Search Within
P3532
Applied Filters:
Keyword:'P3532'
Showing 1-30 of 675 results for "P3532" within Papers
Marina A Guvakova et al.
The Biochemical journal, 463(2), 257-270 (2014-07-17)
The Ras-related GTPase Rap1 promotes cell adhesion and migration. Although the significance of Rap1 contribution to cell migration is increasingly being recognized, little is known about the biochemical mechanisms driving this process. In the present study, we discovered a previously
Michaela Liegertová et al.
Scientific reports, 5, 11885-11885 (2015-07-15)
Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here
Masako Yokota et al.
PloS one, 9(7), e101693-e101693 (2014-07-09)
Apert syndrome is an autosomal dominantly inherited disorder caused by missense mutations in fibroblast growth factor receptor 2 (FGFR2). Surgical procedures are frequently required to reduce morphological and functional defects in patients with Apert syndrome; therefore, the development of noninvasive
Xuejun Guo et al.
Environmental science & technology, 49(13), 7926-7933 (2015-06-10)
Hydrophobic organic chemicals (HOCs) are of special ecotoxicological concern because they can be directly incorporated and bioconcentrated in living organisms. However, the effects of self-clustering of HOCs on their environmental behavior and toxicology have not yet received enough attention. With
Philip Hasel et al.
Biochimica et biophysica acta, 1853(9), 2066-2076 (2014-12-30)
Neurodegenerative and neurological disorders are often characterised by pathological changes to dendrites, in advance of neuronal death. Oxidative stress, energy deficits and excitotoxicity are implicated in many such disorders, suggesting a potential vulnerability of dendrites to these situations. Here we
Hailong Li et al.
Cell calcium, 56(6), 457-466 (2014-12-03)
Mitochondrial Ca(2+) plays a critical physiological role in cellular energy metabolism and signaling, and its overload contributes to various pathological conditions including neuronal apoptotic death in neurological diseases. Live cell mitochondrial Ca(2+) imaging is an important approach to understand mitochondrial
Daniel J Spade et al.
Biology of reproduction, 93(5), 110-110 (2015-09-25)
In utero exposure to some phthalate esters adversely affects the development of the rat seminiferous cord, causing germ cell loss and increasing the number of multinucleated germ cells (MNGs). To understand the timing of MNG formation and determine whether it
B E Pippenger et al.
Osteoarthritis and cartilage, 23(11), 1865-1869 (2015-11-03)
The cellular component of subchondral bone is thought to be responsible for aberrant bone remodeling in osteoarthritis (OA). Direct phenotypical analysis of the cellular compartment is critical to better understand the OA disease process. This study provides proof-of-principle for flow
Tsz-Leung To et al.
Cell, 179(5), 1222-1238 (2019-11-16)
Mitochondrial dysfunction is associated with a spectrum of human conditions, ranging from rare, inborn errors of metabolism to the aging process. To identify pathways that modify mitochondrial dysfunction, we performed genome-wide CRISPR screens in the presence of small-molecule mitochondrial inhibitors.
Nynke M Evers et al.
Chemico-biological interactions, 220, 222-230 (2014-07-12)
The aim of the present study was to investigate modulation of the interaction of ERα and ERβ with coregulators in the ligand dependent responses induced by the ER antagonistic compounds 4OHT and fulvestrant. Comparison with the modulation index (MI) profiles
Mugdha Patki et al.
Biochemical and biophysical research communications, 457(3), 404-411 (2015-01-15)
Estrogen (E2) supports breast cancer cell growth but suppresses invasiveness and both actions are antagonized by anti-estrogens. As a consequence, anti-estrogen treatment may increase the invasive potential of estrogen receptor (ER)+ tumor cell sub-populations that are endocrine resistant due to
Xiaoxiao Han et al.
Veterinary journal (London, England : 1997), 203(1), 79-84 (2014-12-04)
Mycoplasma bovis is a major pathogen of bovine respiratory disease (BRD) in China and a live attenuated vaccine has recently been developed. This study aimed to establish an IgG avidity test to differentiate between naturally infected and vaccinated animals. An
R Ranjan et al.
Free radical research, 49(1), 25-34 (2014-10-08)
The production of microRNAs (miRNA) is influenced by various stimuli, including environmental stresses. We hypothesized that reactive oxygen species (ROS)-associated stress could regulate macrophage miRNA synthesis. miRNAs undergo unique steps of maturation processing through either one of two pathways of
B L Timm et al.
Parasitology, 141(10), 1272-1276 (2014-04-17)
Chagas' disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America. Its unsatisfactory chemotherapy stimulates the search for novel antiparasitic compounds. Amidines and related compounds exhibit well-known activity towards different
Chungmin Han et al.
Scientific reports, 5, 11891-11891 (2015-07-07)
Various spheroid formation techniques have been widely developed for efficient and reliable 3-D cell culture research. Although those efforts improved many aspects of spheroid generation, the procedures became complex and also required unusual laboratory equipment. Many recent techniques still involve
Shu-Guang Gao et al.
