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Showing 1-30 of 195 results for "P1291" within Papers
Angad Garg et al.
Molecular and cellular biology, 39(13) (2019-04-24)
Pho7 is the Schizosaccharomyces pombe fission yeast Zn2Cys6 transcriptional factor that drives a response to phosphate starvation in which phosphate acquisition genes are upregulated. Here we report a crystal structure at 1.6-Å resolution of the Pho7 DNA-binding domain (DBD) bound
Shane A Liddelow et al.
PloS one, 9(9), e106592-e106592 (2014-09-12)
To maintain the precise internal milieu of the mammalian central nervous system, well-controlled transfer of molecules from periphery into brain is required. Recently the soluble and cell-surface albumin-binding glycoprotein SPARC (secreted protein acidic and rich in cysteine) has been implicated
Salma Sohrabi-Jahromi et al.
eLife, 8 (2019-05-29)
RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast Saccharomyces cerevisiae. The
Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation.
Anuradha Bhattacharya et al.
EMBO reports, 25(2), 813-831 (2024-01-18)
Autophagy is initiated by the assembly of multiple autophagy-related proteins that form the phagophore assembly site where autophagosomes are formed. Atg13 is essential early in this process, and a hub of extensive phosphorylation. How these multiple phosphorylations contribute to autophagy
Hong-Yeoul Ryu et al.
The EMBO journal, 38(16), e102003-e102003 (2019-07-18)
Many eukaryotic proteins are regulated by modification with the ubiquitin-like protein small ubiquitin-like modifier (SUMO). This linkage is reversed by SUMO proteases, of which there are two in Saccharomyces cerevisiae, Ulp1 and Ulp2. SUMO-protein conjugation regulates transcription, but the roles
Chen-Chun Pai et al.
Cell reports, 20(11), 2693-2705 (2017-09-14)
Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both
Alba Duch et al.
Nature communications, 9(1), 379-379 (2018-01-27)
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope with sudden increases of transcription while replicating. Here, we report
Zoltan Villanyi et al.
PLoS genetics, 10(10), e1004569-e1004569 (2014-10-24)
Recent studies have suggested that a sub-complex of RNA polymerase II composed of Rpb4 and Rpb7 couples the nuclear and cytoplasmic stages of gene expression by associating with newly made mRNAs in the nucleus, and contributing to their translation and
Chihiro Yamada et al.
iScience, 25(2), 103675-103675 (2022-02-11)
Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition. However, some cells eventually override mitotic arrest by mitotic slippage. Here, we show that inactivation of TORC1 kinase elicits mitotic slippage in budding yeast and human cells.
Rupam Choudhury et al.
Genes & development, 33(9-10), 550-564 (2019-03-08)
Epigenetic modifications can maintain or alter the inherent symmetry of the nucleosome. However, the mechanisms that deposit and/or propagate symmetry or asymmetry are not understood. Here we report that yeast Set1C/COMPASS (complex of proteins associated with Set1) is dimeric and
Geoffray Monteuuis et al.
Nucleic acids research, 47(11), 5777-5791 (2019-06-20)
Utilization of non-AUG alternative translation start sites is most common in bacteria and viruses, but it has been also reported in other organisms. This phenomenon increases proteome complexity by allowing expression of multiple protein isoforms from a single gene. In
Lionel Tafforeau et al.
The EMBO journal, 25(19), 4547-4556 (2006-10-04)
We describe a new member of the F-box family, Pof14, which forms a canonical, F-box dependent SCF (Skp1, Cullin, F-box protein) ubiquitin ligase complex. The Pof14 protein has intrinsic instability that is abolished by inactivation of its Skp1 interaction motif
Fabrizio Simonetti et al.
eLife, 6 (2017-08-26)
In fission yeast, meiosis-specific transcripts are selectively eliminated during vegetative growth by the combined action of the YTH-family RNA-binding protein Mmi1 and the nuclear exosome. Upon nutritional starvation, the master regulator of meiosis Mei2 inactivates Mmi1, thereby allowing expression of
Sari Kassem et al.
Nucleic acids research, 45(3), 1186-1199 (2017-02-10)
Acetylation of histones regulates gene expression in eukaryotes. In the yeast Saccharomyces cerevisiae it depends mainly upon the ADA and SAGA histone acetyltransferase complexes for which Gcn5 is the catalytic subunit. Previous screens have determined that global acetylation is reduced
Heidi M Blank et al.
