CN
Search Within
P4417
Applied Filters:
Keyword:'P4417'
Showing 1-30 of 274 results for "P4417" within Papers
Marta Ząbczyńska et al.
Biomolecules, 10(2) (2020-01-26)
Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in destruction of thyroid tissue in Hashimoto's thyroiditis (HT). N-glycosylation of the Fc fragment affects the effector functions of IgG by enhancing or suppressing the cytotoxicity effect. The aim of
Xu Chen et al.
International journal of biological macromolecules, 129, 433-441 (2019-02-05)
The objective of this study was to investigate the porcine pancreatic α-amylase (PPA) inhibitory activity of botanical food proteins, represented by soy protein isolate (SPI) and wheat gluten protein (WGP). The half maximal inhibitory concentration (IC50) was determined, and the
Purushothama Rao Tata et al.
Developmental cell, 44(6), 679-693 (2018-03-28)
We show that the loss or gain of transcription factor programs that govern embryonic cell-fate specification is associated with a form of tumor plasticity characterized by the acquisition of alternative cell fates normally characteristic of adjacent organs. In human non-small
Germana Cocozza et al.
Brain, behavior, and immunity, 73, 584-595 (2018-07-08)
Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration. Understanding the mechanisms leading to microglia activation in
Nicholas J Hunt et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(2), 278-285 (2019-06-15)
Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were
Wenwen Yu et al.
Food chemistry, 241, 493-501 (2017-09-30)
The conversion of barley starch to sugars is a complex enzymic process. Most previous work concerned the biotechnical aspect of in situ barley enzymes. However, the interactions among the macromolecular substrates and their effects on enzymic catalysis has been little
Marcelo Bueno Batista et al.
Nucleic acids research, 46(8), 3953-3966 (2018-03-13)
Bacteria adjust the composition of their electron transport chain (ETC) to efficiently adapt to oxygen gradients. This involves differential expression of various ETC components to optimize energy generation. In Herbaspirillum seropedicae, reprogramming of gene expression in response to oxygen availability
Agnieszka Kamińska et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
For this study, we tested and optimized silicon surface functionalization procedures for capturing urinary extracellular vesicles (uEVs). The influence of the silane type (APTES or GOPS) and protein concentration on the efficiency of uEVs binding was investigated. Human lactadherin protein
Fengbo Zhao et al.
Scientific reports, 10(1), 4197-4197 (2020-03-08)
Serum small extracellular vesicles (sEVs) have recently drawn considerable interest because of the diagnostic and therapeutic potential of their miRNAs content. However, the characteristics of human, mouse and rat serum sEVs and their differences in small RNA contents are still
Alex Burton et al.
Microsystems & nanoengineering, 7, 62-62 (2021-09-28)
Implantable deep brain stimulation (DBS) systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic pain. However, long-term efficacy of DBS is limited, and chronic neuroplastic changes and associated therapeutic mechanisms are not well understood. Fundamental
R Alvarez et al.
Journal of virology, 82(1), 471-486 (2007-10-19)
Understanding why human immunodeficiency virus (HIV) preferentially infects some CD4(+) CD45RO(+) memory T cells has implications for antiviral immunity and pathogenesis. We report that differential expression of a novel secreted factor, ps20, previously implicated in tissue remodeling, may underlie why
Pawan Kumar Raghav et al.
Life sciences, 214, 84-97 (2018-10-12)
The biological mechanisms underlying the effects of stem cell factor (SCF) and an inhibitor, NSC87877 (N) of the c-Kit negative regulator (SHP-1 and SHP-2) on cell proliferation are different. Therefore, we compared the cell's response to these two either alone
Hany Aly et al.
Journal of perinatal medicine, 47(4), 470-477 (2019-02-23)
Background The pathogenesis of bronchopulmonary dysplasia (BPD) includes arrest of alveolar septation and enhanced fibrosis. We hypothesized that mesenchymal stromal cells (MSC) and transforming growth factor-β1 (TGF-β1) in tracheal aspirates of mechanically ventilated premature infants differ in BPD and non-BPD
Stefano Garofalo et al.
Nature communications, 11(1), 1773-1773 (2020-04-15)
In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron (MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands on MNs. Using
Jingyu Yao et al.
Autophagy, 14(7), 1226-1238 (2018-06-27)
Mutations in the genes necessary for the structure and function of vertebrate photoreceptor cells are associated with multiple forms of inherited retinal degeneration. Mutations in the gene encoding RHO (rhodopsin) are a common cause of autosomal dominant retinitis pigmentosa (adRP)
Patricia A Trimmer et al.