Experimental and therapeutic medicine, 9(5), 1979-1983 (2015-07-03)
Previous studies have demonstrated that osteopontin (OPN) levels are elevated in the synovial fluid and articular cartilage, and are associated with the severity of knee osteoarthritis (OA). However, the role of OPN in the pathogenesis of OA has yet to
Moran Zur et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 61, 11-17 (2013-11-23)
While the solubility parameter is fairly straightforward when assigning BCS classification, the intestinal permeability (Peff) is more complex than generally recognized. In this paper we emphasize this complexity through the analysis of codeine, a commonly used antitussive/analgesic drug. Codeine was
Gisela G Slaats et al.
PLoS genetics, 10(10), e1004594-e1004594 (2014-10-24)
We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney disease nephronophthisis. Here we examine the functional role of CEP164 in nephronophthisis-related ciliopathies and concomitant fibrosis. Live cell
Lance Heinle et al.
Combinatorial chemistry & high throughput screening, 18(5), 442-452 (2015-04-02)
A high throughput, semi-automated clearance screening assay in hepatocytes was developed allowing a scientist to generate data for 96 compounds in one week. The 384-well format assay utilizes a Thermo Multidrop Combi and an optimized LC-MS/MS method. The previously reported
Saskia Busch et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1646-1653 (2015-01-16)
5-Lipoxygenase (5-LO) is the key enzyme in leukotriene biosynthesis. Leukotrienes are mediators of the innate immune system and inflammatory processes, and they might also be involved in cancer development. MicroRNAs (miRNAs) are important translational regulators and have been shown to
Xiaozhen Liu et al.
Toxicology, 326, 1-8 (2014-09-23)
In the present study, experiments were performed to investigate the effects of nonylphenol (NP) isomers (4-[1,2, 4-trimethylhexyl]-phenol (NP41), 4-[1,2, 5-trimethylhexyl]-phenol (NP42)) on Sertoli TM4 cells. NP41 decreased mRNA expression levels of androgen receptor and toll-like receptor (TLR)-4 in 20-40μM (P<0.05)
Marek Scholz et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(4), 700-713 (2015-01-17)
The present work provides a proof-of-concept that the singlet oxygen-sensitized delayed fluorescence (SOSDF) can be detected from individual living mammalian cells in a time-resolved microscopy experiment. To this end, 3T3 mouse fibroblasts incubated with 100 μM TPPS4 or TMPyP were
Adolf Michael Sandbichler et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 181(8), 1023-1034 (2011-05-26)
A primary culture system of rainbow trout gill pavement cells grown on permeable support (single-seeded insert, SSI) was used to examine histological and physiological changes induced by the addition of the corticosteroid hormone cortisol. Pavement cell epithelia were cultured under
Nataliya K Tarasova et al.
Journal of proteome research, 14(9), 3940-3947 (2015-07-29)
Monocytes are blood-borne cells of the innate immune system. They can be differentiated and activated into proinflammatory macrophages that might be employed in tumor immune therapy. Monocyte exposure to lipopolysaccharide (LPS) is a standard method to induce a proinflammatory macrophage
Young Taek Oh et al.
The Journal of biological chemistry, 290(21), 13178-13190 (2015-04-18)
When V. cholerae encounters nutritional stress, it activates (p)ppGpp-mediated stringent response. The genes relA and relV are involved in the production of (p)ppGpp, whereas the spoT gene encodes an enzyme that hydrolyzes it. Herein, we show that the bacterial capability
Susmita Bhunia et al.
Langmuir : the ACS journal of surfaces and colloids, 27(24), 15322-15329 (2011-10-27)
An ecofriendly solid catalyst has been synthesized by anchoring vanadium(IV) into organically modified MCM-41. First, the surface of Si-MCM-41 was modified with 3-aminopropyl-triethoxysilane (3-APTES), the amine group of which upon condensation with ortho-hydroxy-acetophenone affords a N(2)O(2)-type Schiff base moiety in
Elyse Rosa et al.
Neurobiology of aging, 36(8), 2406-2413 (2015-05-31)
In Alzheimer's disease, accumulation of amyloid-β (Aβ) is associated with loss of brain-derived neurotrophic factor (BDNF), synapses, and memory. Previous work demonstrated that Aβ decreases activity-induced BDNF transcription by regulating cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation. However
Seyed Mehdi Rajaei et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 45(4), 825-829 (2015-01-31)
The objective of this study was to determine the aqueous fraction of the tear film using the phenol red thread test (PRTT) and paper point tear test (PPTT) in healthy adult European pond turtles (Emys orbicularis). Twenty-four healthy adult European
Chiuhui Mary Wang et al.
The EMBO journal, 33(12), 1354-1364 (2014-05-21)
Organization of immune responses requires exchange of information between cells. This is achieved through either direct cell-cell contacts and establishment of temporary synapses or the release of soluble factors, such as cytokines and chemokines. Here we show a novel form
Vivian Morad et al.
The Journal of clinical endocrinology and metabolism, 99(9), 3460-3467 (2014-05-07)
Exposure to sex steroids is associated with increased breast cancer risk, and adipokines, leptin and adiponectin have been implicated in cancer progression. However, it is not known whether sex steroids affect adipokine secretion in breast tissue. To elucidate the role
Page 1 of 23