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Showing 1-30 of 68 results for "P1793" within Papers
Successful treatment of Morgellons disease with pimozide therapy.
Erika Elise Reid et al.
Archives of dermatology, 146(10), 1191-1193 (2010-10-20)
Lyndsey E Collins et al.
Pharmacology, biochemistry, and behavior, 100(3), 498-505 (2011-11-01)
Dopamine D2 and adenosine A(2A) receptors interact to regulate aspects of motor and motivational function, and it has been suggested that adenosine A(2A) antagonists could be useful for the treatment of parkinsonism and depression. The present experiments were performed to
Joseph I Friedman et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(6), 1289-1295 (2011-02-25)
Despite its superior efficacy, clozapine is helpful in only a subset of patients with schizophrenia unresponsive to other antipsychotics. This lack of complete success has prompted the frequent use of various clozapine combination strategies despite a paucity of evidence from
Willem A van Vloten
Dermatology online journal, 9(2), 3-3 (2003-03-18)
Pimozide is widely used in psychiatry for chronic psychoses, schizophrenia, the syndrome of Gilles de la Tourette and to a certain extent, also in dermatology. The only dermatological indication is for delusions of parasitosis. Though there is a good rationale
David G Covell
PloS one, 7(10), e44631-e44631 (2012-10-12)
Studies into the genetic origins of tumor cell chemoactivity pose significant challenges to bioinformatic mining efforts. Connections between measures of gene expression and chemoactivity have the potential to identify clinical biomarkers of compound response, cellular pathways important to efficacy and
Sundee Dees et al.
Cancer biology & therapy, 21(6), 506-521 (2020-03-14)
Triple-negative breast cancer (TNBC) displays an aggressive clinical course, heightened metastatic potential, and is linked to poor survival rates. Through its lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)
Zhengqi Wang et al.
Antioxidants (Basel, Switzerland), 10(6) (2021-07-03)
Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the development of
Veit Roessner et al.
Neuropharmacology, 68, 143-149 (2012-06-26)
The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and
A Sultana et al.
The Cochrane database of systematic reviews, (2)(2), CD001949-CD001949 (2000-05-05)
Pimozide was first formulated in the late 1960s and marketed for the care of those with schizophrenia or related psychoses such as delusional disorder. To assess the effects of pimozide for people with schizophrenia, non-affective psychotic mental illness and delusional
Dorothée Duluc et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5776-5788 (2014-05-20)
Recent compelling evidence indicates that Th17 confer host immunity against a variety of microbes, including extracellular and intracellular pathogens. Therefore, understanding mechanisms for the induction and activation of Ag-specific Th17 is important for the rational design of vaccines against pathogens.
Xiaochen Yuan et al.
Biochemical and biophysical research communications, 514(3), 1023-1029 (2019-05-10)
It has been previously reported that the blockade of interleukin-7 receptor (IL-7R) promotes functional recovery following spinal cord injury (SCI), however, the direct function and molecular mechanism of IL-7 involved in this pathogenic process are unclear. Here, we report that
A Sultana et al.
The Cochrane database of systematic reviews, (3)(3), CD001949-CD001949 (2000-07-25)
Pimozide was first formulated in the late 1960s and continues to be marketed for the care of those with schizophrenia or related psychoses such as delusional disorder. Pimozide is generally well tolerated apart from extrapyramidal side effects. It has, however
Niraj S Trasi et al.
The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand the factors that influence
C L Colvin et al.
Drug intelligence & clinical pharmacy, 19(6), 421-424 (1985-06-01)
The orphan drug pimozide was recently approved for marketing in the U.S. for the treatment of Tourette's syndrome (TS). TS is characterized by recurrent, involuntary motor movements and vocal tics, and is believed to be due to neurochemical dysfunction. Pimozide's
Meghana Mothi et al.
The Cochrane database of systematic reviews, 11(11), CD001949-CD001949 (2013-11-07)
Pimozide, formulated in the 1960s, continues to be marketed for the care of people with schizophrenia or related psychoses such as delusional disorder. It has been associated with cardiotoxicity and sudden unexplained death. Electrocardiogram monitoring is now required before and
Tamara Pringsheim et al.
