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Showing 1-30 of 177 results for "P3627" within Papers
Sonsoles Botella et al.
The Journal of clinical endocrinology and metabolism, 98(11), E1740-E1748 (2013-09-05)
Bone turnover markers (BTMs) may identify changes in bone remodeling within a relatively short time interval before changes in bone mineral density can be detected. New markers such as osteoprotegerin, receptor activator of nuclear factor-κB ligand, and sclerostin have emerged
Takaaki Tomofuji et al.
Lipids in health and disease, 12, 1-1 (2013-01-09)
Dyslipidemia increases circulating levels of oxidized low-density lipoprotein (OxLDL) and this may induce alveolar bone loss through toll-like receptor (TLR) 2 and 4. The purpose of this study was to investigate the effects of dyslipidemia on osteoclast differentiation associated with
H G Yu et al.
The Journal of cell biology, 145(3), 425-435 (1999-05-04)
We have identified a maize homologue of yeast MAD2, an essential component in the spindle checkpoint pathway that ensures metaphase is complete before anaphase begins. Combined immunolocalization of MAD2 and a recently cloned maize CENPC homologue indicates that MAD2 localizes
P Virkkunen et al.
Biochemical and biophysical research communications, 202(1), 49-57 (1994-07-15)
Structural comparison of human and rat prostate-specific acid phosphatase (hPAP and rPAP) genes indicate that the exon number is different between these species. The hPAP gene contains 10 exons, whereas the rPAP gene was 11 exons. However, exons 2-9 of
Calcium hydroxide suppresses Porphyromonas endodontalis lipopolysaccharide-induced bone destruction.
J Guo et al.
Journal of dental research, 93(5), 508-513 (2014-03-08)
Porphyromonas endodontalis and its main virulence factor, lipopolysaccharide (LPS), are associated with the development of periapical diseases and alveolar bone loss. Calcium hydroxide is commonly used for endodontic therapy. However, the effects of calcium hydroxide on the virulence of P.
Bernd Schröder et al.
Traffic (Copenhagen, Denmark), 8(12), 1676-1686 (2007-09-28)
We searched for novel proteins in lysosomal membranes, tentatively participating in molecular transport across the membrane and/or in interactions with other compartments. In membranes purified from placental lysosomes, we identified 58 proteins, known to reside at least partially in the
Sneha Shah et al.
Genes & development, 28(3), 231-244 (2014-02-05)
Numerous noncoding transcripts of unknown function have recently been identified. In this study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1-repressing transcript) regulating expression of the pho1 gene. A product of this gene, Pho1
Youjun Zhang et al.
FEBS letters, 588(20), 3726-3731 (2014-09-01)
Changes in carbon flow and sink/source activities can affect floral, architectural, and reproductive traits of plants. In potato, overexpression (OE) of the purple acid phosphatase 2 of Arabidopsis (AtPAP2) resulted in earlier flowering, faster growth rate, increased tubers and tuber
Hao Yuan et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(4), 764-772 (2014-03-19)
In surgery-first accelerated orthognathic surgery, the clinical phenomenon of accelerated orthodontic tooth movement after osteotomy is a benefit compared with the conventional approach. However, because much of the literature on this phenomenon is based on empirical evidence and case reports
Aranganathan Shanmuganathan et al.
Protein expression and purification, 88(2), 196-200 (2013-01-15)
PAPf39 is a 39 residue peptide fragment from human prostatic acidic phosphatase that forms amyloid fibrils in semen. These fibrils have been implicated in facilitating HIV transmission. To enable structural studies of PAPf39 by NMR spectroscopy, efficient methods allowing the
Lynette C Foo et al.
Glia, 61(9), 1533-1541 (2013-07-10)
The metabolic enzyme for folate, Aldh1L1, has been shown to be expressed robustly in astrocytes of the brain. It is now well accepted that astrocytes in certain regions of the adult brain also serve as neural stem cells. Here, we
Norbert Sträter et al.
Journal of molecular biology, 351(1), 233-246 (2005-07-05)
The crystal structure of human purple acid phosphatase recombinantly expressed in Escherichia coli (rHPAP(Ec)) and Pichia pastoris (rHPAP(Pp)) has been determined in two different crystal forms, both at 2.2A resolution. In both cases, the enzyme crystallized in its oxidized (inactive)
E Stein et al.
Genes & development, 12(5), 667-678 (1998-04-16)
Eph family receptor tyrosine kinases (including EphA3, EphB4) direct pathfinding of neurons within migratory fields of cells expressing gradients of their membrane-bound ligands. Others (EphB1 and EphA2) direct vascular network assembly, affecting endothelial migration, capillary morphogenesis, and angiogenesis. To explore
A I Cassady et al.
