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Showing 1-30 of 211 results for "O3129" within Papers
Vanessa Piechotta et al.
The Cochrane database of systematic reviews, 2019(11) (2019-11-26)
Multiple myeloma is a bone marrow-based hematological malignancy accounting for approximately two per cent of cancers. First-line treatment for transplant-ineligible individuals consists of multiple drug combinations of bortezomib (V), lenalidomide (R), or thalidomide (T). However, access to these medicines is
H Chu et al.
Journal of applied microbiology, 125(2), 554-563 (2018-04-21)
This study investigates pinewood nematode's impacts on root mycoflora of Pinus tabulaeformis. The biomass, colonization rate, community structure and diversity of root-associated fungi were investigated in pinewood nematode-infected and nematode-noninfected P. tabulaeformis. The results indicated that the roots of P.
Annachiara Scalzone et al.
Frontiers in bioengineering and biotechnology, 8, 712-712 (2020-07-23)
Nature provides biomaterials that tend to be effective to control both their adhesive and cohesive properties. A catecholamine motif found in the marine mussels, the mytilus edulis foot protein, can play adhesiveness and cohesiveness. Particularly, acidic pH drives catechol (Cat)
Rosa Purgatorio et al.
ChemMedChem, 16(3), 589-598 (2020-11-07)
Different Mannich base derivatives have been studied with the aim of addressing the poor aqueous solubility of the recently disclosed 6-phenethyl-2,3,4,5-tetrahydroazepino[4,3-b]indol-1(6H)-one (1), a human butyrylcholinesterase inhibitor (hBChE, IC50 13 nM) and protective agent in NMDA-induced neurotoxicity, in in vivo assays. The N-(4-methylpiperazin-1-yl)methyl
Siyuan Feng et al.
Frontiers in microbiology, 11, 413-413 (2020-04-09)
There is growing evidence that GreA aids adaptation to stressful environments in various bacteria. However, the functions of GreA among mycobacteria remain obscure. Here, we report on cellular consequences following deletion of greA gene in Mycobacterium spp. The greA mutant
Jun-Cheng Guo et al.
Psychiatry investigation, 15(4), 407-412 (2018-03-20)
To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to
Yan Gao et al.
Environmental pollution (Barking, Essex : 1987), 230, 469-478 (2017-07-09)
Bacterial communities in rivers receiving untreated domestic wastewater may show specific spatial assemblage patterns due to a wide range of physicochemical conditions created by periodic algal bloom. However, there are significant gaps in understanding environmental forces that drive changes in
Zhiwei Ma et al.
The journal of physical chemistry. B, 125(9), 2288-2298 (2021-03-03)
Rapid identification of inhibitors for a family of proteins and prediction of ligand specificity are highly desirable for structure-based drug design. However, sequentially docking ligands into each protein target with conventional single-target docking methods is too computationally expensive to achieve
Chengyuan Su et al.
Bioresource technology, 288, 121508-121508 (2019-05-28)
The aim of the present paper was to investigate the effects of hydraulic retention time (HRT) on the performance and microbial community dynamics of an anaerobic baffled reactor-bioelectricity Fenton (ABR-BEF) coupling reactor for treating traditional Chinese medicine (TCM) wastewater. The
Fernanda A H Batista et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 639-649 (2020-02-13)
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are molecular
Meiyao Wang et al.
BMC genomics, 21(1), 410-410 (2020-06-20)
Coilia nasus (C. nasus) is an important anadromous fish species that resides in the Yangtze River of China, and has high ecological and economical value. However, wild resources have suffered from a serious reduction in population, attributed to the over-construction
Michal Wlodarski et al.
Physical biology, 14(1), 015005-015005 (2017-02-17)
While the action of many antimicrobial drugs is well understood at the molecular level, a systems-level physiological response to antibiotics remains largely unexplored. This work considers fluctuation dynamics of both the chromosome and cytosol in Escherichia coli, and their response
Ji Won Park et al.
Free radical biology & medicine, 121, 149-156 (2018-05-02)
Nitric oxide (NO) is an essential signaling molecule in the body, regulating numerous biological processes. Beside its physiological roles, NO affects drug metabolism by modulating the activity and/or expression of cytochrome P450 enzymes. Previously, our lab showed that NO generation
Félicien Le Louedec et al.
Pharmaceuticals (Basel, Switzerland), 14(2) (2021-03-07)
Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUCIBRU) instead of trough concentration (Cmin,ss) because of a limited accumulation in plasma. Our objective was to identify a limited sampling strategy (LSS)
Qianwei Li et al.
