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Showing 31-60 of 68 results for "P1793" within Papers
Veit Roessner et al.
Neuropharmacology, 68, 143-149 (2012-06-26)
The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and
Qin Liang et al.
Nature chemical biology, 10(4), 298-304 (2014-02-18)
Protein ubiquitination and deubiquitination are central to the control of a large number of cellular pathways and signaling networks in eukaryotes. Although the essential roles of ubiquitination have been established in the eukaryotic DNA damage response, the deubiquitination process remains
Zhiyong Liao et al.
Molecular cancer therapeutics, 14(8), 1777-1793 (2015-05-31)
Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico
Pimozide.
Robert Smyj et al.
Profiles of drug substances, excipients, and related methodology, 37, 287-311 (2012-04-04)
Avril Coghlan et al.
PLoS neglected tropical diseases, 17(9), e0011205-e0011205 (2023-09-05)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be
Mariangela Gulisano et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32(6), 1213-1217 (2011-07-07)
The pharmacotherapy for tic management in Tourette syndrome (TS) relies on neuroleptics, which have been associated with electrocardiographic abnormalities, including QTc interval prolongation. This study assessed the cardiovascular safety of the newer antipsychotic aripiprazole in comparison with the neuroleptic pimozide
Changes in the product label for pimozide illustrate both the promises and the challenges of personalized medicine.
Sheldon H Preskorn
The Journal of clinical psychiatry, 73(9), 1191-1193 (2012-10-13)
Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins.
Ishine, T.
American Journal of Physiology. Heart and Circulatory Physiology, 278 (2000)
Hawk Kim et al.
Annals of hematology, 94(5), 739-746 (2014-12-17)
The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities
Mark R Davies et al.
Cell reports. Medicine, 1(5), 100076-100076 (2020-11-19)
There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with computational models
Owen Randlett et al.
Current biology : CB, 29(8), 1337-1345 (2019-04-09)
Habituation is a simple form of learning where animals learn to reduce their responses to repeated innocuous stimuli [1]. Habituation is thought to occur via at least two temporally and molecularly distinct mechanisms, which lead to short-term memories that last
H-W Cheng et al.
Cell death & disease, 6, e1753-e1753 (2015-05-08)
Glioblastoma (GBM) is a common and malignant tumor with a poor prognosis. Glioblastoma stem cells (GSCs) have been reported to be involved in tumorigenesis, tumor maintenance and therapeutic resistance. Thus, to discover novel candidate therapeutic drugs for anti-GBM and anti-GSCs
Felix J Hartmann et al.
Nature communications, 5, 5056-5056 (2014-10-04)
Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these
Francesco Borriello et al.
European journal of immunology, 45(7), 2042-2051 (2015-04-01)
Basophil-derived IL-4 is involved in the alternative activation of mouse monocytes, as recently shown in vivo. Whether this applies to human basophils and monocytes has not been established yet. Here, we sought to characterise the interaction between basophils and monocytes
William A Schmalhofer et al.
Assay and drug development technologies, 8(6), 714-726 (2010-12-17)
The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Inhibition of IKr increases the duration of the ventricular action potential, reflected as a
José M Guzmán et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 158(2), 235-245 (2010-11-30)
The Senegalese sole (Solea senegalensis) is a flatfish that exhibits severe reproductive dysfunctions in captivity. This study aimed at investigating the existence of a dopamine (DA) inhibitory tone on the reproductive axis of this species. Four groups of Senegalese sole
Gordana Panic et al.
PLoS neglected tropical diseases, 9(7), e0003962-e0003962 (2015-08-01)
As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds. Drug repurposing might be an inexpensive and effective source of novel
J Finlay-Schultz et al.
Oncogene, 34(28), 3676-3687 (2014-09-23)
Progesterone (P4) has emerged as an important hormone-regulating mammary stem cell (MaSC) populations. In breast cancer, P4 and synthetic analogs increase the number of stem-like cells within luminal estrogen receptor (ER)- and progesterone receptor (PR)-positive breast cancers. These cells gain
Pimozide treatment of tic and Tourette disorders.
A K Shapiro et al.
Pediatrics, 79(6), 1032-1039 (1987-06-01)
Cristina Sempio et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 1-7 (2014-09-15)
The aim of the study was to develop and validate a simple, sensitive and specific method for the detection and quantitative determination of 88 substances among psychoactive drugs and their metabolites in whole blood, and to apply the procedure to
Marzia Raimondi et al.
Autophagy, 15(4), 613-630 (2018-10-20)
ULK1 (unc-51 like autophagy activating kinase 1) is a core component at multiple steps of canonical macroautophagy/autophagy. The activity of ULK1 is tightly regulated by several post-translational modifications, including ubiquitination, yet the deubiquitinase (DUB) responsible for its reversible deubiquitination has
Anwar Anwar-Mohamed et al.
Toxicology letters, 230(3), 382-392 (2014-08-17)
Acquired cardiac long QT syndrome (LQTS) is a frequent drug-induced toxic event that is often caused through blocking of the human ether-á-go-go-related (hERG) K(+) ion channel. This has led to the removal of several major drugs post-approval and is a
Mi Yang et al.
The Cochrane database of systematic reviews, (1)(1), CD004029-CD004029 (2011-01-21)
Non-antiepileptic drugs have been used in the management of trigeminal neuralgia since the 1970s. The objective was to systematically review the efficacy and tolerability of non-antiepileptic drugs for trigeminal neuralgia. For this updated review we searched the Cochrane Neuromuscular Disease
Salvatore Grosso et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 16(4), 390-395 (2012-01-17)
Status dystonicus (SD) is a medical emergency weighed by a relevant morbidity and mortality. It mainly affects patients with primary or secondary dystonia and is often triggered by events such as fever, infections, exposure medications or their abrupt cessation. We
J Rathbone et al.
The Cochrane database of systematic reviews, (3)(3), CD001949-CD001949 (2007-07-20)
Pimozide, formulated in the 1960s, continues to be marketed for the care of people with schizophrenia or related psychoses such as delusional disorder. It has been associated with cardiotoxicity and sudden unexplained deaths. Electrocardiogram monitoring is now required before and
Holger H H Erb et al.
PloS one, 15(8), e0237248-e0237248 (2020-08-14)
Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of transcription (STAT) 5 plays a role in tumour progression and
Delusions of parasitosis: ethical and clinical considerations.
Stephanie Fabbro et al.
Journal of the American Academy of Dermatology, 69(1), 156-159 (2013-06-19)
S M Sharaf
Theriogenology, 77(8), 1709-1716 (2012-03-01)
Nine groups each of four fish were injected with a single intramuscular dose of the following preparations: Physiological saline (0.9% NaCl) as a control group, 0.5 ml kg(-1) Ovaprim, 20 and 40 μg kg(-1) BW of GnRHa, 8 and 16
Erik A Nelson et al.
Blood, 117(12), 3421-3429 (2011-01-15)
The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting survival. BCR/ABL kinase inhibitors have
L A Opler et al.
The Journal of clinical psychiatry, 52(5), 221-233 (1991-05-01)
Pimozide, a diphenylbutylpiperidine neuroleptic which is FDA-approved as a backup treatment for Gilles de la Tourette's syndrome, has been used abroad for many years as a treatment of schizophrenia and has been recently reported to be particularly effective in treating
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