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Showing 1-30 of 41 results for "P2663" within Papers
Christiane E Carney et al.
Bioconjugate chemistry, 26(5), 899-905 (2015-04-02)
Nanodiscs are monodisperse, self-assembled discoidal particles that consist of a lipid bilayer encircled by membrane scaffold proteins (MSP). Nanodiscs have been used to solubilize membrane proteins for structural and functional studies and deliver therapeutic phospholipids. Herein, we report on tetramethylrhodamine
M A Morini et al.
Colloids and surfaces. B, Biointerfaces, 131, 54-58 (2015-05-08)
The purpose of the work is to compare the influence of the multilamellarity, phase state, lipid head groups and ionic media on the origin of the surface potential of lipid membranes. With this aim, we present a new analysis of
Rina Ogawa et al.
PloS one, 10(7), e0131668-e0131668 (2015-07-07)
We employed a multivalent peptide-library screening technique to identify a peptide motif that binds to phosphatidic acid (PA), but not to other phospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS). A tetravalent peptide with the sequence motif of
Ana M Cardoso et al.
Molecular pharmaceutics, 12(3), 716-730 (2015-01-31)
Gene delivery targeting mitochondria has the potential to transform the therapeutic landscape of mitochondrial genetic diseases. Taking advantage of the nonuniversal genetic code used by mitochondria, a plasmid DNA construct able to be specifically expressed in these organelles was designed
Joana Ortega-Anaya et al.
Biochimica et biophysica acta, 1848(12), 3166-3174 (2015-09-24)
Hydrogenation of linoleic acid and other polyunsaturated fatty acids is a detoxification mechanism that is present in the Lactobacillus genus of lactic bacteria. The first stage in this multi-step process is hydration of the substrate with formation of 10-hydroxy-9-cis-octadecenoic acid
Hairong Wang et al.
Environmental science & technology, 49(1), 529-536 (2014-12-03)
Polycyclic aromatic hydrocarbons (PAHs) are persistent environmental organic contaminants due to their low water solubility and strong sorption onto organic/mineral surfaces. Here, nanoparticle-supported lipid bilayers (NP-SLBs) made of 100-nm SiO2 nanoparticles and the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) are investigated as
Claudia Monteiro et al.
Biochimica et biophysica acta, 1848(5), 1139-1146 (2015-02-15)
Antimicrobial peptides (AMPs) are a class of broad-spectrum antibiotics known by their ability to disrupt bacterial membranes and their low tendency to induce bacterial resistance, arising as excellent candidates to fight bacterial infections. In this study we aimed at designing
Maayke M P Kuijten et al.
Scientific reports, 5, 17220-17220 (2015-11-28)
Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. We have synthesized a new liposome containing gadolinium-DOTA lipid bilayer
Jelena Drazenovic et al.
Biochimica et biophysica acta, 1848(2), 532-543 (2014-12-03)
Nano-differential scanning calorimetry (nano-DSC) is a powerful tool in the investigation of unilamellar (small unilamellar, SUVs, or large unilamellar, LUVs) vesicles, as well as lipids on supported bilayers, since it measures the main gel-to-liquid phase transition temperature (Tm), enthalpies and
Sabine Castano et al.
Biochimie, 91(6), 765-773 (2009-05-21)
The lipid bis(guanidinium)-tren-cholesterol (BGTC) is a cationic cholesterol derivative bearing guanidinium polar headgroups used for gene transfection either alone or formulated as liposomes with the zwitterionic lipid 1,2-di-[cis-9-octadecenoyl]-sn-glycero-3-phosphoethanolamine (DOPE). Previous investigations have shown its ability to strongly interact with DNA
Upendra Kumar Singh et al.
Journal of photochemistry and photobiology. B, Biology, 149, 1-8 (2015-05-31)
The present work is focused on the interaction between membrane bound gramicidin and 1-butyl-1-methyl-2-oxopyrrolidinium bromide (BMOP) ionic liquid. Ionic liquids (ILs) are solvents that are often liquid at room temperature and composed of organic cation and appropriate anion. The gramicidin
Saara Laulumaa et al.
PloS one, 10(6), e0128954-e0128954 (2015-06-13)
Myelin protein P2 is a fatty acid-binding structural component of the myelin sheath in the peripheral nervous system, and its function is related to its membrane binding capacity. Here, the link between P2 protein dynamics and structure and function was
Xiaoming Zhang et al.
Scientific reports, 5, 16559-16559 (2015-11-10)
Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane
Haiming Luo et al.
ACS nano, 8(5), 4334-4347 (2014-04-29)
Current treatment of advanced-stage nasopharyngeal carcinoma (NPC) is not satisfactory. Targeted therapies offer hope for extending survival. Here, we developed simple, robust, and NPC-specific therapeutic lipid nanoparticles based on a fusion peptide, α-NTP, made up of an amphipathic α-helical peptide
Dominika Wrobel et al.