Molecular biology of the cell, 31(10), 1069-1084 (2020-03-05)
Establishing the pattern of abundance of molecules of interest during cell division has been a long-standing goal of cell cycle studies. Here, for the first time in any system, we present experiment-matched datasets of the levels of RNAs, proteins, metabolites
David M Hollenstein et al.
Nature communications, 12(1), 7194-7194 (2021-12-12)
Autophagosomes form at the endoplasmic reticulum in mammals, and between the vacuole and the endoplasmic reticulum in yeast. However, the roles of these sites and the mechanisms regulating autophagosome formation are incompletely understood. Vac8 is required for autophagy and recruits
Adrien Le Thomas et al.
Genes & development, 28(15), 1667-1680 (2014-08-03)
Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the genomic regions that give rise to piRNAs, the so-called piRNA clusters, are transcribed
Tommaso Villa et al.
Cell reports, 32(3), 107942-107942 (2020-07-23)
A large share of the non-coding transcriptome in yeast is controlled by the Nrd1-Nab3-Sen1 (NNS) complex, which promotes transcription termination of non-coding RNA (ncRNA) genes, and by the nuclear exosome, which limits the steady-state levels of the transcripts produced. How
The rod signaling pathway in marsupial retinae
Lutz ND, et al.
Testing, 13(8), e0202089-e0202089 (2018)
Monika Feigenbutz et al.
PloS one, 8(11), e80752-e80752 (2013-11-14)
Rrp6 is a conserved catalytic subunit of the eukaryotic nuclear exosome ribonuclease complex that functions in the productive 3' end maturation of stable RNAs, the degradation of transiently expressed noncoding transcripts and in discard pathways that eradicate the cell of
Kyumin Kim et al.
The Journal of biological chemistry, 291(25), 13229-13242 (2016-04-15)
The yeast Nrd1 interacts with the C-terminal domain (CTD) of RNA polymerase II (RNApII) through its CTD-interacting domain (CID) and also associates with the nuclear exosome, thereby acting as both a transcription termination and RNA processing factor. Previously, we found
Lei Wei et al.
Nature structural & molecular biology, 23(3), 209-216 (2016-02-09)
The MCM DNA helicase is a central regulatory target during genome replication. MCM is kept inactive during G1, and it initiates replication after being activated in S phase. During this transition, the only known chemical change to MCM is the
Cathrine A Bøe et al.
Scientific reports, 8(1), 6880-6880 (2018-05-04)
Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate replication initiation
Hong-Yeoul Ryu et al.
Nucleic acids research, 48(21), 12151-12168 (2020-11-25)
Histones are substrates of the SUMO (small ubiquitin-like modifier) conjugation pathway. Several reports suggest histone sumoylation affects transcription negatively, but paradoxically, our genome-wide analysis shows the modification concentrated at many active genes. We find that trans-tail regulation of histone-H2B ubiquitylation
Lauren J Hodkinson et al.
BMC genomic data, 24(1), 54-54 (2023-09-22)
Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. Regulatory factors concentrate in a nuclear body known as the
The dynamin-related protein Vps1 and the peroxisomal membrane protein Pex27 function together during peroxisome fission.
Ekal, et al.
Journal of Cell Science, 136 (2023)
Jérémy Scutenaire et al.
Nucleic acids research, 51(2), 517-535 (2022-08-08)
N6-Methyladenosine (m6A), one of the most abundant internal modification of eukaryotic mRNAs, participates in the post-transcriptional control of gene expression through recruitment of specific m6A readers. In Saccharomyces cerevisiae, the m6A methyltransferase Ime4 is expressed only during meiosis and its
Ying Zhang et al.
Nature communications, 12(1), 782-782 (2021-02-06)
The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins, containing a single C-terminal transmembrane domain, to the ER. Here we uncover how the yeast GET pathway component Get4/5 facilitates capture of tail-anchored proteins
Yaofeng Zhu et al.
International journal of molecular medicine, 44(4), 1414-1424 (2019-08-01)
The balance between glutamate (cortex and thalamus) and dopamine (substantia nigra) inputs on striatal neurons is of vital importance. Dopamine deficiency, which breaks this balance and leads to the domination of cortical glutamatergic inputs, plays an important role in Parkinson's
Agustin I Seoane et al.
Current biology : CB, 27(18), 2849-2855 (2017-09-19)
Robust progression through the cell-division cycle depends on the precisely ordered phosphorylation of hundreds of different proteins by cyclin-dependent kinases (CDKs) and other kinases. The order of CDK substrate phosphorylation depends on rising CDK activity, coupled with variations in substrate
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