Marine pollution bulletin, 128, 475-482 (2018-03-25)
The environmental behaviors and migration patterns of antibiotic resistance genes (ARGs) have attracted considerable research interest. However, there has been little research concerning the effects of corresponding and non-corresponding contaminants on the fate of ARGs in coastal environments. In the
Chao Zhu et al.
PloS one, 13(11), e0205990-e0205990 (2018-11-02)
Polymer nanocomposites have been widely used in the preparation of coating agents in the leather industry. Considering the complex bio-effect and ecological risk of nanomaterial, research on the biodegradability and biocompatibility of polyacrylate/metal nanocomposites in activated sludge system is of
Giulio Poli et al.
Frontiers in chemistry, 6, 229-229 (2018-07-05)
Herein we present the algorithm and performance assessment of our newly developed conformer generator iCon that was implemented in LigandScout 4.0. Two data sets of high-quality X-ray structures of drug-like small molecules originating from the Protein Data Bank (200 ligands)
Meraj A Khan et al.
Scientific reports, 7, 41749-41749 (2017-02-09)
Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional activity reflects
Katrine Bugge et al.
Structure (London, England : 1993), 26(5), 734-746 (2018-04-17)
Communication within cells relies on a few protein nodes called hubs, which organize vast interactomes with many partners. Frequently, hub proteins are intrinsically disordered conferring multi-specificity and dynamic communication. Conversely, folded hub proteins may organize networks using disordered partners. In
Guokun Yang et al.
Journal of molecular endocrinology, 58(4), 179-191 (2017-03-12)
CTRP9 is a member of the C1q/TNF-related protein (CTRP) superfamily and has been studied in mammals, whereas the comparative studies of CTRP9 in non-mammalian species are still absent. In this study
Laurent M A Favié et al.
Clinical pharmacology and therapeutics, 108(5), 1098-1106 (2020-05-29)
Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and treatment. A better understanding of underlying pharmacokinetic principles is essential
Keith T Schmidt et al.
Cancer chemotherapy and pharmacology, 86(4), 475-486 (2020-09-09)
NLG207 (formerly CRLX101) is a nanoparticle-drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT release from nanoparticles using a population PK (popPK)
Jidong Liang et al.
Chemosphere, 266, 128984-128984 (2020-11-26)
DNA-stable isotope probing (SIP) with 13C labeled phenanthrene (PHE) as substrate was used to identify specific bacterial degraders during natural attenuation (NA) and bioaugmentation (BA) in petroleum contaminated soil. BA, with the addition of a bacterial suspension mixture named GZ
Jiqing Liu et al.
Developmental and comparative immunology, 107, 103657-103657 (2020-02-25)
As a multifunctional protein, cyclophilin A (CypA) plays an important role in cell apoptosis. In our previous work, we found that CypA from Apostichopus japonicus (AjCypA), as a cofactor, could modulate nuclear translocation of NF-κB. However, the immune function of
Lijian Zhao et al.
Ecotoxicology and environmental safety, 190, 110070-110070 (2019-12-17)
Microplastic polyamide 66 (PA66) was used to explore its mechanism of influence on the contaminants removal from aerobic granular sludge (AGS) and the corresponding change to the microbial community. Results showed that the removal pollution efficiency of the experimental groups
Gang Wang et al.
Viruses, 11(4) (2019-04-03)
Transmissible gastroenteritis virus (TGEV) is the etiologic agent of transmissible gastroenteritis in pigs, and the N-terminal domain of TGEV spike protein is generally recognized as both the virulence determinant and enteric tropism determinant. Here, we assembled a full-length infectious cDNA
Hayley Dingsdale et al.
Translational psychiatry, 11(1), 62-62 (2021-01-20)
Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression. However, little is known about BDNF levels in the blood
Zhi Ma et al.
Food research international (Ottawa, Ont.), 125, 108520-108520 (2019-09-27)
S. enterica is an important foodborne pathogen worldwide. As some strains can form biofilms which may offer protection against antimicrobials, it is of interest to explore ways to prevent biofilm formation by S. enterica. In this study, we engineered a
Muting Yan et al.
The Science of the total environment, 631-632, 840-848 (2018-05-08)
The Three Gorges Project significantly impacted water quality and ecological balance in this area. The special engineered aquatic environment could be an important reservoir for antibiotic resistance genes (ARGs). Fifteen ARGs corresponding to three groups of antibiotics (tetracyclines, sulfonamides and
Songqing Wu et al.
PloS one, 11(1), e0147855-e0147855 (2016-01-28)
Monochamus alternatus Hope is the main vector in China of the Pine Wilt Disease caused by the pine wood nematode Bursaphelenchus xylophilus. Although chemical control is traditionally used to prevent pine wilt disease, new strategies based in biological control are
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