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Showing 1-30 of 618 results for "P1223" within Papers
Edward S Parsons et al.
Nature communications, 10(1), 2066-2066 (2019-05-08)
The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about
Qing Yao et al.
ACS applied materials & interfaces, 9(38), 32520-32533 (2017-09-06)
In this study, we described an "all-in-one" polymer-lipid conjugate (PEG2k-ppTAT-PEG1k-PE) that could self-assemble to matrix metalloproteinase 2 (MMP2)-sensitive multifunctional micelles. The assembled micelles had several key features, including a protective long chain poly(ethylene glycol) (PEG2k) (the outer shell), an MMP2-sensitive
Laura L Thomas et al.
Developmental cell, 48(1), 100-114 (2018-12-12)
Correct localization of Rab GTPases in cells is critical for proper function in membrane trafficking, yet the mechanisms that target Rabs to specific subcellular compartments remain controversial. Guanine nucleotide exchange factors (GEFs) activate and consequently stabilize Rab substrates on membranes
Hua Su et al.
Molecular cell, 67(6), 907-921 (2017-08-29)
The class III phosphoinositide 3-kinase VPS34 plays a key role in the regulation of vesicular trafficking and macroautophagy. So far, we know little about the molecular mechanism of VPS34 activation besides its interaction with regulatory proteins to form complexes. Here
Maria Teresa Calejo et al.
Acta biomaterialia, 101, 327-343 (2019-11-13)
In vitro cell culture models representing the physiological and pathological features of the outer retina are urgently needed. Artificial tissue replacements for patients suffering from degenerative retinal diseases are similarly in great demand. Here, we developed a co-culture system based
Xavier Rovira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 116-130 (2014-10-25)
Type 4 metabotropic glutamate (mGlu4) receptors are emerging targets for the treatment of various disorders. Accordingly, numerous mGlu4-positive allosteric modulators (PAMs) have been identified, some of which also display agonist activity. To identify the structural bases for their allosteric action
G Weitsman et al.
Oncogene, 36(25), 3618-3628 (2017-02-07)
Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the improvement
Yamin Li et al.
Advanced healthcare materials, 8(6), e1800996-e1800996 (2018-12-20)
Protein- and peptide-based therapeutics with high tolerance and specificity along with low off-target effects and genetic risks have attracted tremendous attention over the last three decades. Herein, a new type of noncationic lipidoid nanoparticle (LNP) is reported for His-tagged protein
Carolyn L Westhoff et al.
Contraception, 95(5), 456-463 (2017-01-16)
Venous thromboembolism (VTE) risk increases within months of combination oral contraceptive (COC) initiation. Because elevated endogenous thrombin potential (ETP) has been found in several studies to be a VTE risk factor, we evaluated the extent of ETP changes during the
Chiara Fondello et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 290-301 (2016-10-25)
We explored the potential of a chemogene therapy combination to eradicate melanoma tumor initiating cells, key producers of recurrence and metastatic spread. Three new human melanoma cell lines, two obtained from lymph nodes and one from spleen metastasis were established
Bing Wang et al.
European journal of medicinal chemistry, 136, 585-595 (2017-05-28)
Although numerous cationic lipids have been developed as non-viral gene vectors, the structure-activity relationship (SAR) of these materials remains unclear and needs further investigation. In this work, a series of lysine-derived cationic lipids containing linkages with different rigidity were designed
Arafeh Bigdeli et al.
ACS nano, 10(3), 3723-3737 (2016-02-18)
To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome-protein corona (PC) aspects. As a powerful tool in this data mining
M Wiktor et al.
Biochimica et biophysica acta, 1860(6), 1384-1393 (2018-03-27)
Lipoproteins are important for bacterial growth and virulence and interest in them as targets for antibiotic development is growing. Lipoprotein N-acyl transferase (Lnt) catalyzes the final step in the lipoprotein posttranslational processing pathway. The mature lipoprotein can remain in the
Peter D Martin et al.
Biophysical journal, 114(11), 2573-2583 (2018-06-07)
We have used site-directed spin labeling and electron paramagnetic resonance (EPR) to map interactions between the transmembrane (TM) domains of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) and phospholamban (PLB) as affected by PLB phosphorylation. In the cardiac sarcoplasmic reticulum, PLB binding
Carlos E S Guedes et al.
PloS one, 10(8), e0134925-e0134925 (2015-08-05)
After phagocytosis by mammalian macrophages, promastigote forms of Leishmania parasites settle inside intracellular parasitophorous vacuoles (PVs) in which they transform into amastigote forms and replicate. Here, using a variant of the 'inverted emulsion' method, we succeeded in encapsulating living L.
Sang-Soo Kim et al.
Cancer letters, 369(1), 250-258 (2015-09-02)
Although temozolomide (TMZ) is the current first-line chemotherapy for glioblastoma multiforme (GBM), most patients either do not respond or ultimately fail TMZ treatment. Both intrinsic tumor resistance and limited access of TMZ to brain tumors as a result of the
Arisa Yamada et al.