Gene, 130(2), 201-207 (1993-08-25)
The gene (mT5AP) encoding murine type-5 acid phosphatase has been isolated and completely sequenced while the gene (hT5AP) encoding human T5AP has been partly sequenced. The murine gene spans 4 kb and contains five exons. Exon 1 is completely non-coding
V Ia Berezovs'kyĭ et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 47-51 (2013-07-05)
Our purpose was to investigate the oxygen partial pressure changes on the osteometric and biochemical markers of bone tissue in rats. It was shown that breathing of altered gas mixture did not change the mass, general length, sagittal diameter and
Minqi Li et al.
Histology and histopathology, 28(3), 327-335 (2013-01-26)
The purpose of this study was to examine histological alterations on osteoblasts from the alveolar bone of transgenic mice with targeted ablation of osteoctyes. Eighteen weeks-old transgenic mice based on the diphtheria toxin (DT) receptor-mediated cell knockout (TRECK) system were
Aline Heilmann et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(11), 1845-1850 (2013-07-03)
Sphingosine-1-phosphate (S1P) has recently been recognized as a crucial coupling molecule of osteoclast and osteoblast activity provoking osteoanabolic effects. Targeting S1P receptors could, therefore, be a potential strategy to support bone formation in osteopenic diseases or in fracture repair. Here
S G Gregory et al.
Nature, 441(7091), 315-321 (2006-05-20)
The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes
C M Ketcham et al.
The Journal of biological chemistry, 264(1), 557-563 (1989-01-05)
The type 5, iron-containing, tartrate-resistant acid phosphatase (TR-AP) constitutes a relatively minor intracellular isozyme of acid phosphatase in the human that is immunologically related to uteroferrin, a secreted progesterone-induced protein of the porcine uterus. Here, the purification of small amounts
Todd D Taylor et al.
Nature, 440(7083), 497-500 (2006-03-24)
Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were
T Yoneda et al.
Journal of dental research, 92(8), 735-739 (2013-05-23)
Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention of age-related inflammatory reactions. We examined the effects of topically applied rCoQ10 on
Masafumi Tomita et al.
Toxicology, 319, 63-68 (2014-03-04)
There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of
Weiqiang Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6040-6045 (2014-04-16)
Arthritogenic alphaviruses including Ross River virus (RRV), Sindbis virus, and chikungunya virus cause worldwide outbreaks of musculoskeletal disease. The ability of alphaviruses to induce bone pathologies remains poorly defined. Here we show that primary human osteoblasts (hOBs) can be productively
Suiyi Tan et al.
PloS one, 8(3), e59777-e59777 (2013-04-02)
Polyanionic candidate microbicides, including cellulose sulfate, carrageenan, PRO 2000, were proven ineffective in preventing HIV-1 transmission and even cellulose sulfate showed increased risk of HIV acquisition in the Phase III efficacy trials. Semen plays critical roles in HIV-1 sexual transmission.
S A Alfaqeeh et al.
Journal of dental research, 92(12), 1129-1135 (2013-10-25)
The tooth works as a functional unit with its surrounding bony socket, the alveolar bone. The growth of the tooth and alveolar bone is co-ordinated so that a studied distance always separates the 2, known as the tooth-bone interface (TBI).
Ryosuke Yamaguchi et al.
Rheumatology (Oxford, England), 53(12), 2191-2195 (2014-06-25)
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis
Patrick Hardinge et al.
Science & justice : journal of the Forensic Science Society, 53(1), 34-40 (2013-02-06)
The detection of semen in forensic science is essential in cases of sexual assault but can be problematic in the absence of spermatozoa. Choline is known to occur in high concentrations in seminal fluid and the Florence Iodine test for
Dongmei Xu et al.
Bulletin of environmental contamination and toxicology, 91(5), 577-582 (2013-09-27)
Fluorescence spectroscopy was used to study the quenching mechanism, the type of force and the binding sites of perfluorooctane sulfonate (PFOS) on wheat germ acid phosphatase (ACPase). The results showed that the quenching effect of PFOS on ACPase was mainly
P Tailor et al.
European journal of biochemistry, 262(2), 277-282 (1999-05-21)
The low molecular weight protein tyrosine phosphatase (LMPTP) is an 18-kDa enzyme that it distantly related to other protein tyrosine phosphatases. The single gene for LMPTP is known to undergo an alternative splicing event in which exon 3 or exon
L L Shekels et al.
Protein science : a publication of the Protein Society, 1(6), 710-721 (1992-06-01)
We have partially purified an 18-kDa cytoplasmic protein from 3T3-L1 cells, which dephosphorylates pNPP and the phosphorylated adipocyte lipid binding protein (ALBP), and have identified it by virtue of kinetic and immunological criteria as an acid phosphatase (EC 3.1.3.2). The
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