Molecular neurodegeneration, 4, 26-26 (2009-06-19)
It has been hypothesized that reduced axonal transport contributes to the degeneration of neuronal processes in Parkinson's disease (PD). Mitochondria supply the adenosine triphosphate (ATP) needed to support axonal transport and contribute to many other cellular functions essential for the
Mehmet Erten et al.
Cytokine, 115, 116-120 (2018-11-28)
Myocardial infarction (MI) is one of the most important reason of mortality into worldwide. Visfatin is a novel adipokine which was reported increased in metabolic syndrome and obesity. Moreover, it is known that visfatin increases in aterosclerotic endotelial dysfunction. In
Riccardo Funari et al.
Biosensors & bioelectronics, 169, 112578-112578 (2020-09-11)
The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to active research in its associated diagnostics and medical treatments. While quantitative reverse transcription polymerase chain reaction (qRT-PCR) is the most reliable method to detect viral
Rebecca Soffe et al.
PloS one, 14(6), e0218102-e0218102 (2019-06-07)
Artificial surfaces are routinely used instead of leaves to enable a reductionist approach in phyllosphere microbiology, the study of microorganisms residing on plant leaf surfaces. Commonly used artificial surfaces include, flat surfaces, such as metal and nutrient agar, and microstructured
Campylobacter jejuni in penguins, Antarctica.
Petra Griekspoor et al.
Emerging infectious diseases, 15(5), 847-848 (2009-05-01)
Simon C Drew et al.
PloS one, 5(12), e15875-e15875 (2011-01-07)
The amyloid-β (Aβ) peptide is the primary component of the extracellular senile plaques characteristic of Alzheimer's disease (AD). The metals hypothesis implicates redox-active copper ions in the pathogenesis of AD and the Cu(2+) coordination of various Aβ peptides has been
Zahide Betül Gündüz et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 30(10), 1013-1023 (2021-09-13)
Ischemia-reperfusion models are used to evaluate treatment options that may minimize cellular damage after ischemia. To investigate the effects of amantadine and topiramate on apoptosis and cellular oxidative damage. This experiment was performed using 30 male Wistar albino rats. The
Riccardo Cristofani et al.
Autophagy, 13(8), 1280-1303 (2017-04-14)
Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent misfolded protein toxicity, cells activate a
Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation.
John Garner et al.
Journal of controlled release : official journal of the Controlled Release Society, 262, 201-211 (2017-07-29)
Tissue expansion is the process by which extra skin is generated using a device that applies pressure from underneath the skin. Over the course of weeks to months, stretching by this pressure creates a flap of extra tissue that can
Min Wang et al.
Journal of colloid and interface science, 445, 84-92 (2015-01-18)
Phospholipids fulfill an important role in joint lubrication. They, together with hyaluronan and glycoproteins, are the biolubricants that sustain low friction between cartilage surfaces bathed in synovial fluid. In this work we have investigated how the friction force and load
Luke J Tucker et al.
Marine drugs, 19(3) (2021-04-04)
Thermosensitive chitosan hydrogels-renewable, biocompatible materials-have many applications as injectable biomaterials for localized drug delivery in the treatment of a variety of diseases. To combat infections such as Staphylococcus aureus osteomyelitis, localized antibiotic delivery would allow for higher doses at the
Céline Robo et al.
Journal of the mechanical behavior of biomedical materials, 82, 70-76 (2018-03-24)
Vertebroplasty (VP) is a minimally invasive surgical procedure commonly used to relieve severe back pain associated with vertebral compression fractures. The poly(methyl methacrylate) bone cement used during this procedure is however presumed to facilitate the occurrence of additional fractures next
Francesco P Zummo et al.
Autophagy, 1-17 (2021-08-03)
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1
Jessie R Liu et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 66(9), 643-662 (2018-04-24)
The structure and functions of the extracellular matrix (ECM), its spatial distribution and pericellular association of ECM molecules remain poorly understood. Colocalization of ECM molecules with cell phenotypes through immunohistochemistry can provide crucial insights into their juxtacrine signaling role as
Nicholas James Strausfeld et al.
eLife, 9 (2020-03-04)
Descriptions of crustacean brains have focused mainly on three highly derived lineages of malacostracans: the reptantian infraorders represented by spiny lobsters, lobsters, and crayfish. Those descriptions advocate the view that dome- or cap-like neuropils, referred to as 'hemiellipsoid bodies,' are
Page 1 of 10