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Showing 31-60 of 211 results for "O3129" within Papers
Assessment of the Diversity of
Jun Chen et al.
Frontiers in microbiology, 8, 1748-1748 (2017-10-03)
Rui Duan et al.
Journal of computer-aided molecular design, 32(1), 103-111 (2017-11-12)
D3R 2016 Grand Challenge 2 focused on predictions of binding modes and affinities for 102 compounds against the farnesoid X receptor (FXR). In this challenge, two distinct methods, a docking-based method and a template-based method, were employed by our team
Rosa Purgatorio et al.
European journal of medicinal chemistry, 177, 414-424 (2019-06-04)
Due to the role of butyrylcholinesterase (BChE) in acetylcholine hydrolysis in the late stages of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been recently envisaged, besides acetylcholinesterase (AChE) inhibitors, as candidates for treating mild-to-moderate AD. Herein, synthesis and
Meng-Hsien Chuang et al.
Integrative cancer therapies, 16(4), 516-525 (2016-10-05)
JC-001 is a Chinese medicine that has been used to treat liver disease; however, its significance in cancer treatment has not been characterized. In this study, we used an immunocompetent tumor model to characterize the antitumor activity of JC-001. A
Daniel J White et al.
Journal of computational biology : a journal of computational molecular cell biology, 24(9), 874-881 (2017-04-18)
Applying high-throughput sequencing to pathogen discovery is a relatively new field, the objective of which is to find disease-causing agents when little or no background information on disease is available. Key steps in the process are the generation of millions
Ncediwe Tsolekile et al.
Scientific reports, 10(1), 4936-4936 (2020-03-20)
The toxicity of heavy metals present in binary semiconductor nanoparticles also known as quantum dots (QDs) has hindered their wide applications hence the advent of non-toxic ternary quantum dots. These new group of quantum dots have been shown to possess
Takashi Nakahara et al.
Journal of gastroenterology, 53(2), 269-280 (2017-07-26)
The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g
Nehaz Muhammad et al.
Parasitology research, 118(7), 2213-2221 (2019-06-12)
The Centrorhynchidae (Acanthocephala: Palaeacanthocephala) is a cosmopolitan family commonly found in various avian and mammalian hosts. Within Centrorhynchidae, species of the genus Sphaerirostris Golvan, 1956 are usually parasitic in the digestive tract of various passerine birds. In the present study
Hongmei Liu et al.
Research in veterinary science, 125, 212-217 (2019-07-05)
Goose parvovirus (GPV) is the etiological agent of Derzsy's disease, with a natural reservoir consisting only of geese and Muscovy ducks. However, the pathological changes in the immune organs of ducklings experimentally infected with GPV remain unknown. In this study
Yuanyi Xu et al.
International journal of molecular medicine, 42(5), 2737-2749 (2018-09-19)
In the present study, the effect of dextran sulfate (DS) on the metastasis and invasion of human gastric cancer cells and its key underlying mechanism were investigated. The levels of hypoxia‑inducible factor 1α (HIF‑1α), transforming growth factor β (TGF‑β) and
Yuan Yue et al.
RNA biology, 14(10), 1399-1410 (2017-03-10)
Exon or cassette duplication is an important means of expanding protein and functional diversity through mutually exclusive splicing. However, the mechanistic basis of this process in non-arthropod species remains poorly understood. Here, we demonstrate that MRP1 genes underwent tandem exon
Haiming Zou et al.
Environmental science and pollution research international, 26(22), 23061-23069 (2019-06-13)
A distinctive process (BCE-MFC) was developed to explore the methyl orange (MO) degradation and simultaneous bioelectricity generation based on the functional collaboration of biofilm, electrolysis, constructed wetland, and microbial fuel cell. The biofilm-cathode electrode-microbial fuel cell (BCE-MFC) was capable of
Zhiwei Ma et al.
The journal of physical chemistry. B, 125(9), 2288-2298 (2021-03-03)
Rapid identification of inhibitors for a family of proteins and prediction of ligand specificity are highly desirable for structure-based drug design. However, sequentially docking ligands into each protein target with conventional single-target docking methods is too computationally expensive to achieve
Muting Yan et al.
The Science of the total environment, 631-632, 840-848 (2018-05-08)
The Three Gorges Project significantly impacted water quality and ecological balance in this area. The special engineered aquatic environment could be an important reservoir for antibiotic resistance genes (ARGs). Fifteen ARGs corresponding to three groups of antibiotics (tetracyclines, sulfonamides and
Fernanda A H Batista et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 639-649 (2020-02-13)
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are molecular
Lijian Zhao et al.
Ecotoxicology and environmental safety, 190, 110070-110070 (2019-12-17)
Microplastic polyamide 66 (PA66) was used to explore its mechanism of influence on the contaminants removal from aerobic granular sludge (AGS) and the corresponding change to the microbial community. Results showed that the removal pollution efficiency of the experimental groups
Giulio Poli et al.
