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Showing 1-30 of 327 results for "P2308" within Papers
Xiuqun Zou et al.
Cell death & disease, 14(6), 382-382 (2023-06-29)
The transcriptional repressor Snail induces EMT during embryonic development and tumor metastasis. Growing evidence indicates that Snail functions as a trans-activator to induce gene expression; however, the underlying mechanism remains elusive. Here, we report that Snail cooperates with GATA zinc
Aaron T Balana et al.
Nature chemistry, 13(5), 441-450 (2021-03-17)
A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area focused on O-GlcNAc modification of the amyloid-forming proteins themselves. Here we used synthetic protein chemistry
Maxime Mivelaz et al.
Molecular cell, 77(3), 488-500 (2019-11-26)
Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of downstream factors. The mechanisms by which pTFs overcome the chromatin barrier are not well understood. Here, we reveal, using single-molecule fluorescence
Chao Wang et al.
Journal of medicinal chemistry, 56(6), 2527-2539 (2013-03-06)
The small molecule fusion inhibitors N-(4-carboxy-3-hydroxyphenyl)-2,5-dimethylpyrrole (NB-2) and N-(3-carboxy-4-hydroxyphenyl)-2,5-dimethylpyrrole (A12) target a hydrophobic pocket of HIV-1 gp41 and have moderate anti-HIV-1 activity. In this paper, we report the design, synthesis, and structure-activity relationship of a group of hybrid molecules in
Eva Dvorakova et al.
BMC neurology, 13, 126-126 (2013-09-26)
The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform encephalopathies (TSEs). Cellular prion protein is normally linked to the cell
Thom M Molenaar et al.
Journal of cell science, 135(19) (2022-09-03)
Cell size varies between cell types but is tightly regulated by cell intrinsic and extrinsic mechanisms. Cell size control is important for cell function, and changes in cell size are frequently observed in cancer. Here, we uncover a role for
Ester Vázquez-Fernández et al.
PloS one, 7(11), e50111-e50111 (2012-11-28)
Elucidation of the structure of PrP(Sc) continues to be one major challenge in prion research. The mechanism of propagation of these infectious agents will not be understood until their structure is solved. Given that high resolution techniques such as NMR
Application of a high-throughput microcrystal delivery system to serial femtosecond crystallography.
Donghyeon Lee et al.
Journal of applied crystallography, 53(Pt 2), 477-485 (2020-04-14)
Microcrystal delivery methods are pivotal in the use of serial femtosecond crystallography (SFX) to resolve the macromolecular structures of proteins. Here, the development of a novel technique and instruments for efficiently delivering microcrystals for SFX are presented. The new method
Roza B Lemma et al.
Scientific reports, 11(1), 9008-9008 (2021-04-28)
The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB levels. Despite much accumulated molecular knowledge of MYB, we
Sreenivas Adurthi et al.
Scientific reports, 7(1), 17289-17289 (2017-12-13)
Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. We report that ERα ligand
Kelley L Ledford et al.
Developmental biology, 426(2), 418-428 (2017-04-26)
The eye field transcription factor, Six6, is essential for both the early (specification and proliferative growth) phase of eye formation, as well as for normal retinal progenitor cell differentiation. While genomic regions driving six6 optic cup expression have been described
Antifouling potential of enzymes applied to reverse osmosis membranes.
Khani, et al.
Biofilm, 5, 100119-100119 (2023)
Alexander R A Szojka et al.
Frontiers in bioengineering and biotechnology, 9, 739438-739438 (2021-09-21)
Meniscus fibrochondrocytes (MFCs) experience simultaneous hypoxia and mechanical loading in the knee joint. Experimental conditions based on these aspects of the native MFC environment may have promising applications in human meniscus tissue engineering. We hypothesized that in vitro "mechano-hypoxia conditioning"
Mercè Martí et al.
Nature protocols, 8(2), 223-253 (2013-01-12)
Characterization of pluripotent stem cells is required for the registration of stem cell lines and allows for an impartial and objective comparison of the results obtained when generating multiple lines. It is therefore crucial to establish specific, fast and reliable
Yu-Hsin Chen et al.