Biochimica et biophysica acta, 1848(7), 1490-1501 (2015-04-07)
The influence of maltose-modified poly(propylene imine) (PPI) dendrimers on dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (DMPC/DMPG) (3%) liposomes was studied. Fourth generation (G4) PPI dendrimers with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers
1, 2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
Domracheva I, et al.
Toxicology Reports, 2, 377-383 (2015)
Hager Souabni et al.
Biochimie, 107 Pt A, 33-42 (2014-12-03)
The NADPH-oxidase complex, which plays beneficial or detrimental role in the inflammatory and degenerative diseases, is a membrane multi-subunit complex tightly regulated in order to produce superoxide anions, precursor of oxygen reactive species (ROS), in cells. The flavocytochrome b(558) (Cytb(558))
Elisa J Cabré et al.
PloS one, 10(5), e0126434-e0126434 (2015-05-08)
Division site selection is achieved in bacteria by different mechanisms, one of them being nucleoid occlusion, which prevents Z-ring assembly nearby the chromosome. Nucleoid occlusion in E. coli is mediated by SlmA, a sequence specific DNA binding protein that antagonizes
Melissa C Hanson et al.
The Journal of clinical investigation, 125(6), 2532-2546 (2015-05-06)
Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading
Cholesterol-induced changes in hippocampal membranes utilizing a phase-sensitive fluorescence probe.
Roopali Saxena et al.
Biochimica et biophysica acta, 1848(8), 1699-1705 (2015-05-13)
The function of membrane receptors in the nervous system depends on physicochemical characteristics of neuronal membranes such as membrane order and phase. In this work, we have monitored the changes in hippocampal membrane order and related parameters by cholesterol and
Boris Dzikovski et al.
The journal of physical chemistry. B, 119(42), 13330-13346 (2015-10-23)
The large values of spin relaxation enhancement (RE) for PC spin-labels in the phospholipid membrane induced by paramagnetic metal salts dissolved in the aqueous phase can be explained by Heisenberg spin exchange due to conformational fluctuations of the nitroxide group
Ying Jia et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(36), 12709-12714 (2015-08-01)
Yolk-shell nanoreactors with metal nanoparticle core and ultrathin porous polymer shells are effective catalysts for heterogeneous reactions. Polymer shells provide size-selectivity and improved reusability of catalyst. Nanocapsules with single-nanometer porous shells are prepared by vesicle-templated directed assembly. Metal nanoparticles are
Kristyna Bousova et al.
Biophysical chemistry, 205, 24-32 (2015-06-15)
The transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective ion channel broadly expressed in a variety of tissues. Receptor has been identified as a crucial modulator of numerous calcium dependent mechanisms in the cell such as immune response
Fabiana Rached et al.
Journal of lipid research, 55(12), 2509-2520 (2014-10-25)
To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls
Sea H Kim et al.
PloS one, 10(8), e0135130-e0135130 (2015-08-11)
The objective of this study is to transport and deliver resveratrol to intracellular sites using apolipoprotein E3 (apoE3). Reconstituted high-density lipoprotein (rHDL) bearing resveratrol (rHDL/res) was prepared using phospholipids and the low-density lipoprotein receptor (LDLr)-binding domain of apoE3. Biophysical characterization
T Lajunen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 23-32 (2014-05-09)
Drug delivery from topically instilled eye drops to the posterior segment of the eye has long been one of the greatest challenges of ocular drug development. We developed methods of liposome preparation utilizing a microfluidizer to achieve adjustable nanoparticle size
Rudra N Purusottam et al.
Biochimica et biophysica acta, 1848(12), 3134-3139 (2015-09-17)
A straightforward way to visualize gel to liquid-crystalline phase transition in phospholipid membranes is presented by using ¹³C magic-angle spinning NMR. The changes in the 13C isotropic chemical shifts with increasing temperature are shown to be a sensitive probe of
Liyang Cui et al.
ACS nano, 9(4), 4484-4495 (2015-04-02)
PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles' vascular circulation by mitigating the reticuloendothelial system uptake. However, there remain many concerns in regards to its immunogenicity, targeting efficiency, etc., which inspires pursuit of alternate, non-PEGylated systems. We
Ludovic Carlier et al.
Biophysical chemistry, 196, 40-52 (2014-10-08)
Plasticins (PTC) are dermaseptin-related antimicrobial peptides characterized by a large number of leucine and glycine residues arranged in GXXXG motifs that are often described to promote helix association within biological membranes. We report the structure and interaction properties of two
Assessment of the effects of hydrocarbon contamination on the sedimentary bacterial communities and determination of the polar lipid fraction purity: relevance of intact phospholipid analysis
Mazzella N, et al.
Marine Chemistry, 103(3-4), 304-317 (2007)
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