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Showing 1-30 of 190 results for "P4649" within Papers
William Parkinson et al.
Development (Cambridge, England), 140(24), 4970-4981 (2013-11-15)
Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most compromised N-glycosylation condition that survive long
Amaia M Arranz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6164-6176 (2014-05-03)
Hyaluronan (HA), a large anionic polysaccharide (glycosaminoglycan), is a major constituent of the extracellular matrix of the adult brain. To address its function, we examined the neurophysiology of knock-out mice deficient in hyaluronan synthase (Has) genes. Here we report that
B Burwinkel et al.
American journal of human genetics, 62(4), 785-791 (1998-06-13)
Deficiency of glycogen phosphorylase in the liver gives rise to glycogen-storage disease type VI (Hers disease; MIM 232700). We report the identification of the first mutations in PYGL, the gene encoding the liver isoform of glycogen phosphorylase, in three patients
Phosphorylase Is Regulated by Allosteric Interactions and Reversible Phosphorylation
Berg JM, et al.
Biochemistry (2011)
Trevor C Stevens et al.
American journal of physiology. Lung cellular and molecular physiology, 306(10), L915-L924 (2014-04-08)
Exoenzyme Y (ExoY) is a Pseudomonas aeruginosa toxin that is introduced into host cells through the type 3 secretion system (T3SS). Once inside the host cell cytoplasm, ExoY generates cyclic nucleotides that cause tau phosphorylation and microtubule breakdown. Microtubule breakdown
F A Gorin et al.
Journal of neurogenetics, 4(6), 293-308 (1987-12-01)
We have cloned the cDNA encoding human liver glycogen phosphorylase (glycogenosis type VI) from a fetal brain cDNA library. Liver(L) and muscle(M) phosphorylase cDNA probes were used to determine the relative abundance of mRNA encoding the L- and M-isozymes of
Toshio Ota et al.
Nature genetics, 36(1), 40-45 (2004-01-01)
As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to
Brian A Lewis et al.
The Journal of biological chemistry, 289(50), 34440-34448 (2014-10-23)
O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator. The enzymes of O-GlcNAc cycling, OGT and O-GlcNAcase, act in mitochondria, the cytoplasm
Erica W Taylor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(1), 10-21 (2014-01-02)
Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory. The post-translational addition and removal of O-linked β-N-acetylglucosamine (O-GlcNAc) also occurs on
Ting Wang et al.
Biochemical and biophysical research communications, 456(3), 821-826 (2014-12-17)
Here we show that d,l-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), a glycosphingolipid biosynthesis inhibitor, increases the sensitivity of pancreatic cancer cells to the novel MEK-ERK inhibitor AZD-6244. AZD-6244 and PDMP co-administration induced massive pancreatic cancer cell death and apoptosis, more potently than either drug
V L Rath et al.
Molecular cell, 6(1), 139-148 (2000-08-19)
Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate, which enters glycolysis to fulfill the energetic requirements of the organism. Maintaining control of blood glucose levels is critical in minimizing the debilitating effects of diabetes, making liver glycogen phosphorylase a
S Tsujino et al.
Muscle & nerve. Supplement, 3, S23-S27 (1995-01-01)
Glycogen phosphorylase catalyzes the first step of glycogen catabolism. Hereditary defects of muscle phosphorylase lead to a myopathy characterized by exercise intolerance, cramps, and myoglobinuria (McArdle's disease). We have identified ten mutations in the myophosphorylase gene in patients with McArdle's
John W Bullen et al.
The Journal of biological chemistry, 289(15), 10592-10606 (2014-02-25)
Nutrient-sensitive pathways regulate both O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK), cooperatively connecting metabolic homeostasis to regulation of numerous intracellular processes essential for life. Similar to phosphorylation, catalyzed by kinases such as AMPK, O-GlcNAcylation is a highly dynamic Ser/Thr-specific
Chengchao Xu et al.
Science (New York, N.Y.), 340(6135), 978-981 (2013-05-25)
Newly synthesized polypeptides fold and assemble with assistance from protein chaperones. Full maturation can take multiple attempts, exchanging chaperones at each round. Improperly folded molecules must exit folding cycles and be degraded. In the endoplasmic reticulum (ER), prolonged substrate cycling
Satoshi Yamasaki et al.
Annals of hematology, 94(1), 65-69 (2014-07-25)
The uridine diphosphate glucuronosyltransferase (UGT) gene 1A1*6 polymorphism, which affects irinotecan metabolism, has been associated with improved survival in lymphoma patients treated with of carboplatin, dexamethasone, etoposide and irinotecan (CDE-11). This study assessed the efficacy of CDE-11 relative to the
Bradley R Keel et al.
