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Showing 31-60 of 68 results for "P1793" within Papers
L Schafranek et al.
Leukemia, 29(1), 76-85 (2014-05-13)
Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However
Changes in the product label for pimozide illustrate both the promises and the challenges of personalized medicine.
Sheldon H Preskorn
The Journal of clinical psychiatry, 73(9), 1191-1193 (2012-10-13)
R M Pinder et al.
Drugs, 12(1), 1-40 (1976-01-01)
Pimozide 1-(1-[4,4-bis(4-fluorophenyl)butyl]-4-peperidinyl)-2-benzimidazolone, is the first of a new series of psychotropic drugs, the kiphenylbutylpiperidines. It is advocated for once-daily use as maintenance therapy in chronic schizophrenia and for the treatment of psychic and functional disorders induced by personality traits. Published
Pimozide.
Robert Smyj et al.
Profiles of drug substances, excipients, and related methodology, 37, 287-311 (2012-04-04)
Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins.
Ishine, T.
American Journal of Physiology. Heart and Circulatory Physiology, 278 (2000)
S M Sharaf
Theriogenology, 77(8), 1709-1716 (2012-03-01)
Nine groups each of four fish were injected with a single intramuscular dose of the following preparations: Physiological saline (0.9% NaCl) as a control group, 0.5 ml kg(-1) Ovaprim, 20 and 40 μg kg(-1) BW of GnRHa, 8 and 16
Francesco Borriello et al.
European journal of immunology, 45(7), 2042-2051 (2015-04-01)
Basophil-derived IL-4 is involved in the alternative activation of mouse monocytes, as recently shown in vivo. Whether this applies to human basophils and monocytes has not been established yet. Here, we sought to characterise the interaction between basophils and monocytes
Mariangela Gulisano et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32(6), 1213-1217 (2011-07-07)
The pharmacotherapy for tic management in Tourette syndrome (TS) relies on neuroleptics, which have been associated with electrocardiographic abnormalities, including QTc interval prolongation. This study assessed the cardiovascular safety of the newer antipsychotic aripiprazole in comparison with the neuroleptic pimozide
Avril Coghlan et al.
PLoS neglected tropical diseases, 17(9), e0011205-e0011205 (2023-09-05)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be
Erik A Nelson et al.
Blood, 117(12), 3421-3429 (2011-01-15)
The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase inhibitors have
Hawk Kim et al.
Annals of hematology, 94(5), 739-746 (2014-12-17)
The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities
Felix J Hartmann et al.
Nature communications, 5, 5056-5056 (2014-10-04)
Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these
Zhiyong Liao et al.
Molecular cancer therapeutics, 14(8), 1777-1793 (2015-05-31)
Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico
Qin Liang et al.
Nature chemical biology, 10(4), 298-304 (2014-02-18)
Protein ubiquitination and deubiquitination are central to the control of a large number of cellular pathways and signaling networks in eukaryotes. Although the essential roles of ubiquitination have been established in the eukaryotic DNA damage response, the deubiquitination process remains
Owen Randlett et al.
Current biology : CB, 29(8), 1337-1345 (2019-04-09)
Habituation is a simple form of learning where animals learn to reduce their responses to repeated innocuous stimuli [1]. Habituation is thought to occur via at least two temporally and molecularly distinct mechanisms, which lead to short-term memories that last
Mark R Davies et al.
Cell reports. Medicine, 1(5), 100076-100076 (2020-11-19)
There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with computational models
L A Opler et al.
The Journal of clinical psychiatry, 52(5), 221-233 (1991-05-01)
Pimozide, a diphenylbutylpiperidine neuroleptic which is FDA-approved as a backup treatment for Gilles de la Tourette's syndrome, has been used abroad for many years as a treatment of schizophrenia and has been recently reported to be particularly effective in treating
Renata Rizzo et al.
Pediatric neurology, 47(6), 419-422 (2012-11-07)
This study assessed the metabolic effects of aripiprazole and pimozide in pediatric Tourette syndrome, a neurodevelopmental condition characterized by multiple motor and phonic tics. Patients receiving aripiprazole (n = 25) or pimozide (n = 25) were compared with medication-free patients
Holger H H Erb et al.
PloS one, 15(8), e0237248-e0237248 (2020-08-14)
Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of transcription (STAT) 5 plays a role in tumour progression and
C Sprissler et al.
Blood cancer journal, 4, e240-e240 (2014-08-26)
The spleen tyrosine kinase (SYK) was identified as an oncogenic driver in a broad spectrum of hematologic malignancies. The in vivo comparison of three SYK containing oncogenes, SYK(wt), TEL-SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a general myeloexpansion and the
Delusions of parasitosis: ethical and clinical considerations.
Stephanie Fabbro et al.
Journal of the American Academy of Dermatology, 69(1), 156-159 (2013-06-19)
Mi Yang et al.
The Cochrane database of systematic reviews, (1)(1), CD004029-CD004029 (2011-01-21)
Non-antiepileptic drugs have been used in the management of trigeminal neuralgia since the 1970s. The objective was to systematically review the efficacy and tolerability of non-antiepileptic drugs for trigeminal neuralgia. For this updated review we searched the Cochrane Neuromuscular Disease
Cristina Sempio et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 1-7 (2014-09-15)
The aim of the study was to develop and validate a simple, sensitive and specific method for the detection and quantitative determination of 88 substances among psychoactive drugs and their metabolites in whole blood, and to apply the procedure to
Gordana Panic et al.
PLoS neglected tropical diseases, 9(7), e0003962-e0003962 (2015-08-01)
As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds. Drug repurposing might be an inexpensive and effective source of novel
William A Schmalhofer et al.
Assay and drug development technologies, 8(6), 714-726 (2010-12-17)
The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Inhibition of IKr increases the duration of the ventricular action potential, reflected as a
Maria Stella Ritorto et al.
Nature communications, 5, 4763-4763 (2014-08-28)
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to
Sager J Gosai et al.
PloS one, 5(11), e15460-e15460 (2010-11-26)
The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, however, live animal drug screening is labor and resource
M J Tueth et al.
Southern medical journal, 86(3), 344-349 (1993-03-01)
One of the more difficult psychopharmacologic aspects of current clinical psychiatry is finding a neuroleptic drug that adequately treats delusional states. Furthermore, many chronic schizophrenics remain resistant to standard antipsychotic medication, and clozapine is effective in only 30% to 50%
Salvatore Grosso et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 16(4), 390-395 (2012-01-17)
Status dystonicus (SD) is a medical emergency weighed by a relevant morbidity and mortality. It mainly affects patients with primary or secondary dystonia and is often triggered by events such as fever, infections, exposure medications or their abrupt cessation. We
Pimozide treatment of tic and Tourette disorders.
A K Shapiro et al.
Pediatrics, 79(6), 1032-1039 (1987-06-01)
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