The Cochrane database of systematic reviews, (2)(2), CD006996-CD006996 (2009-04-17)
Neuroleptic drugs with potent D-2 receptor blocking properties have been the traditional treatment for tics caused by Tourette Syndrome. Pimozide is the most studied of these. Use of these medications is declining because of concerns about side effects, and new
Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells.
M Bar-Natan et al.
Leukemia, 26(6), 1407-1410 (2011-12-03)
John J Enyeart et al.
American journal of physiology. Cell physiology, 308(11), C899-C918 (2015-03-20)
In whole cell patch-clamp recordings, we characterized the L-type Ca(2+) currents in bovine adrenal zona fasciculata (AZF) cells and explored their role, along with the role of T-type channels, in ACTH- and angiotensin II (ANG II)-stimulated cortisol secretion. Two distinct
Handan Gunduz-Bruce et al.
Schizophrenia research, 143(2-3), 344-347 (2012-12-12)
A substantial number of patients with treatment-resistant schizophrenia respond only partially to clozapine. Therefore, it has been common practice to use augmentation strategies to maximize clozapine's effect. But the efficacy of this strategy remains poorly established. We have conducted a
L Schafranek et al.
Leukemia, 29(1), 76-85 (2014-05-13)
Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However
Luis A Zarazaga et al.
The Journal of endocrinology, 211(3), 263-272 (2011-09-10)
This research examines which neural mechanisms among the endogenous opioid, dopaminergic, serotonergic and excitatory amino acid systems are involved in the stimulation of LH secretion by melatonin implantation and their modulation by nutritional level. Female goats were distributed to two
Cynthia R Lorenzo et al.
American journal of clinical dermatology, 5(5), 339-349 (2004-11-24)
Pimozide is an antipsychotic drug of the diphenylbutylpiperidine class. In the US, it is FDA-approved only as a backup treatment for Gilles de la Tourette syndrome, although it has been used in other countries for many years as a treatment
Hobart L Rogers et al.
The Journal of clinical psychiatry, 73(9), 1187-1190 (2012-10-13)
The occurrence of pimozide-induced arrhythmias is concentration dependent. Hence, it is important for prescribers to consider causes of increased pimozide exposure. This article summarizes the U.S. Food and Drug Administration's (FDA's) review of drug interaction and pharmacogenomic studies and discusses
Ayako Nogami et al.
Oncotarget, 6(11), 9189-9205 (2015-04-01)
FLT3-ITD and FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid leukemia (AML), with the former associated with poor prognosis. Here, we show that the PI3K inhibitor GDC-0941 or the Akt inhibitor MK-2206 induced apoptosis through the mitochondria-mediated
Apoorvi Tyagi et al.
Theranostics, 12(13), 5949-5970 (2022-08-16)
Background: Cisplatin is one of the frontline anticancer agents. However, development of cisplatin-resistance limits the therapeutic efficacy of cisplatin-based treatment. The expression of microtubule-associated serine/threonine kinase 1 (MAST1) is a primary factor driving cisplatin-resistance in cancers by rewiring the MEK
M Bancila et al.
Fundamental & clinical pharmacology, 25(4), 469-478 (2010-11-03)
Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors
The Role of a Natural Amphibian Skin-Based Peptide, Ranatensin, in Pancreatic Cancers Expressing Dopamine D2 Receptors.
Laskowska, et al.
Cancers, 14 (2022)
Barry Ladizinski et al.
Journal of drugs in dermatology : JDD, 9(12), 1531-1532 (2010-12-02)
Delusions of parasitosis (DOP) is a psychiatric disorder characterized by the fixed false belief that one is infested with parasites or other organisms. Historically, pimozide, a first-generation antipsychotic, has been the treatment of choice for DOP, although there is risk
Hui Li et al.
Gene, 551(2), 279-289 (2014-09-10)
The signal transducer and activator of transcription 5a (Stat5a) modulates genes involved in proliferation and survival and plays pivotal roles in regulating the function of the mammary gland during pregnancy, lactation, and involution. However, there is little information about the
Chiara Vantaggiato et al.
Brain : a journal of neurology, 146(3), 1103-1120 (2022-08-28)
SPG15 is a hereditary spastic paraplegia subtype caused by mutations in Spastizin, a protein encoded by the ZFYVE26 gene. Spastizin is involved in autophagosome maturation and autophagic lysosome reformation and SPG15-related mutations lead to autophagic lysosome reformation defects with lysosome
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