Tennessee medicine : journal of the Tennessee Medical Association, 106(10), 33-33 (2013-11-29)
McArdle's Disease is a rare glycogen disease involving deficiency in muscle phosphorylase. This deficiency can lead to rhabdomyolysis and subsequently renal failure. McArdle's Disease has a similar presentation as several other metabolic myopathies with exercise-induced fatigue, myalgias, weakness or unexplained
Takako Yoshida-Moriguchi et al.
Science (New York, N.Y.), 341(6148), 896-899 (2013-08-10)
Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine-β3-N-acetylglucosamine-β4-(phosphate-6-)mannose] is required for dystroglycan to bind laminin-G domain-containing extracellular proteins with high affinity in muscle and brain. However, the enzymes that produce this structure have not been fully elucidated. We found that glycosyltransferase-like domain-containing 2 (GTDC2)
Hideyuki Ihara et al.
Biochemical and biophysical research communications, 450(2), 953-960 (2014-06-29)
Although core α1,6-fucosylation is commonly observed in N-glycans of both vertebrates and invertebrates, the responsible enzyme, α1,6-fucosyltransferase, has been much less characterized in invertebrates compared to vertebrates. To investigate the functions of α1,6-fucosyltransferase in insects, we cloned the cDNA for
Joseph M Pickard et al.
Nature, 514(7524), 638-641 (2014-10-03)
Systemic infection induces conserved physiological responses that include both resistance and 'tolerance of infection' mechanisms. Temporary anorexia associated with an infection is often beneficial, reallocating energy from food foraging towards resistance to infection or depriving pathogens of nutrients. However, it
David A Baltzegar et al.
The Journal of endocrinology, 220(1), 61-72 (2013-11-07)
Osmoregulation is critical for survival in all vertebrates, yet the endocrine regulation of this metabolically expensive process is not fully understood. Specifically, the function of leptin in the regulation of energy expenditure in fishes, and among ectotherms, in general, remains
Kyu-pyo Kim et al.
Cancer chemotherapy and pharmacology, 71(6), 1609-1617 (2013-04-19)
UGT1A1 genotypes are important when considering treatment with irinotecan-containing regimens. In this study, we determined the dose, efficacy, and tolerability of irinotecan according to UGT1A1 genotypes when combined with capecitabine in patients with metastatic colorectal cancer. Patients with histologically confirmed
Thomas R Burkard et al.
BMC systems biology, 5, 17-17 (2011-01-29)
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties
Leena Rauhala et al.
The Journal of biological chemistry, 288(25), 17999-18012 (2013-05-07)
Hyaluronan, a major epidermal extracellular matrix component, responds strongly to different kinds of injuries. This also occurs by UV radiation, but the mechanisms involved are poorly understood. The effects of a single ultraviolet B (UVB) exposure on hyaluronan content and
Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells.
Chiu WH, Chen HH, Chang JY, et al.
Cancer Letters, 349(2), 144-151 (2014)
The Se(w) FUT2 mutation A385T does not result in a nonsecretor allele.
Stephen Henry
Transfusion, 54(12), 3255-3255 (2014-12-17)
[TET-OGT interaction potentiates transcription by regulating histone H3 methylation].
Benjamin Delatte
Medecine sciences : M/S, 30(6-7), 619-621 (2014-07-12)
Sung-Hoon Lee et al.
Archives of microbiology, 196(8), 601-609 (2014-06-13)
Dental caries is induced by oral biofilm containing Streptococcus mutans. Probiotic bacteria were mainly studied for effect on the gastrointestinal tract and have been known to promote human health. However, the information of probiotics for oral health has been lack
J Burke et al.
Proteins, 2(3), 177-187 (1987-01-01)
The intron/exon organization of the human gene for glycogen phosphorylase has been determined. The segments of the polypeptide chain that corresponds to the 19 exons of the gene are examined for relationships between the three-dimensional structure to the protein and
Christopher L Howerton et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9639-9644 (2014-07-01)
Maternal stress is a key risk factor in neurodevelopmental disorders, which often have a sex bias in severity and prevalence. We previously identified O-GlcNAc transferase (OGT) as a placental biomarker in our mouse model of early prenatal stress (EPS), where
Katsuyuki Imamura et al.
The Journal of biological chemistry, 289(14), 9865-9879 (2014-02-25)
Human immunodeficiency virus type 1 enhancer-binding protein 3 (Hivep3) suppresses osteoblast differentiation by inducing proteasomal degradation of the osteogenesis master regulator Runx2. In this study, we tested the possibility of cooperation of Hivep1, Hivep2, and Hivep3 in osteoblast and/or chondrocyte
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