Aging, 14(6), 2607-2627 (2022-03-23)
Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per year. Neuronal cell death and brain injury after TBI, including apoptosis, inflammation, and excitotoxicity, have led to detrimental effects in TBI. 2, 3
Zhi-Wei Zhang et al.
Cell reports, 41(4), 111530-111530 (2022-10-27)
SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m6A methylation participates in regulation of cerebellar development. Here we investigate whether dysregulated m6A methylation contributes to
Chiara Milanese et al.
Antioxidants & redox signaling, 28(1), 44-61 (2017-08-18)
This study was designed to explore the neuroprotective potential of inorganic nitrite as a new therapeutic avenue in Parkinson's disease (PD). Administration of inorganic nitrite ameliorates neuropathology in phylogenetically distinct animal models of PD. Beneficial effects are not confined to
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability.
Sarni, et al.
Cell Reports, 40, 111397-111397 (2022)
TUNEL assay for apoptotic cells.
V M Heatwole
Methods in molecular biology (Clifton, N.J.), 115, 141-148 (1999-03-31)
Karl-Uwe Reusswig et al.
Nature communications, 13(1), 7014-7014 (2022-11-19)
DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer development. Here, we engineer genetic systems in budding yeast to induce unscheduled
The specificity of proteinase K against oxidized insulin B chain.
E Kraus et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 357(2), 233-237 (1976-02-01)
Jens-Erik Dietrich et al.
EMBO reports, 16(8), 1005-1021 (2015-07-05)
Mammalian development begins with the segregation of embryonic and extra-embryonic lineages in the blastocyst. Recent studies revealed cell-to-cell gene expression heterogeneity and dynamic cell rearrangements during mouse blastocyst formation. Thus, mechanistic understanding of lineage specification requires quantitative description of gene
Nicolas Buisine et al.
Cold Spring Harbor protocols, 2018(8) (2018-06-14)
Proper gene expression involves communication between the regulatory elements and promoters of genes. Because regulatory elements can be located over a large range of genomic distances (from as close as a few hundred bp to as much as several Mb
Edoardo Morandi et al.
Nature methods, 18(3), 249-252 (2021-02-24)
RNA structure heterogeneity is a major challenge when querying RNA structures with chemical probing. We introduce DRACO, an algorithm for the deconvolution of coexisting RNA conformations from mutational profiling experiments. Analysis of the SARS-CoV-2 genome using dimethyl sulfate mutational profiling
Manthan Patel et al.
BMC genetics, 21(1), 84-84 (2020-07-31)
The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF. Interdependence between regulation of cytosine methylation and CTCF occupancy by CGGBP1 remains unknown. By analyzing methylated DNA-sequencing data obtained
PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation.
Se Won Park et al.
Nucleic acids research, 50(14), 7856-7872 (2022-07-14)
Autophagy is a catabolic pathway that maintains cellular homeostasis under various stress conditions, including conditions of nutrient deprivation. To elevate autophagic flux to a sufficient level under stress conditions, transcriptional activation of autophagy genes occurs to replenish autophagy components. Thus
Gul Shad Ali et al.
Applied and environmental microbiology, 82(2), 478-490 (2015-11-01)
Bacterial biological control agents (BCAs) are largely used as live products to control plant pathogens. However, due to variable environmental and ecological factors, live BCAs usually fail to produce desirable results against foliar pathogens. In this study, we investigated the
Paulien Vinke et al.
Scientific reports, 9(1), 10160-10160 (2019-07-17)
Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of cardiac and skeletal muscle. This study investigated the effects of a multi-targeted nutritional intervention with extra protein, leucine
John Arne Dahl et al.
Nature protocols, 3(6), 1032-1045 (2008-06-10)
Interactions of proteins with DNA mediate many critical nuclear functions. Chromatin immunoprecipitation (ChIP) is a robust technique for studying protein-DNA interactions. Current ChIP assays, however, either require large cell numbers, which prevent their application to rare cell samples or small-tissue
Wen Si Hu et al.
Scientific reports, 10(1), 21090-21090 (2020-12-05)
Bacteria can form biofilms, complex microbial communities protected from environmental stress, on food contact surfaces. Brassicaceae plant has been shown to contain bioactive compounds with antimicrobial activities. The objective of this study was to evaluate the synergistic effects of Brassicaceae
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