance-associated protein 3 (MRP3) in the liver samples of patients treated with omeprazole compared with those who were not. However, evidence is still lacking to show the mechanisms
[Recent topics on important drugs for H. pylori eradication: Omeprazole].
Hiromi Kataoka et al.
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 11, 333-337 (2005-12-21)
Michael A Schumacher et al.
The Journal of physiology, 593(8), 1809-1827 (2015-01-22)
An in vitro approach to study gastric development is primary mouse-derived epithelium cultured as three-dimensional spheroids known as organoids. We have devised two unique gastric fundic-derived organoid cultures: model 1 for the expansion of gastric fundic stem cells, and model
Sam Vanherle et al.
Journal of extracellular vesicles, 12(12), e12394-e12394 (2023-12-21)
Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effector functions remain poorly understood. Here, we
A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.
Lars Olbe et al.
Nature reviews. Drug discovery, 2(2), 132-139 (2003-02-04)
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