Biomacromolecules, 16(8), 2356-2362 (2015-06-30)
We report the development of environmentally responsive fluorescent polymers. The reversible temperature-induced phase transition of copolymers composed of N-isopropylacrylamide and a fluorescent monomer based on the fluorescein (FL), coumarin (CO), rhodamine (RH), or dansyl (DA) skeleton was used as a
Jie Gao et al.
International journal of nanomedicine, 12, 1251-1264 (2017-03-01)
Cationic liposomes (CLs) have been widely examined as vaccine delivery nanoparticles since they can form complexes with biomacromolecules, promote delivery of antigens and adjuvant molecules to antigen-presenting cells (APCs), and mediate cellular uptake of vaccine components. CLs are also known
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression.
Sara Palchetti et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183159-183159 (2019-12-21)
The past three decades have witnessed fast advances in the use of cationic liposome-DNA complexes (lipoplexes) for gene delivery applications. However, no lipoplex formulation has reached into the clinical practice so far. The primary drawback limiting clinical use of lipoplexes
Chenchen Qin et al.
Nanoscale, 7(47), 20197-20210 (2015-11-18)
To optimize synergistic cancer therapy, we rationally assemble an inorganic-organic nanocomplex using a folate-modified lipid bilayer spread on photosensitizer-entrapped mesoporous silica nanoparticle (MSN) coated gold nanorods (AuNRs). In this hybrid bioconjugate, the large specific surface area and pore size of
Katarzyna M Targowska-Duda et al.
Journal of biomolecular structure & dynamics, 37(2), 411-439 (2018-01-25)
The binding site locations and structural components for type I and type II positive allosteric modulators (PAMs) of the α7 nicotinic acetylcholine receptor (nAChR) have not been fully characterized yet. In this regard, homology models of the human α7 nAChR
Omkara Swami Muddineti et al.
Photodiagnosis and photodynamic therapy, 29, 101633-101633 (2019-12-25)
To develop a photosensitizer, chlorin e6 (Ce6)-based amphiphilic polymer, DP-Ce6, where DOPE and PEG are conjugated to Ce6, which would self-assemble to form polymeric micelles (DP-Ce6-M) in aqueous environment. DP-Ce6-M were characterized for particle size, zeta potential, and singlet oxygen
Manju Kanamala et al.
International journal of pharmaceutics, 548(1), 288-296 (2018-07-08)
To facilitate the development of PEG-cleavable pH-sensitive liposomes (CL-pPSL), this study aimed to fully characterize a new pH-sensitive polymer, PEGB-Hz-CHEMS. Polyethylene glycol (PEG) functionalised with 4-carboxybenzaldehyde (PEGB) was linked to cholesteryl hemisuccinate (CHEMS) via an acid labile hydrazide-hydrazone hybrid bond
Zhiming Chen et al.
Journal of the American Chemical Society, 138(44), 14616-14622 (2016-10-30)
N-BAR proteins such as endophilin are thought to bend lipid membranes via scaffolding (the molding of membranes through the crescent protein shape) and membrane insertion (also called wedging) of amphipathic helices. However, the contributions from these distinct mechanisms to membrane
Alison T Isaacs et al.
BMC genomics, 19(1), 225-225 (2018-03-29)
To combat malaria transmission, the Ugandan government has embarked upon an ambitious programme of indoor residual spraying (IRS) with a carbamate class insecticide, bendiocarb. In preparation for this campaign, we characterized bendiocarb resistance and associated transcriptional variation among Anopheles gambiae
Mira Oswald et al.
International journal of pharmaceutics, 497(1-2), 293-300 (2015-11-17)
Functionalized phospholipids are indispensable materials for the design of targeted liposomes. Control over the quality and quantity of phospholipids is thereby key in the successful development and manufacture of such formulations. This was also the case for a complex liposomal
X Gao et al.
Biochemical and biophysical research communications, 179(1), 280-285 (1991-08-30)
A novel cationic derivative of cholesterol, 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol), has been synthesized and used to prepare sonicated liposomes with dioleoylphosphatidylethanolamine. This novel cationic liposome reagent facilitates efficient DNA mediated transfection in A431 human epidermoid carcinoma cells, A549 human
Aaron H Rose et al.
Human vaccines & immunotherapeutics, 11(9), 2305-2311 (2015-06-20)
Adjuvants for DNA vaccination are designed to promote transformation of transgenes into target cells and increase inflammation in the site of injection, with resultant immune cell recruitment. Numerous studies indicated cationic liposomes as effective adjuvants for DNA vaccination due to
Emmanuel Nji et al.
Nature communications, 9(1), 4253-4253 (2018-10-14)
Membrane bilayers are made up of a myriad of different lipids that regulate the functional activity, stability, and oligomerization of many membrane proteins. Despite their importance, screening the structural and functional impact of lipid-protein interactions to identify specific lipid requirements
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