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Showing 1-30 of 377 results for "P2222" within Papers
Daniel Bury et al.
Biochemical pharmacology, 93(2), 141-150 (2014-12-03)
The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan macromolecule. The essential function of the GT makes it an attractive antimicrobial
Tiago Sousa et al.
Journal of pharmaceutical sciences, 103(10), 3171-3175 (2014-08-06)
Azo-bonded prodrugs of 5-aminosalicylic acid (mesalazine)-sulfasalazine, balsalazide, and olsalazine, which are used in the treatment of ulcerative colitis, rely on colonic bacteria to cleave the azo bond and liberate the active drug in the large intestine. The aim of this
Min Song et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1252-1260 (2014-05-16)
KRO-105714 [N-(5-benzoyl-2-(4-(2-methoxyphenyl)piperazin-1-yl)thiazol-4-yl)pivalamide] is a 2,4,5-trisubstituted 1,3-thiazole derivative that exerts anti-atopic dermatitis activity via robust suppression of the sphingosylphosphorylcholine receptor. This study used high-resolution/high-accuracy tandem mass spectroscopy (HRMS) and recombinant cDNA-expressed cytochrome P450 (P450) isoforms to identify the metabolic pathway and
Susanne DiSalvo et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(36), E5029-E5037 (2015-08-26)
Symbiotic associations can allow an organism to acquire novel traits by accessing the genetic repertoire of its partner. In the Dictyostelium discoideum farming symbiosis, certain amoebas (termed "farmers") stably associate with bacterial partners. Farmers can suffer a reproductive cost but
Lívia G Castilhos et al.
BMC complementary and alternative medicine, 15, 189-189 (2015-06-20)
Considering that adjuvant arthritis is an experimental model of arthritis widely used for preclinical testing of numerous anti-arthritic agents, which were taken by a large number of patients worldwide, it is of great interest to investigate the therapeutic action of
Quentin Denost et al.
Surgery, 158(6), 1714-1723 (2015-08-16)
Tissue engineering may provide new operative tools for colorectal surgery in elective indications. The aim of this study was to define a suitable bioscaffold for colorectal tissue engineering. We compared 2 bioscaffolds with in vitro and in vivo experiments: porcine
Liselotte B Christiansen et al.
American journal of physiology. Heart and circulatory physiology, 308(10), H1237-H1247 (2015-03-15)
Mitochondrial dysfunction and oxidative stress are important players in the development of various cardiovascular diseases, but their roles in hypertrophic cardiomyopathy (HCM) remain unknown. We examined whether mitochondrial oxidative phosphorylation (OXPHOS) capacity was impaired with enhanced mitochondrial oxidative stress in
Alexandre Minami Fioroto et al.
Journal of agricultural and food chemistry, 63(28), 6331-6337 (2015-07-03)
In vitro gastrointestinal digestion of babassu mesocarp in the absence and presence of milk and lignin was performed to evaluate the bioaccessibility of Cu, Fe, and Zn. Extractions using NaOH solutions (pH 7 and 12) were carried out to evaluate
Yong Xu et al.
PloS one, 9(5), e98115-e98115 (2014-05-27)
Escherichia coli O157:H7 is a major foodborne human pathogen causing disease worldwide. Cattle are a major reservoir for this pathogen and those that shed E. coli O157:H7 at >104 CFU/g feces have been termed "super-shedders". A rich microbial community inhabits
Nobuyuki Zakoji et al.
Biological & pharmaceutical bulletin, 38(2), 257-262 (2015-03-10)
Nitric oxide (NO), a known relaxant, is produced in cells from L-arginine (L-Arg). Because the relaxation of retinal pericytes alters the microcirculatory hemodynamics, it is important to understand the manner of NO production in retinal pericytes. The purpose of this
Joana Guerreiro et al.
Probiotics and antimicrobial proteins, 6(2), 95-104 (2014-03-29)
Bacteriocin B231 produced by Lactobacillus pentosus, isolated from an artisanal raw cow's milk protected designation of origin Portuguese cheese, is a small protein with an apparent relative mass of about 5 kDa and active against a large number of Listeria
Pieterjan Lenain et al.
Biosensors & bioelectronics, 69, 34-39 (2015-02-24)
An affinity sensor based on capacitive transduction was developed to detect a model compound, metergoline, in a continuous flow system. This system simulates the monitoring of low-molecular weight organic compounds in natural flowing waters, i.e. rivers and streams. During operation
Nurdan Yıldız et al.
International journal of urology : official journal of the Japanese Urological Association, 22(6), 598-603 (2015-03-27)
To investigate the effect of intravesical hyaluronic acid on Escherichia coli-induced cystitis and cystitis-induced hypercontractility in rats. Bacterial cystitis was induced in Wistar female rats by intravesical inoculation of E. coli. Isotonic saline was instilled in the control group (n = 6). The
Vlastimil Mazánek et al.
Nanoscale, 7(32), 13646-13655 (2015-07-28)
The availability of well-defined modified graphene derivatives such as fluorographene, graphane, thiographene or hydroxygraphene is of pivotal importance for tuning the resulting material properties in numerous potential applications. A series of fluorinated graphene with various contents of fluorine was synthesized
Giuseppe Palma et al.