Frontiers in chemistry, 6, 229-229 (2018-07-05)
Herein we present the algorithm and performance assessment of our newly developed conformer generator iCon that was implemented in LigandScout 4.0. Two data sets of high-quality X-ray structures of drug-like small molecules originating from the Protein Data Bank (200 ligands)
Romi Dasgupta et al.
Archives of physiology and biochemistry, 124(5), 436-441 (2017-12-28)
Betel nut of Areca catechu is chewed by millions of people for increased capacity to work and stress reduction, but it contains arecoline that causes hypothyroidism. The aim is to investigate the role of arecoline on thyroid activity in cold
Yangyang Pan et al.
Journal of cellular biochemistry, 121(2), 1087-1100 (2019-08-28)
Autophagy is one of the basic cellular mechanism during preimplantation development of mammalian embryos, and it plays crucial role in several physiological processes. It is induced by interleukin (IL)-1β in mammalian cells. Our present study shows that IL-1β is important
P Banerjee et al.
Chemistry and physics of lipids, 77(1), 65-78 (1995-08-01)
Membrane proteins are typically extracted by detergent concentrations of 0.5-2.0%, using detergent/protein ratios of 1:1 to 3:1. We have compared the ability of 14 different detergents from seven different structural and ionic classes, at a concentration of 2.0% and a
C J Maurer et al.
Clinical neuroradiology, 25(4), 397-402 (2014-07-06)
Acute major stroke with high-grade stenosis or occlusion of the extracranial internal carotid artery (ICA) and additional intracranial large artery occlusion is increasingly treated with a mechanical endovascular approach by extracranial stenting and intracranial thrombectomy due to poor response to
Yongxin Dai et al.
Plant physiology and biochemistry : PPB, 146, 177-186 (2019-11-23)
Frost-induced embolism and frost fatigue are two major aspects of frost damage to xylem water transport in trees. In this study, three species of each ring-porous, diffuse-porous, and coniferous trees growing in situ were used to explore their differences in
Yue Hu et al.
Immunologic research, 64(2), 540-547 (2016-01-13)
The effect of corticotropin-releasing factor (CRF) on gastrointestinal tract inflammation via modulation of the immune system cells such as dendritic cells (DCs) is not known. We investigated the expression of CRF and its receptors CRFR1 and CRFR2 in a colonic
Xingxu Lu et al.
ACS applied materials & interfaces, 11(24), 21515-21525 (2019-05-28)
Supported metal catalysts are one of the major classes of heterogeneous catalysts, which demand good stability in both the supports and catalysts. Herein, layered protonated titanate-derived TiO2 (LPT-TiO2) nanowire arrays were synthesized to support platinum catalysts using different loading processes.
Liting Jiang et al.
International journal of biological macromolecules, 135, 113-118 (2019-05-28)
Our previous work indicated that fibrinogen-related protein (AjFREP) from sea cucumber (Apostichopus japonicus) plays important roles in innate immunity. To understand AjFREP expression regulation in A. japonicus, we cloned the AjFREP promoter and characterized the putative transcription-factor binding motifs. The
Wenshu Zou et al.
Inflammation, 42(1), 103-112 (2018-08-23)
The oxysterone α-mangostin is isolated from mangosteen husks and is widely used in the treatment of abdominal pain, diarrhea, and dysentery. In this study, we established a lipopolysaccharide (LPS)-induced inflammatory model of rat intestinal epithelial cells (IEC-6 cells), at the
Jingjing Zhang et al.
Marine drugs, 17(2) (2019-02-24)
Quorum sensing (QS) is closely associated with the production of multiple virulence factors in bacterial pathogens. N-acyl homoserine lactones (AHLs) are important QS signal molecules that modulate the virulence of gram-negative pathogenic bacteria. Enzymatic degradation of AHLs to interrupt QS
Helmy Yusuf et al.
International journal of pharmaceutics, 533(1), 179-186 (2017-09-10)
There is a pressing need for effective needle-free vaccines that are stable enough for use in the developing world and stockpiling. The inclusion of the cationic lipid DDA and the PEG-containing moiety TPGS into liposomes has the potential to improve
Hiba Zalloum et al.
Breast cancer (Tokyo, Japan), 27(2), 213-224 (2019-09-29)
Breast cancer is one of the most lethal types of cancer in women worldwide. The human epidermal growth factor receptor 2 (HER2) is considered as a validated target in breast cancer therapy. Previously, we have used quantitative structure activity relationship
Annachiara Scalzone et al.
Frontiers in bioengineering and biotechnology, 8, 712-712 (2020-07-23)
Nature provides biomaterials that tend to be effective to control both their adhesive and cohesive properties. A catecholamine motif found in the marine mussels, the mytilus edulis foot protein, can play adhesiveness and cohesiveness. Particularly, acidic pH drives catechol (Cat)
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