International journal of pharmaceutics, 473(1-2), 55-63 (2014-07-06)
With the aim to find novel therapeutical approaches for triple-negative breast cancer (TNBC) treatment, we have developed a powder for i.v. injection based on cyclodextrins and docetaxel (DTX)-loaded polyethyleneglycol-poly(epsilon-caprolactone) nanoparticles (DTX-NPs). Nanoparticles are designed to concentrate at tumor level by
A G Venkatesh et al.
Biosensors & bioelectronics, 70, 462-468 (2015-04-12)
Point-of-care (POC) diagnostic biosensors offer a promising solution to improve healthcare, not only in developed parts of the world, but also in resource limited areas that lack adequate medical infrastructure and trained technicians. However, in remote and resource limited settings
Jill R Blankenship et al.
Eukaryotic cell, 13(11), 1403-1410 (2014-09-14)
Septin proteins are conserved structural proteins that often demarcate regions of cell division. The essential nature of the septin ring, composed of several septin proteins, complicates investigation of the functions of the ring, although careful analysis in the model yeast
Shijie Yao et al.
Cancer chemotherapy and pharmacology, 75(4), 719-728 (2015-01-31)
Camptothecins contain a lactone ring that is necessary for antitumor activity, and hydrolysis of the lactone ring yields an inactive carboxylate species. Human serum albumin (HSA) and alpha-1 acid glycoprotein (AGP) are clinically significant plasma proteins thought to have important
M Stefanič et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 8-15 (2014-05-23)
The purpose of this research was to predict the in vivo dissolution of lansoprazole from enteric coated pellets in the fasted state using a biorelevant flow-through dissolution method with low flow rates and volumes close to those in vivo. Additionally
Abdullah Al Loman et al.
Archives of oral biology, 60(12), 1721-1728 (2015-10-04)
The aim of this study was to compare arabitol with its better studied isomer xylitol for their inhibitory effects on cell growth and acid production of oral bacteria. Streptococcus mutans, Streptococcus salivarius and Streptococcus sobrinus were used as representatives of
Qinggang Wang et al.
Journal of pharmaceutical and biomedical analysis, 111, 288-296 (2015-04-29)
Drug degradation that occurs in HPLC analysis, during either sample preparation or chromatographic separation, can greatly impact method robustness and result accuracy. In this work, we report a case study of drug dimerization in HPLC analysis where proximate causes were
Gautam Das et al.
International journal of nanomedicine, 10 Spec Iss, 55-66 (2015-09-09)
An electrochemical biosensor based on sulfonated graphene/polyaniline nanocomposite was developed for urea analysis. Oxidative polymerization of aniline in the presence of sulfonated graphene oxide was carried out by electrochemical methods in an aqueous environment. The structural properties of the nanocomposite
Nils H Janzen et al.
Bioprocess and biosystems engineering, 38(9), 1685-1692 (2015-05-15)
Optical chemical sensors are the standard for pH monitoring in small-scale bioreactors such as microtiter plates, shaking flasks or other single-use bioreactors. The dynamic pH range of the so far commercially available fluorescent pH sensors applied in small-scale bioreactors is
Farzad Foroutan et al.
ACS nano, 9(2), 1868-1877 (2015-01-28)
Ultrasound imaging is a powerful tool in medicine because of the millisecond temporal resolution and submillimeter spatial resolution of acoustic imaging. However, the current generation of acoustic contrast agents is primarily limited to vascular targets due to their large size.
Dawn E Holmes et al.
Bioresource technology, 193, 8-14 (2015-06-27)
Several experiments were conducted to determine whether protozoan grazing can reduce current output from sediment microbial fuel cells. When marine sediments were amended with eukaryotic inhibitors, the power output from the fuel cells increased 2-5-fold. Quantitative PCR showed that Geobacteraceae
Paula Clemente et al.
Nucleic acids research, 43(15), 7398-7413 (2015-07-15)
Mitochondrial gene expression is largely regulated by post-transcriptional mechanisms that control the amount and translation of each mitochondrial mRNA. Despite its importance for mitochondrial function, the mechanisms and proteins involved in mRNA turnover are still not fully characterized. Studies in
Min-Kyu Ji et al.
Journal of hazardous materials, 229-230, 298-306 (2012-06-26)
The potential of several surface coating agents to inhibit the oxidation of metal sulfide minerals from Young-Dong coal mine and the Il-Gwang gold mine was examined by conducting laboratory scale batch experiments and field tests. Powdered pyrite as a standard
Yin Hui Chow et al.
Journal of bioscience and bioengineering, 120(1), 85-90 (2015-01-03)
In this paper, a linear relationship is proposed relating the natural logarithm of partition coefficient, ln K for protein partitioning in poly (ethylene glycol) (PEG)-phosphate aqueous two-phase system (ATPS) to the square of tie-line length (TLL(2)). This relationship provides good
Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.
Yanping Geng et al.
The Journal of biological chemistry, 290(28), 17250-17261 (2015-05-30)
Members of the YidC/Oxa1/Alb3 protein family mediate membrane protein insertion, and this process is initiated by the assembly of YidC·ribosome nascent chain complexes at the inner leaflet of the lipid bilayer. The positively charged C terminus of Escherichia coli YidC
Imad Younus Hasan et al.
Soft matter, 11(27), 5571-5579 (2015-06-16)
For studies involving biomimetic phospholipid membrane systems, such as membrane-protein interactions, it is crucial that the supported membrane is biomimetic in its physical properties as well as in its composition. Two often overlooked aspects of biomimicry are the need for
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